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Alcohol researchers confirm molecular culprit of alcohol-induced liver damage

A study found that tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in early liver damage caused by alcohol consumption. The researchers used gene knockout technology to show that TNF-alpha mediates the development of liver injury, leading to potential new drug therapies for conditions affecting millions of Americans.

Immune molecule found to kill indirectly by closing receptor to live-saving help

Researchers found an immune molecule that kills damaged cells indirectly by closing receptors to a life-saving protein, shedding new insight on neurodegenerative diseases such as Alzheimer's and stroke. The findings could lead to targeted treatments for brain injuries and diseases involving neurodegeneration.

SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalProceedings of the National Academy of Sciences·DateAug 17, 1999