Articles tagged with Ceramides
Research finds ceramide metabolism differences between Black and white individuals with metastatic castration-resistant prostate cancer influence treatment outcomes. Genetic ancestry-related variants affect ceramide levels and ratios, which promote cell survival or death.
Researchers at University of Utah Health have found that AKI is triggered by ceramides, which cause serious injury by damaging kidney mitochondria. Using a backup drug candidate, the team was able to preserve mitochondrial integrity and prevent kidney injury in mice.
Researchers developed a novel RNA-based therapy using lipid nanoparticles to silence a gene causing ceramide buildup in the liver, reducing inflammation and scarring. The treatment shows promise for millions of patients worldwide and could eventually benefit those with heart disease, obesity, and diabetes.
Researchers at Weill Cornell Medicine found that decreased ceramide levels in blood vessels can cause chronic illnesses. Ceramides regulate blood vessel tone and prevent blood clots, but low levels increase inflammation, high blood pressure, and glucose levels, leading to cardiometabolic conditions.
The study marked a significant milestone in lipidomics, establishing reference values for ceramides and plasma lipids involved in cardiovascular disease risk prediction. The global network of laboratories achieved better-than-anticipated comparability in results using different methods and instrumentations.
The first phase of the Ceramide Ring Trial has been published in Nature Communications, representing a significant landmark in lipidomics. The trial established ceramide reference values, which are essential for understanding the roles of lipids in health and disease.
Researchers at MUSC Hollings Cancer Center discover targeting an immunosuppressive protein on two fronts reduces metastasis and restores sensitivity to immunotherapy in a preclinical model. TNBC cells become resistant to immunotherapy due to membrane instability, enabling PD-L1 protein to drop inside the cell.