Articles tagged with Myotubes
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Researchers at the University of Houston have discovered a potential therapeutic strategy for counteracting muscle wasting in pancreatic cancer by blocking a specific cell pathway. Muscle wasting, also known as cachexia, is a debilitating syndrome affecting 60-85% of patients with pancreatic cancer.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
Scientists have discovered that MYOD protein can act as a gene silencer, clearing out old 'furniture' to reset the cell's identity. This finding challenges dogma and opens up new avenues for understanding cellular reprogramming and regenerative medicine therapies.
The study identified DUSP13 and DUSP27 as crucial enzymes that regulate the transition of proliferating skeletal muscle stem cells into the differentiation stage. Mice lacking these genes exhibited delayed muscle regeneration, highlighting their importance in maintaining muscle function.
Scientists at the Terasaki Institute for Biomedical Innovation have developed a new bioink that enhances the formation of mature skeletal muscle tissue from muscle precursor cells, increasing efficiency and potential therapies for muscle loss or injury. The bioink's sustained delivery of IGF-1 promotes muscle regeneration and repair.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
Researchers from Tokyo Metropolitan University have discovered a protein called PDGF-B that not only promotes muscle growth but also enhances myotube maturation, leading to increased contractile strength. The findings offer a game-changing approach to treating muscle injuries and atrophy.
Researchers from Tokyo Metropolitan University have developed a method to directly measure the strength of skeletal muscle myotubes by analyzing wrinkles formed on an elastic substrate when stimulated with electric pulses. This new technique is more sensitive than existing measures and has great potential for accelerating drug discover...
Researchers at the University of Connecticut have developed a potential breakthrough treatment for rotator cuff tears, using an advanced polymer to stimulate regeneration of both the tendon and muscle. This approach addresses the real problem of muscle degeneration and fat accumulation that often leads to re-injury after surgery.
Researchers at USC have developed a new method to grow stronger muscles using gelatin instead of traditional methods. The 'muscles-on-a-chip' technology has shown promising results in studying human muscle development and disease, including amyotrophic lateral sclerosis (ALS).