Articles tagged with Dna Binding Domains
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Frank Buchholz's ERC project DC-PGE aims to develop fully programmable DNA editing enzymes that minimize off-target effects and increase safety in gene therapy. The goal is to create a platform for efficient and accurate genome editing tools to treat various genetic disorders.
Researchers uncover new insights into protein signal transduction, revealing key details about GRB2 and SOS1's role in passing signals. They discovered differences in the domains' dynamics and binding affinities, providing a more detailed mechanism for liquid-liquid phase separation.
Researchers have identified two novel DOF family transcription factors that enhance wheat regeneration and genetic transformation. These findings provide new insights into the transcriptional regulatory network involved in boosting wheat regeneration, offering opportunities for improving crop improvement.
Researchers at Rice University have discovered a new way protein structures communicate with each other to regulate hormone activity. This finding could lead to improved therapies for breast cancer and other diseases.
The study shows that the CTD and OD domains of mtp53 R273H play key roles in mutant p53 GOF, pertaining to processes associated with DNA replication. The authors investigated the role of these domains in cell proliferation, DNA replication, and cell cycle progression in breast cancer cells.
Researchers found that overexpression of hPCL3S promotes proliferation, anchorage-independent growth, and migration in human LNCaP prostate cancer cells. Silencing of endogenous hPCL3S in DU145 and PC3 prostate cancer cells impairs these effects.
Researchers develop peptoid-coated DNA origami that maintains structural integrity and functionality in different physiological environments, enabling potential use in delivering anti-cancer drugs and proteins. The method involves designing peptoids to stabilize DNA origami, with the brush-type architecture achieving optimal protection.
Researchers at Washington University in St. Louis have discovered a mechanism by which plants regulate the hormone auxin, affecting growth and development. The sticky properties of Aux/IAA repressor proteins allow them to bind to DNA-binding domains, controlling transcription.
A new study reveals how LuxO, a key response regulator in Vibrio cholerae's quorum-sensing cascade, regulates the pathogenicity of the disease-causing bacterium. The researchers discovered an unusual inhibitory mechanism that permanently switches on LuxO, opening doors for potential therapeutic interventions.
Researchers have identified mutations in the STAT3 protein that can block its ability to act as a transcription factor, suggesting a basis for new cancer treatments. The discovery reinforces the importance of targeting transcription factors like STAT3 in fighting cancer.
Researchers at UMass Medical School have developed a new CRISPR/Cas9 technology that improves gene editing accuracy by nearly 100 fold. The system combines the CRISPR/Cas9 complex with a programmable DNA-binding domain to verify an additional genetic feature before cutting the genome, reducing off-target changes.
A new study reveals that viruses share common DNA replication mechanisms, with the SV40 T-ag protein facilitating DNA binding and assembly of complex proteins. This discovery sheds light on a complex process previously difficult to investigate in eukaryotes.
Researchers at The Wistar Institute successfully determined the three-dimensional structure of the p53 protein bound as a dimer to DNA, revealing new insights into its anti-cancer activity. The study's findings suggest that the interface between the two proteins in the dimer is crucial for proper functioning and binding to DNA.
A study by Nikola Pavletich and colleagues reveals that BRCA2 protein binds to damaged DNA, repairing it. This discovery sheds light on the mechanism of breast cancer development and opens new avenues for treatment strategies.