Articles tagged with Cancer
A new AI tool, FaceAge, estimates a person's biological age from their facial characteristics, which is associated with cancer survival outcomes. The tool outperforms clinicians in predicting short-term life expectancies for patients receiving palliative radiotherapy.
The introduction of standardized criteria for amino acid PET in brain metastases diagnosis and treatment could improve patient care and accelerate innovative treatment strategies. The new criteria may allow a more precise distinction between true tumour changes and therapy-related effects.
Researchers discovered 500 cryptic peptides found only in pancreatic tumors, which could be targeted by vaccines or engineered T cells to attack the cancer. The peptides were identified using immunopeptidomics and shown to slow down tumor growth in mice.
A single blood test could identify early-stage cancer in up to half of cases, potentially preventing late-stage disease and improving patient outcomes. Regular MCED testing showed more favourable diagnostic rates than usual care alone, with annual screenings having a higher impact on stage shift.
The study found increasing incidence rates for five cancer types without corresponding increases in late-onset age groups. The greatest increases were seen in female breast cancer, colorectal cancer, kidney cancer, and uterine cancer.
A new study reveals that over half of Black and Latina women reported using personal care products with formaldehyde-releasing preservatives, highlighting critical safety gaps in product regulation. The study found that these chemicals are present in a wide range of products, including shampoo, lotions, and eyelash glue.
A study found that removing ovaries and fallopian tubes in women with BRCA1 and BRCA2 genetic variants significantly reduces the risk of early death from cancer. This procedure, known as bilateral salpingo-oophorectomy (BSO), also decreases the risk of developing a second cancer without any serious side effects.
The ESMO Breast Cancer 2025 congress will cover topics such as circulating tumour DNA, immunotherapies, and emerging therapies for managing breast cancer. The event will feature key findings on predictive biomarkers, ctDNA, and tumour-infiltrating lymphocytes.
A European research team will explore radiation therapy approaches to improve treatment outcomes and prevent secondary tumors in adolescents and young adults. The KAYAC+ project aims to investigate the clinical results of particle therapy and its impact on cancer development.
A study led by the Badalona Neuromuscular Research Group found that HDAC11 deficiency reduces muscle mass loss, promotes muscle regeneration, and improves overall muscle function in aged murine models. This discovery proposes a new therapeutic strategy to slow down age-related muscular decline and promote healthier ageing.
A new AI tool, SALSA, has been developed to automate the detection and monitoring of liver tumors with high precision. The tool, which uses deep learning algorithms, demonstrates superior accuracy in cancer detection and quantification of tumor burden, surpassing state-of-the-art models.
The NCCN Policy Summit brought together experts to discuss ways to strengthen collaborative cancer care, from early detection to survivorship. Key findings include the need for better communication and coordination between primary care and oncology providers.
A study published in Human Reproduction found that healthy childhood diets are associated with delayed onset of menstruation, independent of body mass index (BMI) or height. The research suggests that a diet high in fruits, vegetables, and whole grains may help reduce the risk of chronic diseases such as diabetes and breast cancer.
Researchers identified ADH4 as a key suppressor of HCC and found that silencing it increases tumor growth; forced ADH4 expression reverses oncogenic traits. RA production counteracts the Wnt/β-catenin signaling pathway, driving cellular proliferation.
Researchers found AI outperformed physicians in answering GI cancer questions, with oncologists preferring ChatGPT's responses nearly 80% of the time. Additionally, fewer patients are getting surgery for benign colon polyps as endoscopic techniques rise, reducing serious complications and mortality rates.
Researchers found that a chemical modification on messenger RNAs triggers disposal while being read by the ribosome, but during cell stress, this process is halted, allowing stress-response proteins to accumulate and help cells recover. The study may have implications for cancer therapies targeting m6A modifications.
A new study published in the Journal of the National Cancer Institute suggests that artificial intelligence can help detect interval breast cancers earlier, potentially reducing their rates by 30%. The research used AI software to analyze mammograms and identify subtle signs of cancer that were missed by radiologists.
Anal cancer is increasing rapidly among older, white and Hispanic women due to HPV vaccination delays. The study found a significant increase in anal cancer rates for these groups, reaching 11.4 cases per 100,000 in 2021.
A McGill University-led study found that 75% of Canadian adults spend at least 30 minutes in the sun on summer days, with nearly half staying out for two hours or more. Young adults are more likely to get sunburned and use tanning beds, making them less likely to wear protective clothing.
A recent study has identified the 'cell of origin' of lung squamous cell carcinoma (LUSC), a second most common type of lung cancer among smokers. The research found that basal cells expressing the gene Krt5 become dominant in the trachea and eventually invade large areas of the lung, forming tumors.
Researchers from the University of Southampton engineered a new type of super-strong antibody that triggers a stronger response from the immune system compared to naturally produced antibodies. The study confirms that making subtle increases in rigidity stimulates immune activity, creating a powerful immune response against disease.
Researchers from Kyushu University found that lipid peroxidation of lysosomes plays a key role in ferroptosis-mediated cell death, leading to iron leakage and membrane permeabilization. Administration of chloroquine promotes ferroptosis even in cancer cells less susceptible to the process.
Pennington Biomedical welcomes Dr. Adithya Hari, MD, with expertise in nuclear oncology and translational science, strengthening cancer research and patient-centered innovation in Louisiana. He will establish a research program focused on nuclear medicine and dedicate time to direct patient care through a clinical partnership.
Researchers investigated the clinical outcomes of concurrent TTFields therapy with CRT in patients with newly diagnosed glioblastoma, finding no significant difference in survival outcomes compared to adjuvant therapy. The study also showed comparable safety profiles for both treatment groups.
Researchers at Osaka Metropolitan University found that plasma-activated medium reduces synovial sarcoma tumor growth in human cells and mice, with no obvious side effects. The treatment was verified through in vitro and in vivo tests, offering a new potential treatment option for this rare form of cancer.
A new review advocates for building confidence in AI applications by implementing robust data governance frameworks, enhancing transparency, and involving stakeholders. The authors emphasize the importance of addressing ethical implications and ensuring equitable access to AI-driven innovations in clinical oncology.
Flinders University researchers found that most people, regardless of age, want more frequent bowel cancer surveillance. A faecal test may provide reassurance for those at risk, particularly younger adults with a higher fear of bowel cancer.
Researchers have developed three-dimensional spheroid cultures that better replicate cell-cell interactions and nutrient gradients, leading to a greater understanding of tumour tissue behaviour and drug responses. The study highlights the importance of mimicking tumour architecture in testing cancer therapies.
Researchers at TUM developed an AI-powered algorithm to predict kidney damage in prostate cancer patients undergoing lutetium-177 PSMA therapy. Early detection could enable personalized treatment adjustments to prevent organ damage.
A new study highlights the success of a financial toxicity tumor board in reducing cancer treatment costs. The board has assisted over 9,321 patients with copay assistance and provided free medication to 16,495 patients, resulting in total savings of $393 million.
Regular exercise can reduce side effects of cancer treatment, such as heart damage, nerve damage, and brain fog. It also improves psychological wellbeing, sleep quality, and overall quality of life in people with cancer.
A study found that most head-and-neck cancer survivors who underwent radiation don't know about survivorship care, despite grapple with side effects such as dry mouth, swallowing problems, and psychological distress. The survey also found that 40% of survivors still struggle with dry mouth and nearly a quarter reported trouble swallowing.
A study has identified a specific mode of fat uptake by immune cells in tumors that serves as a metabolic checkpoint against anti-cancer immune responses. Researchers developed an antibody, PLT012, to dismantle this barrier and restore anti-tumor immunity in mouse models of hepatocellular carcinoma and liver metastases of colon cancer.
A study reveals that HSF2, a transcription factor, helps activate gamma-herpesviruses causing cancer. Increasing HSF2 levels boosts viral gene activity, while reducing it leads to a significant drop. The protein binds to key genes, making chromatin more open for activation.
Scientists have developed a cutting-edge technology to analyze protein turnover in individual cells, enabling them to identify treatment-resistant cancer cells and understand the impact of specific drugs. This breakthrough could lead to advancements in disease diagnostics and treatment strategies.
A recent study found significant elevated expression of AID enzyme in B cells during Plasmodium falciparum malaria, linking the parasite to the development of Burkitt lymphoma. Elevated AID levels were also observed in Kenyan children with uncomplicated malaria.
Research found that bad habits like smoking, heavy drinking, and lack of exercise can lead to declines in health as young as 36, with effects more pronounced over the long-term. The study tracked hundreds of people for 30 years and found that three unhealthy behaviors were linked to poorer mental and physical health.
Researchers at the University of Groningen discovered that mefloquine can enhance the effect of aminoglycosides to override faulty stop signals in proteins. This could lead to the development of new drugs tackling genetic diseases.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
A combination therapy that targets the differentiation barrier in AML cells has been identified, showing potential to treat some AML subtypes. The treatment involves activating genes that drive cell differentiation while suppressing those that promote cancer growth.
Combining AI with traditional mathematical modeling can improve cancer treatment outcomes by providing specificity and accuracy. The researchers emphasize the importance of ethically sharing health data to create reproducible science, protecting patient privacy while promoting scientific integrity.
A cohort study found that women with screen-detected estrogen receptor–positive or human epidermal growth factor receptor 2–negative breast cancer who underwent prior screening had an earlier stage of diagnosis and lower breast cancer mortality compared to those who did not undergo prior screening.
Researchers analyzed CRC tumors with high tumor mutation burden to characterize BRAF-associated mutations and decipher their role in carcinogenesis. They found TMB-high tumors likely arise from a heterogeneous population of cells harboring numerous gene mutations distinct from driver oncogenes.
A multicenter retrospective study found that routine caudate lobe resection does not significantly improve long-term survival and recurrence for patients with HCCA. However, achieving a negative margin is crucial for improving prognosis.
Current computed tomography (CT) imaging may lead to up to 103,000 future cancers over a patient's lifetime. If practices persist, CT-associated cancer could account for 5% of all new diagnoses annually.
Researchers developed a simple, cost-effective blood test that detects Parkinson's disease long before symptoms emerge by analyzing transfer RNA fragments. The test has an accuracy surpassing existing clinical diagnostic tools and may alleviate uncertainty faced by patients and clinicians.
Scientists have created a detailed map of U2OS cells, revealing previously unknown protein functions and assemblies. The study will help researchers understand how mutated proteins contribute to childhood cancers and provide a blueprint for mapping other cell types.
Scientists at City of Hope have identified a new molecular target for treating pancreatic cancer, using an experimental drug to slow tumor growth and damage tumor cells. The approach showed promise in clinical trials with two patients, resulting in up to a 49% shrinkage in liver metastases.
Isowalsuranolide activates autophagy-dependent cell death by targeting TrxR1/2, leading to ROS-mediated lysosomal biogenesis and reduced cell growth. The study reveals the TrxR1/2-p53-TFEB/TFE3 axis as a key regulator of cellular homeostasis in cancer.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.
A team of scientists has developed a new ultrasound technique called nonlinear sound sheet microscopy that images specifically labelled cells in 3D with ultrasound. This method allows for non-invasive imaging of whole organs and provides information about how cells behave in their natural environment.
Researchers developed bacteria-enhanced graphene oxide nanoparticles that effectively destroy tumors through a three-pronged mechanism. The nanocomposites combine chemotherapy, immune activation, and photothermal heating to suppress tumor growth and activate strong immune responses in mice.
A 'master regulator' gene, ZNFX1, has been identified that may help guide treatment in patients with therapy-resistant ovarian cancer. The expression of this biomarker correlates with improved survival outcomes.
Aging (Aging-US) journal announces a commemorative collection honoring Dr. Mikhail Blagosklonny, a pioneer in aging biology. The special issue will explore key themes central to his scientific contributions, including mechanistic insights and translational approaches.
A University of Iowa-led study has revealed the unexpected structure adopted by the DNA repair protein RAD52 as it binds and protects replicating DNA in dividing cells. This understanding may help researchers develop new anti-cancer drugs targeting RAD52.
A new study suggests AI-driven smart devices can revolutionize healthcare by detecting cardiac issues early, triggering emergency responses. The Internet of Medical Things (IoMT) technology enables real-time patient monitoring and analysis, improving efficiency and reducing costs.
A survey by the Annenberg Public Policy Center found that over half of Americans believe drinking alcohol increases their chances of developing cancer. The Surgeon General's advisory on alcohol and cancer risk also contributed to increased public awareness, with nearly 3 in 10 respondents saying they would be less likely to accept a dr...
A new form of tumor infiltrating lymphocyte (TIL) therapy improved treatment's effectiveness in patients with metastatic gastrointestinal cancers. Objective responses were seen in multiple types of gastrointestinal cancers, including colon, rectum, pancreas, and bile duct tumors.
Jennifer L. West, UVA Engineering Dean and Saunders Family Professor of Engineering, has been awarded the 2025 Pierre Galletti Award for her innovative research in biomaterials and nanomedicine. Her work has led to breakthroughs in treating cancer with precision, offering new hope to patients battling hard-to-treat cancers.
A new study led by the University of Michigan Rogel Cancer Center found that patients with three specific variants face no extra risk of dying from their cancer. The researchers used data from the Surveillance, Epidemiology and End Results programs in Georgia and California, looking at a total of about 78,000 patients with breast, colo...