Articles tagged with Hyperalgesia
Studies have shown that emotional or psychological stress enhances pain responses, but the effects of social pain transmission remain elusive. Researchers found that ultrasonic vocalizations emitted by mice in response to pain stimuli can induce emotional transmission and hyperalgesia in other mice.
A study from The Hebrew University of Jerusalem found that the brain's braking system fails in chronic pain, leading to increased pain signals. This discovery opens the door to targeted therapies and may help prevent pain from becoming chronic.
A new study reveals that paracetamol blocks pain signals before they reach the brain by acting on nerve endings. This discovery opens the door to developing safer pain treatments. The active metabolite AM404 targets specific sodium channels in pain-sensing neurons, stopping pain signals.
Researchers at Texas Tech University Health Sciences Center have received a $1.94 million grant to study inhibitors that target peripheral neuropathic pain. The project aims to develop novel non-opioid and non-addicting therapies capable of effectively managing chronic pain.
The study investigates how the brain perceives pain and finds that the Surprise Hypothesis better explains the mechanism. Participants in the experiment reported stronger pain when they were surprised by painful stimuli, confirming the importance of reducing the gap between expected and unexpected events.
Researchers at the University of Alabama at Birmingham found that blocking Tiam1 activity in spinal neurons abrogates morphine tolerance and hyperalgesia in a mouse model. Prolonged morphine treatment increased activated Tiam1 levels, leading to dendritic spine morphological changes.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
Researchers from Tokyo University of Science found that chronic social defeat stress (cSDS) induced mice showed higher intestinal transit ratio and visceral pain-related behaviors, similar to IBS. The study suggests that prolonged psychological stress can cause IBS-like symptoms in mice without intestinal lesions.
A study found that mice exhibit hyperalgesia when housed with withdrawal mice, and inhibiting a specific brain region reverses this effect. The findings suggest a neural overlap between physically-induced and socially-transferred hyperalgesia.
Researchers discovered that naked mole-rats' unique TrkA receptors alter protein building blocks, reducing signal-relaying action and making them insensitive to thermal hyperalgesia. This finding may lead to new pain therapies by blocking NGF and TrkA interactions.
New research reveals that a small change in the naked mole rat's TrkA receptor makes it less sensitive to pain signals, allowing them to survive in crowded underground colonies. This adaptation may help conserve energy and aid in thermoregulation.
Researchers found that observing a person in pain can lead to nocebo hyperalgesia, while unexplained interventions also elevate pain experience. The study suggests taking these factors into account in medical practice and research to better understand nocebo hyperalgesia.
Studies in animal models reveal that mTOR activation contributes to morphine tolerance and hyperalgesia, while mitochondrial iron accumulation promotes doxorubicin-associated cardiotoxicity. These findings suggest potential therapeutic targets for improving pain management and limiting cardiotoxicity.
Research finds mTOR activation in neurons of dorsal horn contributes to morphine tolerance and hyperalgesia; rapamycin treatment improves opioid tolerance and hyperalgesia in rats. Targeting the mTOR pathway may enhance pain management.
Researchers found that dexmedetomidine alleviated symptoms of opioid-induced hyperalgesia in patients receiving high doses of remifentanil. Patients treated with dexmedetomidine reported less pain and used less morphine compared to those receiving placebo.
Researchers discovered that radiation treatment inhibits monocyte entry into the optic nerve head, preventing neuronal damage in a mouse model of glaucoma. This breakthrough sheds light on a potential prevention strategy for glaucoma, which is one of the leading causes of vision loss and blindness worldwide.
Researchers found B-vitamins to be effective in treating various painful conditions, including neuropathic pain. The study suggests that B1, B6, and B12 inhibit chemical- and heat-induced pain and activate the cGMP-PKG signaling pathway, which contributes to their analgesic effects.