Articles tagged with Phospholipases
Researchers developed a computer model of lipoprotein-associated phospholipase A2, shedding light on its mechanism and substrate specificity. This knowledge creates opportunities for therapeutic interventions against cardiovascular disease.
A study published in the Journal of Clinical Investigation has identified an enzyme called secreted phospholipase A2 group IIA as a key mechanism driving COVID-19 severity. The enzyme is found to be associated with increased mortality rates, particularly when its levels are high, and could provide a new therapeutic target for reducing ...
Scientists have discovered that some retina cells may be using an ancient light-sensing mechanism, which suggests a possible connection to the earliest photoreceptors. This finding was made in mice and has implications for understanding vision and its relationship to other biological processes.
Lysosomal phospholipase A2, a unique enzyme, interacts with various substrates and modifies phospholipids. Researchers identified Asp13 as a crucial catalytic residue contributing to the enzyme's properties. In contrast, a study on chronic kidney disease found no strong correlation between HDL protein content and cardiovascular risk.
A team of microbiologists and plant scientists has identified a genetic weakness in the cholera pandemic that could lead to future treatments. The discovery reveals a new signaling network for cyclic GMP-AMP (cGAMP) in the human cholera pathogen, which is responsible for the seventh pandemic's ability to thrive.
Researchers at Duke University have discovered a potential new class of drugs that may prevent the development of temporal lobe epilepsy. A small-protein drug called pY816 was found to reduce both the likelihood and severity of epilepsy in mice after an episode of prolonged seizures.
Men are less susceptible to inflammatory diseases due to higher testosterone levels, which suppress phospholipase D and reduce pro-inflammatory substance production. This knowledge can inform new therapies for inflammatory diseases, requiring 'customized' treatments for men and women.
Researchers at NYU Langone Medical Center have discovered a new targeted intervention for Barth Syndrome, a genetic disorder causing heart and muscle failure in children. The study identified iPLA2-VIA as a potential target for therapeutic intervention, showing promise for treating the disease.
A new NIH grant will investigate the molecules that direct activation of eggs during fertilization, with the ultimate goal of applying this knowledge to infertility and contraception. The grant will also fund summer work for researchers and equipment for the study.
Researchers at the Medical College of Georgia found that glycerin helps skin cells mature properly, which can aid in treating diseases like psoriasis and non-melanoma skin cancers. Glycerol was shown to produce a signal that directs normal skin cell maturation, and its absence may lead to hyper-proliferative, thick skin.