Articles tagged with Recombinant Dna
Researchers have identified a key gene crucial for vitamin D uptake and metabolism, offering new avenues for precision medicine in cancer therapy and potential benefits for autoimmune diseases. Inhibiting this gene may selectively kill cancer cells while leaving healthy tissues unharmed.
Frank Buchholz's ERC project DC-PGE aims to develop fully programmable DNA editing enzymes that minimize off-target effects and increase safety in gene therapy. The goal is to create a platform for efficient and accurate genome editing tools to treat various genetic disorders.
A new study found that recombinant adeno-associated virus (rAAV) capsids contain single-stranded DNA impurities derived from plasmid and host cell DNA. The researchers suggest that the adverse effects of these impurities may differ from those of double-stranded DNA, highlighting the need for further evaluation.
The Asilomar conference set the groundwork for evidence-based safety guidelines, but regulations hinder scientific innovation. A new focus issue in Trends in Biotechnology explores how genetic modification is regulated.
Researchers identified the integration site pattern of lentiviral gene therapies in patient cells, shedding light on treatment safety and efficacy. The study found that integration near nuclear pores is associated with improved safety and effectiveness, avoiding oncogene regions where earlier technologies failed.
Researchers developed a novel nanobody-based detection method for recombinant human interferon α2b (rhIFNα2b), which has a lower detection limit than existing methods. The assay's operation time was shortened from two days to a few minutes, making it suitable for rapid market counterfeit detection and early diagnosis of hepatitis.
Researchers used next-generation DNA sequencing to detect residual disease in patients treated with CAR-T therapy for acute lymphoblastic leukemia. The study found that DNA sequencing was more sensitive and accurate than flow cytometry in predicting relapse, enabling earlier intervention.
A new DNA construction software, j5, streamlines the process by identifying cost-effective strategies and automating protocols. This enables researchers to focus on primary interests while reducing labor-intensive tasks.
The Recombinant DNA Advisory Committee has played a central role in developing responsible research practices and establishing criteria for the safe use of recombinant DNA technology. The committee's work has enhanced opportunities within modern genetics and influenced the conduct of science globally.
Researchers at Cornell University's Boyce Thompson Institute have developed a novel approach to genetically modifying plants by using chimeraplasty, a method that coats gold particles with short chimeric DNA/RNA molecules. This technique has the potential to improve crop yields and nutritional value without involving foreign DNA.