Articles tagged with Cell Transplantation
Researchers have successfully transplanted human embryonic stem cells into monkeys with Parkinson's disease, demonstrating robust survival and integration of the cells. The study found that the gene expression of dopamine-producing neurons was transient after transplantation, highlighting the need for further research to optimize cell ...
A study provides statistically-based guidelines for determining suitability of stem cell transplants in older patients with MDS. Reduced intensity transplants are recommended for high-risk patients, while non-transplant treatments are preferable for lower-risk patients.
Researchers at Washington University School of Medicine have identified a way to trigger the reproduction of human insulin-producing beta cells in a laboratory setting, potentially removing a significant obstacle to transplanting these cells as a treatment for patients with type 1 diabetes. This new technique uses a cell conditioning s...
Scientists found that immune cells only need to contact specific antigens on the transplanted organ to be activated and reject it. This discovery could lead to new anti-rejection therapies for organ transplantation.
Two studies published in the Journal of Clinical Investigation found that chemokine stimulation is not required for T cell migration to transplanted organs. Instead, immune-stimulating proteins expressed by the organ direct T cells to migrate. Additionally, researchers identified a protein called TRAIL that causes cell death and can be...
Researchers at the University of California at San Francisco have made a breakthrough in treating epilepsy by transplanting new inhibitory nerve cells into the brains of adult mice. This innovative approach has shown promising results in reducing seizure occurrence and reversing associated learning and memory problems.
Researchers at UCSF controlled seizures in epileptic mice with a one-time transplantation of MGE cells, which inhibit signaling in overactive nerve circuits. The treatment showed promising results, eliminating seizures in half of the treated mice and reducing spontaneous seizures in the rest.
A study found fractal patterns in T cell receptor families of stem cell transplant donors and recipients, which may help predict transplant complications. The researchers hope this information will aid in understanding immune system recovery after transplantation.
Researchers at Stanford University School of Medicine have successfully transformed skin cells directly into oligodendrocyte precursor cells, which can insulate neurons. This breakthrough could lead to cell therapies for diseases like multiple sclerosis and spinal cord injuries.
New technique allows for direct reprogramming of human cells into nerve cells, opening possibilities for treating Parkinson's disease and other conditions. Researchers at Lund University have made a breakthrough in the field of cell therapy by successfully reprogramming skin cells and support cells into nerve cells.
Researchers found that allogeneic hematopoietic stem cell transplantation with mesenchymal stem cells from third-party donors improved poor graft function in five patients with acute GVHD and two with chronic GVHD. The treatment also showed promise in reducing morbidity and mortality.
A study published in Blood journal found that cord blood stem cells are effective and safe alternatives to matched donor bone marrow stem cells in treating children with Hurler's syndrome. The research showed improved engraftment rates, enzyme levels, and survival rates among patients who received cord blood transplants compared to tho...
Researchers compared ASCs and BMSCs from an elderly male donor to treat myocardial infarction in a rat model, finding that ASCs preserved more cardiac function. The study suggests age and health status of cell donors may impact the efficacy of stem cells in treating myocardial infarction.
Scientists at Johns Hopkins Medicine have created a way to monitor the survival of transplanted cells using nanoscale pH sensors and MRI machines. This innovation has the potential to revolutionize cell replacement therapies for conditions like liver failure and type 1 diabetes by providing reliable means of detecting dead cells.
Scientists at the University of Melbourne have successfully transplanted neural stem cells into mice, which then migrated to the gut and developed into functional neurons. This breakthrough could lead to new treatments for intestinal motility disorders such as Hirschsprung's disease.
Researchers have found that transplanted neural stem cells can migrate to the gut and develop into functional neurons, providing a promising new treatment for gastrointestinal motility disorders. Additionally, a protein called MFGE8 has been identified as an important regulator of inflammation, blocking inflammasome activity and limiti...
Researchers found that iron oxide nanoparticles can effectively label human endothelial cells for in vivo magnetic resonance tracking. However, high concentrations of INOPS can induce cell death and affect cell activity.
Researchers have shown that transplanted neural stem cells slow ALS onset and progression, improving motor function and survival time. The study also found that these cells promote the production of protective molecules and reduce inflammation.
In a groundbreaking study, researchers found that transplanted neural stem cells slow ALS disease onset and progression by producing protective molecules and reducing inflammation. The treatment improves motor function and prolongs survival in ALS mice, offering new hope for treating this devastating disease.
Researchers found that transplanting neural stem cells into mice with familial ALS slowed disease onset and progression, improved motor function, and extended survival. The study suggests targeting detrimental roles played by non-neuronal cells to develop more effective therapeutics.
Researchers have made significant breakthroughs in optimizing stem cells and transplant approaches to treat patients with blood disorders. A new study has shown that the addition of vorinostat to standard therapy can safely reduce the incidence and severity of graft-versus-host disease, a life-threatening complication associated with h...
University of Rochester Medical Center scientists have discovered a new approach to speed up blood stem cell recovery after a vulnerable period following a stem-cell transplant. Prostaglandin E2 boosts blood production and protects the surrounding microenvironment, offering new hope for patients with leukemia or other blood disorders.
A new process of creating islet cell clusters has been successfully developed to improve pancreatic transplantation. The clusters were engineered to overcome challenges such as hypoxic conditions and immune reactions, resulting in higher viability rates and potential cure for type I diabetes.
Researchers at Sanford-Burnham Medical Research Institute have successfully transplanted human stem cell-derived neurons into a rodent hippocampus, stimulating existing neurons to fire high-frequency oscillations. This breakthrough may lead to the restoration of brain activity and motor function in patients with neurodegenerative condi...
Researchers at the University of Pennsylvania School of Medicine have found that injecting synthetic, misfolded α-Syn protein into healthy mice recapitulates Parkinson's disease progression, leading to dopamine neuron death and Lewy body formation. The study establishes a mechanistic link between α-Syn transmission and neurodegeneration.
Researchers at Baylor University discovered that low temperatures can prevent hypoxia-induced damage to islet cells, improving insulin secretion. In a second study, neural cells derived from induced pluripotent stem cells showed altered oxygen metabolism associated with schizophrenia, offering potential targets for treatment.
Scientists at Lund University are using optogenetics to investigate the behavior of transplanted brain cells in a model of Parkinson's disease. The study aims to determine whether light can be used to reinforce dopamine production and improve the effectiveness of nerve cell transplantation.
A two-year clinical trial found no survival difference between patients receiving peripheral blood stem cells and bone marrow stem cells from unrelated donors. However, peripheral blood stem cell transplants were associated with a higher incidence of chronic graft-versus-host disease (GVHD).
Scientists at UCSF have successfully transplanted embryonic neurons into newborn mice brains, defying the prevailing theory on cell death in developing brains. The study suggests that a fraction of cells may die due to unknown 'signals' rather than competition for survival factors.
A study found that transplantation within a 72-hour time window resulted in early functional recovery and reduced brain atrophy. The optimal therapeutic time window was determined to be between 72 hours and 120 hours after stroke onset, with no benefit observed when transplanted at 14 days.
In a preliminary clinical trial, half-matched bone marrow transplants successfully eliminated sickle cell disease in 11 of 17 patients. The transplants, which used donated marrow from partially matched donors, also improved blood test results and reduced the need for pain medications.
Researchers aim to develop a biologic cure for diabetes by addressing immunosuppression, poor islet viability, and implantation issues. The new funding will support the development of bioactive scaffolds and conformal coatings to protect implanted cells from the immune response.
A special issue of Cell Transplantation features studies on clinical translational medicine for successful neurorestoration in human patients with various neurological conditions. The field of neurorestoratology aims to optimize regimes and develop treatment guidelines through the integration of current methods.
Researchers found that insulin-like growth factor (IGF1) enhances migration and integration of photoreceptor cells into the adult mouse retina by manipulating the retinal recipient microenvironment. This study suggests a potential novel strategy for retinal repair using stem cell replacement therapy.
Researchers at Ruhr-University Bochum successfully transformed spinal cord stem cells into immature nerve cells using sodium chlorate. This development holds promise for improving cell replacement therapies in diseases such as Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis.
A new cancer drug, brentuximab vedotin (Adcetris), has dramatically improved survival rates for Hodgkin lymphoma patients who have failed other treatments. In a multi-center study, 65% of patients were alive at 24 months, and 25% had no progression of the disease.
Researchers used magnets to guide iron oxide nanoparticles-laden cells to damaged heart sites, improving homing and retention. Visualizations revealed a good correlation between MRI tracking and cell fate assessment.
Researchers found that fresh islet cells are superior to cultured islet cells in terms of success rate and blood glucose levels after transplantation. However, the results of islet isolation did not correlate with clinical outcomes for kidney transplantations from non-heart-beating donors.
Researchers found that olfactory neural stem cells can be derived from a patient's own cells and have shown promise in pre-clinical models of disease. They demonstrated multipotency by acquiring the phenotype of resident cells, making them a potential source for cell therapy.
Researchers found that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells after transplantation into liver-injured rats. The mature hepatocytes continued to survive and proliferate for up to one year, while the stem/progenitor cells died within two months.
Researchers found that autologous lung-derived mensenchymal stem cell transplantation improved functional outcomes in sheep with emphysema, with increased blood perfusion and ECM content. The study suggests a practical alternative to conventional stem cell therapy for treating emphysema.
Researchers from South Korea, Sweden, and the US have successfully transplanted HD-induced pluripotent stem cells into animal models, exhibiting significant behavioral recovery. The study provides new insights into the underlying disease process and potential treatments for Huntington's disease.
Researchers at Lund University developed a new technique that converts stem cells into brain cells with improved safety and efficiency. The method mimics the brain's natural development process, reducing the risk of tumour formation and improving cell integration.
Researchers at UCSF have successfully treated chronic neuropathic pain in mice by transplanting immature embryonic nerve cells into the spinal cord. The transplanted cells integrated into the nerve circuitry, forming synapses and signaling pathways with neighboring neurons, leading to a significant reduction in pain hypersensitivity.
Researchers have successfully transplanted embryonic cells into adult mouse spinal cords to alleviate persistent pain. The study suggests that this approach may not only treat symptoms but also correct underlying disease pathology. This new therapy offers hope for patients with neuropathic pain, a condition with limited treatment options.
A study published in Cell Transplantation found that human umbilical cord-derived mesenchymal cells effectively reduced clinical and pathological severity of induced colitis in test mice. The treatment inhibited pro-inflammatory cytokine expression, indicating its potential for treating inflammatory bowel diseases.
Scientists at University College London have successfully transplanted photoreceptors into adult mice with degenerate retinas, restoring their vision. The study suggests that this approach could lead to effective treatments for thousands of people affected by degenerative eye disorders.
Researchers found that autologous bone marrow-derived mononuclear cell transplants can significantly induce vascular growth, reducing the number of amputations in patients with diabetes suffering from critical limb ischemia. The study showed a significant increase in neovasculogenesis and a decrease in PAD mortality.
A combination of treatments including a polymer scaffold, neurotrophin-3, and chondroitinase enhanced the benefits of neural stem cell transplantation in rat models. This approach promoted nerve growth, improved cell survival and migration, and restored neuroplasticity.
Researchers have found that bone marrow-derived stem cells can contribute to various neural cell types in different areas of the brain, including the olfactory bulb, through mechanisms of plasticity. This discovery suggests a new potential for using these cells for repairing damaged brain tissue and restoring lost neural function.
A study found that a combined immunosuppressive regimen improved the survival of human spinal stem cells in ALS rats. The results suggest that this treatment approach may be a potential therapy for ALS, a degenerative neurological disease.
Researchers have developed a therapy using FT1050 that improves stem cell engraftment in umbilical cord blood transplant recipients, allowing for faster recovery and reduced complications. The treatment accelerates the process of stem cells taking root in patients, resulting in improved outcomes.
Researchers found that patients receiving bone marrow transplants from unrelated donors had the same survival rates as those receiving blood stem cell transplants. However, PBSCs resulted in better engraftment but higher rates of chronic graft-versus-host disease (GVHD), a serious post-transplant complication.
Researchers at Penn School of Medicine have developed a technique to expand immune cells in umbilical cord blood prior to transplants, leading to quicker immune system rebuilding and lower risk of infections. The method paves the way for future salvage therapy options and increased use of public cord blood banks.
A new study found no survival advantage with filgrastim-mobilized peripheral blood stem cells compared to bone marrow transplants from unrelated donors. PBSC transplants are associated with higher rates of chronic graft-versus-host disease (GVHD), particularly in patients receiving unrelated donor transplants.
Researchers found that dental pulp stem cells can inhibit nerve cell death, promote nerve regeneration, and replace lost support cells in rats with severe spinal cord injuries. The study aims to translate this approach into an effective treatment for severe spinal cord injury.
Researchers have successfully transplanted immature neurons from healthy mouse embryos into adult mice with a genetic deficiency, restoring leptin signaling and partially normalizing their metabolism. The study demonstrates the potential of neuronal replacement therapy for treating metabolic disorders.
Researchers successfully transplanted young neurons into diseased brain circuitry, repairing defective circuits and enabling mice to respond to leptin. This breakthrough suggests new therapeutic approaches for conditions like spinal cord injury, autism, and Parkinson's disease.
A team of Wisconsin scientists reports that lab-grown neurons can successfully fuse with the brain's wiring and send/receive signals. The study uses optogenetics to modulate transplanted cells, opening doors for light-based stimulation technology in treating neurodegenerative disorders.
A new regimen of conditioning therapy before stem cell transplant has improved survival outcomes for older patients with hematologic malignancies. The study found that 5-year overall survival rates were around 35%, and progression-free survival rates were around 32%.