Articles tagged with Topoisomerase
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Researchers at the University of Bologna have identified a specific location and genomic context where DNA breaks occur due to topoisomerase I inhibition. This discovery could lead to new cancer treatments by inducing DNA damage and genomic instability in cancer cells.
Researchers at IISc designed a short peptide that targets topoisomerases in disease-causing bacteria, including antibiotic-resistant species. The peptide effectively killed bacterial cells and reduced infection in animal models, providing leads for combination therapy with existing antibiotics.
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
Etoposide's impact on DNA structure has been untangled by Cornell researchers using optical tweezers and magnetic tweezers. The study found that etoposide promotes DNA loop trapping and barrier formation by topoisomerase II, enabling the creation of sensitive screening tools for improving patient treatment.
A germline mutation of topoisomerase II B affects the movement of proteins in the nuclei of cells with this mutation. The study reveals that the mutation impacts nuclear dynamics and provides a platform to understand the biological relevance of such mutations.
A team of scientists has discovered that the enzyme DNA topoisomerase VI plays a critical role in removing chromosome tangles in plants, which may lead to new antimalarial drug targets. The study provides unprecedented insight into the mechanism of action of this enzyme and its potential applications in plant breeding.
The study reveals that DNA's twisted structure actively regulates genes, particularly those responding to stress and stimuli. Topoisomerase TOP2A eliminates negative supercoiling at gene promoters, allowing for quick activation of these genes.
Scientists have used super-resolution microscopy to identify physical connections between five human chromosomes, revealing a shared sequence encoding ribosomal DNA that holds the chromosomes together. The findings suggest that these inter-chromosomal linkages are pervasive in healthy and diseased tissue, and may play a role in chromos...
Researchers at University of Eastern Finland found ciprofloxacin inhibits topoisomerase 2, impairing mitochondrial DNA replication and transcription. This leads to impaired energy production and cellular differentiation.
Researchers used computer modeling to understand how E. coli bacteria can unlink tangled DNA by a local reconnection process. The study found that undoing one link at a time is the preferred route to separate the circles of DNA, with implications for other complex systems in nature.
Researchers have developed a novel method to rapidly screen hundreds of chemicals for their anti-cancer properties by harnessing the power of knotted DNA structures. By detecting the activity of an enzyme crucial to cancer cell survival, this technique offers a promising tool for identifying potential new treatments.
Researchers at Baylor College of Medicine discovered calcein inhibits TopBP1 activities, leading to anti-tumor effects. The study found calcein has potential as a treatment for multiple cancers, including breast and ovarian cancer.
Researchers discovered that Topoisomerase II is required to resolve DNA threads connecting homologous chromosomes, allowing them to separate. Without this enzyme, chromosomes get stuck together, preventing meiosis from completing and resulting in infertility and birth defects.
Researchers explore nano-channels to selectively unknnot DNA, with potential applications in sequencing and understanding cell metabolism. The study reveals varying channel widths can drastically change DNA knot complexity.
Researchers used magnetic tweezers to study the action of topoisomerase I enzyme in yeast cells, revealing that topotecan's ability to kill cancer cells comes from forcing DNA into positive supercoils. The accumulation of these supercoils triggers cell suicide.
The study reveals the three-dimensional structure of the smallpox virus topoisomerase-DNA complex, providing crucial insights into how the viral enzyme recognizes and activates specific DNA sequences. This knowledge will facilitate the design of targeted agents to combat poxvirus infections and prevent smallpox replication.
Using computer simulations, researchers found that linked and unlinked DNA loops can be identified by their touching points. This discovery has implications for designing new drugs to treat cancer and infectious diseases.
Topoisomerase IB helps unwind DNA during cell division to reduce torsional forces that can delay or stop cell division. The study's findings may lead to improved cancer treatments by enhancing the enzyme's functionality.
Scientists have detailed the structure of yeast topoisomerase II, a key player in cell division. This knowledge could lead to the development of new anticancer drugs that target this enzyme. The discovery also has implications for the design of antimicrobial drugs and the treatment of cancer.