Articles tagged with Goblet Cells
Researchers have discovered that goblet cells act as dynamic guardians of gut immunity, engaging in multiple protective actions beyond pathogen defense. They produce specialized structures called GAPs, which enable immune cells to access gut contents while maintaining tolerance and preventing immunogenic responses.
The Organoid group at the Hubrecht Institute produced the first organoid model of the human conjunctiva, which functions like real human conjunctiva. The researchers discovered a new cell type called tuft cells that become more abundant under allergy-like conditions and play a role in eye's reaction to allergies.
Researchers have identified a new cell state in embryonic airway development, which may lead to new approaches for treating chronic respiratory diseases. The discovery highlights the crucial role of cellular heterogeneity in shaping airway biology.
Researchers from Juntendo University found that sialylated mucins secreted by conjunctival goblet cells encapsulate allergens, protecting the eye from allergic conjunctivitis. Mice with intact St6galnac1 gene showed reduced antigen response and better protection against allergies.
A new study reveals that pain neurons in mice regulate mucus production and stimulate intestinal cells to release more mucus during inflammation. This protective mechanism helps maintain gut homeostasis and prevent colitis.
Researchers have developed a non-invasive imaging method to examine conjunctival goblet cells (CGCs) in live rabbit eyes, which are similar to human eyes. The study found that CGC density decreased with dry eye disease (DED) and recovered over time.
Conjunctival goblet cells play a crucial role in tear film stability, and their dysfunction is linked to various ocular surface diseases. A new microscopy system allows for non-invasive examination of CGCs in live animal models and humans, enabling precise diagnosis and treatment of ocular surface diseases.
Researchers have discovered a new set of signals that control the production of goblet cells in the lung, which are often increased in lung diseases. The study found that altering these signals can increase or decrease goblet cell production, offering potential therapeutic avenues for treating conditions like asthma and COPD.
A new study from the University of Gothenburg suggests that defective goblet cells may contribute to ulcerative colitis by damaging the mucus protection layer. The research team identified specific types of goblet cells and found that their premature rejection leads to inflammation and increased cancer risk.
A significant loss of intestinal goblet cells following allogeneic stem cell transplantation leads to bacterial invasion and poor prognosis. Administering IL-25 prior to transplantation can significantly reduce bacterial invasion by maintaining the mucus layer.
Researchers at the University of Pittsburgh discovered that mechanical cues can drive goblet cell regeneration on the surface of frog embryonic organoids. The study, published in Nature Communications, shows that changing the stiffness of the environment can induce significant changes in cell behavior. This finding has implications for...
Researchers have developed a combined experimental and computational pipeline to understand the role of genes in IBD. The study uses organoids to analyze gene expression and identifies 'master regulators' that overlap with IBD-related processes. This breakthrough enables design of new experiments to explore IBD-related processes further.
A new imaging technology assesses conjunctival goblet cells with high definition and contrast, overcoming limitations of existing methods. This non-invasive approach enables precise diagnosis of dry eye syndromes and evaluation of treatment effects, paving the way for precision medicine.
A study by researchers at the University of Kansas reveals a new function for APC in protecting against chronic colitis-induced inflammation and tumor development. The team found that functional nuclear APC is necessary to suppress Wnt signaling pathway, controlling goblet cell differentiation.
Goblet cells, previously thought to only secrete mucus, have been found to chaperone food antigens in the intestine, connecting them to dendritic cells. This discovery provides new insights into intestinal immunity and potential targets for therapies against inflammatory bowel disease, celiac disease, and food allergies.
Sulfomucins, secreted by intestinal goblet cells, provide critical protection to the intestinal mucosa. Inflammatory cues from microbes and host inflammatory cells modulate sulfomucin production, which is associated with both inflammatory bowel disease and colorectal cancer.
A foodborne bacterium invades the body by binding to E-cadherin on goblet cells, which produce slippery mucus. The reorganization required to expel the mucus exposes E-cadherin, allowing Listeria to cause systemic infection.
Researchers have identified a single 'master switch' enzyme, aldose reductase, as crucial in producing excess mucous that clogs airways of people with asthma and COPD. The discovery could lead to improved therapies for the 510 million people worldwide suffering from these diseases.
Research reveals that SPDEF regulates mucus hyperproduction in common lung diseases through goblet cell differentiation. The study found that this network is active in patients with chronic lung diseases, suggesting new therapeutic targets.
Researchers discover that cellular transformation in mice and humans with asthma and chronic bronchitis leads to overproduction of mucus. A combination of two drugs, EGFR and IL-13 inhibitors, can prevent this transformation and normalize airway lining in patients.