Articles tagged with Lipid Bilayers
A team in Japan has created a propellor-shaped lipid mimic molecule that forms stable 'islands' in a 'sea' of lipid, achieving phase separation and high thermal stability. This new design principle can be used to engineer domains in artificial membrane materials for various applications.
Researchers at the University of Pennsylvania designed a new recipe for mRNA vaccines by adding phenol groups, which reduce inflammation and improve vaccine effectiveness. The modified lipids improved vaccine performance in various diseases, including COVID-19, cancer, and genetic diseases, with enhanced efficacy and reduced side effects.
Scientists from UC San Diego develop an artificial cell membrane that can remodel itself through metabolic activity, shedding light on how life may have emerged on prebiotic Earth. This breakthrough could lead to advancements in drug delivery, biomanufacturing and environmental remediation.
Researchers discovered that mammalian membranes have drastically different phospholipid abundances between their two leaflets, contradicting a major assumption of cell biology. The asymmetry is enabled by cholesterol's unique properties, which act as a buffer to redistribute between the leaflets and maintain robust barriers.
Research discovered lipids concentrate on graphene oxide in cell membrane models, revealing a mechanism for lipid domain formation. The findings have implications for concentrating and separating lipids and membrane proteins, essential for medicine and drug discovery.
Luis Cuello, a professor at TTUHSC, has developed a method to express human potassium channels in bacteria, allowing for large-scale biophysical studies. This technology will be used to target several channels relevant to diseases such as epilepsy, arrhythmia, and diabetes.
Researchers at Kyoto University have discovered a vital role of two proteins, ABCA1 and Aster-A, in maintaining the asymmetric distribution of cholesterol within cells. This process allows for selective control over substances entering and leaving cells.
Scientists discovered that an artificial cell membrane can exhibit long-term potentiation, a hallmark of biological learning and memory, persisting for many hours. This finding has the potential to revolutionize next-generation computing materials and architectures by merging functions of processing and memory in neuromorphic computers.
Researchers developed a nanoparticle-lipid bilayer hybrid-based computing platform that enables parallel computation using nanoparticles. The system consists of mobile Nano-Floaters and immobile Nano-Receptors, which can perform AND, OR, and INHIBIT logic operations, and are modularly wired to form complex logic circuits.
Research reveals that lipids in artificial cell membranes form clusters and domains due to interactions with hydrophilic polymer chains, similar to glycolipids in cell membranes. The study used fluorescence microscopy and AFM to examine the effects of PEG-modified lipids on domain formation.
A study by Toyohashi University of Technology found that cell membrane components form isolated domains within an artificial lipid bilayer, separated from the surrounding membrane. The findings provide valuable information for understanding membrane protein functions and developing experimental techniques.
A new screening method uses lipid bilayer properties to predict toxicity, identifying probable cytotoxic drugs at an early stage in development. The Gramicidin-Based Fluorescence Assay (GBFA) tracks changes in protein function as a way of monitoring lipid bilayer alterations.
The study used atomic force microscopy and surface forces apparatus to measure the strength of adhesion between healthy and diseased myelin bilayers. Researchers found that healthy myelin adsorbs proteins better, maintaining optimal insulation and nerve function.
Researchers determined the three-dimensional structure of the dengue virus, providing insights into viral infection processes. The discovery may aid in developing antiviral compounds to target flavivirus diseases.