Articles tagged with Transcriptional Response
A new tool named retriever extracts disease-specific drug response signatures to predict cancer treatment combinations, improving personalized treatment strategies. The tool refines predictions using single-cell RNA sequencing data and demonstrates its potential in identifying effective treatments for triple-negative breast cancer.
Researchers at Colorado State University have identified an alternate method to study changes during the DNA replication process in lab settings using genetically modified yeast. This new approach provides a less toxic and quickly reversible alternative to hydroxyurea, allowing for better insight into cell cycle arrest mechanisms.
In this study, researchers from Tokyo Institute of Technology found that hydrogen sulfide-dependent transcription factor YgaV regulates iron uptake dynamics in Escherichia coli. The team observed elevated intracellular H2S levels resulting in increased antibiotic resistance and upregulated genes involved in sulfur metabolism.
Researchers discuss lurbinectedin as a method to treat neuroendocrine tumors (NETs), with encouraging results from phase II basket studies demonstrating activity in platinum-sensitive relapsed SCLC and other malignancies. Lurbinectedin's mechanism of action involves inhibiting oncogenic transcription, promoting apoptosis and cell death.
Researchers developed a method to design weaker transcription factors that work together to activate genes without activating naturally occurring genes. This approach, called cooperative assembly, strengthens the factors as a group but weakens them individually, ensuring targeted gene activation and long-term circuit stability.
Researchers found women's immune responses to herpes simplex virus (HSV) vaccine are stronger, while those with prior exposure have different type I IFN signatures. This interaction may affect vaccine effectiveness.
Researchers at the University of Chicago discovered that yeast cells use membrane-less compartments to drive high-level gene expression in response to environmental stress, mirroring a mechanism used by mammalian cells. This finding has implications for understanding human diseases such as cancer and neurodegeneration.
Researchers found that SEUSS condensates rapidly form upon hyperosmotic stress, enabling Arabidopsis to tolerate salt and drought. Loss of SEU dramatically compromises stress-tolerance gene expression.
Researchers identified seven distinct subpopulations of kidney resident macrophages, each with unique transcriptomic signatures and functions. These subpopulations are associated with different portions of the nephron and have distinct roles in protecting the kidney from infection and maintaining tissue health.
Researchers found a unique bivalent histone-mark switch specific to critical transcription factors that induce genes essential for angiogenesis. The histone modifiers responsible for this modification are vital for postnatal angiogenesis.
Researchers at Insilico Medicine developed a new AI model that combines generative biology and chemistry to generate novel molecular structures for a desired transcriptional response. The Bidirectional Adversarial Autoencoder can be used for virtual screening, discovering new molecular structures and predicting transcriptional responses.
Lehman et al. show that PGC-1 is limiting for mitochondrial proliferation in cardiac muscle, directing changes in mitochondrial population across cells. Overexpressing PGC-1 increases fatty acid oxidation capacity and coupled OxPhos, but constitutive expression leads to dilated cardiomyopathy.