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Marsupials key to discovering the origin of heater organs in mammals

Research from Stockholm University reveals that marsupials possess a not fully evolved form of brown fat, a crucial finding for understanding the origin and regulation of this heat-producing organ. The study suggests that the gene networks required to enable thermogenesis existed before the divergence of marsupials and placental mammals.

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Sap beetles vs wind: what pollinates screw pines?

Researchers found that Amystrops sap beetles pollinate fragrant screw pines, contrary to previous assumptions about wind-pollination. The study also revealed floral thermogenesis in male and female flowers of Pandanus odorifer.

Study reveals molecular mechanisms behind hibernation in mammals

The study reveals changes in motor protein structure and energy consumption during hibernation, highlighting key differences between large and small hibernators. Myosin plays a crucial role in non-shivering thermogenesis, with smaller mammals experiencing increased ATP consumption at lower temperatures.

Time of day may determine the amount of fat burned by exercise

A new study from Karolinska Institutet found that exercising in the early active phase increased gene expression involved in fat breakdown and thermogenesis, leading to a higher metabolic rate. This effect was independent of food intake and may prove beneficial for people who are overweight.

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Protein Sirtuin 7 suppresses heat production in brown adipose tissue

Researchers found that Sirtuin 7 regulates brown adipose tissue functions, leading to suppressed energy expenditure and thermogenesis. The study reveals a molecular pathway involving protein deacylation and mRNA binding, which will have implications for treating hypermetabolic conditions like cancer and obesity.

DARPA grant will fund hunt for drug that can keep people warm

Researchers aim to develop a drug that enhances brown adipose tissue response to cold exposure, potentially treating hypothermia and arctic exploration challenges. The new screening method could also optimize drug development for diseases and infections, reducing costs and time.

Immune cells in the liver regulate body temperature

Scientists at CNIC discovered a complex network between liver tissue connections that allows the liver to regulate body temperature. The secretion of IL-12 by liver-infiltrating macrophages blocks FGF21 production, reducing heat generation by brown fat in mice.

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Change of temperature causes whole body reprogramming

Researchers at UNIGE discovered that temperature changes trigger organ-specific effects in all tissues, leading to distinct gene expression profiles. The study's web-based application provides access to thousands of gene expression profiles, enabling further research and potential therapeutic applications.

Hypoxia tolerance: naked mole-rats may provide secret to low oxygen survival

Researchers discovered that naked mole-rats rapidly decrease uncoupling protein 1 (UCP1) in brown adipose tissue to conserve energy in hypoxia. This mechanism may hold secrets for humans to survive and thrive in low-oxygen environments, particularly in relation to diseases like stroke and chronic pulmonary disorders.

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People who eat a big breakfast may burn twice as many calories

A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that eating a large breakfast instead of a large dinner creates twice as high diet-induced thermogenesis. This process measures how well metabolism is working, and can differ depending on mealtime.

Food activates brown fat

Researchers at TUM demonstrated that food increases thermogenesis in brown fat, contrary to the long-held assumption that it only responds to cold. This discovery could lead to new ways to prevent obesity and diabetes.

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Enduring cold temperatures alters fat cell epigenetics

A new study reveals that cold temperatures can transform white fat cells into 'beige' cells, which perform thermogenesis like brown fat cells. This process could potentially reduce the symptoms of metabolic diseases such as diabetes and obesity.

Cinnamon turns up the heat on fat cells

New research reveals cinnamaldehyde's ability to induce thermogenesis in fat cells, improving metabolic health. The compound may offer a non-pharmacological approach to combating obesity and related health issues.

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Stored fat fights against the body's attempts to lose weight

A study published in Nature Communication found that a protein called sLR11 acts to inhibit thermogenesis, or heat production, in fat cells, making it harder for the body to burn excess fat. This protein is produced by fat cells and increases with total fat mass, suggesting its role in storing energy over long periods.

Drug boosts fat tissue's calorie-burning ability in lab

A new drug has been found to increase the amount of energy burned by fat tissue, leading to significant weight loss and improved metabolic health. The drug, GC-1, mimics the activity of thyroid hormone and has been shown to promote thermogenesis in white adipose tissue.

Making metabolism more inefficient can reduce obesity

Researchers found that inactivating key genes involved in 'fat-burning' can increase energy expenditure and lower diet-induced obesity. By forcing the body to use less efficient methods, mice became resistant to obesity despite consuming a high-fat diet.

Hot peppers really do bring the heat

Capsaicin from hot peppers directly induces thermogenesis by altering muscle protein SERCA, leading to increased heat production. This process could be used to design more potent compounds for treating hypothermia.

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Researchers identify pathway that helps keep weight in check

Diet-induced thermogenesis is an intricate system of communications masterminded by the brain that produces heat and helps prevent obesity. By removing beta adrenergic receptors, researchers found that mice fed a high-fat diet grew massively obese, highlighting the importance of this pathway in preventing weight gain.