Articles tagged with Antibody Dependent Enhancement
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Researchers discover antibody-dependent enhancement of toxicity (ADET), a phenomenon where antibodies can amplify venom's potency. The breakthrough contributes to expediting the development of a new generation of antivenom, potentially saving millions from snakebites yearly.
A multi-institutional study found that dengue virus sequences have evolved dramatically in India, with different serotypes deviating from their ancestral sequences. Dengue 2 has become more dominant across the country, while Dengue 4 is making a niche for itself in South India.
Researchers found that prior infection with common human coronaviruses does not provide immunity against SARS-CoV-2 due to limited cross-reactive antibodies. This suggests no significant adverse effects from antibody-dependent enhancement, reducing the risk of COVID-19 complications.
Researchers at California Institute of Technology have discovered how antibodies recognize and block the Zika virus. The study found that antibodies produced in response to Zika virus are effective against other flaviviruses like dengue type 1, but less effective against West Nile and other types of dengue.
A new antibody has shown broad-spectrum protection against multiple flaviviruses, including dengue, Zika, and West Nile. The discovery could provide a blueprint for safe and effective vaccines against these deadly diseases.
Researchers at La Jolla Institute for Immunology discovered that antibodies against one virus can make another more severe. However, a specific type of T cell can counteract this effect. The study suggests the need for future vaccines to elicit a balanced response from both antibodies and T cells.
A new study found that maternal Zika immunity can increase the severity of dengue disease in mouse pups, which has significant implications for vaccine development. The study suggests that a pan-flavivirus vaccine could be an effective way to elicit maximal protection against both diseases.
Researchers used high-tech tools to analyze Amazonian Dark Earths and found lower biomass, tree height, and tree cover at sites with past human settlement. These areas are more susceptible to drought, indicating the forests still show impacts from pre-Columbian occupation.
A recent study conducted in São Paulo, Brazil found that prior dengue infection does not intensify Zika disease severity. The research involved 65 individuals who contracted Zika virus during the 2016 epidemic, and analyzed their viral loads, finding no significant difference between those with prior dengue exposure and those without.
A study by Brigham and Women's Hospital found that computer order entry systems significantly reduced preventable adverse drug events (ADEs) in community hospitals. The system showed a 34% reduction in preventable ADEs, but an increase in potential ADEs or near-misses following implementation.
A new study published in PLoS Medicine reexamines the development of dengue hemorrhagic fever (DHF), contradicting the long-held antibody-dependent enhancement (ADE) model. Researchers found that maternal antibodies protect infants from full-spectrum dengue disease, and a higher weight-for-age is associated with DHF risk.
Researchers at Washington University School of Medicine have identified a blood-borne immune system compound that suppresses antibody-dependent enhancement (ADE) of infection, a phenomenon linked to some viral disease outbreaks. C1q, a key immune compound, blocks ADE by blocking the virus' ability to hijack antibodies.
Computer models aid understanding of antibody-dependent enhancement in the spread of dengue fever, finding that enhanced viruses can spread faster but face extinction due to over-exploitation. The research has implications for designing optimal dengue vaccination strategies.
Research suggests that chronic alcohol consumption leads to long-lasting brain changes that promote relapse. Stressful cues and environmental triggers also contribute to relapse drinking. Understanding these factors is crucial for developing effective treatments, such as medications and behavioral therapies.