Articles tagged with Liver Damage
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Researchers found pyronaridine-artesunate to be as effective as currently used artemisinin-based combination therapies for treating uncomplicated P. falciparum malaria. Mild liver injuries were observed in some patients but no severe damage was reported. The treatment holds promise for areas with rising artemisinin resistance.
Scientists have found a drug combination that can halt the progression of fibrosis, a condition responsible for almost half of all deaths. The study, published in European Urology, tested a combination of phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators on cells and animals.
A new study reveals that CD26/DPP-4 is a key player in the regeneration of acute liver wounds and may serve as a valuable biomarker for detecting hepatic disease. The molecule's enzymatic activity was shown to increase with reduced liver immune cell population, suggesting its potential use in non-invasive diagnosis.
A new scientific study reveals that there is no safe level of drinking alcohol, with nearly 3 million deaths globally attributed to alcohol use in 2016. The study finds massive health risks associated with alcohol consumption, including premature death, cancer, and cardiovascular problems.
A new study found that genetic variation in Caucasians with chronic hepatitis B infection increases the risk of severe liver damage and inflammation. Researchers identified a link between the STAT4 gene and liver fibrosis, suggesting that genetic factors may play a role in disease progression.
A genetic marker associated with an adverse drug reaction in people with multiple sclerosis has been found. The discovery may lead to more individualized approaches to MS treatment and care.
A study found that gut-inhabiting Enterobacter cloacae increases subcutaneous fat mass and causes liver damage in mice. Researchers observed hypertrophic obesity and insulin resistance in affected mice.
Researchers have discovered how nutmeg helps protect the liver, using a mouse animal model of liver toxicity. The spice was shown to restore healthy levels of lipids and acylcarnitines, and a specific compound, myrislignan, had a strong protective effect against liver damage.
A new blood test can accurately predict which patients are at risk of liver damage from paracetamol overdose, enabling targeted treatment and reducing hospital stays. The test detects three specific molecules associated with liver damage, allowing for earlier intervention and more effective care.
A 38-year-old man suffered serious liver damage after using Epsom salts to treat gallstones. He was advised to stop taking the salts and drink plenty of fluids after rapid worsening of fibrosis prompted by excessive salt intake.
A new study suggests that diet may be a crucial factor in the development of liver injuries in mice bred to consume high amounts of alcohol. The research found that mice on a diet of alcohol and water consumed less alcohol than those on an artificial sugar diet, resulting in greater liver injury.
Researchers at Tokyo Medical and Dental University have identified a molecule called YAP that determines whether liver cells proliferate or are eliminated, depending on the presence or absence of injury. This balance is crucial for maintaining organ structure and function.
A recent study found nearly 10% of patients with definite, highly likely, or probable drug-induced liver injury to have a fatal outcome within 2 years. The majority of fatalities were directly attributed to the liver injury, highlighting the severity of this condition.
Investigators at MUSC have identified a critical regulatory mechanism for nitric oxide production in liver endothelial cells following liver injury. The study reveals that inhibition of CAV1 or GRK2 phosphorylation compromises complex formation and reduces eNOS activity, leading to increased portal pressure.
Researchers found that the p53 protein plays a key role in preventing acetaminophen-induced liver damage and promoting regeneration. Activation of p53 helps prevent injury progression while inhibition stimulates liver repair, offering hope for new treatment options.
A new study found that supplements of DHA, an essential omega-3 fatty acid, can prevent the progression of nonalcoholic steatohepatitis (NASH) into more serious health problems like cirrhosis and liver cancer. This breakthrough discovery offers hope to millions of people worldwide who struggle with obesity and poor diet.
Researchers at Michigan State University found that liver injury activates blood clotting, which then stimulates liver repair using an experimental model of high-dosage acetaminophen. The study identified fibrinogen as a critical protein in this process.
Caspase inhibitors may trigger necrotic cell death, despite preventing apoptosis, according to a new study. Researchers found that blocking apoptosis can lead to alternative necrotic cell death in cultured hepatocytes and mouse livers.
A teenage boy's liver injury from paintballing highlights growing pellet-related injuries. Black henna tattoos have also been linked to allergic reactions. A former WWII soldier's body revealed various war injuries, including shrapnel fragments.
Researchers at Oklahoma Medical Research Foundation found that an enzyme thought to be beneficial can pose significant danger to developing embryos. They discovered excessive plasmin activity can lead to liver blood vessels becoming fragile and prone to bleeding.
Researchers found that aerobic fitness protected against metabolic dysfunction in the liver, reducing inflammation and fatty deposits. Chronic alcohol ingestion did not cause significant changes in blood insulin or glucose levels, contrary to expectations.
A recent study published in Biomolecules found that chronic alcohol use combined with repeated binge drinking causes significant liver damage, exceeding previous estimates. The research, conducted on mice, showed that mice exposed to both chronic and binge consumption exhibited the highest levels of liver injury.
A cancer-causing parasitic worm has been discovered to drive wound healing and blood vessel growth, which could lead to accelerated recovery from chronic wounds such as diabetic ulcers. The growth factor secreted by the parasite also increases the risk of developing liver cancer over time.
A first-of-its-kind study identified a potential gene target, FOX03, strongly associated with nonalcoholic fatty liver disease-related liver damage due to miR-182 regulation. The study found suppressed FOX03 protein levels in damaged livers, suggesting its role in the initiation of liver disease.
Capsaicin, the active compound in chili peppers, has been found to have beneficial effects on liver damage. In a study, capsaicin reduced the activation of hepatic stellate cells, which are involved in liver fibrosis. The compound partially improved liver damage and inhibited further progression of the injury in mice models.
Researchers observed a crucial protective role for farnesoid-X receptor in cholestatic liver injury, with oral FXR-agonist INT-747 normalizing dysfunctional intestinal FXR-signaling and changing in intestinal permeability, inflammation, and bacterial translocation. The study suggests potential new therapeutic avenues for liver disease.
A study in mice reveals that dysfunctional ketogenesis promotes fatty liver disease, characterized by excessive hepatic glucose and lipid production. The findings suggest targeting ketogenesis could be a viable approach to treating NAFLD.
A new preservation technique, sequential subnormothermic ex vivo liver perfusion (SNEVLP), has been shown to prevent ischemic type biliary stricture following liver transplantation using grafts from donations after cardiac death (DCD). SNEVLP reduces bile duct and endothelial cell injury post-transplantation compared to cold storage.
A recent study found a significant increase in liver injury caused by herbals and dietary supplements in the US population over a ten-year period. Non-bodybuilding supplements were more likely to result in death or liver transplantation compared to conventional medications.
Researchers found that FOXO3 transcription factor protects against alcoholic liver injury when suppressed, but combination of HCV and alcohol disrupts this protective effect. FOXO3 activation is crucial for autophagy, a cellular degradation pathway that removes damaged mitochondria and prevents liver injury.
A study by CU researchers has identified a soy derivative as the likely cause of liver damage in patients receiving intravenous nutrition. The finding may lead to better treatments for patients with intestinal problems or pancreatitis who rely on intravenous feeding.
Researchers have made a breakthrough in developing better tests for liver toxicity, which could lead to safer medicines and more drugs reaching patients. The new tests can detect liver damage without causing permanent harm, allowing patients to continue taking medications.
A new study published in Gastroenterology reveals a significant increase in drug-induced liver injury cases worldwide. The most common culprits were antibiotics like amoxicillin-clavulante, immunosuppressants such as azathioprine and biologics like infliximab.
A study published in the American Journal of Clinical Nutrition found that dietary fructose rapidly caused liver damage in an animal model, with damage more than doubling over six weeks. The researchers found that high-fructose diets led to increased intestinal bacteria migration and liver damage, even without weight gain.
Researchers have found significant amounts of coumarin in US cinnamon products, particularly cassia cinnamon. Coumarin has been linked to liver damage in sensitive individuals, highlighting concerns over food safety.
A study found that patients taking tumor necrosis factor-alpha (TNF-α) antagonists are at risk of developing acute liver injury, with most cases involving autoimmunity or hepatocellular injury. The condition is typically resolved after discontinuing the drug, but some patients may experience recurrence.
Scientists have identified biomarkers that predict rapid onset of liver damage in hepatitis C patients after a liver transplant. These markers appear soon after the transplant and before clinical evidence of liver damage, offering new hope for personalized monitoring and treatment options.
A study published in CMAJ found that fluoroquinolone antibiotics, particularly moxifloxacin and levofloxacin, are linked to a higher risk of acute liver injury in older adults. The research suggests these drugs should be subject to regulatory warnings due to their potential harm.
Researchers found that despite similar survival rates, trauma patients in the western United States face higher treatment costs than those in the northeastern region. Analysis of national patient records revealed significant regional differences in care costs, with the west spending up to 35% more on liver injury treatments.
A recent study found that Alzheimer's patients who undergo hospitalization are at risk for complications such as delirium, loss of independence, and death. Researchers also highlighted the risks associated with Flavocoxid, a medical food used to treat osteoarthritis, which can cause liver injury in some patients. Additionally, screenin...
A new study explores the progression of diseases leading to liver damage, affecting diverse populations, including young people. The research shows that obesity is putting teens at risk for developing nonalcoholic fatty liver disease, which may lead to lifelong problems and serious consequences.
Researchers have discovered a way to block cell-to-cell communication in the liver, preventing damage caused by toxic drugs like acetaminophen. The approach has potential for improving drug safety and could lead to new treatment options for patients with drug-induced liver injury.
Researchers have found a way to protect the liver from damage caused by certain drugs, which could lead to improved drug safety. By targeting gap junctions in liver cells, they hope to develop new therapies for treating patients with drug-induced liver injury.
Researchers analyzed data from studies on atrial fibrillation, finding that AFib significantly increases the risk for stroke, heart failure, and death. The studies suggest that AFib has a substantial economic impact on the US healthcare system, warranting further investigation to understand its true costs.
Research shows anti-microbial medications are a leading cause of drug-induced liver injury, with women and minorities disproportionately affected. Liver transplantation offers excellent survival rates, but further investigation is needed to understand the impact of alcohol use and diabetes.
A recent study reveals significant variation in coumarin levels among Cassia cinnamon samples, with powder containing up to 63 times more coumarin than Ceylon cinnamon. Researchers highlight the need for further research to identify factors influencing coumarin levels and potentially allow for lower-coumarin harvesting.
The International Serious Adverse Events Consortium (SAEC) will collaborate with Newcastle University to research the genetics of drug-induced liver injury. The collaboration aims to develop larger and more diverse collections of subjects to better understand the genetic effects contributing to these diseases.
Researchers found that 31P MRS can detect changes in liver ATP levels related to liver damage score and pathologic changes. The study showed significant differences in ATP quantification among groups, indicating its potential as a non-invasive method for detecting early acute hepatic radiation injury.
Researchers have discovered genetic markers that predict individuals at risk for serious drug-induced liver injury. The study found that HLA-B*5701 is a major determinant of liver injury induced by flucloxacillin, and variations on chromosome 3 also influence the risk.
A study has found a genetic marker linked to the risk of acetaminophen-induced liver injury in humans. The researchers used a genetically diverse population of mice to identify a gene called CD44, which is significantly associated with elevated serum ALT levels.
New rodent findings show that chronic drinking causes more injury to the liver than acute or binge drinking, with persistent gene-expression changes and deleterious conditioning. This research highlights the importance of daily, excessive drinking in programming the liver to become dependent on alcohol.
Overdoses of acetaminophen lead to two waves of liver cell destruction and immune system activation. Aspirin is found to downregulate pro-inflammatory cytokine production, providing substantial protection from acetaminophen-induced liver damage.
A Yale study suggests simple aspirin can prevent liver damage from common drug side effects, alcohol abuse, and obesity-related diseases. The study found that aspirin reduced mortality caused by an overdose of acetaminophen and blocked inflammation pathways.
A study published in the World Journal of Gastroenterology found that resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion. The results suggest that resveratrol has protective effects against hepatic I/R injury, making it a potential therapeutic drug for liver transplantation.
Scientists at the University of Edinburgh have discovered a link between cyclophilin A levels and liver damage following a paracetamol overdose. They hope to develop a treatment to block this protein's harmful actions, enabling early identification of high-risk patients.
A new study published in Gastroenterology finds that antibiotics are the single largest class of drugs causing liver injury, affecting 73% of cases. Central nervous system agents were also found to be commonly associated with drug-induced liver injury.
Research published in the World Journal of Gastroenterology found that dietary glycine significantly decreased liver injury due to bile duct ligation in rats. Hepatic injury was reduced by a direct effect on hepatocytes, whereas Kupffer cells did not play a major role in cholestatic models.
Prednisolone administration significantly suppressed serum AST and ALT levels, prevented cell membrane bleb formation, and inhibited calpain mu activation. The study's findings suggest that prednisolone's cytoprotective effect is closely associated with the suppression of these inflammatory markers.
Researchers tested two Ayurvedic herbs, Curcuma longa and Tinospora cordifolia, in a clinical trial to evaluate their ability to prevent hepatotoxicity. The results showed that the formulation was safe and effective in preventing liver damage, with only 0.06% incidence of mild hepatotoxicity compared to 14% in the control group.
Researchers found that sea buckthorn leaf extract reduced liver damage in rats, with significant protection observed at higher doses. The study suggests that the leaves' anti-oxidant properties may help ward off liver disease.