Articles tagged with Cell Transplantation
A new treatment approach using a radiolabeled antibody to deliver targeted doses of radiation followed by a stem cell transplant has been shown to be effective in treating advanced leukemia. Forty percent of patients achieved remission, with approximately 35% surviving three years.
A study by the Cell Transplantation Center of Excellence found that autologous brain cell transplants can provide brain protection and repair neural damage in donor primates. The cells survived at an impressive 50% rate for four months post-implantation, offering a promising new approach to treating neurological disorders.
Researchers have developed innovative strategies to eliminate the hidden reservoir of HIV-1 from immune cells, keeping it under control. In another breakthrough, scientists found a way to transiently keep hepatitis C virus levels down in treated patients receiving a new liver transplant.
Researchers at Hiroshima University developed a method to temporarily control HCV levels in patients receiving new livers. Activated immune cells from donor livers were infused into patients, reducing viral activity despite immunosuppressive treatment. Further studies aim to improve this approach.
UCSF researchers found private cord blood banking to be cost-effective only for families with high likelihood of needing a stem cell transplant. The analysis revealed that the process is more expensive than expected, with an additional $1,374,246 per life-year gained.
A study finds substantial improvement in a mouse model of a rare neurodegenerative disease after transplantation of normal human neural stem cells. The transplanted cells provided a critical enzyme missing in the brains of experimental mice, showing promise for a potential therapeutic approach.
Researchers found that patients with aggressive leukemia had few complications and mounted a strong immune system attack after receiving a cancer vaccine shortly after a stem cell transplant. The study suggests that the approach may be more effective than traditional transplant alone, with higher survival rates.
A recent study in mice suggests that the mother's immune response interferes with the fetus's ability to tolerate transplanted donor cells. Researchers found that mouse pups nursed by their biological mothers lost transplanted cells, while those nursed by foster mothers retained them.
Researchers found that fetal immune cells eliminate transplanted allogeneic blood cells, but only triggered by maternal breast milk antibodies. This limits engraftment following in utero hematopoietic cell transplantation.
Researchers have found that placenta-derived stem cells can reduce lung fibrosis and inflammation in mice with bleomycin-induced injury. The study's findings suggest these cells may be useful for cell therapy of fibrotic diseases in the future.
A recent study found that transplanted neurons develop disease-like pathology in Huntington's patients, raising concerns about the therapeutic potential of cell transplantation therapy. The research suggests new mechanisms involved in the development of the disease and offers a new direction for developing novel therapeutic strategies.
Researchers explore two bone marrow cell delivery methods to treat heart attacks and limb ischemia. Studies show that anterograde intra-coronary delivery improves left ventricle function, while bone marrow stem cell transplants increase blood flow in severely ischemic limbs.
Guided fat precursor cells lead to wider nerves and less muscle atrophy in injured peripheral nerves of laboratory rats. The study demonstrates the potential benefit of adult precursor cells, such as those from adipose tissue, for nerve repair and functional recovery.
Dr. Aileen Go has won a prestigious Amgen Foundation Fellowship grant to study treatment options for older leukemia and lymphoma patients. The research aims to develop a reduced-intensity chemotherapy regimen and methods to boost stem cells for patients aged 55-75.
Co-transplanting bone marrow stem cells with embryonic stem cells eliminates tumor formation in spinal cord injury (SCI) laboratory animals. The study suggests that BMSCs induce differentiation of undifferentiated ES cells into a neuronal lineage, resulting in suppression of tumor growth.
Researchers at UBC's Biomedical Research Centre have identified S1P as a molecule that can open the thymic gate for migrating stem cells. This discovery holds promise for increasing the success of blood stem cell transplants, which are currently used to treat diseases such as leukemia and aplastic anemia.
A new study found that transplanted liver cells from older donors work equally well in both young and old recipients, but have lower proliferation rates due to lower growth factor levels. The research suggests that injecting the growth factor IGF1 into older rats may increase hepatocyte cell proliferation.
Scientists have developed a device that protects transplanted pancreatic precursor cells from the immune system, allowing them to mature into functional beta cells. This breakthrough approach could alleviate the need for long-term immunosuppression in cell transplantation therapy.
A survey of US and Canadian pediatric hematopoietic cell transplant physicians found that only 50 out of thousands of transplants involved privately banked cord blood. The respondents generally recommended against private cord blood banking unless a family member is at risk for a blood disease requiring a stem cell transplant.
A new review by Johns Hopkins scientists highlights the importance of platelets in organ transplant rejection, revealing their role in driving inflammatory responses. This research could lead to the development of new strategies using drugs or other means to keep platelets quiet and non-inflammatory.
Researchers explore alternative anatomical sites for islet transplantation, including the pancreas, to improve engraftment potential and patient safety. Bioartificial pancreas engineering and encapsulation technologies are also being developed to overcome challenges in current transplantation methods.
Researchers at Albert Einstein College of Medicine developed a technique to make foreign pancreatic cells invisible to the immune system, dramatically protecting them from rejection. The new method could pave the way for routine use of cell transplants as a therapy for type 1 diabetes in humans.
Researchers investigate the effect of high blood sugar on the immune system in hopes of improving islet cell transplant success rates. High blood glucose levels can temporarily shift the balance between effector and regulatory T cells, giving advantage to regulatory cells that suppress attacks.
Scientists have successfully transplanted a single adult stem cell into a live mammal and shown that it can self-renew and repair damaged tissue. The study used genetically engineered cells to track their dynamics, demonstrating the ability of these cells to proliferate and engraft into injured muscle tissue.
Researchers have successfully transplanted de-differentiated fat (DFAT) cells into animal models, promoting functional recovery and motor function after spinal cord injury. The study suggests that DFAT cells could be a source for cell replacement therapy to treat central nervous system disorders.
Researchers successfully monitored transplanted stem cells using bioluminescent imaging and iron oxide, enabling non-invasive tracking. Three different labeling methods were evaluated for their reliability in detecting transplanted mensenchymal stem cells, with DAPI labeling showing promising results.
A new clinical trial has demonstrated the safety of expanding umbilical cord blood stem cells before transplanting them to patients with advanced leukemias or lymphomas. The study found that expanded stem cell technique is comparable to standard double-cord transplant and shows promise for improved engraftment and survival.
Two studies examine the impact of cord blood, peripheral blood, and bone marrow on transplant success rates in adults with acute leukemia. The research reveals that mismatched cord blood transplants can be a suitable alternative to bone marrow or peripheral blood transplants.
Researchers at Northwestern University found a way to trick the immune system of mice into believing transplanted islets are their own cells. This technique eliminated the need for immunosuppressive drugs in mice with chemically-induced diabetes after islet transplantation, showing high success rates.
Researchers found that direct implantation of mesenchymal stem cells did not remyelinate the damaged area, but still consider MSCs a promising tool for neurological disorders due to their pre-clinical efficacy in treating stroke and MS.
Researchers have discovered that alpha-1-antitrypsin (AAT) can eliminate inflammation in diabetic animals after islet transplantation, allowing the transplanted cells to survive and function for over 120 days. This breakthrough could lead to a safer and more effective treatment for type-1 diabetes patients.
Researchers have discovered two types of astrocyte support cells generated from a common stem cell-like precursor cell, one effective at promoting nerve regeneration and the other causing neuropathic pain. The study offers a promising approach to repairing spinal cord injuries without inducing pain syndromes.
Researchers found that immune-defense cells influenced by embryonic stem cell-derived cells can prevent transplant rejection in mice. The study's results suggest a potential method for reducing the need for immunosuppressive drugs in human organ and bone marrow transplants.
Researchers found that transplantation of human cord blood cells can repair cochlear damage in animal models, with dramatic repair observed despite few human-derived cells migrating to the cochlea. The study suggests a potential treatment strategy for inner ear rehabilitation and hearing impairments caused by cochlear damage.
Researchers found that combining adult cardiomyocytes with bone marrow cells enhances therapeutic effects and reduces programmed cell death. The technique shows promise as a new strategy for myocardial repair, with potential applications in cardiac tissue regeneration.
A study of 50 healthy adult men found that black non-sensitized males had an average of 17.2% more HLA-sensitive B cells than white non-sensitized males, increasing their opportunity for antibody-mediated rejection. This increased number of B cells may be customized in treatments to lessen the likelihood of organ rejection.
A nationwide clinical trial is underway to investigate the use of unrelated donor marrow and cord blood transplants for severe sickle cell disease. The trial, facilitated by the Blood and Marrow Transplant Clinical Trials Network, aims to extend a promising treatment option to more severely affected patients.
Researchers have developed a groundbreaking procedure using tailor-made regulatory cells to avoid lifelong drug use for transplant patients. The technique shows promising findings and has been tested in clinical trials on 17 kidney transplant patients, with encouraging results.
Researchers at the University of Florida have identified a molecular signature based on gene expression that can predict the development of acute graft-versus-host disease (GVHD) in patients receiving liver stem cell transplants. This could lead to better biomarkers for determining patient risk and improving treatment outcomes.
Researchers have found that human umbilical cord blood cells can improve liver damage and function in rats with hepatitis. The study provides an alternative to bone marrow transplants for hepatic regenerative medicine, offering hope for patients suffering from terminal hepatic failure.
Researchers have genetically programmed embryonic stem cells to become nerve cells when transplanted into the brain, resulting in tangible therapeutic improvement in mice with stroke. The new nerve cells integrate into the existing network and provide cognitive benefits.
Transplanting human umbilical cord blood cells into mouse models with ALS delayed disease symptom progression and increased lifespan. The moderate-strength dose of HUCB cells proved most effective in providing neuroprotection for motor neurons.
Researchers at UNC have shown that transplantation of adult stem cells can improve healing of fractures in animal models. The study provides a scientific foundation for future clinical trials and could lead to a new treatment for millions of people suffering from bone union failure.
University of Illinois Chicago researchers modified the procedure for islet cell transplantation and achieved insulin independence in diabetes patients using fewer but better-functioning pancreatic islet cells. The study results are published in the American Journal of Transplantation.
Researchers have identified cells that initiate infant tumors, developing a new mouse model to identify therapeutic targets. A molecule called IRF4 has been found to control inflammation in the gut, while implanting olfactory ensheathing cells promotes neuroplasticity in stroke models.
Researchers have made significant progress in developing neural cell transplants as a potential treatment for Parkinson's disease. Engineered human neural progenitor cells that produce glial-derived neurotrophic factor (GDNF) show promise in promoting functional recovery and improving motor function without causing negative side effects.
A new non-invasive method to determine tumor oxygen levels and image surrounding tissues has been developed, offering promising insights into tumor development. Researchers suggest that this approach could lead to improved diagnosis and treatment strategies for tumors and other diseases.
Researchers at Penn have engineered living human nerve cells into a network that can be transplanted to repair damaged nerves. The three-dimensional neural network, created through the stretch growth technique, maintained its geometry and function after transplantation.
Scientists discovered that HOXA11, a homeobox gene, is essential for the development of uterosacral ligaments, which are weakened in women with pelvic organ prolapse. In another study, researchers found that increased expression of the WNT antagonist sFRP-1 contributes to elevated intraocular pressure in glaucoma patients.
A team of scientists has successfully derived functional immune system blood cells from embryonic stem cells using HOXB4 protein. The study showed that the transplanted cells were able to respond effectively to viruses and vaccines, demonstrating a promising new approach for patients with severe blood and immune disorders.
Researchers found that human mesenchymal stem cells (hMSCs) and bone marrow stromal cells (BMSCs) can migrate to damaged brain tissue after a stroke, improving neural function. The transplanted cells may also enhance tissue repair and functional recovery.
Researchers are enrolling patients in a new study that transplants stem cells from a kidney donor's bone marrow into the recipient, with the goal of gradually eliminating the need for antirejection drugs. The study aims to improve post-transplant quality of life for recipients.
Researchers are conducting a US trial using purified adult stem cells to treat critical limb ischemia, a condition that affects 1.4 million people and can lead to amputation. The study aims to grow new blood vessels and restore circulation in legs with severely blocked arteries.
Researchers have made significant progress in cardiac stem cell therapy, exploring novel delivery methods and strategies to improve cell survival. These advancements aim to overcome the challenges of poor vascular supply and inflammation after a heart attack, paving the way for more effective treatments.
Researchers at the University of Texas M. D. Anderson Cancer Center report that a milder chemotherapy regimen before stem cell transplant resulted in complete remission for 45 of 47 patients with relapsed follicular lymphoma. Long-term follow-up showed improved overall survival and progression-free survival rates.
Researchers at Kyoto University School of Medicine successfully regenerated damaged nerves using bone marrow cells containing adult stem cells. The transplanted cells differentiated into Schwann cells, promoting axon regeneration and healthier vascularity.
Researchers at Stanford University School of Medicine have successfully transplanted new blood-forming stem cells into the bone marrow of mice, effectively replacing their immune systems. This technique could potentially treat autoimmune and genetic blood diseases by introducing a healthy immune system.
Researchers found that skeletal myoblasts can help improve urinary incontinence in female rats with urethral sphincter deficiency when transplanted into their nerve-damaged muscles. The transplanted muscle cells increased urethral pressure, leading to significant improvement in incontinence and near-normal urethral closure pressures.
Scientists have successfully transplanted embryonic pig pancreatic cells into diabetic macaque monkeys, reducing the need for insulin injections without immune suppression. The transplants showed promise for curing type 1 and type 2 diabetes in humans with additional research.
Central nervous system infections are a rare but significant predictor of death among heart transplant recipients. According to a study of 315 patients, 8 developed CNS infections within four years after transplantation, resulting in three deaths and two survivors with mild complications.