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STAT3 as a target in H3K27M-mutant DMGs

Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateOct 10, 2023

Quantitative volumetric analysis of the optic radiation in the normal human brain

Researchers from Korea Research Institute of Standards and Science used diffusion tensor imaging to analyze the optic radiation in 13 healthy volunteers. The study found that the optic radiation fiber tract volume was approximately 0.16% and fractional anisotropy value was about 0.53, enabling accurate detection of probability pathways.

SourceNeural Regeneration Research·JournalNeural Regeneration Research·DateAug 4, 2014

It's good to have a shady side: sun and shade leaves play different roles in tree canopies

New research reveals that tree leaves in different canopy positions respond to varying light conditions by changing shape and physiology. This adaptation allows trees to cope with stress and use resources more efficiently, with outer canopy leaves influencing the inner canopy's ability to utilize diffuse solar radiation.