Researchers at QST discovered that controlled gamma-ray mutagenesis can create heat-tolerant nitrogen-fixing bacteria in weeks, shortening development timelines. The method produces robust, climate-ready microbial products for agriculture, food processing, pharmaceuticals, and biofuel production.
Researchers at UT Health San Antonio are developing APOBEC inhibitors to block tumor mutation rates and slow cancer's evolution. The goal is to strengthen current therapies and improve their long-term effectiveness.
A new study reveals that air pollution contributes to the development of lung cancer in people with no or hardly any history of smoking. The study found a strong association between air pollution and genetic mutations in lung tumors, particularly driver mutations that promote cancer development.
Researchers from the University of Lausanne used genome editing to repair a deleterious domestication mutation in the tomato genome. This resulted in an earlier yielding variety, which could have implications for agriculture and sustainability. The study demonstrates the potential benefits of genome editing for crop breeding.
Researchers from VIB-UGent Center for Plant Systems Biology improved multiplex mutagenesis, reducing the complexity and cost of large-scale genome editing projects. The team optimized CRISPR/Cas9 vector design, achieving a 99% mutation rate with high efficiency.
Researchers developed a robot that uses machine learning to automate microinjection in genetic research, enabling large-scale experiments. The technology has the potential to expand genetic research capabilities while reducing costs.
Researchers developed a method to generate large numbers of homozygous mutant barley plants by treating microspores with ethyl methanesulfonate. This approach provides an efficient way to produce novel genetic resources for pre-breeding and theoretical research.
Researchers from Okayama University found that Actinidia arguta (Sarunashi) juice and its component isoquercetin inhibit lung cancer development in mice, accelerating DNA repair and suppressing Akt-mediated growth signaling. The study suggests Sarunashi juice as an attractive candidate for chemoprevention.
Researchers at the University of Toronto have identified FAM72A as a crucial gene in antibody development, enabling high-quality antibodies by facilitating AID's effect. The findings also suggest that increased levels of FAM72A could spur cancer development and progression.
Researchers have designed a new software called QuasiFlow to analyze the genetic variability of SARS-CoV-2 and identify its weak points. The goal is to develop a combination antiviral therapy that combines lethal mutagenesis with inhibitors to prevent the virus from evading the innate immune response.
Scientists have quantified the rate of Cas9-caused off-target mutagenesis in mice through whole-genome sequencing, revealing that guide RNA design can significantly reduce unwanted mutations. The study highlights the need for improved precision in gene editing, particularly in therapeutic applications.
Scientists discovered that DNA damage, not just errors in DNA doubling, causes many genetic mutations. This challenge traditional views on mutagenesis and its role in hereditary diseases and cancer.
Researchers used single-cell transcriptogenomics to study the cell's defense mechanisms and found that DNA-directed RNA transcription can exclude ENU-mutated alleles, preventing them from being expressed. This novel mechanism may provide a new approach to understanding aging and disease.
SourceElsevier·JournalMutation Research/Genetic Toxicology and Environmental Mutagenesis·DateMar 11, 2015
A recent study from Baylor College of Medicine describes an elaborate gene network that functions in causing mutations during DNA repair in stressed cells. The network, composed of 93 genes, regulates the production of mutations in response to environmental challenges such as starvation or antibiotics.
Researchers suggest that transcriptional mutagenesis, a process where damaged DNA leads to mutant proteins, could contribute to tumor growth. The study highlights the importance of understanding this process to develop new cancer treatments.
The article describes a new approach for targeted mutagenesis in Drosophila melanogaster using ChIP-Seq analysis. The SIRT method combines homologous recombination, site-specific integration, and bacterial recombineering to facilitate efficient genetic variants at specific loci. This novel technique enables researchers to investigate g...
Researchers have discovered that cells can turn on tumor-promoting growth circuits as a result of misreading damaged DNA without copying it. The results suggest that DNA damage, if it hits certain critical genes in a cell, could lead to transcriptional mutagenesis that spurs the cell to divide.
Researchers at Northwestern University are using genome-wide mutagenesis to identify gene mutations that cause sex reversal in mice. The study aims to understand the function of mammalian genes and their role in gonad development, as well as infertility in humans.