The ENCIRCLE trial found that the SAPIEN M3 system significantly reduced mitral regurgitation severity, improved heart failure symptoms, and quality of life for patients with severe mitral regurgitation. Over 95% of patients had little-to-no valve leakage at one year.
Researchers at Sutter's California Pacific Medical Center have identified potential new therapeutic strategies for patients with advanced melanoma who no longer respond to immunotherapy. The study found several druggable genes and pathways, including those involved in MAPK signaling, angiogenesis, and apoptosis.
A landmark review in JAMA calls for a shift in medical thinking to target the biology of aging itself. Geroscience aims to extend healthspan by delaying or preventing multiple conditions at once.
Researchers at Sutter Health tested the performance of the American Heart Association's PREVENT equations in diverse Asian and Hispanic subgroups, showing accurate prediction of cardiovascular disease, atherosclerotic CVD, and heart failure events. The study findings aim to improve cardiovascular healthcare for all populations.
Researchers at Sutter Health have discovered early signs of clinical benefit from niraparib, a PARP inhibitor, in patients with advanced melanoma whose tumors had specific genetic changes impacting DNA repair. The study found a disease control rate of 64% and potential as a biomarker for treatment response.
A Sutter Health study found that an ambient AI platform reduced clinical documentation time and improved clinician satisfaction. The technology also enhanced patient care experiences, with clinicians spending more time listening to patients during appointments.
Researchers developed a new technique using indocyanine green-soaked fiducial markers (ICG-F) to mark peripheral pulmonary lesions before surgery. The study found that this approach improved the accuracy of surgical resection, resulting in smaller and lighter resected specimens compared to unmarked lesions.
Researchers have discovered novel molecular pathways that may be selected for in the metastatic cascade, contributing to our understanding of clonal evolution of melanoma distant metastasis. The study found enrichment of PI3K and MITF pathways in the transition through the metastatic cascade.
A new patient-centered approach identifies melanoma patients most likely to benefit from sentinel lymph node biopsy, offering a more accurate and cost-effective method for selecting patients. The study found that adopting a 10% cutoff for positivity rates could help identify patients best eligible for the procedure.
A new study published in the Journal of the American Geriatrics Society found that higher red blood cell distribution width is associated with increased rates of in-hospital mortality and hospital re-admission among older patients. The study included 94,617 patients aged over 60 who were hospitalized between 2013 and 2017.
A new study published in the Journal of Bone and Mineral Research has found that older men with lower amounts of muscle mass have a significantly increased risk of hip and potentially other fractures. The study, led by investigators at Sutter Health's San Francisco Coordinating Center, used a new measure of muscle mass called D3Cr to e...
Pre-clinical study finds NCOA3 activation contributes to melanoma development after exposure to ultraviolet light, promoting survival advantage and accumulation of DNA damage. A single nucleotide polymorphism in NCOA3 decreases protein production, increasing sensitivity to UV-mediated cell death.
Researchers discovered that PHIP protein resides at the leading edge of GBM cells, enabling other adhesion proteins to deepen the grip of cancerous cells on healthy brain tissue. Suppressing PHIP helped inactivate proteins that form the machinery for tumor cell movement, driving aggressive behavior.