Articles tagged with Activity Assays
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers from the University of California, Davis, present a comprehensive framework for analyzing longitudinal activity and behavior. By employing advanced statistical techniques, they explore the relationship between activity and age-at-death in Mediterranean fruit flies, shedding light on potential links to human lifespan.
Researchers identify the minimum contribution of TACC3 for FGFR3-TACC3 fusion protein activation, revealing a novel target for treating FGFR translocation-driven cancers. The study shows that clinically identified FGFR3-TACC3 fusion proteins differ in biological activity depending on specific breakpoints.
Scientists have devised a method to pinpoint active ingredients from traditional Chinese medicine formulations, revealing 4 analytes with significant anti-inflammatory activity. This breakthrough could improve quality control standards and lead to better herbal remedies.
A team of researchers developed a high-throughput biochemical assay to assess small molecule impact on SARS-CoV-2 nonstructural protein 14, identifying potential inhibitors from FDA-approved drugs. The study aims to deliver therapeutics for the SARS-CoV-2 virus, targeting its critical methyltransferase activity.
Researchers created a novel Drosophila-based disease model for Pitt-Hopkins syndrome (PTHS), which is caused by mutations in the TCF4 gene. The model reveals that certain substances can enhance learning and locomotor abilities in PTHS patients, suggesting potential therapeutic options.
The October edition of SLAS Discovery features a critical review of mass spectrometry applied to imaging in drug discovery, highlighting its potential for pharmacokinetic and pharmacodynamic measurements. The issue also includes original research articles on various topics in life sciences discovery and technology.
A study by Professor Johannes Knobloch found that European coins made from antimicrobial metals like copper display detectable antimicrobial activity against bacteria, reducing bacterial cell counts by up to 99.5% after 24 hours. However, coins may still act as vectors for the transmission of microbes.
InDevR's new VaxArray kit offers a standardized method to measure neuraminidase in influenza vaccines, improving accuracy and precision. This assay is expected to aid in the development of more broadly protective flu vaccines by enabling manufacturers to meet current regulatory requirements.
Researchers have identified plant-derived volatiles with potent vapour-phase-mediated anti-Candida activity, offering a potential solution to the growing problem of drug resistance. Approximately half of the tested essential oils and their components showed activity against the most drug-resistant type of Candida.
A new homogeneous assay detects succinate using luminescence, enabling the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily. This method has significant applications in dioxygenase research and has the potential to impact human diseases.
Researchers developed a high-throughput screening strategy that identified multiple compounds with potent antimicrobial activity against an antibiotic-resistant strain of Klebsiella pneumoniae. The study also showed the potential of these compounds as adjunctive treatments to restore the effectiveness of antibiotics.
Scientists at Scripps Research Institute have developed a device called LIGHTSABR that can screen millions of compounds in a week for about $500. The device overcomes technical challenges in miniaturized screening and allows users to adjust the dose of the compound being tested.
Researchers are developing novel hit-to-lead drug discovery strategies utilizing a combination of high-throughput screening, miniaturization, and advanced data analysis. This approach enables the identification of promising compounds with increased efficiency, leading to faster and more effective disease treatments.
Researchers used bioassay-guided evolution to identify more efficient antibiotic-producing mutants in Escherichia coli, reconstituting the biosynthetic pathways of sugars to yield a new antibiotic. This approach opens doors for harnessing genetics to investigate polyketide synthases and biosynthetic engineering.
Researchers identified two small molecules with remarkable efficacy against botulinum neurotoxin A in animal models. The compounds showed surprisingly little activity in cell-based assays, highlighting the importance of animal-based studies. No significant side effects were observed with either molecule.
Mushrooms contain high levels of polyphenols and ergothioneine, which contribute to their antioxidant properties. The study found portabella and crimini mushrooms have the highest ORAC values, indicating they are a valuable addition to a varied diet.
A study found that telomerase activity in urine has high sensitivity and specificity for detecting bladder cancer, particularly in high-risk subgroups. The test is noninvasive, inexpensive, and easy to perform, making it a promising diagnostic tool for early cancer detection.
Researchers designed a new cyclen-based receptor that strongly binds the fluorescent dye pyranine under near-physiological conditions. The assay enhances the evaluation of developmental drug compounds' properties, improving the development of safer drugs.