Articles tagged with Asthma
A new nuclear medicine imaging test, scintigraphy, has been shown to be highly effective in detecting gastroesophageal reflux disease (GERD) in children with respiratory problems. The test detected GERD in 66.6% of children with asthma or lower respiratory tract infections, outperforming traditional barium X-ray technology.
AstraZeneca has submitted a sNDA for Symbicort, a combination of budesonide and formoterol, for the treatment of asthma in pediatric patients aged 6 to 11 years old. The medication is currently approved for patients 12 years and older.
Researchers discovered a molecular alarm system in the skin that detects defects and triggers an immune response, leading to potentially harmful effects. The study found that genetic abnormalities in the skin can lead to an overproduction of white blood cells, which can be life-threatening.
A study found that babies born by cesarean section showed a reduction in the suppressive function of their regulatory T-cells. This could be an important factor influencing immune system development in the neonate. Further research is needed to explore potential mechanisms.
Two studies using data from the CARDIA cohort provide insights into lung disease and lung function in young adults. Low levels of adiponectin in fat cells are associated with an increased risk of asthma in women, while high levels of ICAM-1 are linked to lower lung function.
A new study found that patients receiving budesonide/formoterol combination therapy reported significantly greater satisfaction with symptom relief, dosing management, and timeliness of medication effects. In contrast, patients treated with fluticasone/salmeterol combination therapy experienced lower levels of satisfaction in these areas.
A new study found that first-born children are more likely to develop asthma and allergy due to specific pregnancy conditions. Researchers investigated immune markers in cord blood IgE and skin prick tests at ages four and ten, revealing a statistically significant higher risk among first-borns.
A new study analyzed SYMBICORT in children with persistent asthma, showing significant improvements in nighttime symptoms, rescue medication use, and lung function. The results indicate that SYMBICORT is effective for treating mild to moderate persistent asthma in children aged 6-15.
A study published in Journal of Allergy and Clinical Immunology found that early life exposure to cats may reduce the risk of developing asthma symptoms. Children with cat ownership were more likely to make allergy-related antibodies and less likely to have wheeze at age five.
A study found that mothers' prenatal stress may increase their babies' sensitivity to allergen exposure and future asthma risk. High levels of IgE expression in cord blood were observed among infants whose mothers experienced higher levels of stress, even with low dust mite exposure.
Researchers at WashU Medicine have identified a new type of immune response linked to severe asthma and COPD, enabling more precise diagnosis and targeted treatment. The study's findings promise to revolutionize the management of chronic inflammatory lung disease by detecting specific biomarkers in the lungs or bloodstream.
Researchers at Mayo Clinic have developed a computer-based simulation program, CASPER, to help patients with asthma manage their disease. The program allows patients to practice making key decisions in a safe, simulated environment, improving their ability to consistently treat their asthma.
Researchers found that girls and children with exposure to secondhand tobacco smoke respond better to montelukast. The medication effectively controls asthma symptoms in these patients by reducing leukotriene levels.
A study by Columbia University's Mailman School of Public Health found that four-year-olds with older siblings are more likely to experience respiratory symptoms such as wheezing. Children with at least two older siblings were 50% more likely to be hospitalized for breathing problems.
Researchers found that teens with asthma dramatically overestimate their ability to control the condition, affecting treatment adherence. A new approach of unplanned planned asthma visits led to improved patient outcomes, including a 30% increase in treatment action plans and 50% reduction in hospitalizations.
A new study reveals that obesity can exacerbate asthma symptoms by increasing dynamic hyperinflation, making it harder for individuals to breathe. The research found significant differences in lung function between obese and non-obese asthmatic women, highlighting the need for more targeted treatment approaches.
Research suggests that areas with more street trees have lower rates of childhood asthma among 4-5 year olds and hospital admissions for older children. Tree density was found to be associated with reduced asthma prevalence, even after controlling for pollution and socioeconomic factors.
Researchers discovered that viral agents can kick-start the body's immune response in the moist nasal lining, leading to inflammation and symptoms like sneezing and congestion. This understanding may lead to new therapies to block the triggering reactions for sinusitis and asthma.
Children with allergic or asthma-prone mothers are at increased risk of wheezing and respiratory issues if they swim before 6 months old. Most infants who swam showed no increase in lower respiratory tract infections or ear inflammation.
A new study finds that air pollution from sulfur dioxide, fine particles, and nitrogen dioxide can cause decreased lung function and increase asthma symptoms in inner-city children. The study suggests that current air quality standards may not be sufficient to protect these vulnerable populations.
Researchers found that chronic use of beta blockers alleviates asthma by helping airways relax and dilate, providing longer-term respiratory function. The study builds on earlier breakthroughs in treating congestive heart failure, where beta blockers improved outcomes despite initial worsening symptoms.
A tiny variation in the CHI3L1 gene increases blood levels of YKL-40, a biomarker for asthma. The genetic variation also lowers YKL-40 levels and protects against asthma. Researchers found similar connections between the CHI3L1 variations, YKL-40 levels and asthma susceptibility in three genetically diverse populations.
A study finds that insufficient hydration of the airway surfaces leads to pathologies typical of chronic obstructive lung diseases in humans. This could lead to a new therapeutic strategy for treating asthma and COPD by improving mucus clearance through sodium channel blockers.
A study found that only 16% of Australians who started using asthma preventer medications regularly, while most new users stopped filling prescriptions after two years. The research highlights a significant gap between guidelines and real-world use.
A new study found that caregivers with moderate to severe depressive symptoms exhibited lower levels of warmth and higher levels of hostility towards their low-income children with asthma. Researchers used data from a longitudinal study examining treatment adherence among these families.
Despite national guidelines for asthma treatment issued in 1997, many patients still do not receive prescription inhalers for the safest and most effective long-term control of the disease. Researchers found that elderly and minority patients were less likely to be prescribed long-acting controller medications.
A large study published in Thorax found that regular low-dose aspirin use cuts the risk of developing asthma among women by 10%. The Women's Health Study involved over 40,000 female healthcare professionals and monitored their health for around 10 years.
A new national survey found that elevated indoor allergen levels are associated with asthma symptoms in allergic individuals, particularly those with allergies. Regular household cleaning and reducing exposure to pets and pests can help alleviate symptoms.
Scientists at Mayo Clinic and VBI aim to understand how environmental fungus Alternaria triggers airway inflammation and bronchial asthma. They plan to develop specific therapies and prevention strategies by studying the role of fungal enzymes in innate immune responses.
A new study from Michigan Medicine found that obese children are more likely to experience difficulties with airway obstruction and other breathing-related functions during surgery. The study also reveals a higher incidence of illnesses such as asthma, hypertension, sleep apnea, and Type II diabetes among obese children.
Researchers from NIST and CU-Boulder have developed a technique using optical frequency comb spectroscopy to detect molecules in breath that may be markers for diseases like asthma or cancer. The technique can identify thousands of different molecules simultaneously, providing highly reliable information about various diseases.
Scientists have identified a key component of the body's response to allergens that can be targeted to reduce allergic reactions in mice. The research confirms that p110delta is a crucial player in allergic reactions and offers hope for therapies that target the real causes, not just symptoms.
Patients with refractory asthma experienced longer term improvement in pulmonary function, improved quality of life, and reduced rescue medication use after undergoing bronchial thermoplasty. The procedure resulted in a significant reduction in corticosteroid use, particularly among those who were able to wean off medication completely.
A Michigan State University physician reports the first nationally documented death from acute asthma caused by environmental tobacco smoke (ETS) in a bar employee. The case highlights the need for legal protections against ETS in workplaces, particularly for vulnerable employees with pre-existing conditions like asthma.
A study found that severe asthma is characterized by air trapping and incomplete reversibility with bronchodilator treatment. This suggests a distinct physiological difference between severe and non-severe asthma, potentially leading to new treatment approaches.
Researchers developed a sensor system that measures airborne pollutants, temperature, and humidity to understand asthma attack causes. The system, worn in a vest, detected higher volatile organic compounds in one volunteer's home, revealing a pollutant pathway causing asthma attacks.
Researchers at UTMB have identified distinct subtypes of asthma using protein profiling, which could lead to tailored treatments. The study found four different asthma subtypes, including one associated with severe and treatment-resistant disease, offering new hope for more effective asthma therapies.
A study found that 13% of children with asthma were uninsured at some point during the year, leading to increased risk of unmet medical needs and hospitalizations. Children without insurance are 14 times more likely to have an unmet need for medication than those with private insurance.
Children whose mothers experience chronic stress during early years have a higher asthma rate than peers. Long-term maternal stress was associated with an increase in nearly a third of childhood asthma prevalence. Maternal distress also intensified risk under specific home environments, such as high-income households or sibling presence.
A new study has found that widely used asthma medication long-acting beta-agonists may not be associated with adverse events based on a patient's genotype. The study analyzed data from two clinical trials and found no differences in asthma symptoms or control between patients with different beta-2 adrenergic receptor genotypes.
Inhibiting PIN1 has been shown to reduce airway fibrosis driven by TGF-beta-1 production in rodents with chronic asthma. Mice lacking PIN1 also exhibited reduced airway fibrosis when exposed to allergens.
The Columbia Center for Children's Environmental Health has received a DISCOVER grant to conduct four related studies on the effects of prenatal and early postnatal exposure to air pollutants on lung development and immune system function. The research aims to better prevent childhood asthma and improve clinical treatment.
A Johns Hopkins study finds activating a specific protein on immune cells can reduce allergic reactions and asthma attacks. By targeting this protein, researchers hope to develop new treatments for allergies.
Exposure to traffic pollution may increase respiratory problems and reduce lung volumes in children with asthma. Living in areas with high road density also increased respiratory symptoms in asthmatic children, even if they didn't have pre-existing conditions.
A new study by Imperial College London found that diesel exhaust fumes increase asthmatic symptoms, reduce lung capacity, and cause inflammation in people with mild and moderate asthma. The research measured air quality and lung function in volunteers walking along Oxford Street, where only diesel-powered vehicles are allowed.
A study by Columbia University's Mailman School of Public Health found a significant link between asthma and post-traumatic stress disorder (PTSD) among adults. The research suggested that the association is not primarily due to genetic influences, but rather may be related to immune system functioning or common risk factors.
A study of 3,065 male twin pairs found that those suffering from PTSD symptoms were 2.3 times more likely to have asthma compared to those with fewer symptoms. The association between asthma and PTSD was not primarily explained by genetic factors.
A study by Yale researchers suggests that YKL-40 may play a role in severe asthma, with elevated levels correlating to increased inflammation and lung function. The discovery brings hope for developing a blood test to identify patients with severe asthma, which affects 2.5 million Americans.
Researchers found that severe respiratory viral infections induce an allergic-type immune response, leading to long-term changes in the airways of mice. Interfering with this process could potentially prevent childhood asthma.
A study of over 1,300 youths found that those with asthma are 1.9 times more likely to develop depressive or anxiety disorders. Young people with both conditions often struggle to manage their asthma, leading to impaired physical functioning and increased risk of smoking.
A study suggests that urban children with asthma, even mild cases, require more frequent check-ups than current guidelines recommend. This is due to unpredictable symptoms that can worsen over time, especially in inner-city kids.
Uncontrolled asthma is linked to significantly more school and work absences, with a new study showing up to 2-3 times more days absent. Antismoking classes may improve young children's knowledge about tobacco smoke, while phone triage programs provide safe and cost-effective care for ventilator-dependent children.
Asthma diaries found to improve self-efficacy and reduce doctor visits in women with severe asthma. Research also links iron deficiency to increased coughing in women and neck size to sleep apnea severity, especially in women. Furthermore, a high prevalence of sexual dysfunction is found in pre-menopausal women with obstructive sleep a...
A new study shows that 32.1% of patients with asthma or COPD use their dry powder inhalers (DPIs) incorrectly, leading to increased morbidity and mortality. The error rate increases with age and severity of airway obstruction.
Research reveals greater asthma severity and poorer perceived control increase the risk of death among adults. Additionally, uncontrolled asthma leads to more school/work absenteeism and may result in fewer doctor visits for those keeping an asthma diary, according to a new study.
A new study reveals that only a quarter of NCAA-affiliated athletic trainers have a pulmonologist on their team, leading to inadequate asthma management guidelines and equipment availability. The presence of a pulmonologist increases adherence to national guidelines, potentially improving athlete care.
Researchers found that pitrakinra significantly reduced asthma symptoms in patients, with a maximum decrease of 17.1% in forced expiratory volume (FEV1) compared to placebo groups. The study suggests that pitrakinra may be an effective treatment option for asthma, offering promising results.
A University of Alberta study found that farm children are less likely to develop asthma compared to those living in non-farm rural or urban environments. The two-year cumulative incidence of asthma was 2.3% among farm kids, significantly lower than other groups.
Researchers found that frequent use of household cleaning sprays can raise asthma risk in nonprofessional users, increasing the risk by 30-50% compared to those who rarely or never use such products. Cleaning sprays, especially air fresheners and glass cleaners, had a particularly strong effect.
A study found that children with dysfunctional families and living in poor neighborhoods experience greater asthma symptoms and poorer lung function. Family support was linked to reduced inflammation, while neighborhood problems led to increased smoking and exposure to smoke.