Articles tagged with Pain
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Patients with peripheral artery disease (PAD) who are physically active have a significantly lower death rate than inactive individuals. A study published in Circulation found that higher physical activity levels are associated with a lower risk of cardiovascular disease and death in PAD patients.
Researchers discovered that heat, specifically above 40 degrees Celsius, blocks pain receptors by inhibiting chemical messengers. This finding has implications for developing pain relief drugs targeting P2X3 receptors.
A study of 23 clinical trials found that weight loss can predict a significant reduction in physical disability in patients with knee osteoarthritis. The research suggests that achieving a moderate weight loss of over 7.6% can lead to at least a moderate clinical effect on physical disability.
A study found that cherry juice can significantly reduce muscle strength loss and improve average pain scores in individuals with muscle damage. The study suggests that cherry juice may be a potentially safer alternative to prescription drugs for treating conditions like arthritis and gout.
A study of 14 volunteers found that drinking cherry juice before and after exercise resulted in a significant reduction in muscle pain and a slight increase in muscle strength. The antioxidant and anti-inflammatory properties of cherry juice were found to be effective in preventing muscle damage.
Researchers found a significant decrease in muscle cramps with Pycnogenol supplementation, including a 25% reduction for normal crampers and a 40% reduction for those with venous insufficiency. The study also showed improved blood flow to muscle tissue, reducing pain in patients with diabetic microangiopathy.
A novel colonoscope using the NeoGuide System reduces looping and discomfort during colonoscopies, while entonox sedation provides effective pain relief and faster recovery. These advancements increase rates of colorectal cancer screening and improve patient satisfaction.
Researchers found that St. John's Wort increased bladder contraction intervals in rats with bladder inflammation, reducing bladder hyperactivity and associated pain. The study suggests that the herbal supplement may be a viable treatment option for women suffering from interstitial cystitis, affecting 700,000 Americans.
A new marijuana-derived drug, IP 751, has shown significant promise in suppressing bladder overactivity and alleviating painful symptoms in animal models of interstitial cystitis. Researchers at the University of Pittsburgh School of Medicine developed a liposome-based delivery system to overcome the hydrophobic properties of the drug.
A new procedure utilizes plasma-mediated radiofrequency energy to gently remove soft tissue from spinal tumors, reducing damage to healthy tissue. The technique, called Coblation SpineWand, provides pain relief and improved mobility for patients with decreased risk of complications.
A neurobiology study found that dread influences human decision-making by activating the brain's pain network and attention centers. The researchers discovered two types of individuals: mild and extreme dreaders, who differed in their brain activity patterns.
A study of 157 women with acute pelvic pain found that both CT scans and ultrasounds were highly sensitive and accurate in diagnosing the condition. The researchers concluded that patients are unlikely being over-imaged, and that both imaging techniques can be used effectively in emergency settings.
Patients' views on treatments that may worsen their condition shift as their health declines. After experiencing a decline in functional abilities, patients become more willing to accept treatments for mild and severe physical disability. Cognitive impairment and pain remain unacceptable to most participants throughout the study.
A controlled trial found that hypnotherapy significantly improved sense of overall wellbeing and reduced painkiller use, while supportive therapy had no effect. Brain scans show that hypnotherapy affects the brain's processing of painful stimuli.
A recent study found that using forearm supports can significantly reduce neck and shoulder pain as well as hand, wrist, and forearm pain. The study also showed that arm boards and ergonomics training provide the most protective effect against musculoskeletal disorders.
Researchers measured pain in premature infants through brain scans during routine care procedures, finding evidence of processed pain in the higher levels of the brain. The study highlights the need for effective pain management in preterm babies, who experience repeated painful procedures daily.
Researchers have found that the sensory ion channel TRPA1 is responsible for the pain response evoked by mustard oil, garlic, and acrolein. The study suggests potential new avenues for the development of anti-inflammatory and pain medications.
Researchers found Computed Tomographic Angiography (CTA) quickly and accurately ruled out coronary artery disease in 67% of cases, reducing hospital stay by 45% and saving $300 per patient. Advanced care paramedics also improved STEMI heart attack management, reducing mortality rates from 9% to less than 2%.
Researchers found that obese participants exhibited a greater physical response to electrical stimulation than non-obese individuals, indicating lower tolerance for painful stimuli. The study suggests that obese people may not cognitively experience pain during exercise, increasing the risk of severe pain later on.
A study found that less than half of residents with predictably recurrent pain were prescribed scheduled pain medication, highlighting the need for improved pain management practices. The use of evidence-based process measures is intended to address persistent problems in pain management and improve overall quality of life.
A large-scale study found that glucosamine combined with chondroitin sulfate provided significant pain relief for participants with moderate-to-severe knee osteoarthritis pain, but not those with mild pain. The treatment was shown to be effective in reducing pain by 20% or more compared to placebo.
The GAIT study found that glucosamine and chondroitin sulfate were ineffective in patients with mild knee pain, while those with moderate to severe pain saw significant relief when taking the supplements in combination. The results suggest that a personalized approach to managing osteoarthritis pain may be necessary.
Millimeter wave therapy has been used in Eastern Europe to alleviate over 50 conditions, including heart disease and cancer. A new Temple University study aims to investigate its effectiveness for pain relief, immune system modulation, and chemotherapy improvement, with the goal of introducing a non-invasive treatment option.
A randomized, double-blind study found that morphine and topical local anesthesia (tetracaine) combination reduced pain during catheter placement more effectively than either alone or no analgesia. Local anesthesia was found to be a weak analgesic.
A study by the University of Toronto found that morphine and a combination of morphine and tetracaine are effective in treating pain in newborns undergoing central line placements. The study also identified potential side effects of these medications.
A Dutch study published in European Heart Journal reveals that 43% of total heart attacks had been clinically unrecognised. Women are more likely to have atypical symptoms and may be less likely for their symptoms to be recognized by doctors.
Research shows that a unique brain region acts as an integrative centre, modifying pain sensations when people are thirsty. Elite athletes can push through normal thresholds of pain and thirst due to their ability to balance this 'priority switch',
A recent study has found that a specific genetic variation, ALDH2*2, is responsible for the reduced effectiveness of nitroglycerin in Asian populations. This variation affects the enzyme aldehyde dehydrogenase-2 (ALDH2), which plays a crucial role in metabolizing nitroglycerin.
Researchers found that anxious fathers can increase a mother's pain experience after a caesarean delivery. Preparing the birth partner through antenatal classes and pre-operation support may reduce post-operative pain and improve the birth experience.
Researchers found that delaying surgery for men with hernias that don't cause discomfort can be a safe option. Patients who underwent surgical repair showed significant improvement in performing everyday activities compared to those who waited.
A study found that delaying surgery for men with asymptomatic inguinal hernias has similar outcomes to surgical repair, with lower risk of post-operative complications. Watchful waiting can be a viable alternative for these patients.
A study at Rush University Medical Center found that 96% of patients underwent minimally invasive knee replacement surgery could be discharged the same day without any complications. The key to this success was a comprehensive team approach, including pre-surgical education, optimized care pathways, and post-operative rehabilitation.
A study of 173 children aged 2-16 years found that fentanyl patches improved subjective pain and quality of life. The patches were well-tolerated with no significant adverse effects compared to adults, making them a suitable option for managing chronic severe pain in pediatric patients.
Research shows women with acute coronary syndromes are under-treated, leading to more ongoing heart problems. The study analyzed data from the CURE trial and found that women were 35% less likely to undergo invasive procedures than men.
The study focuses on two main areas: dyspareunia and vaginismus, exploring their connection to fear and developing more effective treatments. Researchers aim to improve therapies for women suffering from genital pain associated with menopause.
A randomized controlled trial found that cannabis-based medicine (CBM) significantly improved pain on movement, pain at rest, quality of sleep, inflammation, and intensity of pain in patients with rheumatoid arthritis. CBM reduced pain scores by an average of 2-3 points across several measures.
A study by researchers at the University of Chicago found that activating specific cells in the brain stem allows animals to suppress pain while performing essential tasks. This mechanism, known as
Researchers at Cedars-Sinai Medical Center found that shortness of breath can signify a higher risk of dying from cardiac disease. The study, which evaluated nearly 18,000 patients, revealed that patients with shortness of breath were four times more likely to suffer death from a cardiac cause than asymptomatic patients.
A recent study found that single men with bone metastases are less likely to seek multiple radiation treatments, potentially due to lack of social support. The study suggests clinicians should be sensitive to the greater likelihood of negative outcomes in single male patients.
A study found that nearly half of US adults have inadequate health literacy, which is associated with chronic conditions such as high blood pressure and diabetes. Individuals with low health literacy were more likely to report activity limitations and pain interfering with daily activities.
Hereditary Neuralgic Amyotrophy is characterized by repeated attacks of pain and paralysis in the affected area, often accompanied by facial features. Researchers have identified a genetic defect in the Septin 9 protein as the underlying cause of the disorder.
A Mayo Clinic study found no pain relief from magnetic insoles, suggesting the cushioning may be effective. The placebo effect was noted, with participants experiencing improvement when believing the magnets could help, but this did not translate to actual pain relief.
In rats with spinal cord injury, third order neurons in the thalamus abnormally fire signals without incoming stimuli. Targeted molecular agents suppress these rogue neurons' activity, reducing phantom pain.
A study published in BMC found that regular exercise can significantly reduce musculoskeletal pain in older adults. Participants who exercised regularly experienced 25% less pain than those who were less active, with the reduction persisting until age 62-76.
This study recommends wheelchair setup and propulsion techniques to reduce upper limb injuries, including using smooth strokes and a light-weight wheelchair. Rehabilitation also improves wheelchair propulsion ability, with greater gains in men, younger persons, and those with paraplegia.
Researchers found that women who labored between noon and 6 p.m. received an average of 27 percent longer pain relief from a single dose of spinal-epidural medication fentanyl compared to those who labored between 8 p.m. and 2 a.m.
A study found that expectations about pain can significantly affect its intensity. Participants who expected lower levels of pain reported a 28% decrease in pain ratings compared to those who expected higher levels. This suggests that the brain plays a crucial role in shaping the perception of pain.
Scientists create ceramic nanospheres to fill fluid-filled channels in teeth, reducing sharp pain. The novel approach has the potential to be a game-changer for treating dental hypersensitivity.
Researchers found that IP 751 significantly suppressed bladder overactivity without affecting contractility, offering a new option for IC treatment. The study's results are promising for patients with interstitial cystitis, a chronic pelvic pain disorder affecting millions of Americans.
Researchers found that women with ovarian cancer were more likely to present to physicians with abdominal swelling or pelvic pain up to 12 months before diagnosis. Diagnostic testing showed only a minority of patients received necessary tests, highlighting the need for earlier detection.
Researchers found deficits in trunk and hip strength, hamstring flexibility, and back proprioception in golfers with a history of low-back pain. These findings can inform the development of injury prevention programs and exercise programs for golfers to prevent or rehabilitate low-back injuries.
A large study found that acupuncture significantly improves symptoms in patients with osteoarthritis of the knee. However, its effectiveness when compared to standard treatment remains uncertain, and further research is needed to confirm its benefits.
A University of Michigan study found that wealthier seniors experience fewer symptoms, including pain and shortness of breath, in their final year. This disparity persists even after controlling for factors such as age, gender, and diagnosis.
Vertebroplasty and kyphoplasty treatments offer pain relief for osteoporosis sufferers, with the National Osteoporosis Foundation estimating 44 million Americans over 50 affected. The procedures stabilize fractured bones and prevent movement, providing significant cost savings.
A study published in Arthritis & Rheumatism found that doxycycline slowed joint space narrowing by 40-33% compared to a placebo. While it didn't reduce joint pain severity, it did decrease frequent increases in knee pain. The treatment was well-tolerated with minimal side effects.
Researchers have discovered a link between stress-induced analgesia and endocannabinoids, finding that natural marijuana-like chemicals in the brain play a key role in pain suppression. A novel inhibitor molecule has been developed to boost the analgesic effect of the specific cannabinoid compound most directly related to pain relief.
Researchers have discovered that naturally occurring cannabinoids, such as 2-AG, play a role in stress-induced analgesia. A new drug targeting the enzyme monoacylglycerol lipase could manipulate these compounds to provide pain relief without psychoactive side effects.
A randomized controlled trial found that liposomal lidocaine significantly improved cannulation success rates and reduced pain and procedure time in children. The study suggests that liposomal lidocaine can be recommended for cutaneous analgesia in children, providing a promising new approach to pediatric procedural care.
A new topical pain cream has been shown to decrease pain during IV cannulation and even facilitate the procedure, leading to improved outcomes for children. The study, conducted at Sick Kids Hospital in Toronto, found that 74% of children who received the cream successfully had their IV inserted on first attempt.
Researchers found that placebo treatment reduced subjects' ratings of unpleasant pictures and activity in emotional centers. The study generalizes the concept of placebo effect and its underlying neural mechanisms for both pain perception and emotional stimuli.