Adhesion Signaling
Articles tagged with Adhesion Signaling
Under the hood: Probing the molecular mechanisms of metastasis
A team of researchers has revealed the molecular mechanisms underlying the binding of small extracellular vesicles to host cells, which could lead to the development of more effective cancer treatments. The study found that EVs primarily bind to laminin via CD151-associated integrin heterodimers and GM1, eliciting responses in recipien...
Substance use accelerates brain aging through distinct molecular pathways, groundbreaking study reveals
Researchers identified unique biological mechanisms that cause premature aging in the brains of individuals with alcohol, opioid, and stimulant use disorders. Different substances appear to hijack the brain's natural aging rhythm through distinct molecular mechanisms, though some pathways are shared across different substance types.
Small messengers called extracellular vesicles deliver molecules between cells using protein signal
Researchers discovered a new process by which cancer cells use small extracellular vesicles to spread to healthy tissue. The study found that these vesicles are primarily internalized by clathrin-independent endocytosis via galectin-3, which is facilitated by an increase in intracellular calcium concentration.
Signaling circuit interplay pushes newborn neurons out of the neuronal nest
Developing neurons rely on multiple signaling pathways to migrate from the germinal zone. An antagonistic circuit between Netrin-1 'pushing' and Siah2 'pulling' ensures proper cerebellum development by balancing adhesion and guidance cues.
Wnt happens in kidney development?
Researchers found that low Wnt signaling levels regulate NPC self-renewal, while higher levels initiate differentiation into mature kidney cell types. The studies also reveal the role of beta-catenin in aggregating NPCs to form early kidney structures.
Visceral surgery: Gut bacteria aggravate adhesions after abdominal surgery
Researchers have discovered that intestinal bacteria can lead to more severe adhesions after abdominal surgery. The study found that mesothelial cells and EGFR signaling play a crucial role in the formation of these adhesions. The findings suggest that targeting EGFR may be a potential approach to reducing adhesion risk.
Swirling bacteria mimic Van Gogh’s ‘The Starry Night’
Researchers from Rice University and the University of Wyoming discovered self-organization into circular aggregates in Myxococcus xanthus, a model system for social cooperation. The circular behavior is linked to TraAB protein overexpression, which creates a sticky bond between cells, preventing reversals.
How cells use mechanical tension sensors to interact with their environment
Researchers discovered that actin filaments serve as tiny stretchy tension sensors in cells, transmitting mechanical signals to other proteins. The findings have significant implications for understanding how cells mechanically control movement, including cardiac cell contraction and motile cell migration.
Researchers discover communication signal for tissue development
Researchers at Rensselaer Polytechnic Institute have identified a crucial signaling pathway involved in tissue growth and wound healing. The discovery provides new insights into how cells interact during tissue remodeling and may lead to novel therapeutics for diseases such as cancer and arthritis.