Ten Yale researchers have been named AAAS Fellows in recognition of their distinguished efforts to advance science, including Paul Anastas and Sankar Ghosh. The new fellows will be inducted at the 2008 AAAS Annual Meeting.
The Yale School of Medicine researchers are studying how cancer cells mend their own chromosomes and DNA after damage caused by radiation and chemotherapy. They hope to create an 'Achilles heel' for cancer cells that would make them more vulnerable to traditional cancer therapies.
Researchers at Yale University's Stem Cell Center discovered piRNAs, a recently identified class of tiny RNAs, play a crucial role in regulating gene function and stem cell fate. The study found over 13,000 piRNAs in fruit flies, revealing their importance in controlling chromatin and gene expression.
Researchers identified a 41-gene signature in blood cells that distinguishes TAA patients from those without the disease with accuracy rates of 78-85%, paving the way for new detection and treatment methods.
A study by Yale School of Medicine researchers found that 80% of participants who 'heard' phrases in length developed a schizophrenia-related illness. The finding suggests an early warning sign for the condition, which could be identified through inexpensive preventive drug therapy.
David Spiegel, a Yale chemist, has received a $1.5 million NIH Director's New Innovator Award to develop a 'rational' approach for using antibodies to target various cells and diseases. He aims to design DNP-compounds that recognize pathogens and attract anti-DNP antibodies, destroying diseased cells.
Fedorov's work focuses on understanding abrupt climate changes, including simulations of sudden climate change and investigation into permanent El Niño-like conditions. His research has significant social importance, with potential consequences for global ecosystems and economies.
Researchers at Yale University discovered that Legionella proteins work together to survive by hijacking cellular compartments. The bacteria manipulate macrophages to transport them to nutrient-rich organelles, where they replicate in high numbers.
Researchers at Yale University have discovered a massive stellar black hole, located in a distant galaxy, which challenges the current understanding of how these objects form. The black hole has a mass of 15.65 times that of the sun and was detected using precise measurements of its gravitational effects on nearby stars.
A new study found that when one spouse improves their health behavior, the other is also more likely to do so, particularly in behaviors like smoking and drinking. This phenomenon suggests that interventions targeting spouses can be an effective way to promote healthy habits.
A Yale University study found that structural changes to the human genome, including missing or rearranged segments, contribute to individual differences. These variations were identified using Paired-End Mapping and rapid sequencing methods.
Researchers at Yale have made two major breakthroughs in advancing quantum computing, enabling the transfer of information between distant qubits and paving the way for more complex quantum computers. By developing a superconducting communication 'bus,' they can now store and transfer information efficiently between qubits on a chip.
Researchers found that SWCNTs can kill bacteria like E. coli by severely damaging their cell walls, and this effect is only seen when there is direct contact between the nanotubes and the bacteria.
Yale researchers found that gene regulation plays a crucial role in shaping differences between species. By mapping DNA binding sites and analyzing regulatory regions, they discovered functional differences in yeast species, shedding light on the balance between gene content and regulation.
A recent Yale University study found that 16% of chronically ill elderly patients refuse recommended medical and surgical interventions. The most frequently refused treatments were cardiac catheterization and surgery, with a combined refusal rate over 10%. Patients who refused treatments often cited fear of side effects as the primary ...
Astronomers have witnessed the rare sight of four galaxies crashing into each other, kicking up billions of stars and forming a single, massive galaxy. The merger, observed using NASA's Spitzer Space Telescope and WIYN Telescope, provides unprecedented insight into how the most massive galaxies in the universe form.
A study published in The American Journal of Medicine found that emergency angioplasty use has increased, but 10% of eligible patients are still going untreated for life-saving treatment after a heart attack. Patients without typical symptoms or from underrepresented groups are most likely to miss out on this critical care.
A Yale University study published in Archives of Internal Medicine found that top-ranked hospitals may not necessarily provide better care for heart attack patients. The research compared death rates among patients treated at both ranked and non-ranked hospitals, revealing a surprising disparity between the two groups.
A Yale-developed weight management program cut diabetes risk and improved BMI in overweight children by increasing insulin sensitivity and reducing body fat. The Bright Bodies program, which combined nutrition education, behavior modification, and exercise, was more effective than traditional clinic-based counseling.
Researchers used genome sequencing to detect rare viral mutations and found that low-frequency resistant HIV strains can lead to premature therapy failure. The study aimed to determine if patients who fail treatment early were initially infected with drug-resistant strains.
A special issue of Yale's Journal of Industrial Ecology explores the global impact of cities, showcasing their role in driving environmental changes. The study reveals that cities produce greenhouse gases with worldwide effects and stimulate resource extraction beyond city borders.
A team of Yale chemists is working on converting sunlight into chemical fuels with the goal of increasing the nation's energy supply. They are part of a $12.8 million initiative funded by the US Department of Energy to develop efficient photocatalytic cells for water cleavage with visible-light power.
Researchers from Yale University and others report that injecting human neural stem cells into primates with severe Parkinson's disease improved symptoms such as tremors and motor function. The study found that the stem cells survived, migrated, and had a functional impact, suggesting a potential therapeutic value.
A Yale University study found that limiting medical residents to 80-hour workweeks improved patient care by reducing transfers to intensive care and minimizing medication errors. More patients were discharged home or to rehabilitation centers instead of nursing homes.
A new study finds that the TRPM8 ion channel plays a crucial role in detecting cold temperatures by activating neural impulses. The research suggests that TRPM8 is not the sole receptor responsible for detecting extreme cold, indicating possible alternative pathways.
Researchers at Yale University have identified a new regulatory target for the Fragile X mental retardation protein (FMRP), which may lead to new treatments for Fragile X syndrome. The study also found implications for autism, as both conditions share common physiological pathways.
A study at Yale University found that older drivers who underwent a physical conditioning program showed improved driving performance, including reduced critical errors. The program, led by researchers, aimed to enhance flexibility, coordination, and speed of movement relevant to driving.
Toddlers with ASD show unusual attention patterns when viewing faces, spending more time on eyes than other features. They have difficulty recognizing familiar faces, but exhibit improved performance when adopting typical facial scanning patterns.
A new protein fragment called pHLIP has been demonstrated to target and accumulate in human breast tumors, enabling detection and potentially treating cancer. The protein's ability to navigate acidic environments makes it a promising tool for detecting various disease states.
Researchers at Yale University have identified a tortoise with half its genes in common with Lonesome George, the famous Galápagos tortoise. The discovery raises hopes for a conservation success story and potentially sets up a captive breeding program to recover the species.
A study of female waterfowl reproductive tracts reveals two unexpected structures that may be designed to selectively exclude the male phallus. The findings suggest a dynamic co-evolution between male and female genitalia in response to sperm competition and forced copulations.
Thomas Steitz received the 2007 Gairdner International Award for his work on the structure and function of the large subunit of the ribosome, which has led to a better understanding of human disease and the development of new antibiotics. His research has also highlighted the importance of basic discoveries in medical science.
Researchers at Yale University have discovered a molecular mechanism that dynamically alters brain network connections, influencing working memory and cognitive function. Closing ion channels can strengthen connectivity, improving working memory and reducing distractibility.
A study by Yale School of Medicine researchers found that cigarette smoking status can be used as a clinical indicator for alcohol misuse, which presents an opportunity for intervention. Non-daily smokers are five times more likely to have a problem with alcohol compared to people who have never smoked.
Researchers find that shared protons vibrate between molecules as local oscillators, creating distinct vibrational patterns associated with the bridging proton. The study reveals how the chemical properties of tethered molecules affect proton localization.
The MiniBooNE experiment has confirmed the behavior of neutrinos, clarifying their fundamental properties. The study ruled out the presence of a fourth, 'sterile' type of neutrino, which was initially suggested by earlier experiments like LSND.
Researchers at Yale and Wesleyan Universities have found that the sensitivity of Earth's climate to changes in carbon dioxide has been consistent for 420 million years. The study confirms that each doubling of atmospheric CO2 translates to an average global temperature increase of about 3° Celsius.
Alan Garen and Zhiwei Hu have developed a way to target and destroy tumor blood vessels using nanoparticles. The technology uses a synthetic gene that activates an immune response, allowing for selective destruction of tumors while leaving normal tissue unharmed.
Preeclampsia researchers found specific proteins in placentas that damage maternal blood vessels, including plasminogen activator inhibitor-1 and soluble Flt-1. Microparticles from the placenta contain high levels of a mysterious protein with unknown function.
Researchers at Yale University developed a new procedure to estimate individual embryo reproductive potential, potentially reducing multiple births. The method uses proton NMR spectroscopy to analyze metabolic profiles of embryos, correlating with pregnancy outcomes.
Researchers at Yale University have discovered four genetic variants associated with spontaneous preterm birth in Hispanic women. The study found that mothers carrying these polymorphisms were significantly more likely to experience preterm birth. Notably, the ENPP1 variant was linked to the highest risk of preterm birth.
Researchers will collect DNA samples from 3,000 autism patients to identify variants and develop treatments. The project will advance knowledge on subtypes of autism, promoting targeted therapies.
A recent study found that financial constraints hinder heart attack patients from seeking healthcare services or taking vital medications, resulting in poorer health outcomes. Patients with unaffordable medications had a 50% higher chance of being re-hospitalized for cardiac conditions.
Researchers at Yale University identified a potential autism gene through a global genome scan involving 120 scientists from 50 institutions. The study found two genes linked to autism: neurexin 1 and a gene on chromosome 11, which may contribute to the disorder's susceptibility.
Researchers at Yale University have identified triptolide, a compound from Traditional Chinese Medicines, as a potential drug for treating polycystic kidney disease. The study shows that triptolide causes cell growth arrest and reduces cyst formation in mouse models of the disease.
Researchers at Yale University identified a rare defect in the LRP6 gene, which alters Wnt signaling activity and contributes to cardiovascular disease. The study highlights a new approach to improving health by targeting this pathway.
Researchers at Yale University discovered that ice sheets sometimes mesh together when colliding, forming a series of interlocking blocks dubbed finger rafting. This curiosity has puzzled scientists for over 50 years.
Researchers at Yale University and the University of Leicester have discovered an ancient solar observatory at Chankillo, Peru, dating back to the 4th century B.C. The site features a line of 13 towers aligned with the sun's position throughout the year, making it the oldest complete solar observatory in the Americas.
Researchers at Yale University have identified key virulence genes in A. baumannii bacteria, which cause highly resistant infections in combat troops. The study's findings suggest new targets for antimicrobial drugs and provide insight into the evolution of bacterial virulence.
Frank Slack studies genetic switches controlling development and aging, while Sandra Wolin investigates RNA damage contributing to senescence and neurodegenerative diseases. Both researchers aim to improve understanding of aging processes.