Articles tagged with Basophils
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Researchers at Institute of Science Tokyo found that basophils suppress lung inflammation during ARDS recovery, suggesting potential treatment strategies. Basophils release interleukin-4, which helps immune cells coordinate responses and alleviate lung inflammation.
Researchers from Institute of Science Tokyo discovered that tristetraprolin (TTP) regulates inflammatory responses in basophils by promoting mRNA degradation. In TTP-deficient mice, aggravated allergic inflammation was observed, suggesting TTP as a key regulator of basophil-mediated immune responses.
Researchers from Tokyo Medical and Dental University have identified a previously unknown intermediate cell type, pre-basophils, which plays a critical role in the differentiation of precursor cells into mature basophils. These newly discovered cells exhibit higher proliferation capacity and distinct surface protein expression profiles...
Engineers at Stanford University have developed a microfluidic system that isolates allergen-reactive basophils from blood samples using magnetic nanoparticles. The device achieves purities and recovery over 95% in just 10 minutes, making it accessible to clinics and diagnostic labs.
A new study from Karolinska Institutet in Sweden found that COVID-19 disease severity is linked to the characteristics of white blood cells called granulocytes. Combined measurements of granulocyte characteristics and widely used biomarkers can predict key clinical features such as respiratory function and multiorgan failure.
Researchers used mouse models to explain the developmental process behind COPD, finding that immune cells called basophils induce airway degeneration by triggering a cascade of immune responses. The study's findings may lead to therapies targeting basophils or related immune cells to slow down emphysema progression.
Basophils, a rare type of white blood cell, have been found to play a crucial role in preventing sepsis. By releasing protein tumor necrosis factor (TNF), basophils trigger an immune response that helps protect against infection and prevents the progression to sepsis.
Researchers have discovered that basophils, immune cells long believed to only cause allergic reactions, are essential for proper lung development and homeostasis. They interact with other cell types to produce growth factors and cytokines, suggesting a potential target for novel immunotherapies in lung diseases.
Researchers identify TSLP and basophils as key players in promoting esophageal inflammation in response to food allergens. This discovery suggests novel therapeutic targets for treating eosinophilic esophagitis, a debilitating food allergy-associated disease affecting millions.
Researchers discovered that gut bacteria play a crucial role in controlling allergic inflammation by regulating basophil responses and limiting IgE production. The study's findings suggest that targeting the commensal bacterial population may be beneficial in treating allergic diseases, offering new therapeutic options for asthma and o...
A team of international scientists identified the protein TSLP as a key regulator of multiple allergic diseases, including eczema, food allergies, and asthma. They found that TSLP elicits the maturation of distinct basophils that promote allergic inflammation.
Researchers discovered that activated basophils cause kidney damage in a mouse model of lupus nephritis, potentially leading to new treatments with an asthma medication. The study found increased IgE responses and activated basophils in people with SLE, strongly associated with disease activity.
Researchers at Rush University Medical Center discovered that proton channels in basophils respond to agents triggering histamine release, with zinc inhibiting these currents. This finding points to a new approach to reduce the consequences of asthma and allergic reactions.