Articles tagged with Metabolic Regulation
Researchers discovered a novel mechanism by which non-coding 7S RNA regulates mitochondrial gene expression in human cells. The study found that 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization, shedding light on the molecular basis of this process.
Researchers developed novel cofactor engineering strategies to enhance NADPH, FAD(H2), and SAM supply, re-localization, and recycling in yeast. This led to the efficient synthesis of phenolic acids, providing a sustainable platform for complex natural product production.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
Researchers discovered multiple levels of torpor in hummingbirds, including shallow and deep states, as well as a transition stage between normal sleep and torpor. This flexible control allows hummingbirds to conserve energy while minimizing potential costs, such as increased vulnerability to disease or predation.
Researchers at UNIGE found that fat can aid pancreatic beta cells in adapting to excess sugar levels. The study reveals a dynamic cycle of fat storage and mobilization allows cells to maintain near-normal insulin secretion. Regular physical activity may help give this beneficial cycle a chance to be active.
Researcher Jennifer Hurley is using in-vivo experimentation and big data analytics to identify environmental cues that tune the circadian clock's control over metabolism. Her study aims to find genes responsive to environmental signals, such as nutrients, to understand how environment affects sleep-wake cycle.
A team of researchers simulated the loss of physical activity during COVID19 lockdowns to study its effects on metabolism. They found that mice's energy sources shifted based on their diet composition after a sharp decline in exercise, leading to weight gain.
Researchers have discovered folate metabolism as a common mechanism underlying aging and lifespan extension across different species. The study found that altering folate metabolism increases lifespan in worms and mice by up to 30 percent, suggesting a potential new approach to improving human health during aging.
Recent studies have highlighted the significant role of Shp2, a phosphatase protein, in governing signaling response amplitude and regulating cell differentiation and growth. Dysregulation of Shp2 has been linked to various types of leukemia, including acute myeloid, juvenile myelomonocytic, and B-cell acute lymphoblastic leukemia.
Galanin-like peptide (GALP) plays a key role in regulating feeding behavior and energy metabolism. Recent research has shown that GALP administration leads to decreased respiratory quotient, indicating accelerated lipid metabolism.
Researchers summarize vinegar's anti-bacterial, antioxidant, and weight loss capabilities due to organic acids, polyphenols, and acetic acid. The review also highlights potential anticancer activities of certain grain vinegars.
Researchers have identified widespread regulation of proteins involved in metabolism by the mitochondrial sirtuin, SIRT5. This study found that SIRT5 selectively removes specific sites of succinyl modifications in over 140 different proteins, leading to disruptions in metabolic pathways.
A recent study published in the Journal of Clinical Investigation has shed new light on the relationship between type 2 diabetes and mitochondrial function. Researchers found that heat shock protein 60 (HSP60) is crucial for appropriate mitochondrial function and insulin responses, while leptin plays a key role in regulating HSP60.
Researchers discover that selective activation of nonclassical ER-alpha signaling may help reduce postmenopausal obesity risk by normalizing energy balance. The study found that this type of estrogen signaling is crucial for regulating body weight and preventing metabolic disorders.
A new mouse model has been created to study how lipid sensing and metabolism in the brain relate to energy balance and body weight. The research found that mice with a deficiency of lipoprotein lipase in neurons became obese on a standard diet, leading to decreased food intake and increased sedentary behavior.
A new study published in Environmental Health Perspectives ties rodent data to predictions of human health effects from BPA, suggesting human exposure is much higher than estimated and likely from unknown sources. The study's findings renew the call for governmental agencies to identify all products containing BPA.
A new mathematical model of physiological regulation of body weight suggests several steady states to which an animal's weight tends to gravitate, rather than a single set point. The model combines aspects of two competing theories and accounts for leptin resistance, suggesting new strategies for weight loss.
Researchers at Montreal Neurological Institute have identified two proteins involved in copper regulation that play a key role in maintaining the balance of copper between different cellular compartments. The study suggests that these findings could lead to better therapies for several neurological diseases.
Researchers at UCSD found that E. coli exhibits only six distinct functional states regardless of the carbon source or electron acceptor used, suggesting a surprising level of simplicity in its metabolic processes. The study suggests that this principle may be generalizable to other species.
Dr. Goldstein and Dr. Brown will discuss their research on the regulated intramembrane proteolysis (RIP) of sterol regulatory element binding proteins (SREBPs), which regulates lipid biosynthesis and plasma cholesterol levels. Their work has been recognized with numerous awards, including Nobel Prize in Physiology or Medicine.