Articles tagged with Asthma
Researchers identified rhinovirus as the biggest contributor to future asthma development in children. Wheezing with RV during early childhood increased asthma odds by nearly 10-fold, with children who wheezed at three years of age facing a 30-fold risk.
Researchers at Children's Hospital of Pittsburgh have identified T Helper Type 17 (Th17) cells as potential mediators of steroid-resistant asthma. These cells may provide a new target for developing drugs to better control the condition.
A new study found that measuring exhaled nitric oxide in adolescents with asthma did not improve disease control. Despite initial improvements, participants who received treatment with exhaled NO monitoring had similar asthma symptoms and exacerbations as those without
Research has identified distinct pathogenic phenotypes, or endotypes, of asthma that can lead to improved classification and targeted treatment efforts. Additionally, studies have shown associations between paracetamol use in infancy, gene-environment interactions, and the risk of developing inflammatory airway disease.
A study by John Hollingsworth at Duke University Medical Center found that a maternal diet rich in methyl donors can increase the development and severity of asthma in mice offspring. The researchers discovered that genes modified by methylation due to methyl donor exposure were likely responsible for this increased risk.
Measuring exhaled nitric oxide (NO) has no clinically significant impact on asthma control when used in conjunction with conventional treatment. Patients in the NO monitoring group received higher doses of inhaled corticosteroids, but this did not lead to better symptom control.
A large prospective study found that rhinitis is a powerful predictor of adult-onset asthma, with non-allergic and allergic rhinitis groups showing significant increased risks. The study suggests that treating allergic rhinitis may reduce the incidence of asthma, but more research is needed to confirm this.
A study published in The Lancet found that early childhood asthma risk factors are strongly associated with adult asthma onset. The researchers identified key factors including wheezing onset, persistent wheezing, and sensitisation to allergens as predictive of chronic asthma at age 22.
A study published in The Lancet found that using paracetamol in the first year of life increases the risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years. The study analyzed data from over 200,000 children across 31 countries.
Monitoring exhaled nitric oxide levels did not improve asthma management in patients managed according to NIH guidelines, but may benefit specific subgroups. The study suggests that most patients can control their asthma with relatively easy-to-measure symptoms and lung function.
Researchers at National Jewish Health found that glucocorticoids are 40% less effective in overweight and obese asthma patients than in those of normal weight. The study suggests a potential mechanism involved in the resistance, which could lead to therapeutic targets for future medications.
Researchers have identified a gene variant associated with childhood asthma in European children, and also found it plays a role in asthma of any severity level among white American children. Further studies are needed to determine if other genes outside the region occupy by ORMDL3 contribute to asthma susceptibility.
A Kaiser Permanente study found that obese adults with asthma are nearly five times more likely to be hospitalized for their condition. The study controlled for various risk factors and found that obese people with asthma have significantly worse asthma control and lower quality of life.
A recent New Zealand study investigated the relationship between obesity and asthma, ruling out systemic inflammation as a common factor. Despite not finding evidence of its involvement, researchers suggest that other possibilities, such as changes in innate immunity or dynamic lung function, may be worth exploring.
A recent study found that children who experienced physical or sexual abuse were more than twice as likely to have asthma. The researchers also discovered an association between stress, violence, and decreased glucocorticoid response, leading to airway inflammatory responses.
Researchers at Texas Instruments have developed a low-cost, portable spirometer using microelectromechanical system (MEMS) technology. The device can measure airflow and volume in a patient's lungs and is ideal for remote monitoring by healthcare workers.
Girls are more likely to experience persistent asthma, whereas boys tend to outgrow the condition. After nine years of monitoring, researchers found that girls' airway reactivity did not change significantly over time, while boys became increasingly tolerant to larger doses of methacholine.
Athletes with asthma face increased risk of symptoms due to high minute ventilation and poor air quality during exercise. Individualized management plans are crucial to comply with anti-doping regulations.
Researchers at Rush University Medical Center discovered that proton channels in basophils respond to agents triggering histamine release, with zinc inhibiting these currents. This finding points to a new approach to reduce the consequences of asthma and allergic reactions.
Research led by the University of New South Wales found that individuals with atopic diseases such as asthma and hay fever are up to 40% less likely to develop NHL if they have multiple conditions. Chronic atopy is associated with a reduced risk, particularly in B-cell NHL cases.
A team of University of Iowa investigators are applying findings from heart research to the study of asthma, focusing on an enzyme known to play a role in heart failure. They aim to learn more about airway smooth muscle cells and their response to the enzyme CaM kinase II.
Researchers at Duke University Medical Center discovered that inhaling stomach fluid can drive the development of asthma by altering the immune system's response. This study suggests chronic micro-aspiration of gastric fluid may be a key factor in linking GERD and asthma, offering new directions for treatment options.
A new study led by NYU Langone Medical Center researchers found that children who carry Helicobacter pylori are nearly 59% less likely to have asthma. The bacteria, which has co-existed with humans for at least 50,000 years, may strengthen the immune system and reduce the risk of allergic reactions.
A new study found that pregnant women who eat nuts or peanut butter daily during pregnancy increase their children's risk of developing asthma by more than 50 percent. The researchers also noted a small effect of daily maternal fruit consumption on reducing wheeze in children.
Researchers found no therapeutic benefit in low-sodium diets for adults with asthma, contrary to past studies. The study suggests that further dietary research should focus on factors other than sodium.
Researchers discovered a three percent higher incidence of visits for asthma attacks on days following thunderstorms in the metro Atlanta area. The study, published in Thorax, could lead to improved intervention strategies and emergency services planning.
Srivastava aims to examine the link between aldose reductase and lung inflammation in asthma. His research group has previously demonstrated the enzyme's role in other inflammatory diseases.
A study by Johns Hopkins Children's Center found that 40% of pediatricians wouldn't reduce medication doses even if a child is well-controlled. The researchers suggest that pediatricians might benefit from a step-by-step tool to apply treatment guidelines and use different disease dimensions in their practice.
A new study suggests that more aggressive treatment of childhood eczema could help reduce the incidence of asthma in later life. The study, conducted by the University of Melbourne and others, found a strong association between childhood eczema and asthma into middle age.
A federally funded consortium of researchers led by Baylor College of Medicine found that children treated for HIV are at higher risk of developing asthma. CD4 cells increase in these children, leading to inflammation in lung tissue and worsening asthma symptoms.
A study published in Nature Genetics has identified over 30 genetic regions associated with Crohn's disease, revealing surprising links between the condition and other common diseases like asthma. The research also highlights the complexity of the disease, suggesting hundreds of genes may be involved.
A new study found that up to 90% of people with asthma use their inhalers incorrectly, leading to poor control and increased healthcare costs. Pharmacists who received training on correct inhaler technique and provided personalized stickers for patients showed significant improvements in asthma severity and patient behavior.
Researchers have identified a key role for fish-based fatty acid molecule RvE1 in resolving airway inflammation and promoting its resolution in mice. The study provides insight into the potential therapeutic use of RvE1 in asthma prevention.
A new study based on data from 1.7 million births found that babies born by Caesarean section have a significantly higher risk of developing asthma in childhood. The study also revealed an even greater association between emergency Caesarean sections and the development of asthma.
A new nuclear medicine imaging test, scintigraphy, has been shown to be highly effective in detecting gastroesophageal reflux disease (GERD) in children with respiratory problems. The test detected GERD in 66.6% of children with asthma or lower respiratory tract infections, outperforming traditional barium X-ray technology.
AstraZeneca has submitted a sNDA for Symbicort, a combination of budesonide and formoterol, for the treatment of asthma in pediatric patients aged 6 to 11 years old. The medication is currently approved for patients 12 years and older.
Researchers discovered a molecular alarm system in the skin that detects defects and triggers an immune response, leading to potentially harmful effects. The study found that genetic abnormalities in the skin can lead to an overproduction of white blood cells, which can be life-threatening.
Two studies using data from the CARDIA cohort provide insights into lung disease and lung function in young adults. Low levels of adiponectin in fat cells are associated with an increased risk of asthma in women, while high levels of ICAM-1 are linked to lower lung function.
A study found that babies born by cesarean section showed a reduction in the suppressive function of their regulatory T-cells. This could be an important factor influencing immune system development in the neonate. Further research is needed to explore potential mechanisms.
A new study found that patients receiving budesonide/formoterol combination therapy reported significantly greater satisfaction with symptom relief, dosing management, and timeliness of medication effects. In contrast, patients treated with fluticasone/salmeterol combination therapy experienced lower levels of satisfaction in these areas.
A new study found that first-born children are more likely to develop asthma and allergy due to specific pregnancy conditions. Researchers investigated immune markers in cord blood IgE and skin prick tests at ages four and ten, revealing a statistically significant higher risk among first-borns.
A new study analyzed SYMBICORT in children with persistent asthma, showing significant improvements in nighttime symptoms, rescue medication use, and lung function. The results indicate that SYMBICORT is effective for treating mild to moderate persistent asthma in children aged 6-15.
A study published in Journal of Allergy and Clinical Immunology found that early life exposure to cats may reduce the risk of developing asthma symptoms. Children with cat ownership were more likely to make allergy-related antibodies and less likely to have wheeze at age five.
A study found that mothers' prenatal stress may increase their babies' sensitivity to allergen exposure and future asthma risk. High levels of IgE expression in cord blood were observed among infants whose mothers experienced higher levels of stress, even with low dust mite exposure.
Researchers at WashU Medicine have identified a new type of immune response linked to severe asthma and COPD, enabling more precise diagnosis and targeted treatment. The study's findings promise to revolutionize the management of chronic inflammatory lung disease by detecting specific biomarkers in the lungs or bloodstream.
Researchers at Mayo Clinic have developed a computer-based simulation program, CASPER, to help patients with asthma manage their disease. The program allows patients to practice making key decisions in a safe, simulated environment, improving their ability to consistently treat their asthma.
Researchers found that girls and children with exposure to secondhand tobacco smoke respond better to montelukast. The medication effectively controls asthma symptoms in these patients by reducing leukotriene levels.
A study by Columbia University's Mailman School of Public Health found that four-year-olds with older siblings are more likely to experience respiratory symptoms such as wheezing. Children with at least two older siblings were 50% more likely to be hospitalized for breathing problems.
Researchers found that teens with asthma dramatically overestimate their ability to control the condition, affecting treatment adherence. A new approach of unplanned planned asthma visits led to improved patient outcomes, including a 30% increase in treatment action plans and 50% reduction in hospitalizations.
A new study reveals that obesity can exacerbate asthma symptoms by increasing dynamic hyperinflation, making it harder for individuals to breathe. The research found significant differences in lung function between obese and non-obese asthmatic women, highlighting the need for more targeted treatment approaches.
Research suggests that areas with more street trees have lower rates of childhood asthma among 4-5 year olds and hospital admissions for older children. Tree density was found to be associated with reduced asthma prevalence, even after controlling for pollution and socioeconomic factors.
Researchers discovered that viral agents can kick-start the body's immune response in the moist nasal lining, leading to inflammation and symptoms like sneezing and congestion. This understanding may lead to new therapies to block the triggering reactions for sinusitis and asthma.
Children with allergic or asthma-prone mothers are at increased risk of wheezing and respiratory issues if they swim before 6 months old. Most infants who swam showed no increase in lower respiratory tract infections or ear inflammation.
A new study finds that air pollution from sulfur dioxide, fine particles, and nitrogen dioxide can cause decreased lung function and increase asthma symptoms in inner-city children. The study suggests that current air quality standards may not be sufficient to protect these vulnerable populations.
A tiny variation in the CHI3L1 gene increases blood levels of YKL-40, a biomarker for asthma. The genetic variation also lowers YKL-40 levels and protects against asthma. Researchers found similar connections between the CHI3L1 variations, YKL-40 levels and asthma susceptibility in three genetically diverse populations.
Researchers found that chronic use of beta blockers alleviates asthma by helping airways relax and dilate, providing longer-term respiratory function. The study builds on earlier breakthroughs in treating congestive heart failure, where beta blockers improved outcomes despite initial worsening symptoms.
A study finds that insufficient hydration of the airway surfaces leads to pathologies typical of chronic obstructive lung diseases in humans. This could lead to a new therapeutic strategy for treating asthma and COPD by improving mucus clearance through sodium channel blockers.
A study found that only 16% of Australians who started using asthma preventer medications regularly, while most new users stopped filling prescriptions after two years. The research highlights a significant gap between guidelines and real-world use.
Despite national guidelines for asthma treatment issued in 1997, many patients still do not receive prescription inhalers for the safest and most effective long-term control of the disease. Researchers found that elderly and minority patients were less likely to be prescribed long-acting controller medications.
A new study found that caregivers with moderate to severe depressive symptoms exhibited lower levels of warmth and higher levels of hostility towards their low-income children with asthma. Researchers used data from a longitudinal study examining treatment adherence among these families.