Articles tagged with Cancer
Researchers discovered biomarkers in gut bacteria and metabolites that can help diagnose and treat gastrointestinal diseases. The study found that certain biomarkers could predict multiple diseases, including gastric cancer and inflammatory bowel disease.
Researchers identified a new biomarker, TTF-1, that predicts survival outcomes for patients with advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC) treated with sotorasib. Patients with low TTF-1 levels responded poorly to sotorasib, while those with high TTF-1 levels showed improved outcomes.
Researchers from Mayo Clinic Comprehensive Cancer Center will present practice-changing studies on chemotherapy approaches, AI applications in oncology, and new therapies for breast and melanoma. The event will feature 59 abstracts highlighting advancements in cancer care.
Researchers identify five distinct immunotypes in tongue squamous cell carcinoma, shedding light on why current immunotherapies fail. The study's findings highlight the need for immune-based assessments to guide treatment decisions and suggest a new approach to personalized medicine.
The study found that teenagers experienced the longest median time to diagnosis (8.7 weeks), while infants under one year had the shortest (3.7 weeks). Bone tumours were associated with a longer diagnostic interval, highlighting the need for faster diagnoses in certain groups.
The University of Houston has launched a $3M Cancer Immunotherapy Biomarker Core to accelerate early diagnosis and treatment response in cancer. The core will offer comprehensive targeted proteomic cancer biomarker screens, enabling researchers to identify better biomarkers for cancer.
The European Society for Medical Oncology (ESMO) has released the latest version of the ESMO-MCBS scale, which measures the clinical benefit of cancer treatments. The new version incorporates 13 critical amendments to improve evaluation and accuracy, with a focus on patient preferences and toxicity annotations.
Autophagy and lysosomal pathways orchestrate the unconventional secretion of PARK7, a PD-associated protein, in response to cellular stress. The study reveals a unique mechanism involving coordinated actions of macroautophagy and chaperone-mediated autophagy.
Researchers discovered a novel mechanism by which glioblastoma cells exploit astrocytes to evade immune responses. The study highlights an astrocyte-driven mechanism used by GBM to escape protective immune responses and could guide novel immunotherapies for the treatment of this aggressive brain cancer.
Researchers from MD Anderson Cancer Center present notable studies on immunotherapy and CAR T cell therapy for various cancer types. These findings show promising results for patients with aggressive and rare cancers.
A study published in PNAS reveals that colorectal cancer cells utilize a protein called TBX3, which regulates embryo development, to contribute to their aggressiveness and metastasis. The discovery opens up possibilities for developing targeted therapies to prevent tumor cell spread.
Researchers at UC San Diego develop new approach using artificial intelligence to predict therapy outcomes and match patients with right treatments, improving cancer care and patient outcomes.
Four Weill Cornell Medicine investigators received the Ritu Banga Healthcare Disparities Research Awards to tackle disparities in cancer care, racial and ethnic differences in pediatric Hodgkin lymphoma, and access barriers to high-quality surgical cancer care. The awards support innovative research aimed at improving health outcomes f...
A rare form of childhood brain cancer called Diffuse Midline Glioma (DMG) hijacks gene control machinery to fuel its growth. A specific gene-silencing complex, CBX4/PCGF4-cPRC1, is essential for tumour growth and could be a promising drug target.
A systematic review and meta-analysis found elevated circPVT1 expression associated with poorer overall survival in patients with solid tumors. The study also revealed correlations between circPVT1 levels and larger tumor size, lymph node metastasis, distant metastasis, and advanced tumor-stage.
A study by Ludwig Princeton's Asael Roichman and Joshua Rabinowitz found that diet can alter cancer treatment outcomes, with certain plant-based foods influencing gut bacteria to clear PI3K inhibitors more quickly.
Researchers developed a genomic risk assessment score to predict disease progression in patients with precursor conditions for multiple myeloma. The score assesses the severity of disease and risk of progression, allowing for more personalized care and early intervention strategies.
Researchers review clinical and scientific advances combining radiation therapy with immunotherapy to strengthen the immune response and improve disease control. The approach may offer new treatment options for patients facing hard-to-treat forms of bladder cancer.
Researchers developed a technique to analyze DNA methylation marks, identifying changes in blood production that occur with age. By age 50, many blood stem cells begin to drop out and larger clones take over, leading to a decline in diversity and resilience.
A randomized controlled trial found that additional imaging techniques such as fast MRI and contrast mammography can detect early-stage cancers in women with dense breasts that were missed by mammograms. The study showed a cancer detection rate of 1.7% for fast MRI and 1.9% for contrast mammography, compared to 0.4% for ultrasound.
A UCLA study found that selective serotonin reuptake inhibitors (SSRIs) can significantly enhance the ability of T cells to fight cancer and suppress tumor growth across various cancer types in mouse and human tumor models. SSRIs increased access to serotonin signals, making killer T cells happier and more effective at killing cancer c...
Researchers at UCSF found that certain gut bacteria can reduce chemotherapy side effects by clearing excess drugs and producing the protective vitamin K2. Patients with more beneficial bacteria had fewer side effects, suggesting that probiotics may help mitigate chemotherapy's impact.
Researchers have developed a new treatment combining venetoclax and inobrodib that shows promising results in killing B-ALL cells, potentially reducing toxic chemotherapy needs. The approach could be less toxic than current treatments and effective in all age groups.
Researchers at MIT developed a method to quickly measure cell density, which can predict whether immunotherapies will work in patients or how tumors will respond to drug treatment. The technique uses a combined microfluidic device and fluorescent microscope to measure up to 30,000 cells in an hour.
Researchers at The University of Osaka found that localized oxygen deficiency in colon tumors can promote tumor growth by transforming normal fibroblasts into inflammatory fibroblasts. These altered cells release factors that help tumors grow, offering a potential new target for cancer therapy.
UT Dallas bioengineers have created an enhanced light-activated immunotherapy approach to target advanced stomach cancer. Lab-designed molecules are primed with far-red or near-infrared light to activate the immune system against stubborn cancer cells, reducing side effects.
US survivors of adolescence and young adult cancer experience significantly worse mental health outcomes into middle age and older adulthood. Cancer clinicians should acknowledge this mental health burden and take steps to address it.
A recent study identifies LPCAT1 as a critical culprit in TNBC's aggressive behavior, which can be silenced with siRNA-delivering nanoparticles. This approach starves tumors of their energy supply, dramatically reducing tumor growth and lung metastasis.
A nationwide cohort study found that immune checkpoint inhibitors significantly increase the risk of myocarditis in NSCLC patients, with a 7.4-fold increase in risk compared to non-users. Cardiac monitoring for at least six months following ICI initiation is recommended.
A study found that blood cancer survivors are more likely to face financial hardship and take fewer medications due to high-cost immunotherapy treatments. Financial strain affects both Medicare-insured and uninsured patients, highlighting the need for better financial support and policy strategies.
Researchers from Sylvester will present on various cancer-related topics, including multiple myeloma, hematopoietic stem cell transplantation, and melanoma. The presentations focus on innovative treatments and supportive care interventions.
Research reveals specific mtDNA mutations drive cancer initiation, impairing mitochondrial function and increasing ROS production. Elevated oncogenic potential is observed in cells with low to moderate levels of MT-ND5 heteroplasmy.
Researchers found that stereotactic body radiotherapy (SBRT) is as safe as conventional treatment, with similar side effects and quality of life. SBRT shortens treatment time and may have biological advantages in targeting prostate cancer.
A new study from Uppsala University found that people with high fitness levels in late adolescence have a lower risk of dying prematurely, but the association between physical fitness and reduced mortality risk may be overstated. The researchers examined data from over 1 million Swedish men and found no significant difference in the ri...
A study by Mass General Brigham found that patients with glioblastoma who received gabapentin lived longer than those who didn't. The medication was shown to confer a four-month survival benefit, with patients on gabapentin surviving an average of 16 months compared to 12 months for those without the drug.
The American Society for Radiation Oncology (ASTRO) will host its 67th Annual Meeting in San Francisco from September 27 to October 1, 2025. The meeting will feature over 2,500 research presentations and posters on advances in radiation oncology and non-cancer indications.
A new clinical trial has shown that a lower dose of radiotherapy can lead to higher levels of complete disappearance of cancer and fewer short-term side effects. The treatment approach, led by Professor David Sebag-Montefiore, aims to reduce the burden on patients and healthcare systems.
Scientists discovered that taurine drives leukemia growth by promoting glycolysis and is produced by normal cells in the bone marrow microenvironment. Researchers identified taurine transporter expression as essential for leukemia cell growth, leading to potential new therapeutic targets.
The National Comprehensive Cancer Network (NCCN) is joining forces with global organizations to address gaps in cancer control plans, promoting data-driven decision-making and comprehensive implementation. The Cancer Planners Forum aims to optimize care for people touched by cancer globally.
Researchers created a new nanoparticle that combines focused ultrasound and chemotherapy to destroy tumors more precisely and prevent recurrence. The treatment shows promising results in preclinical models, offering a potential breakthrough in cancer therapy.
A new study found that adults diagnosed with type 1 diabetes after age 40 have a higher risk of cardiovascular disease and death compared to those diagnosed earlier. Poor glucose control, obesity, and smoking are the main risk factors identified in the study.
A systematic review and meta-analysis found that individuals with blood type A have a significantly higher risk of developing breast cancer compared to those with blood type O. The research, which pooled data from over 13,000 breast cancer patients and 717,000 controls, suggests an 18% increased risk associated with blood type A.
Researchers at the University of Chicago Medicine discovered a new phenomenon where high doses of radiation cause growth in existing metastatic tumors. The 'badscopal effect' is attributed to increased production of amphiregulin, which weakens the immune system and makes cancer cells more resistant.
Breast cancer remains a significant health challenge worldwide, with nanotechnology offering a ray of hope. Nanoparticles improve diagnostic imaging, biomarker detection, and therapy by enhancing drug solubility, stability, and targeted delivery.
A new study identified six distinct breast tissue patterns associated with an increased risk of invasive breast cancer, particularly among Black women. The radiomic phenotypes may help predict the likelihood of false-negative mammograms or interval cancer diagnoses.
Researchers found that x-ray sterilization effectiveness differs depending on dose rate and bacterial nutrient conditions. Long-term low-dose irradiation was more effective in nutrient-poor environments, while short-term high-dose irradiation achieved higher efficiency in nutrient-rich environments.
DiffInvex identifies evolutionary shifts in driver gene repertoires during tumorigenesis and chemotherapy, pinpointing mutational escape routes that let cancers resist treatment. The framework reveals which genes may ignite resistance to anticancer drugs, suggesting a core circuitry boosting strategy.
The study demonstrated the diagnostic utility of endobronchial ultrasound elastography for detecting benign and malignant lymph nodes. The combined index of elastography grading score and short diameter yielded an area under the receiver operating characteristic curve of 0.702, indicating moderate accuracy.
A study led by MUSC Hollings Cancer Center researcher Amanda Palmer found that young males, especially those who have used cigarettes or e-cigarettes before, are more likely to use oral nicotine pouches. Although usage is relatively low, the trend suggests a potential beneficial alternative to combustible cigarettes.
Researchers have developed a new compound, SHP1705, that selectively attacks glioblastoma stem cells by hijacked circadian clock proteins. The compound was found to be safe and well-tolerated in humans during a phase 1 clinical trial.
Researchers found that GLP-1 receptor agonists have a direct effect on reducing obesity-related cancer beyond weight-loss, with a 41% lower relative risk compared to bariatric surgery. The study also suggests that these medications work through multiple mechanisms, including reducing inflammation.
A new $4 million grant will test whether Prostate Specific Membrane Antigen (PSMA)-Positron Emission Tomography (PET) Computed Tomography (CT) can improve prostate cancer monitoring while reducing screening-related harms. The study aims to reduce the need for biopsies in men with low- or intermediate-risk prostate cancers.
Researchers found that phospholipids in ascites fluid disrupt immune cell function, particularly NK cells, leading to impaired anti-tumor activity. Blocking these lipids can restore NK cell activity, providing a promising therapeutic target.
Recent advances and challenges in T cell immunotherapy highlight the need for deeper understanding of T cell fate determination mechanisms to overcome immunotherapy resistance. Key regulatory factors, transcription factors, and metabolic pathways govern T cell differentiation and function.
Researchers discovered that ascites fluid produced by ovarian cancer suppresses cytotoxic lymphocytes, crippling immune cells' ability to kill cancer cells. Fats in ascites cripple NK cells, T cells, and innate T cells, which are attractive candidates for cellular immunotherapies.
A new study suggests that multi-strain probiotics can alleviate chemotherapy-related side effects such as fatigue, nausea, and weakness. Probiotics have been shown to improve blood urea nitrogen levels and enable patients to perform daily activities more independently.
Researchers discovered that METTL3, an oncogene, regulates the expression of SMAD4 via miR-146a-5p in OSCC. This pathway can potentially have therapeutic implications for treating oral squamous cell carcinoma.
A single blood test could identify early-stage cancer in up to half of cases, potentially preventing late-stage disease and improving patient outcomes. Regular MCED testing showed more favourable diagnostic rates than usual care alone, with annual screenings having a higher impact on stage shift.
The study found increasing incidence rates for five cancer types without corresponding increases in late-onset age groups. The greatest increases were seen in female breast cancer, colorectal cancer, kidney cancer, and uterine cancer.
A systematic review found a strong association between ultra-processed food consumption and adverse health outcomes. The study suggests that limiting intake of such foods may offer measurable health benefits.