Articles tagged with Talens
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have developed chicken eggs without the protein that causes egg white allergies, confirming their safety profile. The modified eggs, called OVM-knockout, were tested and found to be free from ovomucoid proteins, making them a potential solution for individuals with egg allergies.
Scientists have discovered the orf137 gene responsible for male sterility in tomato plants, enabling the development of an efficient F1 hybrid breeding system. The study also demonstrates targeted mutagenesis and homologous recombination mechanisms underlying this trait.
Researchers have discovered that TALEN is up to five times more efficient than CRISPR-Cas9 in targeting densely packed DNA regions, including those causing fragile X syndrome and sickle cell anemia. This breakthrough adds to the need for a broader selection of genome-editing tools to target all parts of the genome.
Researchers at Johns Hopkins Medicine have successfully used CRISPR to precisely and efficiently alter human stem cells, showcasing its potential for treatment and disease research. The findings suggest that CRISPR may be a useful tool for editing genes in human-induced pluripotent stem cells with minimal risk of off-target effects.
Researchers used iPS cells to correct genetic mutations in Duchenne muscular dystrophy (DMD), a severe muscular degenerative disease. Engineered nucleases TALEN and CRISPR were successfully used to edit the genome of iPS cells generated from DMD patient skin cells, resulting in the disappearance of the mutation responsible for DMD.
Researchers at the Max F. Perutz Laboratories have developed a method for generating specific and inheritable mutations in the marine bristle worm Platynereis, enabling detailed in vivo functional analyses and advancing research in neurobiology, chronobiology, evolutionary developmental biology, and marine biology.
Scientists develop a new approach to eliminate mutated DNA in mitochondria using TALEN technology inspired by plant-infecting bacteria. The method shows promise for treating mitochondrial diseases, including Leber hereditary optic neuropathy, and could lead to effective treatments for various eye diseases.
Scientists have developed a new method to create genetically modified mice that accelerates the process by four months, using TALEN enzymes. This technique allows for the efficient production of mouse models for diseases like dementia, reducing the need for numerous test animals.
Researchers successfully used TALENS to edit the mosquito genome, changing eye color and enabling a new approach to controlling disease transmission. This breakthrough technology holds promise for developing pathogen-resistant mosquitoes and blocking virus transmission by the mosquito.
A new method for cutting DNA using a bacterial enzyme and RNA binding has been demonstrated to work in human cells, overcoming a major bottleneck in genome engineering. The technique, known as CRISPR-Cas9, is precise, inexpensive, and easy to program, holding promise for treating genetic diseases and curing AIDS.
Mayo Clinic researchers have developed an efficient editing toolkit for customizing zebrafish genomes, eliminating a bottleneck in biomedical research. This breakthrough enables targeted genetic modifications for studying human diseases, including modeling point mutations and regulating gene expression.
A new gene-editing tool using TALENs has been developed, enabling researchers to target any DNA sequence with high accuracy. The FLASH system allows for the automated construction of up to 96 TALENs in a single day at a low cost.
Researchers have determined the 3-D structure of a TAL effector bound to DNA, allowing scientists to better understand its ability to recognize and stick to specific sequences. This discovery will improve scientists' ability to target the proteins to different locations in a genome and predict their binding to unintended sites.
Researchers have successfully manipulated targeted genes in human embryonic and induced pluripotent stem cells using zinc finger nucleases and transcription activator like effector nucleases. This precision enables the study of genetic diseases and the development of disease-modifying drugs.
New Urbanism's core values focus on environmental and spatial aspects, such as compact living and reduced land consumption. The trend promotes mixed-income housing to achieve social equity goals, rather than community bonding.