Articles tagged with Cell Transplantation
Researchers found that maternal tissue types can improve survival rates of slightly mismatched kidney transplants. The study suggests adding maternal HLA typing to the routine family workup could expand the pool of optimal donors.
The largest series of unrelated cord blood transplants confirms the feasibility of transplantation for patients without a matching donor. The study demonstrates success in children and mismatched transplants with reduced acute graft versus host disease incidence.
A five-year study aims to define long-term issues and positive growth in bone marrow transplant survivors, while evaluating factors that impact their survival and quality of life. Researchers will assess physical and psychological health, neuropsychological changes, and menopausal symptoms in over 200 participants.
A Georgia Tech study found that sensory neurons in animal limbs play a critical role in determining what information is received and what behaviors result. Researchers successfully transplanted female feeding claws onto males, demonstrating novel input processing by the brain.
Duke University chemists have developed novel liquid polymers that can be solidified by laser light to seal transplanted insulin-producing cells inside a selectively permeable capsule. The microcapsules reduce excessive blood sugar levels in experimental diabetic rats for up to eight days.
A study by Weizmann Institute of Science and Perugia University in Italy has found that mismatched bone marrow transplants can be as effective as fully matched transplants, overcoming key obstacles such as graft failure and immunological reaction. The method, which uses extremely large doses of donor marrow, has raised hopes for increa...
Researchers at the University of Pittsburgh Medical Center have successfully transplanted lab-grown brain cells into a patient with paralysis and speech loss after a stroke, marking a significant breakthrough in stroke medicine. The study uses tissue grown in the lab to avoid ethical concerns surrounding fetal tissue use.
Physicians at UPMC are evaluating LBS-Neurons for treating stroke patients with a clinical human neuron transplant. The transplanted neurons aim to improve damaged host neurons or replace destroyed ones, showing promise in correcting cognitive and motor deficits.
A team of physicians and scientists successfully demonstrated the long-term function of transplanted human liver cells in a patient with Crigler-Najjar Syndrome Type I. The procedure reduced the patient's daily phototherapy needs from 12 hours to six hours, significantly improving her quality of life.
A study at Temple University Health System investigates whether donor bone marrow can coax recipients' immune systems to coexist without rejection of the transplanted hearts. If successful, it could lead to longer survival and reduced need for re-transplantations.
A new hybrid antibody developed at National Jewish Medical and Research Center can selectively turn off only the CD4 T cells attacking transplanted organs, allowing the immune system to fight other illnesses without suppression. Clinical trials are estimated to take approximately two years.
Researchers have successfully transplanted cryopreserved human neuronal cells into rats with stroke, restoring movement and behavioral recovery. The treatment has shown promise as an alternative to fetal tissue in treating strokes and neurodegenerative disorders.
Researchers have developed a gene therapy technique that makes recipient's immune system tolerant of newly engrafted organs, eliminating the need for lifelong immunosuppressive drug therapy. The approach involves introducing a vector carrying the CTLA4Ig protein into an organ preservation solution before transplant surgery.
Researchers from Case Western Reserve University have successfully regenerated axons in adult rat brains using transplanted nerve cells. The study's findings suggest a potential for regeneration in the adult central nervous system, offering new hope for treating neurological disorders.
A new procedure called in utero stem cell transplantation has shown promise in treating genetic disorders such as sickle cell anaemia and thalassaemia. The technique involves transplanting primitive blood forming cells into an affected fetus, which can cure the disease before damage occurs.
Researchers developed an iNOS gene therapy that prevents chronic organ rejection and transplant arteriosclerosis in animal models. The study found that the gene therapy suppressed the disease process by triggering production of nitric oxide, which blocks blood flow in transplanted organs.
Researchers at UT Southwestern Medical Center have developed an oral vaccine that may prevent rejection of corneal transplants. The vaccine involves feeding processed corneal cells from donor corneas to recipients over time, training their immune system to accept donated corneas without the need for powerful immunosuppressive drugs.
A novel surgical technique developed at the UPMC has improved graft survival rates in patients receiving combined pancreas and kidney transplants. The technique protects the pancreas from injury during removal and transport, resulting in higher patient survival rates.
A team of researchers has made a promising discovery using gene therapy to protect dopamine-producing neurons in the brain from Parkinson's disease. The study found that injecting a modified virus carrying a specific gene into the brain led to improved neuron survival rates.
Scientists at the University of Wisconsin-Madison have successfully transplanted nervous system cells into dogs with diseased spinal cords, achieving significant myelination and growth. This breakthrough finding offers new hope for multiple sclerosis treatment and may be applicable to other demyelinating disorders.
Researchers at the University of Maryland Medical Center have developed a new approach to treating long-term diabetic patients by transplanting their pancreas alone. The study found that using two new anti-rejection drugs, Prograf and Cellcept, resulted in a one-year pancreas survival rate of 77 percent for patients.
The NHLBI is launching a 5-year, $30 million study to investigate the safety and effectiveness of cord blood transplantation as an alternative to bone marrow transplantation for various cancers, blood diseases, and genetic disorders. The study aims to provide answers to scientific and ethical questions surrounding this procedure.