Articles tagged with Cell Transplantation
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Scientists successfully transplanted light-sensing cells into the eyes of mice with retinal degeneration, restoring their visual function. The technique has implications for degenerative eye diseases and suggests that changes in stem cells may be necessary for transplantation to succeed.
The St. Jude technique enables blood stem cells from parents or unmatched adult siblings, reducing the need for harsh treatments and boosting the chance of cure. The modified transplantation method accelerates immune system recovery and reduces the risk of infections.
Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The transplanted stem cells develop into nerve cells that make substantial connections with existing nerves.
Scientists successfully transplanted motor neurons into paralyzed rats, restoring function and improving hind limb grip strength. The study demonstrates the potential for treating spinal cord injuries and diseases like ALS.
Researchers at Joslin Diabetes Center found that circulating bone-marrow derived cells do not produce oocytes or facilitate their ovulation. The study used a parabiotic mouse model and hormones to stimulate ovulation, demonstrating that oocytes are not seeded by blood-borne cells.
Researchers developed a new type of stem cell that can repair spinal cord injuries by promoting nerve fiber growth and suppressing scar tissue. The transplanted cells restored function in rats with spinal cord injuries, allowing them to walk normally within two weeks.
Researchers found that rituximab reduced the severity of chronic GVHD in 70% of study participants, with nearly three-fourths experiencing complete remissions. The therapy also enabled patients to reduce corticosteroid use by over 50%.
A University of Calgary bioengineering team has successfully grown insulin-producing cells in a lab, which could lead to the production of human tissue for transplantation. The breakthrough brings the team one step closer to addressing the serious condition that requires multiple daily insulin injections.
Researchers discovered that bone marrow stromal cells can improve brain receptor function in patients with cerebral stroke, showing potential for neural tissue regeneration. The study may provide a 'missing link' needed in understanding receptor function, possibly leading to safe and ethical cell transplantation therapy.
Researchers at Emory University Health Sciences Center successfully transplanted porcine islets into nonhuman primates, achieving insulin independence. The study suggests that xenotransplantation using CD28/CD154 costimulation blockade may be a safe method for reversing human type 1 diabetes.
Diabetic rhesus macaques achieved sustained insulin independence after receiving neonatal porcine islets transplanted with an anti-rejection protocol. The study's success suggests that xenotransplantation may be a viable solution for type 1 diabetes treatment.
Researchers have successfully used pig islet cells to reverse type 1 diabetes in humans through transplantation. The demand for islet cells far outweighs the supply, but this breakthrough offers a potential solution. The University of Minnesota has made significant progress in developing a safe and reliable source of islet cells.
A study published by Northwestern Memorial HealthCare found that high-dose chemotherapy and autologous stem cell transplant can result in disease remission and improvement or salvage of residual organ function in the majority of patients with life-threatening lupus. The treatment's lower toxicity rate compared to previous studies may b...
The study found that infant transplant patients resisted infections despite having low T cell counts, a crucial component in fighting viruses and cancer tumors. This discovery could lead to improved treatments for AIDS, cancers, and diseases of aging related to declining immune function.
Researchers at UW-Madison report that transplanted stem cells can develop into heart muscle and blood vessels in damaged hearts, improving function. The study's results demonstrate the therapeutic potential of embryonic stem cells for treating heart disease.
A new cell transplantation technique has successfully restored insulin production in diabetic patients by injecting donor islet cells into the portal vein. The procedure, which uses a steroid-free protocol and sandwich closure method, showed promising results with all 13 patients producing insulin without major complications.
Researchers have identified a potential new treatment for insulin-dependent diabetes by targeting natural killer T cells. The study shows that multiple doses of alpha-galactosylceramide can reduce the production of interferon-gamma, which helps destroy transplanted islet cells.
A randomised trial found that blood stem cell transplant improved disease-free survival in children with high-risk acute lymphoblastic leukaemia, compared to chemotherapy. The study showed a significant gap between the two strategies as patient risk profiles worsened.
A North Carolina woman has successfully undergone an experimental islet cell transplant procedure, allowing her to become insulin-free. The procedure, performed at Carolinas Medical Center, is still in its early stages but holds promise for millions of people with Type 1 diabetes.
CellCept shows benefits for liver transplant patients, similar to those seen in kidney transplant recipients, with reduced risk of acute rejection and improved kidney function. The treatment also promotes safe steroid-free regimens and reduces liver fibrosis.
A new study assesses the feasibility and effectiveness of personalized immunosuppression using CellCept, a leading immunosuppressant in kidney transplantation. The study found that tailored dosing strategies can minimize toxicity while maximizing efficacy, offering improved patient care.
A steroid-free regimen with CellCept was found to be comparable to standard therapy in liver transplantation, without increasing the risk of hepatitis C recurrence. The study involved 312 adult patients and showed that the CellCept-based regimen demonstrated comparable efficacy and safety profiles.
Patients who survived at least two years post-transplant showed reduced risk of death each year after the fifth anniversary. Mortality not related to relapse was increased in patients with specific chemotherapy regimens and stem cell sources.
Researchers at Duke University Medical Center have developed a life-saving treatment for newborns with Krabbe Disease using umbilical cord blood stem cells. The study shows that 11 asymptomatic newborns and 14 symptomatic infants were successfully treated, with all asymptomatic babies surviving and 43% of symptomatic babies surviving.
Researchers found that freedom from rejection after 12 months was 10% higher with those treated with CellCept (63%) compared to azathioprine (53%). Additionally, the one-year survival rate was significantly better in CellCept patients (96%), compared to only 87% of AZA patients.
The level of signal-joint TRECs (sjTRECs) in the blood appears to directly reflect the ability of the transplant recipient's thymus gland to process donated stem cells. High levels of sjTRECs indicate a successful reconstitution of the T cell population, improving patient outcomes.
Researchers at City of Hope Cancer Center have successfully treated 17 out of 20 HIV-positive patients with refractory lymphoma using high-dose chemotherapy and autologous stem cell rescue. The study shows promising results with an 85% survival rate, paving the way for further investigation into this potential cure.
Researchers successfully transplanted monkey embryonic stem cells to reverse Parkinson's disease symptoms in primates. The study demonstrated the potential of this approach to treat neurodegenerative diseases, despite low survival rates of transplanted neurons.
Researchers identified a novel oncogene in Chernobyl residents with papillary thyroid cancer, resulting from the fusion of the AKAP9 and BRAF genes. This study provides evidence that chromosomal inversions are a common molecular lesion in post-Chernobyl thyroid cancers.
A new reduced-intensity stem cell transplant regimen has shown superior results in pediatric patients, allowing early recovery of immune function and nearly eliminating transplant rejection. The procedure, which uses a shorter and lower-dose treatment of Campath-1H, also reduces the incidence and severity of graft vs. host disease.
A patient with a 20-year history of heavy drinking underwent liver transplantation in 1999 and experienced progressive recovery of strength in both legs. The authors suggest that peripheral neuropathy in patients with alcoholic cirrhosis is reversible and should not be a contraindication to liver transplantation.
Researchers have found that stem cells can preserve vision in mice with damaged retinas, holding hope for treatments of macular degeneration and other retinal diseases. The transplanted cells were found to migrate to the damaged area and regain or retain function in cone cells.
Researchers transplanted adult olfactory bulb stem cells into genetically engineered mice with ALS, showing a significant delay in disease symptoms and improved functional outcomes. The study suggests these stem cells may hold potential for treating ALS, but further laboratory work is needed.
Researchers at Northwestern University are developing novel biomaterials and imaging techniques to improve the survival and function of transplanted islet cells in patients with type 1 diabetes. The grant will fund efforts to create microenvironments favorable for islet survival and function via controlled delivery of biological factors.
A new study published in Science suggests that enhancing the homing of hematopoietic stem cells to bone marrow could increase transplant success rates. By inhibiting or deleting CD26, researchers were able to boost short-term homing and long-term engraftment of these precursor blood cells.
Researchers have successfully generated nerve precursor cells from adult skin cells using a two-step process involving soluble agents called growth factors. This breakthrough raises the possibility of generating nerve cells from an individual's own skin cells, overcoming issues of rejection.
Studies of over 61,000 transplant patients demonstrate CellCept's unique survival benefits for solid organ transplant recipients. Additionally, CellCept reduces acute rejection rates and improves graft function, while also providing a lower risk of infectious death.
Data from over 35,000 organ recipients demonstrated improved patient and graft survival with CellCept-based treatment regimens. The studies found significant improvements in liver and kidney transplant outcomes, reducing infectious deaths and increasing graft survival rates.
A recent study by Dr. Edward Scott and colleagues found that donor cells containing a Y chromosome were present in the brains of three women up to 6 years after bone marrow transplantation. This suggests that bone marrow could be used as a therapeutic source of readily harvestable cells for nerve cell regeneration.
The study found that CellCept significantly reduced the risk of malignancy in patients following heart transplantation, with a 27% lower relative risk compared to azathioprine (AZA). The use of CellCept was also associated with a reduced risk of certain rare cancers, particularly skin cancer.
A new study further reinforces CellCept's cardioprotective profile, demonstrating lower rates of coronary artery disease in patients treated with CellCept compared to azathioprine. This finding could explain the superior survival benefits observed with CellCept.
A simple, inexpensive blood test performed at birth can screen for immune disorders like SCID and increase survival rates. The test, which costs $50, identifies infants with a profound deficiency of lymphocytes and has been shown to be effective in identifying children with other immune disorders.
The European Society for Medical Oncology survey found that stem cell transplants for breast cancer decreased from 2,629 in 1997 to 330 in 2002. The use of autologous transplants continued to rise for certain types of solid tumours, while allogenic transplants saw a slight increase, particularly for metastatic tumours.
Scientists successfully transplanted embryonic pig pancreas cells into rats with diabetes, halting the disease without immune suppression drugs. The breakthrough could lead to a new treatment option for humans, bypassing challenges associated with human insulin-producing cells.
The database provides survival rates of people who received cell grafts, helping doctors evaluate the potential risks and benefits of transplantation in treating disorders like leukemia. Researchers can generate hypotheses on the role of donor matching in blood and marrow stem cell transplants with this new resource.
Researchers develop gene therapy to enhance islet cell function and survival after transplantation. The technique uses a growth factor DNA to induce cell division, improving insulin production and glucose control in rat models. However, standard immunosuppression drug therapy may be harmful, inducing insulin resistance and diabetes.
Researchers at the University of Virginia Health System have discovered that Lisofylline can protect insulin-producing beta cells from autoimmune destruction, allowing transplanted islet cells to function for over 65 days without immunosuppression. This breakthrough could lead to a new treatment approach for type 1 diabetes patients.
Researchers tracked the movement of transplanted stem cells, revealing that they drift throughout the body and settle in specific locations. The study's findings could lead to improved techniques for transplanting bone-marrow stem cells and new therapies for cancer and immunodeficiencies.
Researchers found that stem cells from human peripheral blood improved motor and cognitive performance in transplanted rats, with reduced brain damage in the affected areas. The study suggests that using these stem cells may be a viable treatment option for stroke patients.
Zebrafish provide a unique window into blood cell development, allowing researchers to distinguish individual cell types and transplant genetically altered cells. The technique enables the study of cellular defects in mutant fish, which can inform human transplantation strategies.
Researchers have successfully treated rats with spinal cord injuries using embryonic stem cells, which can potentially treat paralysis and degenerative nerve diseases. The treated rats regained ability to walk after nine weeks, with analysis revealing new myelin sheaths and growth factors that stimulated neuron formation.
Researchers used microPET and optical CCD imaging to track transplanted rat cardiac cells, detecting higher uptake in areas where cells were transplanted compared to background tissues. This study provides valuable insight into cell transplant biology, enabling real-time monitoring of engrafted cells.
Kansas State University researchers successfully transplanted umbilical cord matrix stem cells from a pig into the brain of a live rat without triggering an immune response. The recipient cells survived for over six weeks and began to differentiate into nervous system cells, suggesting a new therapeutic option for Parkinson's disease.
Researchers at the Salk Institute have developed a detailed model of how stem cells produce motor neurons, which could lead to new treatments for spinal cord injuries and diseases affecting motor nerve cells. The study demonstrates an unusually efficient yield of 60 percent motor nerves using two key gene and protein-regulated pathways.
New data from the Roche Organ Transplantation Research Fund challenge the idea that potent immunosuppressants increase cancer risk. People receiving CellCept are less likely to develop lymphoma or post-transplant lymphoproliferative disease, with a lower risk of malignant lymphoma compared to conventional immunosuppressive treatment.
Researchers successfully transplanted adult stem cells into mice, which then developed into various brain cell types, including nerve cells and glial cells. This breakthrough study suggests that these cells can potentially be used to treat neurodegenerative diseases such as Parkinson's and Alzheimer's.
Researchers at Saint Louis University found that injecting human umbilical cord blood cells into rats after a stroke improved sensorimotor function. The treatment may provide a potential source for restoring neuronal function after a stroke.
Researchers at UT Southwestern are developing a new procedure to eliminate graft-versus-host disease in bone-marrow transplants while retaining anti-leukemic activity. The approach uses immunotoxins to selectively target and eliminate harmful immune cells, with promising results in clinical trials.
A recent study has provided the first direct evidence that transplanted muscle cells can form muscle fibers and blood vessels in damaged hearts. Satellite cells from patients' thigh muscles were injected into their heart tissue, surviving and differentiating into mature muscle fibers without triggering an immune reaction.
Researchers successfully transplanted myoblast cells into patients with scarred heart tissue, showing evidence of repair and regeneration. The procedure improved EF rates by 58% in just 12 weeks, offering a potential new hope for treating heart failure.