Articles tagged with Liver Damage
A study found that spaceflight alters liver gene expression and reduces antioxidant capacity in mice, leading to increased oxidative stress. However, exposure to artificial gravity can mitigate some of these effects, suggesting potential for dietary supplementation to offset changes during spaceflight.
A cohort study of 165 patients with hepatitis C-related hepatocellular carcinoma found that treating the virus with direct-acting antivirals reduces tumor progression and metastasis. The study showed a 72% reduction in tumor progression and an 88% reduction in risk of death from HCC.
Researchers found that albino mice with a mutated tyrosinase gene are more susceptible to non-alcoholic steatohepatitis (NASH) than black mice. This study provides new insights into the genetic factors contributing to NASH and its progression.
The American Gastroenterological Association (AGA) has released new clinical guidelines that recommend against extensive preprocedural testing to estimate clotting in patients with cirrhosis. This change aims to reduce the risk of morbidity and mortality associated with unnecessary blood clotting tests.
Researchers found that exogenous phosphatidic acid protects against liver injury caused by acetaminophen overdose. PA activates interleukin-6 signaling, which is crucial for reducing liver damage.
A new study found that every extra 1cm in waist circumference increases the odds of advanced fibrosis by 5% in people with type 2 diabetes. Advanced fibrosis is a late stage of non-alcoholic fatty liver disease (NAFLD), which can lead to serious liver damage.
This study compared drugs associated with hepatotoxicity in the FDA's FAERS database, finding that mitochondrial mechanisms are a leading cause of drug-induced liver injury. The top four drugs with the highest risk were associated with mitochondrial mechanisms, and older patients and females were more likely to be affected.
A new biomarker, HBcrAg, has been found to accurately predict viral load in patients with chronic hepatitis B and reflect response to anti-viral treatments. This discovery may lead to improved monitoring methods for CHB, enabling clinical decisions and potentially improving patient outcomes.
A study in mice and human blood samples found that HDL3 protects the liver by blocking gut bacterial signals that cause inflammation. The researchers identified a special type of HDL called HDL3 that is produced by the intestine, which blocks lipopolysaccharide signals that activate immune cells.
Researchers found that high serum levels of human IL-11 in mice with paracetamol toxicity led to liver cell death. However, blocking IL-11 signalling protected against liver damage and promoted survival. The study suggests a restorative effect when using anti-IL11 therapy.
Researchers have developed a simple blood test that can detect acute liver damage earlier than current methods. The test uses gold nanoparticles to target the antioxidant glutathione, which is depleted in damaged liver cells. This early detection could lead to faster recovery and improved treatment outcomes for patients with liver injury.
Cytoglobin has been identified as a key player in delaying liver fibrosis progression in mice. The enhancement of CYGB on hepatic stellate cells or intravenous injection of recombinant CYGB suppresses liver damage and cirrhosis. This discovery holds promise for developing new anti-fibrotic therapy for human chronic liver diseases.
Researchers found that ACSL1 catalyzes CoA conjugation of propionic acid-class NSAIDs, leading to liver injury through covalent binding with hepatic proteins. This variation in hepatic ACSL1 expression may account for individual susceptibility to toxicities.
Researchers have discovered a gene mutation that protects against liver disease and may offer a 'fountain of youth' for French-Canadian families. The PCSK9Q152H mutation has been found to lower bad cholesterol and prevent cardiovascular diseases, allowing individuals to live longer and healthier into their late 80s and mid-90s.
The Predictive Safety Testing Consortium and Duchenne Regulatory Science Consortium have developed a glutamate dehydrogenase (GLDH) biomarker to detect drug-induced liver injury in patients with inherited muscle disorders. The FDA has agreed to accept the Qualification Plan for GLDH as an important and accurate measurement of DILI.
Researchers found dihydromyricetin (DHM) activates mechanisms that quickly metabolize alcohol and reduce liver harm. The study supports DHM as a dietary supplement to offset acute and long-term risks of alcohol consumption.
Cynthia Ju, a UTHealth scientist, has been awarded $3.6 million in NIH grants to investigate molecules linked to liver injuries. Her research aims to identify potential therapeutic targets to enhance or block the activity of these molecules.
Researchers found that Lactobacillus rhamnosus can restore a balanced intestinal microbiome and counter liver damage caused by chronic alcohol consumption. The probiotic effect of the bacteria reduced inflammation and fat accumulation in the liver, indicating potential therapeutic applications for alcohol-induced liver disease.
A new study finds that an enzyme involved in liver function also triggers a protective response when liver cells are damaged. By boosting the levels of this enzyme, researchers hope to develop new treatments for acute liver injury.
Researchers found that men taking bodybuilding supplements experienced prolonged and difficult-to-treat liver injuries, often accompanied by jaundice and generalized itching. The study also revealed that many products contained illicit anabolic steroids not accurately listed on the label.
A 64-year-old woman developed acute liver injury after taking red yeast rice supplement for six weeks. The supplement contains monacolin K, a chemical found in lovastatin, which carries the same risk of liver damage as statin medication. Doctors warn that more regulation is needed to prevent harmful side effects.
Researchers from the Buck Institute report that MANF regulates metabolism and immune response, and replenishing it shows promise as an anti-aging treatment. MANF deficiency has hallmarks of age-related diseases, including inflammation and liver damage.
Researchers found pyronaridine-artesunate to be as effective as currently used artemisinin-based combination therapies for treating uncomplicated P. falciparum malaria. Mild liver injuries were observed in some patients but no severe damage was reported. The treatment holds promise for areas with rising artemisinin resistance.
Scientists have found a drug combination that can halt the progression of fibrosis, a condition responsible for almost half of all deaths. The study, published in European Urology, tested a combination of phosphodiesterase type 5 inhibitors and selective oestrogen receptor modulators on cells and animals.
A new study reveals that CD26/DPP-4 is a key player in the regeneration of acute liver wounds and may serve as a valuable biomarker for detecting hepatic disease. The molecule's enzymatic activity was shown to increase with reduced liver immune cell population, suggesting its potential use in non-invasive diagnosis.
A new scientific study reveals that there is no safe level of drinking alcohol, with nearly 3 million deaths globally attributed to alcohol use in 2016. The study finds massive health risks associated with alcohol consumption, including premature death, cancer, and cardiovascular problems.
A new study found that genetic variation in Caucasians with chronic hepatitis B infection increases the risk of severe liver damage and inflammation. Researchers identified a link between the STAT4 gene and liver fibrosis, suggesting that genetic factors may play a role in disease progression.
A genetic marker associated with an adverse drug reaction in people with multiple sclerosis has been found. The discovery may lead to more individualized approaches to MS treatment and care.
A study found that gut-inhabiting Enterobacter cloacae increases subcutaneous fat mass and causes liver damage in mice. Researchers observed hypertrophic obesity and insulin resistance in affected mice.
Researchers have discovered how nutmeg helps protect the liver, using a mouse animal model of liver toxicity. The spice was shown to restore healthy levels of lipids and acylcarnitines, and a specific compound, myrislignan, had a strong protective effect against liver damage.
A new blood test can accurately predict which patients are at risk of liver damage from paracetamol overdose, enabling targeted treatment and reducing hospital stays. The test detects three specific molecules associated with liver damage, allowing for earlier intervention and more effective care.
A 38-year-old man suffered serious liver damage after using Epsom salts to treat gallstones. He was advised to stop taking the salts and drink plenty of fluids after rapid worsening of fibrosis prompted by excessive salt intake.
A new study suggests that diet may be a crucial factor in the development of liver injuries in mice bred to consume high amounts of alcohol. The research found that mice on a diet of alcohol and water consumed less alcohol than those on an artificial sugar diet, resulting in greater liver injury.
Researchers at Tokyo Medical and Dental University have identified a molecule called YAP that determines whether liver cells proliferate or are eliminated, depending on the presence or absence of injury. This balance is crucial for maintaining organ structure and function.
A recent study found nearly 10% of patients with definite, highly likely, or probable drug-induced liver injury to have a fatal outcome within 2 years. The majority of fatalities were directly attributed to the liver injury, highlighting the severity of this condition.
Investigators at MUSC have identified a critical regulatory mechanism for nitric oxide production in liver endothelial cells following liver injury. The study reveals that inhibition of CAV1 or GRK2 phosphorylation compromises complex formation and reduces eNOS activity, leading to increased portal pressure.
Researchers found that the p53 protein plays a key role in preventing acetaminophen-induced liver damage and promoting regeneration. Activation of p53 helps prevent injury progression while inhibition stimulates liver repair, offering hope for new treatment options.
A new study found that supplements of DHA, an essential omega-3 fatty acid, can prevent the progression of nonalcoholic steatohepatitis (NASH) into more serious health problems like cirrhosis and liver cancer. This breakthrough discovery offers hope to millions of people worldwide who struggle with obesity and poor diet.
Researchers at Michigan State University found that liver injury activates blood clotting, which then stimulates liver repair using an experimental model of high-dosage acetaminophen. The study identified fibrinogen as a critical protein in this process.
Caspase inhibitors may trigger necrotic cell death, despite preventing apoptosis, according to a new study. Researchers found that blocking apoptosis can lead to alternative necrotic cell death in cultured hepatocytes and mouse livers.
A teenage boy's liver injury from paintballing highlights growing pellet-related injuries. Black henna tattoos have also been linked to allergic reactions. A former WWII soldier's body revealed various war injuries, including shrapnel fragments.
Researchers at Oklahoma Medical Research Foundation found that an enzyme thought to be beneficial can pose significant danger to developing embryos. They discovered excessive plasmin activity can lead to liver blood vessels becoming fragile and prone to bleeding.
Researchers found that aerobic fitness protected against metabolic dysfunction in the liver, reducing inflammation and fatty deposits. Chronic alcohol ingestion did not cause significant changes in blood insulin or glucose levels, contrary to expectations.
A recent study published in Biomolecules found that chronic alcohol use combined with repeated binge drinking causes significant liver damage, exceeding previous estimates. The research, conducted on mice, showed that mice exposed to both chronic and binge consumption exhibited the highest levels of liver injury.
A cancer-causing parasitic worm has been discovered to drive wound healing and blood vessel growth, which could lead to accelerated recovery from chronic wounds such as diabetic ulcers. The growth factor secreted by the parasite also increases the risk of developing liver cancer over time.
A first-of-its-kind study identified a potential gene target, FOX03, strongly associated with nonalcoholic fatty liver disease-related liver damage due to miR-182 regulation. The study found suppressed FOX03 protein levels in damaged livers, suggesting its role in the initiation of liver disease.
Capsaicin, the active compound in chili peppers, has been found to have beneficial effects on liver damage. In a study, capsaicin reduced the activation of hepatic stellate cells, which are involved in liver fibrosis. The compound partially improved liver damage and inhibited further progression of the injury in mice models.
Researchers observed a crucial protective role for farnesoid-X receptor in cholestatic liver injury, with oral FXR-agonist INT-747 normalizing dysfunctional intestinal FXR-signaling and changing in intestinal permeability, inflammation, and bacterial translocation. The study suggests potential new therapeutic avenues for liver disease.
A study in mice reveals that dysfunctional ketogenesis promotes fatty liver disease, characterized by excessive hepatic glucose and lipid production. The findings suggest targeting ketogenesis could be a viable approach to treating NAFLD.
A new preservation technique, sequential subnormothermic ex vivo liver perfusion (SNEVLP), has been shown to prevent ischemic type biliary stricture following liver transplantation using grafts from donations after cardiac death (DCD). SNEVLP reduces bile duct and endothelial cell injury post-transplantation compared to cold storage.
A recent study found a significant increase in liver injury caused by herbals and dietary supplements in the US population over a ten-year period. Non-bodybuilding supplements were more likely to result in death or liver transplantation compared to conventional medications.
Researchers found that FOXO3 transcription factor protects against alcoholic liver injury when suppressed, but combination of HCV and alcohol disrupts this protective effect. FOXO3 activation is crucial for autophagy, a cellular degradation pathway that removes damaged mitochondria and prevents liver injury.
A study by CU researchers has identified a soy derivative as the likely cause of liver damage in patients receiving intravenous nutrition. The finding may lead to better treatments for patients with intestinal problems or pancreatitis who rely on intravenous feeding.
Researchers have made a breakthrough in developing better tests for liver toxicity, which could lead to safer medicines and more drugs reaching patients. The new tests can detect liver damage without causing permanent harm, allowing patients to continue taking medications.
A new study published in Gastroenterology reveals a significant increase in drug-induced liver injury cases worldwide. The most common culprits were antibiotics like amoxicillin-clavulante, immunosuppressants such as azathioprine and biologics like infliximab.
A study published in the American Journal of Clinical Nutrition found that dietary fructose rapidly caused liver damage in an animal model, with damage more than doubling over six weeks. The researchers found that high-fructose diets led to increased intestinal bacteria migration and liver damage, even without weight gain.
Researchers have found significant amounts of coumarin in US cinnamon products, particularly cassia cinnamon. Coumarin has been linked to liver damage in sensitive individuals, highlighting concerns over food safety.
A study found that patients taking tumor necrosis factor-alpha (TNF-α) antagonists are at risk of developing acute liver injury, with most cases involving autoimmunity or hepatocellular injury. The condition is typically resolved after discontinuing the drug, but some patients may experience recurrence.
Scientists have identified biomarkers that predict rapid onset of liver damage in hepatitis C patients after a liver transplant. These markers appear soon after the transplant and before clinical evidence of liver damage, offering new hope for personalized monitoring and treatment options.
A study published in CMAJ found that fluoroquinolone antibiotics, particularly moxifloxacin and levofloxacin, are linked to a higher risk of acute liver injury in older adults. The research suggests these drugs should be subject to regulatory warnings due to their potential harm.