Articles tagged with Stromal Cells
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Research found that umbilical cord-derived mesenchymal stromal cells from women with gestational diabetes have impaired growth, cellular senescence, and metabolic function. The study highlights the potential impact of gestational diabetes on the therapeutic potential of these stem cells.
Researchers discovered that crosstalk between leukemia cells and stromal cells in the spleen is crucial for cancer growth. Blocking chemokine receptor CXCR5 prevents cancer cell entry and proliferation, identifying new targets for future therapies.
Researchers identify physical characteristics of mesenchymal stem cells, allowing them to distinguish MSCs from other immature cells. Isolated MSCs show promise in repairing muscle and bone injuries in mice.
Researchers found that patients with Multiple Sclerosis (MS) can safely tolerate treatment with cells cultured from human placental tissue. Early signals also suggest the potential for repairing damaged nerve tissues, offering a new frontier in treatment for the disease.
A multi-disciplinary team of scientists has discovered that a gene called MED12 is altered in nearly 60% of fibroadenomas, the most common benign breast tumours diagnosed in women. The study's findings have potential applications in distinguishing fibroadenomas from breast cancer and developing targeted therapies.
Researchers found that adipose-derived stromal cells exhibit increased apoptotic rates and decreased viability when attempting to differentiate into astrocytes. This process is hindered by caspase-dependent apoptosis, a crucial strategy for increasing induction efficiency.
Researchers have found that infusing patients with their own bone-marrow stromal cells may lead to improved cure rates for multi-drug resistant tuberculosis. The study showed 16 patients treated with MSCs were deemed cured at 18 months compared to only 5 without MSC treatment.
Researchers at the University of Iowa have created a bio patch that can regrow bone by delivering DNA instructions to cells. The patch successfully regenerated bone in test animals and stimulated new growth in human bone marrow stromal cells. This breakthrough technology has potential uses in dentistry, including rebuilding bone for de...
A laboratory study at the University of Michigan has shown promising results in regenerating cardiac birth defects using amniotic stem cells. The researchers believe this approach could one day help thousands of babies born each year with congenital heart defects.
A LSUHSC researcher has been awarded a five-year, $1.5 million NCI grant to investigate the connection between chronic inflammation and cancer development. The project aims to understand how p53 dysfunction in normal cells surrounding cancer cells can lead to an inflammatory microenvironment that supports tumor growth.
Researchers have successfully transplanted genetically modified adipose cells into mice with liver disease, demonstrating their potential as a therapy. The study used bioluminescent imaging to track the cells' migration and engraftment in the liver, revealing their ability to persist for up to two months.
Researchers have developed a method to expand umbilical cord blood cells on mesenchymal precursor cells, speeding up the establishment of a new blood supply in patients. This approach has shown faster engraftment of white blood cells and platelets, resulting in improved patient outcomes.
Researchers found that ovarian cancer cells hijack surrounding tissues by activating the HOXA9 gene, which induces TGF-β production and stimulates tumor growth. Blocking TGF-β expression reduced tumor growth, suggesting potential therapeutic targets for treating ovarian cancer.
Researchers created a novel 3D long-term bone marrow culture system to investigate stromal cell biological function. This system successfully maintained hematopoietic stem cells (HSCs) for extended periods, enabling the analysis of stromal-cell interactions and regulatory factors.
Scientists have discovered a protein marker on the surface of adipose stromal cells (ASCs), which drive fat expansion in the body. The finding may lead to developing a method to inactivate these cells, potentially treating obesity and improving regenerative therapies.
Researchers have discovered that cancer cells use specific chemokines to create a survival niche in the lymph nodes and spleen, allowing them to grow and develop. This niche is created by the interaction between cancer cells and stromal cells, which secrete increased quantities of chemokines CCL19/CCL21.
Researchers at U-M have developed a new diagnostic tool to predict bronchiolitis obliterans syndrome (BOS), the leading cause of death for lung transplant recipients. A high stem cell count after transplantation is linked to an increased risk of developing BOS.
Scientists have found that chronic lymphocytic leukemia (CLL) cells become resistant to chemotherapy by growing among normal cells in the bone marrow and lymph nodes. This resistance is linked to alterations in Bcl-2 family proteins, which makes CLL cells less susceptible to treatment.
A new study from Massachusetts General Hospital finds that circulating tumor cells prepare a hospitable environment for tumor growth by bringing along noncancerous cells, facilitating metastasis. The presence of these supporting cells is crucial for the initial growth and survival of tumors at a new site.
Researchers at the University of Cambridge have discovered that a type of stromal cell found in many cancers expresses fibroblast activation protein alpha, which suppresses the immune response. Destroying these cells allows the immune system to control tumours, paving the way for improved immunological therapies.
Researchers have discovered a mechanism to detect bacteria in the womb, opening up new possibilities for preventative treatments. This unique environment relies on a simpler form of immunity called the innate system, as the adaptive response is underdeveloped.
Researchers have identified the location of bone generating stem cells in mice and found factors that control their growth. The discovery opens up avenues for studying bone tumor formation and regenerating damaged or injured bone.
Dr. Pamela Gehron Robey, Chief of the Craniofacial and Skeletal Diseases Branch at NIH's NIDCR, receives the award for her groundbreaking work on human bone marrow stromal cells and their application to treat craniofacial diseases.
Researchers found that transplanted bone marrow stromal cells can differentiate into liver cells and may be used for cell replacement therapy. The study also suggests that these cells are not the origin of liver cancer in mice.
Researchers have identified a new target for cancer therapy by targeting the non-malignant cells surrounding tumors, which can stop tumor growth in mice. This approach has shown promise in reducing tumor size and slowing growth of well-established cancers after a single injection of T cells.
A recent study found that chronic viral infections can persist by targeting fibroblastic reticular cells (FRC) in lymphoid organs, disrupting the function of these cells. The researchers discovered a potential link between this mechanism and the PD-1 pathway, which may inhibit immune responses to chronic infections.
Researchers found that MMP-9 is highly expressed by colon cancer cells and is key to initiating metastasis. By blocking the enzyme, colorectal cancer cells cannot metastasize to other tissue, suggesting a new target for preventing metastasis in colon cancer.
Researchers discovered that bone marrow stromal cells can improve brain receptor function in patients with cerebral stroke, showing potential for neural tissue regeneration. The study may provide a 'missing link' needed in understanding receptor function, possibly leading to safe and ethical cell transplantation therapy.
Researchers discover distinct phase of rheumatoid arthritis immediately after symptom onset, enabling early treatment and potentially halting disease progression. The study proposes a new therapeutic window for potent anti-inflammatory therapies during the first few months of clinically apparent disease.
Researchers at Indiana University have successfully transformed adult bone marrow stem cells into auditory neurons, offering new hope for treating deaf patients. The breakthrough involves the use of Sonic hedgehog and retinoic acid molecules to stimulate the growth of nerve cells in patients with profound hearing loss.
A recent study published in Cancer Research found that genetic damage in stromal cells within tumors can play a crucial role in tumor development. This discovery may provide new targets for anti-cancer drugs and present a novel strategy for treating and preventing cancer.
Researchers at Duke University Medical Center have successfully transformed human fat cells into functional nerve cells using a cocktail of growth factors and induction agents. The newly formed cells demonstrated characteristics similar to developing neuronal tissue and responded similarly to normal nerve cells under certain conditions.
Researchers at Johns Hopkins Medicine have found a new method for growing human embryonic stem cells using human marrow stromal cells, eliminating the need for mouse cells as feeders. This breakthrough could potentially lead to significant advancements in treating conditions like Parkinson's disease and diabetes.
Researchers found that rats treated with adult human stromal cells experienced significant improvements in function after a stroke, including enhanced motor and sensory abilities. The study suggests a potential new treatment approach for stroke patients, offering a longer time window for effective treatment.
Researchers explore the role of dopamine in the placebo effect, which shows promise for treating Parkinson's disease, depression, and pain. Meanwhile, preclinical studies on bone-marrow stromal cells suggest potential therapeutic benefits for neural injury treatments like stroke.
Researchers have successfully created viable new heart muscle cells using marrow stromal cells from an animal's own bone marrow. The goal is to replace dead heart muscle cells with new ones, potentially offering a treatment for life-threatening heart failure.