Articles tagged with Cardiomyocytes
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Researchers have devised a new method to fix a broken heart by coaxing adult heart muscle cells into reentering the cell cycle, allowing them to divide and regenerate healthy heart tissue. The key ingredient is neuregulin1, which may one day be used to treat failing human hearts.
Researchers at the Gladstone Institutes have identified a complex signaling process that governs heart cell expansion and division. The study shows that cardiac fibroblasts send signals to cardiomyocytes to divide or grow, which could lead to regenerative therapies after heart attacks.
Researchers found that combining adult cardiomyocytes with bone marrow cells enhances therapeutic effects and reduces programmed cell death. The technique shows promise as a new strategy for myocardial repair, with potential applications in cardiac tissue regeneration.
A new group of stem cells in the epicardium can regenerate cardiomyocytes, smooth muscle cells, endothelial cells, and fibroblasts. This finding advances the hope of recapitulating developmental events to regenerate injured heart tissue, with potential applications for treating adults with heart failure.
Researchers produced human cardiomyocytes from hESCs using a sequential, directed differentiation protocol that did not rely on serum or feeder cells. Echocardiography showed attenuation of left-ventricular end-diastolic and end-systolic diameters in animals receiving cardiomyocytes compared to control groups.
A study published in JCI reveals that Gq/G11-mediated signaling plays a crucial role in transmitting TSH-induced signals, regulating thyroid gland function. Mice lacking the alpha-subunits of both Gq and G11 exhibited reduced thyroid gland function and symptoms similar to hypothyroidism.
Researchers are developing a new system to analyze beating heart stem cells, which could lead to more detailed information on their electrical activity and potentially facilitate their use in regenerating damaged hearts. The team aims to engineer a novel system for real-time analysis of cardiomyocytes during early development.
Researchers demonstrate in rats that a periostin patch can stimulate heart cell regeneration and improve cardiac pumping ability. The treated rats showed improved ventricular remodeling, decreased scarring, and increased cardiomyocyte proliferation.
Researchers at St. Jude Children's Research Hospital found that pieces of cell walls from Streptococcus pneumoniae bacteria hijack a protein on blood vessel lining and enter the brain and heart. Antibiotic therapy contributes to this damage by shedding more cell wall pieces.
Researchers at Boston Children's Hospital developed a two-drug treatment that rescues heart function after a heart attack by promoting blood vessel growth and cell division. The study shows improved heart function and reduced scarring in rats treated with the combination of agents.
Researchers have developed a strategy to deliver PDGF-BB to the infarcted heart using injectable self-assembling peptide nanofibers, protecting cardiomyocytes from death and preserving cardiac function. The therapy reduced infarct size and improved cardiac function in rats.
Researchers developed a strategy to deliver PDGF-BB to cardiomyocytes using self-assembling peptide nanofibers, protecting them from injury and reducing infarct size. This approach holds promise for tissue regeneration after cardiac injury.
Scientists have discovered an enzyme that suppresses heart cell replication, and by inhibiting it, they can enable heart cells to proliferate. This breakthrough could lead to new strategies for regenerating tissue after heart attacks and may be a more practical alternative to stem-cell therapy.
Researchers have discovered that skeletal precursors of cardiomyocytes (Spoc cells) can transform into beating cardiac muscle cells, offering hope for developing cell-based treatments for heart disease. These cells were isolated from adult mice and showed spontaneous rhythmic beating and expressed cardiac markers.
Researchers at Cincinnati Children's Hospital Medical Center have discovered a link between heart disease and neurodegenerative diseases. The study found that toxic protein clusters called beta-amyloids, associated with Alzheimer's disease, are also present in the hearts of patients with heart failure.
Researchers have discovered a direct correlation between Bmp4 activity levels and septum development in congenital heart disease. By manipulating Bmp4 expression, the team recreated the full spectrum of defects seen in AVCD patients, providing a valuable genetic model for future research.
A study published in the Journal of Clinical Investigation found that HIV protease inhibitors directly promote atherosclerosis in mice. In humans, researchers propose a mechanism by which these drugs might contribute to heart disease, suggesting ways to disrupt it.