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University of Rochester


Many common drugs promote tooth decay

Studies found that medications like clonidine and propranolol can significantly increase the risk of tooth decay in individuals with dry mouth. The research suggests that antihistamines, antidepressants, and other medications can alter saliva composition, making it less effective at neutralizing acids and remineralizing teeth.

SourceUniversity of Rochester·JournalCaries Research·DateMay 25, 2000

Nature's cycles in a fractal state of mind

Scientists Yonathan Shapir and Jacob Jorné discovered that natural cycles generate fractal patterns, governing everything from weather to cauliflower heads. This breakthrough enables the prediction of events like car battery lifespan, lawn growth, and tumor cell behavior, with potential applications in engineering and medicine.

SourceUniversity of Rochester·JournalPhysical Review Letters·DateApr 16, 2000

Exploiting evolution to treat prostate cancer

Scientists at the University of Rochester Medical Center are exploring the use of genetic algorithms to treat prostate cancer by improving how radiation is delivered. The formulas have been developed by medical physicist Yan Yu, Ph.D., who heads a task force on the subject for the American Association of Physicists in Medicine.

Scientists target microbe with sleeker antisense agent

Researchers at the University of Rochester have created a remarkably short antisense compound that targets Pneumocystis carinii, an opportunistic pathogen causing pneumonia in people with weakened immune systems. The breakthrough marks a step toward designing drugs that knock out vital sections of molecules essential for the microbe's ...

SourceUniversity of Rochester·JournalProceedings of the National Academy of Sciences·DateJun 25, 1999

For DNA, it's all about fitting in

Scientists at the University of Rochester have discovered that shape plays a crucial role in copying DNA, contradicting previous theories that relied on hydrogen bonds. This finding has significant implications for cancer diagnosis and potential applications in artificial DNA creation.

SourceUniversity of Rochester·JournalNature·DateJun 16, 1999

The Best Molecular Snapshot Yet Of Cells Affected By Alzheimer's Disease

A University of Rochester team has developed a technology that provides the most thorough information yet on cells from the brains of deceased Alzheimer's patients, enabling comparison with healthy and sick cells. The study identified five genes whose expression differed significantly between healthy and Alzheimer's brains.

SourceUniversity of Rochester·JournalProceedings of the National Academy of Sciences·DateAug 3, 1998

Chemist Turns To Self-Assembly To Create New Drugs

Chemist Benjamin Miller has devised a way to create new drugs by using metal atoms to assemble countless combinations of molecules, then selecting the best candidates through a Darwinian process. This method shifts the burden of tedious drug development work off technicians' shoulders, offering a faster and more efficient approach.

SourceUniversity of Rochester·JournalTetrahedron Letters·DateFeb 26, 1998