News on open-access publishing and its reach. Covers journal launches, open-access agreements, and research made freely available.
A new study found that childhood adversity, especially forced childhood migration, is associated with higher cardiometabolic risk and accelerated biological aging in later life. Forced migration was linked to elevated diabetes risk, cardiovascular disease, and hypertension, as well as signs of accelerated biological aging.
A hospital-based study in India found that higher coffee consumption and meat intake were associated with lower odds of prostate cancer. The researchers identified potential biological mechanisms behind these findings, but note that the relationship between diet and prostate cancer is complex and warrants further investigation.
Researchers found that eliminating a protein called DHHC3 in melanoma cells led to increased oxidative stress, cellular senescence, and activation of anti-tumor immune cells. This suggests that DHHC3 plays an immunoregulatory role in melanoma growth.
MDPI's Ethicality system automatically screens manuscripts for research integrity issues, with human editors reviewing flagged cases. The tool detects potential problems such as plagiarism, manipulated images, and AI-generated content.
PolyGenie facilitates the analysis, exploration, and reuse of genomic data by the research community. The platform demonstrates its capabilities using data from the GCAT cohort, revealing over 200,000 potential associations between genetic risk and health-related characteristics.
A nationwide population-based study found that individuals with neovascular age-related macular degeneration had a modest but statistically significant increase in overall cancer risk. However, the increased risk was only observed for specific malignancies, including thyroid, kidney, and prostate cancers.
Systematic reviews and meta-analyses rely on complete data, but many studies lack underlying data. This can lead to unreliable results and assumptions that are difficult to verify. Researchers argue for clearer data sharing requirements to strengthen trust in research and reduce the risk of erroneous conclusions.
Taylor & Francis has published the world's first Plain Language Summary of Publication (PLSP) in veterinary research, making complex findings more accessible to a broader audience. The PLSP bridges the gap between scientific complexity and practical understanding, offering a new way to present veterinary science.
A Phase I/II clinical trial of the HPV therapeutic vaccine PepCan found it to be well-tolerated, with mild injection-site reactions being the most common adverse events. However, the study did not demonstrate a reduction in head and neck cancer recurrence rates, likely due to its small sample size.
The Journal of Research on Research aims to support evidence-informed change in research systems through a unique dual role as both a publisher and researcher. It will occupy a dual role: publish and conduct research on research, providing access to data on publishing processes across its portfolio.
JMIR Publications has partnered with MetaROR to advance open science, elevate peer review quality, and recognize reviewers' contributions. The partnership integrates MetaROR's publish-review-curate platform with JMIRx overlay journals.
The Global Conference on Gerophysics brought together researchers from various disciplines to develop predictive models of aging. Key findings include the application of physical principles, such as thermodynamics and network theory, to biological systems. The conference highlighted the importance of collaboration between theory and ex...
The Consortium of Swiss Academic Libraries (CSAL) has renewed its publishing agreement with MDPI, making open access publishing more accessible to researchers across Switzerland. The partnership grants substantial discounts on article processing charges (APCs), with a 20% discount offered to researchers.
A 28-year-old woman was misdiagnosed with intussusception due to imaging similarities, but surgical removal revealed a rare ileal leiomyoma. Histopathology and immunohistochemistry confirmed the diagnosis, emphasizing the importance of combining imaging, histopathology, and immunohistochemistry for accurate diagnosis.
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
A new study published in Genes & Cancer identifies activated beta-catenin as a key driver of aggressive pediatric osteosarcoma progression. The researchers found that cells expressing active beta-catenin exhibited enhanced invasive capacity and cancer-associated traits, suggesting a potential therapeutic target for this aggressive cancer.
Researchers investigated polyisoprenylated cysteinyl amide inhibitors (PCAIs) for their anticancer effects on pancreatic cancer cells with KRAS mutations. The compounds demonstrated strong activity against cell survival, migration, and invasion pathways. PCAI treatment caused hyperactivation of MAPK and PI3K/AKT pathways, leading to ox...
The DIVINE cohort database contains clinical information from 5,813 COVID-19 patients, including characteristics, risk factors, treatments, and outcomes. The data can be used to study disease progression, identify associated factors, and validate predictive models.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.
A new collection of Frontiers for Young Minds articles reviews breakthrough brain research topics, including artificial intelligence and memory. Young reviewers aged 8-15 collaborated with leading neuroscientists to make complex neuroscience topics accessible to their peers.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
Researchers found that CTHRC1, a secreted protein in tumor microenvironment, promotes colorectal cancer growth by limiting effective immune surveillance. The study suggests targeting CTHRC1 as a promising new strategy for future therapies.
Frontiers won two EPIC Awards for its landmark whitepaper on responsible AI use in research and publishing, and a digital campaign highlighting research integrity. The awards recognize the institution's commitment to making science open and trusted.
A new PLOS report proposes a 'knowledge stack' publishing model to better support open science. This model connects articles with associated outputs like data, code, and methods to create a structured, open record of research. The report highlights the need for coordinated action beyond publishing to address challenges in existing models.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
The Bulgarian Society of Endocrinology's open-access journal, Endocrinologia, has moved to the ARPHA publishing platform developed by Pensoft. The platform provides a fast-track system for authors, reviewers, and editors, improving management and increasing international integration.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
Fayetteville State University and Taylor & Francis have partnered to provide FSU researchers with free access to over 2,500 journals. This three-year agreement eliminates costs associated with open access publishing, enabling FSU scholars to share their research globally and increase its visibility.
The study found that methylene blue significantly enhanced stem cell proliferation and viability while reducing intracellular reactive oxygen species. MB also increased activation of β-catenin signaling, a central pathway involved in hair follicle regeneration, stem cell maintenance, and wound repair.
New review highlights emerging complexity of senescent cell populations playing both protective and harmful roles in aging. Precision geroprotection aims to selectively eliminate maladaptive senescent cells while preserving beneficial ones.
A rare case of esophageal adenocarcinoma is reported, where the tumor grew outside the esophagus and invaded the thoracic spine, causing spinal cord compression. The patient initially had normal endoscopic findings, highlighting the challenge in detecting rare extraluminal growth patterns.
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
Research suggests that aging immune systems compromise the body's ability to control Mycobacterium tuberculosis during treatment with rifampicin and isoniazid. The study identified age-associated immune abnormalities linked to impaired bacterial clearance, including chronic inflammatory signaling and mitochondrial dysfunction.
Preprints.org announces a new award to recognize widely read and shared preprints from the past decade. The platform, which hosts over 126,000 preprints, aims to increase early research dissemination across the scholarly community and the wider public.
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.
A new research paper presents a practical diagnostic approach for detecting high-grade serous ovarian carcinoma using a low-cost, portable color sensor device. The method tracks inorganic phosphate generated during nucleic acid amplification, producing a visible green signal that correlates with the amount of amplified DNA.
A study by Frontiers analyzed three papermill detection tools on over 37,000 manuscript submissions, finding that the tools flag different proportions of manuscripts and have low manuscript-level overlap, highlighting a detection gap. The tools emphasize different types of signals, contributing to the divergence in flagging rates.
A rare case of a small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation showed a strong response to high-dose imatinib, despite the presence of the SDHC mutation. Integrated molecular interpretation is crucial in GIST management.
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
The University of California and JMIR Publications have extended their institutional membership agreement, reinforcing a commitment to advancing open science. The multi-year extension supports over 450 articles published under the agreement, making open access publishing more equitable for UC researchers.
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
A new study found a clear shift in mortality trends in multiple myeloma closely parallels major therapeutic advances. Targeted therapies, including immunomodulatory drugs and CAR T-cell therapies, have significantly improved disease control and induced deep responses.
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
Dr Hendricks-Sturrup brings expertise in biomedical research, bioethics, and policy to lead the editorial board. Her experience will focus on disseminating high-quality research globally.
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
The Frontiers Planet Prize has announced its 25 National Champions, who offer scalable, evidence-based solutions to the planetary crisis. The report highlights the urgent need for national and multilateral policies to incorporate these pioneering scientific solutions.
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
Research finds PDX1 gene plays a tumor-promoting role in human PCa cells by influencing metabolic pathways. The study identifies PDX1 as differentially hypermethylated in prostate cancer tissues, contributing to its aggressive characteristics.
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
The new guidance provides practical routes forward for AI use in every publishing role, promoting accountability, transparency, risk-awareness, and innovation. It introduces structured checkpoints and ready-to-use tools to make responsible AI use practical, not theoretical.
Oncology services are often excluded from emergency health priorities, resulting in delayed diagnosis and treatment interruptions. Vulnerable populations, including women and children, face advanced disease stages due to delays in care.
The Oncotarget Editorial Board discusses the journal's evolving approach to scientific integrity, highlighting the importance of modern image forensics tools. The article emphasizes the need for independent analytical and AI-based tools in journal evaluation.
The Journal of Fast-Track Health will publish original research on global health challenges, including communicable and non-communicable diseases. The journal aims to bridge the gap between urban and national health responses through rigorous science and practice-oriented approaches.