News on open-access publishing and its reach. Covers journal launches, open-access agreements, and research made freely available.
The WIN 2026 Symposium will bring together experts to explore advances in precision oncology and strategies for improving personalized cancer care. The symposium, themed Precision Oncology: Innovation and Equity Across the Globe, will feature an international lineup of distinguished oncology and biomedical research leaders.
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
MRI revealed rare cervical cancer spread into the uterine corpus, which was confirmed by histopathology. The unusual pattern created diagnostic challenges and required careful individual assessment. The study highlights the importance of recognizing less typical imaging features in evaluating suspected cervical malignancy.
Tumor-derived extracellular vesicles exhibit intrinsic organotropism and participate in establishing premetastatic niches, making them promising vehicles for targeted imaging probe delivery. However, current imaging approaches have limitations, including difficulty distinguishing between tumor-derived EVs and normal host cell-derived EVs.
Tumor-infiltrating lymphocyte therapy has shown potential in several types of solid tumors, including metastatic melanoma, breast cancer, and ovarian cancer. Despite challenges, the approach has favorable clinical outcomes, and researchers are exploring combination strategies and advanced technologies to improve treatment durability.
Higher TMAO concentrations were associated with older age, cardiometabolic risk factors, and brain atrophy, but not cognitive performance. The study suggests TMAO may be a marker of systemic aging processes rather than a direct mediator of neurodegeneration.
Six UK universities have renewed their unlimited OA publishing agreement with JMIR Publications, allowing corresponding authors to publish APC-free in all JMIR journals. This sustainable model establishes a more predictable and equitable publishing environment.
The Plant Journal has transitioned to gold open access, removing paywalls and making its research freely available. This change is part of the Society for Experimental Biology's strategy to support the plant science community and ensure discoveries reach the widest audience.
Dr. Sebastian Spethmann joins JMIR Cardio as Editor-in-Chief, bringing expertise in heart failure, cardiomyopathies, and digital health. He aims to integrate digital advancements into routine clinical care, enhancing cardiovascular health systems and patient outcomes.
The MDPI Subject Workshop: Microelectronics, Microsystems, Sensors, and Their Applications will explore a broad range of topics, including microelectronics, microsystems, sensors, and their applications. Researchers and industry professionals will gather to exchange knowledge and discuss emerging technologies.
A new review suggests metformin's interactions with multiple hallmarks of aging, including cellular energy balance, nutrient-sensing pathways, and epigenetic regulation. The study identifies strong evidence for metformin's effects on aging biology, including improved insulin sensitivity and reduced oxidative stress.
A review suggests targeting LRG1 could provide a new approach to cancer therapy, with extracellular blockade and intracellular degradation potentially addressing different components of LRG1 biology. This could complement established anti-angiogenic treatments and enhance apoptosis in cancer cells.
JMIR Publications invites submissions on misinformation in scientific publishing to advance research integrity and quality. The journal explores mechanisms, detection, and mitigation strategies to counter the spread of misinformation in scholarly publishing.
A new precision oncology paper critiques the methodology used in a 2025 study on mRNA vaccine residual DNA, arguing that it systematically underestimates DNA impurities. The analysis highlights key methodological flaws, including primer design, sample preparation, and analytical platform limitations.
Researchers found that silencing POLG1 and POLG2 reduced mtDNA content, impaired mitochondrial function, and decreased stemness-related properties in breast cancer cells. POLG inhibition also suppressed colony formation and mammosphere growth, suggesting its potential as a therapeutic target and prognostic biomarker in breast cancer.
The CHEST Journal received a 2025 Impact Factor of 10.2, indicating its continued impact in the field of pulmonary and critical care medicine. The journal publishes original research, guidelines, and reviews on chest diseases, serving an international audience of clinicians and researchers.
A machine learning-based algorithm analyzes player behavior patterns to estimate risks, providing a transparent frame of reference for regulators. The model, made publicly accessible, can calculate risk scores and compare them to existing systems, leading to more effective player protection.
A study found 161 differentially expressed genes in individuals with opioid dependence, including genes involved in immune and inflammatory processes. The researchers also developed a transcriptomic aging clock that predicts chronological age from gene expression patterns.
Taylor & Francis is sharing standardized metadata for all new journal articles, including funding information and author details. Participating institutions will receive automated real-time notifications when their researchers publish in Taylor & Francis journals.
Taylor & Francis introduces Plain Language Reviews to make technical information accessible to non-specialists. These open-access articles summarize multiple peer-reviewed articles on a single topic, empowering readers with complete understanding.
Researchers develop new CAR-T engineering strategies to address the barriers of solid tumors, including tumor access, targeting specificity, cellular resilience, and patient physiological context. The approaches aim to build cellular fitness and overcome immunosuppressive signals, with promising results in clinical trials.
Researchers find that targeting Trk and IGF1R pathways can delay Ewing sarcoma tumor growth, but effect is temporary. NTRK gene expression associations with patient OS were found, indicating potential biomarker value.
Misha Blagosklonny's work challenged traditional paradigms in aging biology, proposing that persistent growth-promoting signals drive age-related pathology. His hyperfunction theory integrates evolutionary concepts with molecular pathways, offering a comprehensive framework for understanding aging.
A new research perspective proposes that developmental and growth programs continue operating beyond their beneficial period, driving aging. Programmatic mechanisms of aging are supported by evidence from animal models and experimental observations.
JMIR Publications has partnered with UMass Chan Medical School to provide unlimited open access publishing in over 30 high-impact journals. The agreement eliminates individual Article Processing Fees (APF) and is supported by the Lamar Soutter Library at UMass Chan.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
Professor Röthlisberger's work has pioneered ab initio molecular dynamics and QM/MM multiscale simulation methods, providing rigorous frameworks for investigating complex molecular processes. Her research has guided scientific discovery in areas like quantum chemistry, materials science, and sustainable energy.
A rare case of uterine carcinosarcoma was reported, characterized by a dual molecular signature that may refine prognosis and guide treatment decisions. The patient's tumor displayed a high-grade endometrioid homologous uterine carcinosarcoma with TP53 and MSH6 genetic alterations.
Qassim University researchers can now publish their work openly in hundreds of top journals, increasing international collaboration and knowledge exchange. The partnership supports the university's values of transparency, innovation, and collaboration, and aims to amplify its growing research influence.
A new combination therapy selectively targets cancer cells and senescent cells by exploiting metabolic vulnerabilities, improving physical performance and extending lifespan. The treatment eliminates senescent cells, reduces cancer cell viability and improves metabolic profiles in aged mice.
The article proposes a healthspan-focused framework for Italy's National Health Service to promote healthy aging, prevent chronic diseases, and improve functional independence. The framework emphasizes prevention-oriented approaches, personalized healthcare, and multidisciplinary research.
A review highlights the role of culturally rooted practices in oral squamous cell carcinoma (OSCC) risk across global populations. Culturally sensitive prevention strategies combining education, harm reduction, and community engagement are crucial in reducing OSCC incidence and disparities. Dermatologists can play a key role in early c...
Researchers found that long-term systemic treatment with senolytic PROTAC 753b slowed several features of age-related intervertebral disc degeneration in male mice, preserving extracellular matrix protein aggrecan and reducing inflammatory markers. However, female mice showed little improvement, suggesting a sex-specific response.
Two interconnected signaling pathways, MAPK and PI3K/AKT, drive papillary thyroid carcinoma development and progression. Molecular diagnostics and targeted therapies are transforming treatment approaches.
Researchers have identified transmembrane 4 L six family member 1 (TM4SF1) as a highly selective surface marker of senescent β-cells in both mice and humans. This discovery provides an important step toward developing targeted senotherapies that could preserve insulin secretion and slow the progression of type 2 diabetes.
A new precision oncology paper presents a case of a 48-year-old woman with multiple primary cancers, including breast cancer, basal cell carcinoma, ovarian carcinoma, colon cancer, and small bowel adenocarcinoma. The study demonstrates how an international molecular tumor board developed personalized treatment recommendations based on ...
Researchers found that preserving peroxisomes preserves mitochondrial health during aging by maintaining long, interconnected mitochondrial networks and reducing oxidative stress. The study identifies peroxisome homeostasis as a promising area for future aging research.
FAIR² Data Management, powered by Senscience, has been named a 2026 CODiE Award Winner in the category Best AI Data and Analytics Solution. The platform enables researchers to turn data into trusted resources that can be discovered, built upon, and used responsibly with AI.
Researchers discovered that senescent cells accumulate high levels of triacylglycerols and increase glycolytic activity, leading to increased lipid droplet accumulation. This finding suggests that lipid droplets may contribute to the harmful effects of senescent microglia in Alzheimer’s disease.
A rare case report highlights the challenges of diagnosing cervical angioleiomyoma, a benign tumor presenting symptoms similar to those of common gynecological conditions. The study describes a successful surgical excision and excellent clinical outcome for a young woman with persistent heavy menstrual bleeding and pelvic pain.
The Japan Institutional Gateway platform is now available to researchers across Japan, enabling the publication of Japanese-language research at world-class speed and reliability. This expansion aims to support the acceleration of the open research movement promoted by the Japanese government.
Sarcopenia affects over 60% of individuals above age 80 and is influenced by distinct biological mechanisms in women and men. Hormones like apelin, insulin, and oxytocin play a crucial role in maintaining healthy skeletal muscle, with sex-specific differences affecting muscle aging and disease progression.
A new review reveals adaptor proteins play a crucial role in regulating the behavior of tumor-associated macrophages in cancer. These molecular scaffolds coordinate signaling pathways that determine whether macrophages adopt anti-tumor or pro-tumor phenotypes, influencing immune responses within the tumor microenvironment.
Cellular senescence is a stable form of cell-cycle arrest induced by intrinsic and extrinsic stimuli. The review highlights the importance of understanding how different initiating events shape distinct senescent cell phenotypes, contributing to chronic inflammation, tissue dysfunction, cancer, and age-related diseases.
A rare benign kidney tumor, renal oncocytoma, is diagnosed through biopsy and histopathology, guiding individualized treatment decisions. Minimally invasive approaches like percutaneous cryoablation provide effective disease control while preserving kidney function.
A comprehensive systematic review clarifies life expectancy across rare progeria disorders, revealing striking differences among subtypes. The analysis demonstrates that patients with Hutchinson-Gilford progeria syndrome have a median survival of 16 years, while those with mandibuloacral dysplasia type B have a median survival of 37 ye...
A new review investigates the impact of aging, stress, and behavior on endocrine dysfunctions in nonhuman primates. The study finds that older monkeys with depression-like behavior exhibit impaired regulation of stress responses and thyroid function, leading to increased disease risk.
MDPI has acquired three Swiss journals, including SANPP, PHC, and Cardiovascular Medicine, to expand its healthcare portfolio. The journals will be free to read and share via MDPI's OA platform, promoting discussions and integrative clinical care in neurology, psychiatry, and primary healthcare.
Recent research suggests that senescence often limits stem cell activity in normal tissues but can also promote tumor progression in cancer. Understanding the dynamic interplay between these two biological processes is crucial for developing safer regenerative therapies and more effective cancer treatments.
The journal addresses ethical challenges, best practices, and scientific integrity issues through metascience and evidence-based research standards. Emerging technologies like AI are transforming how researchers conduct, communicate, and disseminate their work.
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
Researchers found frequent silencing of TRAIL-R2 in breast tumors through promoter hypermethylation, associated with invasive ductal carcinoma and advanced tumor stage. Lower TRAIL-R2 expression was linked to more aggressive disease and reduced overall survival.
JMIR Publications and Jisc have expanded their Flat-Fee Unlimited Open Access Partnership, making APCs free for researchers affiliated with participating institutions. The agreement allows researchers to prioritize open access publishing without financial burdens.
Combined hepatocellular-cholangiocarcinoma is a rare and aggressive form of primary liver cancer that poses significant diagnostic and therapeutic challenges. The absence of standardized treatment guidelines limits effective management, emphasizing the need for thorough pathological evaluation and multidisciplinary management.
JMIR Publications has extended its agreement with Eindhoven University of Technology for two years, providing researchers with unlimited APC-free publishing in all JMIR's Gold Open Access journals. The partnership eliminates individual Article Processing Charges (APCs) and ensures equity for TU/e researchers.
A new study reveals that p38MAP kinase plays a central role in regulating senescence-related changes in human muscle cells. The researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to drive aging in mature muscle fibers.
The Indonesian Academy of Sciences has launched an open access journal, Journal of the Indonesian Academy of Sciences, with Taylor & Francis to bridge research and policy. The multidisciplinary journal features original research, opinion pieces, and a policy forum, making it an authoritative source for policymakers and practitioners.
In the 2026 Journal Citation Reports (JCR), MDPI journals demonstrate continued growth in visibility and influence of OA research. A total of 33 journals achieved a JIF of 5.0 or higher, with Machine Learning and Knowledge Extraction rising to 8.4.
JMIR Publications' journals have achieved strong rankings, with 12 in the first quartile and 6 in the 90th percentile or higher. The journal of Medical Internet Research has an all-time high Journal Impact Factor of 8.2.
The report reveals cutting-edge technologies affecting physical systems, from energy to medicine and manufacturing. These innovations have the potential to make a meaningful impact on pressing challenges like climate change and food insecurity.