Scientists from Tokyo University of Science have discovered exactly how cell-free DNA (cfDNA) is generated, revealing its crucial role in tumor progression. The study's findings suggest that cfDNA can be targeted using DNase1L3, a novel molecule to prevent tumor metastasis and thrombosis.
Researchers at Tokyo University of Science discover that the anticonvulsant drug papaverine blocks the binding of high-mobility group box 1 (HMGB1) to its receptor, reducing inflammation in sepsis and cancer. The study uses a novel computer-based docking approach to find alternative uses for existing drugs.
Researchers from Tokyo University of Science demonstrate the molecular basis of chloramphenicol's adverse effects on eukaryotic cells. They found that the antibiotic targets appressorium formation in the rice blast fungus, which is critical for its infection cycle.
Researchers study thiolate-protected gold-silver alloys, revealing intra-cluster and inter-cluster metal exchange that affects cluster stability and geometric structure. This understanding is crucial for harnessing novel physical and chemical properties of these clusters.
Researchers at Tokyo University of Science develop novel technique to grow single crystals of IGZO-11 semiconductor. The material exhibits high conductivity, transparency, and optical band gap, making it suitable for optoelectronic devices.
Researchers at Tokyo University of Science have made significant breakthroughs in human body communication (HBC), which uses the human body as a network to transfer information. By analyzing the characteristics of impedance and electrodes, they found that HBC can be used to design more efficient devices with better user interaction.
A novel enzyme from a soil fungus breaks down β-1,2-glucan into sophorose, revealing its potential role in the symbiosis of bacteria and plants. The discovery sheds new light on the diversity of glycoside hydrolases and their applications.
Researchers from Tokyo University of Science develop novel CRISPR/Cas9 strategies for gene disruption and introduction in filamentous fungi. Single-step gene targeting with short homologous sequences and bypassing PAM requirements enhance efficiency and speed.
Researchers at Tokyo University of Science developed a novel rock salt for use in rechargeable magnesium batteries, offering promising results as a cathode material. The synthesized rock salt shows excellent potential for use as the positive electrode material.
The researchers developed a method for identifying the location of point-like scatterers based on fluctuations in physical properties, such as Lame parameters and mass density. This technique can improve tomography efficiency for seismic and electromagnetic exploration in geophysics and nondestructive testing of materials.
Scientists discovered a giant virus, Medusavirus, that turns amoebas into stone-like cysts and harbors ancient proteins crucial to eukaryotic life. This finding suggests a possible relationship between the virus and the emergence of complex life.
Researchers at Tokyo University of Science have discovered a demethylase enzyme that primes gene expression in plants, allowing them to regenerate tissues. This breakthrough could lead to faster and more efficient food production, helping to address global hunger.