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Slime mold-inspired computing

A new, simplified amoeba-inspired computing model streamlines information-processing while enabling physical implementation, breaking volume-conservation law constraints. The model enables diverse materials and physical phenomena, solving combinatorial optimization problems with improved efficiency.

SourceWaseda University·JournalPhysical Review Research·TypeComputational simulation/modeling·DateAug 26, 2026

Could slime mold microbes be a source of potent antimicrobials?

Researchers optimized lab culture conditions to boost levels of low-abundance chlorinated compounds in slime mold cells, identifying CDF-2 and CDF-3 as potent antibiotics against Gram-positive bacteria. The compounds' similar molecular structure suggests a critical role in protecting against harmful bacteria.

SourceWiley·JournalFEBS Open Bio·DateOct 8, 2025

A memory without a brain

Researchers have identified how Physarum polycephalum, a single-celled organism, stores and retrieves information about its environment through its network architecture. The slime mold weaves memories of food encounters into the architecture and uses stored information to make future decisions.

SourceTechnical University of Munich (TUM)·JournalProceedings of the National Academy of Sciences·DateFeb 23, 2021

Slime mold simulations used to map dark matter holding universe together

Researchers have successfully mapped the cosmic web's filamentary structure using a slime mold-inspired algorithm, providing insights into dark matter's role in shaping the universe. The study revealed that denser regions of intergalactic gas are organized into filaments that stretch over 10 million light-years from galaxies.

SourceNASA/Goddard Space Flight Center·JournalThe Astrophysical Journal Letters·DateMar 10, 2020

Slime mold absorbs substances to memorize them

Researchers found that slime molds can store knowledge of salty environments through absorption, allowing for up to a month of retention. The study suggests that the substance itself supports the slime mold's memory, rather than just the environment.

SourceCNRS·JournalPhilosophical Transactions of the Royal Society of London (B )·DateApr 22, 2019

Computing with slime

Researchers created logical circuits using living slime molds, which can process information and carry out Boolean logic operations. The slime mold-based system could potentially be used to build low-cost, biological computing devices and sensors.

SourceElsevier·JournalMaterials Today·DateMar 27, 2014

Slime mold mimics Canadian highway network

Researchers have found that slime mold can compute a complex network similar to the Canadian highway system. This discovery provides evidence that nature is capable of computation, challenging our understanding of its capabilities.

SourceQueen's University·JournalInternational Journal of Natural Computing Research·DateMar 26, 2012

A Dicty mystery solved

Rice researchers found that starving cells in slime mold have an advantage, pushing those that eat into selfless sacrifice. The study reveals a surprising strategy for survival and reproduction in single-cell organisms.

SourceRice University·JournalBiology Letters·DateMay 27, 2010

When the going gets tough, slime molds start synthesizing

Researchers at Salk Institute and MRC discovered how slime molds synthesise the chemical signal DIF-1 using a unique type III PKS domain arrangement. This discovery informs the development of more efficient methods for producing modified polyketides for human use, highlighting the complexity of natural chemicals in biological systems.

SourceSalk Institute·JournalNature Chemical Biology·DateAug 13, 2006