Articles tagged with Cell Transplantation
A new study found no survival advantage with filgrastim-mobilized peripheral blood stem cells compared to bone marrow transplants from unrelated donors. PBSC transplants are associated with higher rates of chronic graft-versus-host disease (GVHD), particularly in patients receiving unrelated donor transplants.
Researchers found that dental pulp stem cells can inhibit nerve cell death, promote nerve regeneration, and replace lost support cells in rats with severe spinal cord injuries. The study aims to translate this approach into an effective treatment for severe spinal cord injury.
Researchers successfully transplanted young neurons into diseased brain circuitry, repairing defective circuits and enabling mice to respond to leptin. This breakthrough suggests new therapeutic approaches for conditions like spinal cord injury, autism, and Parkinson's disease.
Researchers have successfully transplanted immature neurons from healthy mouse embryos into adult mice with a genetic deficiency, restoring leptin signaling and partially normalizing their metabolism. The study demonstrates the potential of neuronal replacement therapy for treating metabolic disorders.
A team of Wisconsin scientists reports that lab-grown neurons can successfully fuse with the brain's wiring and send/receive signals. The study uses optogenetics to modulate transplanted cells, opening doors for light-based stimulation technology in treating neurodegenerative disorders.
A new regimen of conditioning therapy before stem cell transplant has improved survival outcomes for older patients with hematologic malignancies. The study found that 5-year overall survival rates were around 35%, and progression-free survival rates were around 32%.
Researchers from Lund University have developed a method using ultrasound to improve the quality of transplanted blood stem cells. This improvement could lead to better treatment outcomes and reduced risk of graft-versus-host disease and infections.
A clinical trial at the Kimmel Cancer Center found a two-step, half-match bone marrow transplant procedure improves overall survival in blood cancer patients, with 45% and 75% five-year survival rates. The unique approach controls donor T cell dosage and timing to minimize side effects.
Researchers have discovered that human amniotic fluid-derived stem cells (hAECs) can differentiate into various cell types, including those found in the lungs. Transplanted hAECs were shown to reduce pulmonary fibrosis and enhance lung regeneration in animal models of lung disease.
Researchers have found that human Sertoli cells can proliferate in vitro and retain their functionality, making them suitable for therapeutic applications. The cells have also been successfully used as delivery systems for therapeutics in the deep lung areas, potentially providing an effective treatment alternative.
A study published in Cell Transplantation investigated the optimal routes for transplanting neural stem/progenitor cells in animal models of spinal cord injury. Intralesional injection was found to be the best method, with high cell survival rates and no complications. This method holds promise for treating other disorders
A new study found that heart transplant patients are more likely to develop skin cancers, including cutaneous squamous cell carcinoma and melanoma. The incidence increased post-transplant by up to 30-fold, highlighting the need for improved patient education and screening.
A new genetic technique reprograms mature skin cells directly into brain cells without passing through the stem cell stage, opening a field for cell transplants. The discovery represents a fundamental change in the view of mature cell function, offering potential to treat neurodegenerative diseases like Parkinson's.
Patients with aggressive non-Hodgkin lymphoma who receive early stem cell transplants have comparable survival rates to those who undergo chemotherapy alone. Researchers urge caution for patients with poor risk factors, recommending careful consultation with their physician.
A study published in Cell Transplantation found that cryopreserved endothelial progenitor cells have the same phenotypic, structural, and functional properties as non-frozen cells. This discovery eliminates the need for cell isolation procedures before using these cells in clinical transplantation.
Experts recommend collecting peripheral blood stem cells from Fukushima radiation workers to prepare for potential future stem cell transplants. This technique has several advantages over allogeneic transplantation, including reducing the risk of graft-versus-host disease and immunosuppression.
Researchers found that umbilical cord blood-derived mensenchymal stem cells (uMSCs) can delay renal function deterioration and alleviate symptoms of lupus nephritis. Early transplantation with allogenic MSCs showed the most promising results, supporting their potential use in treating systemic lupus erythematosus.
Researchers found periodontal ligament stem cells to be the most efficacious in treating advanced gum disease, outperforming other dental stem cell types. The study suggests PDLSCs may offer a new treatment option for periodontitis, a common cause of tooth loss worldwide.
Researchers have found that stem cells derived from umbilical cord blood cells and menstrual blood may offer therapeutic benefits for disorders such as stroke, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). These cells can differentiate into various types of cells and have anti-inflammatory properties.
A Stanford study finds a short-term treatment with three immune-dampening drugs allows human embryonic stem cells to survive and thrive in mice. The breakthrough may enable humans to accept transplanted stem cells intended for disease or injury treatment without powerful immunosuppressant medications.
Researchers found that transplanted EPCs from human umbilical cord blood significantly accelerated wound closure in diabetic mouse models. The study showed that growth factors and cytokines produced at the wounded skin sites contributed to healing. This experimental study opens the possibility of using endothelial progenitor cells deri...
Two studies investigate the role of bone marrow stem cells in diabetic therapy and islet cell regeneration, offering new therapeutic possibilities. Researchers also focus on improving pancreatic islet culture and preservation techniques to prolong the survival and functionality of islet cells in vitro.
Researchers found that early infusion of donor T cells prevented GVHD in 26 patients who achieved full-donor engraftment, with no chronic GVHD development. The study also showed improved immune system recovery and reduced CMV reactivation.
A recent study suggests that damaged alpha-synuclein proteins can spread between cells in a 'prion-like' manner, contributing to Parkinson's disease pathogenesis. This cell-to-cell transfer mechanism may play a significant role in the progression of neurodegenerative diseases.
Researchers at UCSF have discovered that a mother's immune response prevents fetal acceptance of transplanted blood stem cells, but their own stem cells can be used to overcome this issue. The study suggests that using maternal stem cells could lead to successful treatment of genetic diseases before birth.
Researchers found a statistically significant decrease in peritoneal cavity fluid and clinical and biochemical improvement in many patients. The study suggests that cell transplantation might be clinically significant beyond improving laboratory parameters, potentially through paracrine effects.
Researchers successfully transplanted cord blood-derived cells into a severely brain-injured child, showing improvement after six months. The study found that the cells persisted in the brain hemisphere and improved functional neurological impairment.
Studies reveal that stem cell transplantation is safe and effective in treating various hematologic malignancies, with no significant increase in overall cancer risk. Researchers found a promising new treatment to prevent chronic graft-versus-host disease, a serious complication of stem cell transplantation.
Two studies published in Cell Transplantation found that administering bone marrow stem cells promoted functional recovery and reduced damage after stroke, while VEGF administration provided near complete neurological protection. These findings suggest two potential treatments for stroke and could offer new recourse against its ravages.
A University of Colorado at Boulder-led study found that specific stem cells can prevent the loss of muscle function and mass with aging. The transplanted stem cells doubled in mass and sustained themselves for two years, suggesting a potential treatment for humans with chronic degenerative muscle diseases.
Researchers tested three MRI contrast agents on different stem cell populations and found changes in stem cell proliferation depending on the agent used. The study revealed varying labeling efficiencies with each agent, but no significant alterations in cell phenotypes or differentiation.
The University of Minnesota Masonic Cancer Center will lead national hematopoietic stem cell transplantation and cell therapies research, benefiting thousands of patients worldwide. The center's leading physician-scientists will conduct clinical trials to test new treatments, including umbilical cord blood 'T regulatory cells' and NK c...
Scientists at King's College London have developed protein therapeutics and cell therapy techniques to extend organ transplant life. Protein Mirococept coating protects donor kidneys from damage during transit, while regulatory T cells may prevent immune system over-activation.
The new journal aims to evaluate the safety and effectiveness of cell medicine in treating debilitating and fatal disorders. The journal features a diverse global editorial board and publishes papers on cell therapy with direct clinical relevance.
A team of researchers has developed an approach to repairing spinal cord injuries using manipulated neural stem cells. In a mouse model, the cells were combined with valproic acid and resulted in impressive restoration of hind limb function. Further work is needed to determine if this approach can be used in human patients.
Researchers from Karolinska Institutet are contributing to ESOF 2010 with presentations on topics like neuroscience, intellectual property management, and Parkinson's disease treatment. The university is also organizing workshops and seminars on topics such as entrepreneurship and the future of research.
A study found that more than 40% of patients with treatment-resistant CLL enjoyed long-term freedom from relapse after receiving allogeneic stem cell transplants. The transplants were associated with significant risks but offered a potential cure for this patient population.
Researchers found similar leukaemia-free survival rates for unrelated cord blood transplants and matched bone marrow or peripheral blood progenitor cell transplants. UCB transplantation was also linked to lower rates of acute and chronic graft-versus-host disease.
A team of researchers has developed a more consistent method for isolating pancreatic islet cells from brain-dead donors using ductal injection, resulting in three type 1-diabetes patients becoming insulin-independent. The study's success rate surpasses the standard 50% with an impressive 80% clinical islet transplantation rate.
Researchers developed a novel imaging system to visualize T-cell actions in animal models, providing insights into immune responses and transplant outcomes. The study revealed a clearer understanding of the balance between protective and destructive T-cells in transplanted tissue.
Researchers have identified a previously undiagnosed condition and treated it with a stem cell transplant, saving the patient's life. The key to unlocking the reason for the patient's symptoms was contracting a rare version of glandular fever.
Researchers at Yale University have discovered that endometrial stem cells can repair brain cells damaged by Parkinson's disease, potentially treating women with the condition. The study, published in Journal of Cellular and Molecular Medicine, found that these stem cells can differentiate into dopamine-producing nerve cells.
Researchers have found that olfactory ensheathing cells (OECs) transplanted into children and adolescents with cerebral palsy can improve neurological function without causing significant side effects. The study suggests OEC transplantation may be a promising treatment for this incurable disorder.
A study published in Cell Transplantation has found that using ICG to label human embryonic stem cell-derived cardiomyocytes substantially improves efforts to optically track stem cells after transplanting them into heart tissues. The labeling procedure did not impair the viability or functional integrity of the cells.
Researchers discovered that bone marrow cells produce nerve growth factor, which promotes angiogenesis and prevents hypoxia in transplanted islets. The study, led by Dr. Eba Hathout, found a potential role for NGF in islet transplantation and prevention of graft failure.
Scientists at UCSF successfully created a new period of brain plasticity in juvenile mice by transplanting embryonic cells into the visual cortex. This approach may one day be used to repair neural circuits following injury or disease. The findings suggest that inhibitory neurons play a crucial role in regulating this plasticity period.
Researchers have found that bone marrow cell transplants can improve heart function and relieve symptoms of refractory angina. Apelin, a newly described peptide, was also shown to increase significantly in patients who received the transplants, leading to improved cardiac function.
Researchers at Karolinska Institutet have discovered that stem cells can connect with and rescue threatened neurons through direct contact via gap junctions. The findings suggest a new possible treatment approach for brain damage and neurodegenerative diseases.
Researchers found that transplanted hepatocyte cells and growth factor genes rapidly infiltrate damaged livers, promoting regeneration. Prolonged HSC activation is beneficial for proliferation of transplanted cells.
Researchers demonstrate that transplanted stem cells can rescue diseased neurons from death by sending signals through gap junctions, a newly recognized way of cell communication. This mechanism may play a role in both normal development and many diseases, including Huntington's disease and spinal cord injuries.
Patients who underwent peripheral blood stem cell transplantation (PBSC) had similar overall survival rates as those given bone marrow transplants, with no significant differences in mortality or late effects. However, subgroup analyses revealed improved leukaemia-free survival and overall survival for patients with acute leukaemias
Scientists discovered a new strategy for making embryonic stem cell transplants less likely to be rejected by a recipient's immune system. Bone marrow cells fuse with embryonic stem cells, creating hybrid cells that can evade immune rejection without drugs.
Researchers at Fred Hutchinson Cancer Center have developed a method to expand stem/progenitor cells from cord blood units, resulting in successful treatment of high-risk leukemia. The expanded cells can rapidly give rise to white blood cells and other components of the blood system.
A large-scale study demonstrates that transplanted cells produced dopamine, leading to improved motor symptoms and brain function. Long-term clinical outcomes revealed sustained improvements over a four-year period.
A new study reveals that nerve-cell transplants can promote nurturing growth factors, promoting the healing of an injured nervous system. The transplants helped brain-damaged rats fully recover their cognitive function, including learning and memory.
A phase I/II study at Johns Hopkins Medicine has shown that mini stem cell transplantation can safely reverse severe sickle cell disease in nine out of ten patients. The procedure, which uses intravenous transplants of blood-forming stem cells from healthy donors, promotes the coexistence of host and donor cells.
Research shows human umbilical stem cells can improve corneal transparency and thickness in laboratory mice. The treatment has the potential to replace corneal transplants as an alternative therapy for severe genetic and corneal eye diseases.
Early clinical trial results show bortezomib-based therapy improves control of graft-versus-host disease and immune system recovery. The treatment was safe with little toxicity, and immune cell reconstitution was significantly improved in the early post-transplant period.
Researchers developed a new approach to prevent graft-versus-host disease and enhance immune recovery after haploidentical transplants. The study showed long-term protection from graft-versus-host disease in 25 of 26 patients, with improved immune system reconstitution.
Researchers found that transplanted human-derived umbilical cord blood stem cells had positive therapeutic effects on specific lung and heart disorders in animal models. The study showed that MSCs have anti-inflammatory effects and can differentiate into various cell types, including lung-specific cells.