A fast urban micro-meteorology model was developed to assess regional weather and human comfort index in the central Beijing region. The model captured fine spatial structures of wind, air temperature, humidity, and comfort index, revealing blockage effects on wind fields and sun lights.
Researchers developed an engineered artificial gene circuit device to modulate drug resistance in bladder cancer treatment. The device reduces resistance to vincristine by downregulating the drug-resistant gene OIP5 and blocking other NF-κB-mediated pathways.
Researchers found that actual land cover changes affect surface temperatures differently across latitudes, with warming effects occurring more frequently and strongly than cooling effects. Global temperature increases due to LCCs accounted for up to 44.6% of overall concurrent warming.
Scientists successfully crystallized –COOH-functionalized gold nanoclusters using a novel biomimetic approach, revealing their crystallographic structure and paving the way for investigating their properties. The breakthrough method has broad implications for fields like chemosensing, biosensing, and materials science.
Researchers developed an accurate error prediction model and implemented soft-decision decoding to overcome limitations in hard-decision decoding, extending the upper limit of error correction to infinity.
The researchers developed an innovative approach to identify disease-causal microbes, controlling confounding factors and achieving high significance in statistical tests. VTwins significantly reduces the required sample size for identifying disease-associated microbial features.
A new Early Jurassic sauropodomorph dinosaur, Qianlong, contains three skeletons and five egg clutches, displaying leathery eggshell microstructures similar to other Cretaceous dinosaur eggs. The study suggests that the first dinosaur eggs were leathery, contradicting previous theories of soft or hard-shelled eggs.
The paper proposes an adaptive representation model for geoscience knowledge graphs that can efficiently represent complex spatiotemporal features and relationships. The model uses a unified spatiotemporal ontology to automatically adopt an adaptive tuple structure based on the association of spatiotemporal information.
Research finds that rainfall in southern China can trigger the formation of an anticyclonic anomaly over the Pacific Northwest, intensifying haze in the North China Plain. The study suggests a 27% contribution of rainfall to haze development, highlighting the need for closer monitoring of synchronized dynamics.
China's total N2O emissions increased from 889.6 Gg yr-1 in 1980 to 2295.0 Gg yr-1 in 2020, with agriculture making the largest contribution until 2015. However, industrial and energetic sources exceeded agriculture and became the fastest-accelerating N2O sources due to increasing demand for adipic acid and fossil fuels.
Researchers developed a new hydrogen therapy strategy using solid-state atomic hydrogen, which selectively eliminates reactive oxygen and nitrogen species. This approach promotes wound healing in diabetic wounds by remodeling the microenvironment and alleviating inflammation.
A recent study investigated sporadic early-onset Alzheimer's disease (EOAD), focusing on its clinical features and biomarkers. EOAD patients were found to have more severe executive function deficits, bilateral precuneus atrophy, and elevated phosphorylated tau protein levels compared to late-onset AD patients.
The research highlights the need for improved disaster prevention strategies in response to droughts and floods on the Qinghai-Tibet Plateau. The team proposed a method for predicting and warning of these events, as well as a technical framework for identifying risk-blocking points and adaptive regulation.
Researchers developed stable Lipiodol-drug emulsion with sustainable drug release profiles to improve HCC treatment. The novel microreactor enabled effective induction of ferroptosis in cancer cells via a pH-responsive mechanism, showing promise for transarterial embolization therapy.
Researchers successfully synthesized Chromene derivatives with AIE characteristics in an aqueous micellar system, exhibiting regiostructure-dependent fluorescence. The compounds were found to have potential for ER-specific imaging and modulating cell viability through substituent alteration.
This study uses genetic lineage tracing to investigate the adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes. The results show that β-cells expand through self-replication and rarely trans-differentiate into α or δ cells in young mice, but recover β-cell identity after remarkable dedifferentiation in o...
Research reveals GPCR signaling plays a crucial role in the immune microenvironment of EBV-induced cancers, influencing tumor growth and immune phenotypes. CCR1, a key GPCR, regulates EBV DNA replication, gene expression, and immune checkpoint activation.
A study on rhesus macaques found that spontaneous pelvic organ prolapse (POP) shares similar histological changes with human POP. The research also identified conserved molecular pathways underlying the disease, including ECM dysregulation and immune disorder.
This study tracks rural settlements' spatiotemporal regularity driven by rapid urbanization, revealing slower growth and widening differences. The analysis reveals uneven spatial distribution, with most counties experiencing a 'Convex-I' change type, often far from urban zones.
Researchers leverage neutron imaging to analyze lithium battery evolution, revealing in-depth insights into electrode composition and internal reactions. This technology helps address pressing issues like energy density and safety concerns.
Researchers developed non-planar dielectrics to harness weather-adaptive environmental energy, increasing pyroelectricity and triboelectric output. The new materials improve efficiency without consuming additional energy sources.
The CR-hvKP pathogen is simultaneously multidrug-resistant, highly virulent, and highly transmissible, posing a significant public health challenge. It has been reported in Asian clinical settings, with China being particularly affected.
A team proposes detecting deci-Hertz gravitational waves on the Moon's surface using an array of small laser interferometric seismometers. The experiment aims to observe changes in the Moon's shape and position caused by passing GWs, filling a gap in the GW spectrum covered by existing detectors.
Researchers generated a comprehensive single-cell atlas of postnatal liver development in pigs, uncovering 23 cell types and their dynamic changes. The study highlights the critical role of lymphoid cells in immune function and identifies key transcription factors regulating liver metabolism.
The study estimates a global lifetime cancer risk of 25.10%, with significant differences between countries and regions, as well as between men and women.
Oceanic lithosphere is hydrated through two stages: initial hydration at mid-ocean ridges and secondary hydration at subduction zones. The study found that subduction-related process contributes to most of the mantle hydration, playing a crucial role in plate tectonics and Earth's water cycle
Researchers developed a method to produce highly strong and tough silk by feeding silkworms with rare earth ion-modified diets. The incorporated ions enhance mechanical performance through chemical interactions.
The study revealed that PvrA binds simultaneously to multiple pseudo-palindromic sites for efficient transcription activation, enabling P. aeruginosa to adapt to environmental stress and exhibit increased virulence. This unique regulatory mechanism provides new insights into the structure-function relationship of TetR family regulators.
Scientists create nanoreactor catalyst that significantly improves hydrogenation performance through reactant enrichment. The catalyst, Pt NPs@MnOx, exhibits high catalytic activities and selectivity in various reaction conditions.
Researchers developed a quasi-eutectic electrolyte to regulate the manganese cathode interface in zinc-manganese batteries. The electrolyte increases electrode potential and limits desolvation of zinc ions, resulting in improved stable kinetics during cycling. This leads to higher capacity retention rate, lower voltage polarization, an...
This paper surveys chip design with ML algorithms from an algorithmic perspective, proposing a novel taxonomy for target problems. The authors classify problems into regression, search, and generation problems, and discuss existing works in terms of these problems and corresponding ML algorithms.
A new study prioritizes risk genes at CRC GWAS loci by integrating multi-omics data, identifying 105 high-risk genes. These genes are associated with characteristics of CRC risk genes and are essential for CRC cell growth. The study suggests that integrating multi-omics data can propose candidate risk genes with high confidence.
Researchers developed a new method to improve air quality models by assimilating sulphate reaction rates. This approach resulted in improved accuracy, reducing mean bias for SO4^2− and SO2 concentrations from -13.1 μg/m^3 to 3.5 μg/m^3 and 17.0 μg/m^3 to 6.3 μg/m^3 respectively.
Researchers create angstrom-scale pores in graphene sheets to replicate biological K+ /Na+ selectivity, achieving up to 1295-fold ratio. The design enables new applications like harvesting ionic power and biomimetic devices for water purification and chemical separation.
Researchers developed a novel sparse SAR unambiguous imaging method using mixed-norm optimization to improve image quality and suppress azimuth ambiguity. The proposed method outperforms existing methods in suppressing azimuth ambiguity and obtaining high-quality images, especially for large-scale scenes.
This study found that integrated rice-crayfish farming resulted in significant trade-offs in soil biodiversity, leading to increased supporting services but reduced regulating capacity. The findings highlight the need for attention on environmental risks for long-term sustainability of these systems.
A study investigates lactic acid bacteria diversity and ecological drivers in naturally fermented milk. Researchers found high intra-species genomic and functional gene diversity, with extensive horizontal gene transfer events and a link to microbial composition.
Mei-yu precipitation has become more unstable and extreme due to global warming, leading to increased days without rainfall and intense rainfall events. The research suggests that decreased relative humidity and stronger water vapor transport contribute to these changes.
Researchers developed bifunctional COFs for co-electrolysis of CO2 and methanol, showing excellent activity and long-term stability. The synthesis method is green and efficient, making it a promising strategy for reducing CO2 emissions and producing useful energy fuels.
A new approach is introduced for optimal long-term array design, reducing uncertainty in ENSO predictions and improving their accuracy and reliability. The proposed method will be widely used in establishing stationary observation networks.
A new catalyst, Pt@Beta, combines platinum nanoparticles with sodium ions in beta zeolites to improve n-alkylation of amines with aromatic alcohols. The catalyst achieved high conversion numbers and stability, revealing a synergistic effect that balances dehydrogenation and hydrogen transfer.
Researchers have discovered a special 'herringbone' stacking mode that enables abundant weak interactions between organic ligands and metal halide units, resulting in ultra-long triplet phosphorescent emission. The material also demonstrates potential for information encryption and has excellent air stability.
The study found that the 9-valent HPV vaccine candidate was well-tolerated and immunogenic, with all participants seroconverting to antibodies against HPV types. The vaccine's robustness and low cost make it an attractive option for national immunization programs in countries with limited resources.
Researchers identified key regulatory mechanisms and cell types in follicle development, finding a critical role for FOXO1 in mediating differences between obese mice. Alterations were also seen in extrafollicular cells, including tumor-like cells, which warrant attention given obesity's link to ovarian cancer.
Researchers discovered that bright light treatment activates neurons in the lateral habenula, reducing aversive emotional states and preventing cocaine-driven reinstatement. The study suggests a promising avenue for light-based therapy in treating drug addiction.
Research reveals nitrogen enrichment slows onset of aridity threshold, increasing plant biomass and delaying ecosystem decay. This finding has implications for predicting vegetation responses to climate change.
Scientists designed an mRNA nanovaccine using machine learning to overcome delivery barriers, promoting strong immune responses and activating the STING pathway to kill tumor cells. The therapeutic strategy demonstrated stronger anti-tumor effects in melanoma and colorectal cancer models.
The study found that organic nitrogen aerosols are a crucial external source of nitrogen to ecosystems worldwide, particularly in the Arctic Ocean and boreal forests. Global warming is expected to increase ON aerosol depositions, highlighting the need for further research on their environmental impacts.
Researchers have successfully developed an optical probe to measure local chemical pressure, which can simulate the effects of physical pressure. The approach involves using a site-selective optical probe to detect changes in emission peaks, reflecting the pressure experienced by a polyhedral motif.
Researchers identified 24 genetic loci under recent selection in Han Chinese, including a risk allele for systemic lupus erythematosus that may have improved survival in extreme environments. The study also found novel genes related to alcohol metabolism and olfactory perception under selection.