Researchers are launching a clinical trial testing azeliragon, a RAGE inhibitor, with chemoradiotherapy to re-sensitize brain tumours that resist radiotherapy. The trial aims to predict radioresistance in brain metastasis using liquid biopsy.
Researchers discovered a biomarker, S100A9, that correlates with radiotherapy response in brain cancer patients. A new drug, RAGE inhibitor, can reverse resistance to radiotherapy by targeting this mechanism.
Researchers have identified a genetic signature of 27 microorganisms in stool samples that can predict the risk of pancreatic ductal adenocarcinoma and diagnose patients with earlier stages of the disease. This breakthrough could lead to an effective, non-invasive way to detect pancreatic cancer early.
Researchers at Barts Cancer Institute made a breakthrough finding that blocking PKN2 in healthy cells around tumours can change their behavior, potentially leading to new treatments for pancreatic cancer. Fibroblasts, highly mobile and invasive cells, may play both positive and negative roles in cancer progression.
Researchers have discovered a protein called CPEB4 that plays a key role in diet-induced obesity. Blocking CPEB4 expression in mice protected them from weight gain, inflammation, and improved their microbiome health. The findings could lead to new treatments for diet-induced obesity and its associated cancer risks.
Researchers discovered palmitic acid promotes metastasis in oral carcinomas and melanoma skin cancer, with epigenetic changes allowing cancer cells to communicate and spread. New therapies targeting this process are being developed, with a clinical trial expected to start in the next couple of years.
Researchers at University College London Great Ormond Street Institute of Child Heath have developed a new way to deliver drugs that can shut down cancer-promoting mutations in neuroblastoma. The nanoparticle-based treatment successfully silenced the MYCN gene, causing tumours to grow at a slower pace and prolonging survival.
A new study published in Nature reveals that a commonly used psychiatric drug can boost the fitness of healthy gut stem cells, making them more resistant to cancer. A clinical trial is now underway to investigate whether lithium can prevent bowel cancer in individuals with familial adenomatous polyposis (FAP).
A recent study has shown a significant decline in funding for discovery cancer research since 2006, with the percentage of annual funding falling by around a quarter. Worldwide Cancer Research is urging continued support for this type of research to develop new cancer cures.
Researchers have discovered that Netrin-G1 helps pancreatic cancer cells survive by protecting them from the immune system and supplying them with nutrients. The study found that an antibody targeting Netrin-G1 was able to stunt tumor development in mice, demonstrating its potential as a new treatment.
Researchers have discovered a new drug, FL118, that effectively treats and reverses treatment resistance in advanced multiple myeloma. The drug has shown promise in treating cancer cells from both newly diagnosed and relapsed or treatment-resistant patients.
Scientists have developed a new class of drug that blocks the APOBEC3B enzyme in cancer cells, which is responsible for treatment resistance. This discovery has the potential to support existing cancer therapies and make treatments more effective by targeting cancer evolution.
A study found that female mice replace their entire set of hormone-producing cells within 3 months, while it takes male mice 9 months. This sex-specific difference could lead to sex-specific treatments for diseases like adrenal cancer.