Articles tagged with Dimerization
Researchers created nanoparticles using ultraviolet light crosslinked amino acids, loaded with doxorubicin and coated with tannic acid complex. The nanoparticles exhibited superior stability and drug release under different pH conditions, showing excellent anticancer activity in tumor-bearing mice.
A team of scientists at Kanazawa University used high-speed atomic force microscopy to study the structural dynamics of sodium ion channels in cell membranes. They found that voltage sensor domains can dissociate from pore domains when the channel is in a resting state, leading to dimerization between neighboring channels. These findin...
Researchers identify the minimum contribution of TACC3 for FGFR3-TACC3 fusion protein activation, revealing a novel target for treating FGFR translocation-driven cancers. The study shows that clinically identified FGFR3-TACC3 fusion proteins differ in biological activity depending on specific breakpoints.
The study found that BRAF alterations, particularly Class I mutations like v600E, are associated with improved overall survival in adults with glioma. However, the effectiveness of targeted therapies depends on the specific type and combination of genetic alterations driving the cancer.
Researchers at MIT have synthesized himastatin, a natural compound with antimicrobial properties. The team discovered that the compound kills bacteria by disrupting their cell membranes.
Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.
A team of Lehigh University researchers is studying a promising alternative catalytic process based on solid acid catalysts for ethylene dimerization. Using in situ and operando molecular spectroscopy, they aim to understand the surface structures of the catalyst and design more active catalysts with reduced environmental impact.
Physicists at University of Utah pioneered a method to image virus-like particles in real time, revealing the lattice's dynamic nature. The discovery opens up potential new therapies by understanding how Gag and GagPol proteins rearrange, leading to viral maturation.
New phenothiazine derivatives containing phenyl groups show high potential for use as photochemical agents in surgical operations and cancer treatment. The compounds' stability was ensured through the formation of binary associates, providing greater absorption in near-infrared spectrum.
Researchers at the University of the Basque Country have developed a new method for producing 1-butene via ethylene dimerization using metal-organic frameworks (MOFs) without activators or solvents. The catalysts exhibit high selectivity and stability, making them a promising alternative to traditional homogeneous catalysis.
Researchers develop metal-organic frameworks (MOFs) with tailored defects that enhance the selective catalysis of ethylene dimerization. By simulating realistic MOF systems using computational resources, they found that unsaturated metal centers drive activity while bimetallic nature controls selectivity.
Researchers at Johannes Gutenberg University Mainz have identified a promising strategy to develop an agent against African sleeping sickness. The team discovered a small inhibitor molecule that binds to and deactivates a vital protein of the parasite, rendering it harmless.
Researchers 'remote-controlled' cancer cell behavior with light, finding that activation can cause changes in morphology, proliferation, and gene expression. This breakthrough applies optogenetics to cancer research, offering a precise method for targeting specific cells.
Researchers found that the core protein interacts with non-structural helicase protein, playing a critical role in viral replication. This new understanding supports a potential new therapeutic target for hepatitis C drug development and may prevent production of infectious viral particles.
New measurements at the University of Illinois have resolved a research controversy on myosin VI's function. The study shows that full-length myosin VI can form dimer pairs, walk processively on actin, and transport molecules.