News on open-access publishing and its reach. Covers journal launches, open-access agreements, and research made freely available.
A rare case report highlights the challenges of diagnosing cervical angioleiomyoma, a benign tumor presenting symptoms similar to those of common gynecological conditions. The study describes a successful surgical excision and excellent clinical outcome for a young woman with persistent heavy menstrual bleeding and pelvic pain.
The Japan Institutional Gateway platform is now available to researchers across Japan, enabling the publication of Japanese-language research at world-class speed and reliability. This expansion aims to support the acceleration of the open research movement promoted by the Japanese government.
Sarcopenia affects over 60% of individuals above age 80 and is influenced by distinct biological mechanisms in women and men. Hormones like apelin, insulin, and oxytocin play a crucial role in maintaining healthy skeletal muscle, with sex-specific differences affecting muscle aging and disease progression.
Cellular senescence is a stable form of cell-cycle arrest induced by intrinsic and extrinsic stimuli. The review highlights the importance of understanding how different initiating events shape distinct senescent cell phenotypes, contributing to chronic inflammation, tissue dysfunction, cancer, and age-related diseases.
A new review reveals adaptor proteins play a crucial role in regulating the behavior of tumor-associated macrophages in cancer. These molecular scaffolds coordinate signaling pathways that determine whether macrophages adopt anti-tumor or pro-tumor phenotypes, influencing immune responses within the tumor microenvironment.
A rare benign kidney tumor, renal oncocytoma, is diagnosed through biopsy and histopathology, guiding individualized treatment decisions. Minimally invasive approaches like percutaneous cryoablation provide effective disease control while preserving kidney function.
A comprehensive systematic review clarifies life expectancy across rare progeria disorders, revealing striking differences among subtypes. The analysis demonstrates that patients with Hutchinson-Gilford progeria syndrome have a median survival of 16 years, while those with mandibuloacral dysplasia type B have a median survival of 37 ye...
MDPI has acquired three Swiss journals, including SANPP, PHC, and Cardiovascular Medicine, to expand its healthcare portfolio. The journals will be free to read and share via MDPI's OA platform, promoting discussions and integrative clinical care in neurology, psychiatry, and primary healthcare.
A new review investigates the impact of aging, stress, and behavior on endocrine dysfunctions in nonhuman primates. The study finds that older monkeys with depression-like behavior exhibit impaired regulation of stress responses and thyroid function, leading to increased disease risk.
Recent research suggests that senescence often limits stem cell activity in normal tissues but can also promote tumor progression in cancer. Understanding the dynamic interplay between these two biological processes is crucial for developing safer regenerative therapies and more effective cancer treatments.
The journal addresses ethical challenges, best practices, and scientific integrity issues through metascience and evidence-based research standards. Emerging technologies like AI are transforming how researchers conduct, communicate, and disseminate their work.
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
JMIR Publications and Jisc have expanded their Flat-Fee Unlimited Open Access Partnership, making APCs free for researchers affiliated with participating institutions. The agreement allows researchers to prioritize open access publishing without financial burdens.
Combined hepatocellular-cholangiocarcinoma is a rare and aggressive form of primary liver cancer that poses significant diagnostic and therapeutic challenges. The absence of standardized treatment guidelines limits effective management, emphasizing the need for thorough pathological evaluation and multidisciplinary management.
Researchers found frequent silencing of TRAIL-R2 in breast tumors through promoter hypermethylation, associated with invasive ductal carcinoma and advanced tumor stage. Lower TRAIL-R2 expression was linked to more aggressive disease and reduced overall survival.
A new study reveals that p38MAP kinase plays a central role in regulating senescence-related changes in human muscle cells. The researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to drive aging in mature muscle fibers.
The Indonesian Academy of Sciences has launched an open access journal, Journal of the Indonesian Academy of Sciences, with Taylor & Francis to bridge research and policy. The multidisciplinary journal features original research, opinion pieces, and a policy forum, making it an authoritative source for policymakers and practitioners.
JMIR Publications has extended its agreement with Eindhoven University of Technology for two years, providing researchers with unlimited APC-free publishing in all JMIR's Gold Open Access journals. The partnership eliminates individual Article Processing Charges (APCs) and ensures equity for TU/e researchers.
JMIR Publications' journals have achieved strong rankings, with 12 in the first quartile and 6 in the 90th percentile or higher. The journal of Medical Internet Research has an all-time high Journal Impact Factor of 8.2.
The report reveals cutting-edge technologies affecting physical systems, from energy to medicine and manufacturing. These innovations have the potential to make a meaningful impact on pressing challenges like climate change and food insecurity.
In the 2026 Journal Citation Reports (JCR), MDPI journals demonstrate continued growth in visibility and influence of OA research. A total of 33 journals achieved a JIF of 5.0 or higher, with Machine Learning and Knowledge Extraction rising to 8.4.
A new study found that childhood adversity, especially forced childhood migration, is associated with higher cardiometabolic risk and accelerated biological aging in later life. Forced migration was linked to elevated diabetes risk, cardiovascular disease, and hypertension, as well as signs of accelerated biological aging.
A hospital-based study in India found that higher coffee consumption and meat intake were associated with lower odds of prostate cancer. The researchers identified potential biological mechanisms behind these findings, but note that the relationship between diet and prostate cancer is complex and warrants further investigation.
Researchers found that eliminating a protein called DHHC3 in melanoma cells led to increased oxidative stress, cellular senescence, and activation of anti-tumor immune cells. This suggests that DHHC3 plays an immunoregulatory role in melanoma growth.
MDPI's Ethicality system automatically screens manuscripts for research integrity issues, with human editors reviewing flagged cases. The tool detects potential problems such as plagiarism, manipulated images, and AI-generated content.
PolyGenie facilitates the analysis, exploration, and reuse of genomic data by the research community. The platform demonstrates its capabilities using data from the GCAT cohort, revealing over 200,000 potential associations between genetic risk and health-related characteristics.
A nationwide population-based study found that individuals with neovascular age-related macular degeneration had a modest but statistically significant increase in overall cancer risk. However, the increased risk was only observed for specific malignancies, including thyroid, kidney, and prostate cancers.
Systematic reviews and meta-analyses rely on complete data, but many studies lack underlying data. This can lead to unreliable results and assumptions that are difficult to verify. Researchers argue for clearer data sharing requirements to strengthen trust in research and reduce the risk of erroneous conclusions.
Taylor & Francis has published the world's first Plain Language Summary of Publication (PLSP) in veterinary research, making complex findings more accessible to a broader audience. The PLSP bridges the gap between scientific complexity and practical understanding, offering a new way to present veterinary science.
A Phase I/II clinical trial of the HPV therapeutic vaccine PepCan found it to be well-tolerated, with mild injection-site reactions being the most common adverse events. However, the study did not demonstrate a reduction in head and neck cancer recurrence rates, likely due to its small sample size.
The Journal of Research on Research aims to support evidence-informed change in research systems through a unique dual role as both a publisher and researcher. It will occupy a dual role: publish and conduct research on research, providing access to data on publishing processes across its portfolio.
JMIR Publications has partnered with MetaROR to advance open science, elevate peer review quality, and recognize reviewers' contributions. The partnership integrates MetaROR's publish-review-curate platform with JMIRx overlay journals.
The Global Conference on Gerophysics brought together researchers from various disciplines to develop predictive models of aging. Key findings include the application of physical principles, such as thermodynamics and network theory, to biological systems. The conference highlighted the importance of collaboration between theory and ex...
The Consortium of Swiss Academic Libraries (CSAL) has renewed its publishing agreement with MDPI, making open access publishing more accessible to researchers across Switzerland. The partnership grants substantial discounts on article processing charges (APCs), with a 20% discount offered to researchers.
A 28-year-old woman was misdiagnosed with intussusception due to imaging similarities, but surgical removal revealed a rare ileal leiomyoma. Histopathology and immunohistochemistry confirmed the diagnosis, emphasizing the importance of combining imaging, histopathology, and immunohistochemistry for accurate diagnosis.
A new study reveals substantial differences in gene expression patterns between aging mouse and human skeletal muscle. Fewer than 5% of biological pathways show shared changes, emphasizing the need for cross-species targets in aging research.
A new study published in Genes & Cancer identifies activated beta-catenin as a key driver of aggressive pediatric osteosarcoma progression. The researchers found that cells expressing active beta-catenin exhibited enhanced invasive capacity and cancer-associated traits, suggesting a potential therapeutic target for this aggressive cancer.
Researchers investigated polyisoprenylated cysteinyl amide inhibitors (PCAIs) for their anticancer effects on pancreatic cancer cells with KRAS mutations. The compounds demonstrated strong activity against cell survival, migration, and invasion pathways. PCAI treatment caused hyperactivation of MAPK and PI3K/AKT pathways, leading to ox...
The DIVINE cohort database contains clinical information from 5,813 COVID-19 patients, including characteristics, risk factors, treatments, and outcomes. The data can be used to study disease progression, identify associated factors, and validate predictive models.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
Sebaceous adenoma is a rare, slow-growing benign tumor arising from sebaceous glands. A new case report describes the clinical, histopathological, and immunohistochemical features of this tumor, highlighting its diagnostic challenges and importance of distinguishing it from more aggressive conditions.
A new collection of Frontiers for Young Minds articles reviews breakthrough brain research topics, including artificial intelligence and memory. Young reviewers aged 8-15 collaborated with leading neuroscientists to make complex neuroscience topics accessible to their peers.
Researchers found that senescent myoblasts released EVs carrying specific miRNAs that impaired normal muscle cell development and triggered cellular stress responses in healthy muscle cells. The study suggests that extracellular vesicles may play a role in shaping the aging muscle environment.
Researchers found that CTHRC1, a secreted protein in tumor microenvironment, promotes colorectal cancer growth by limiting effective immune surveillance. The study suggests targeting CTHRC1 as a promising new strategy for future therapies.
Frontiers won two EPIC Awards for its landmark whitepaper on responsible AI use in research and publishing, and a digital campaign highlighting research integrity. The awards recognize the institution's commitment to making science open and trusted.
A new PLOS report proposes a 'knowledge stack' publishing model to better support open science. This model connects articles with associated outputs like data, code, and methods to create a structured, open record of research. The report highlights the need for coordinated action beyond publishing to address challenges in existing models.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
The Bulgarian Society of Endocrinology's open-access journal, Endocrinologia, has moved to the ARPHA publishing platform developed by Pensoft. The platform provides a fast-track system for authors, reviewers, and editors, improving management and increasing international integration.
A new study reveals that nitrosylcobalamin, a vitamin B12 analog, selectively crosses the blood-brain barrier and targets glioblastoma tissue, demonstrating broad antitumor activity. The therapy also shows synergistic activity with existing treatments, offering a promising new strategy for treating this deadly brain cancer.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
Fayetteville State University and Taylor & Francis have partnered to provide FSU researchers with free access to over 2,500 journals. This three-year agreement eliminates costs associated with open access publishing, enabling FSU scholars to share their research globally and increase its visibility.
The study found that methylene blue significantly enhanced stem cell proliferation and viability while reducing intracellular reactive oxygen species. MB also increased activation of β-catenin signaling, a central pathway involved in hair follicle regeneration, stem cell maintenance, and wound repair.
New review highlights emerging complexity of senescent cell populations playing both protective and harmful roles in aging. Precision geroprotection aims to selectively eliminate maladaptive senescent cells while preserving beneficial ones.
A rare case of esophageal adenocarcinoma is reported, where the tumor grew outside the esophagus and invaded the thoracic spine, causing spinal cord compression. The patient initially had normal endoscopic findings, highlighting the challenge in detecting rare extraluminal growth patterns.
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
Research suggests that aging immune systems compromise the body's ability to control Mycobacterium tuberculosis during treatment with rifampicin and isoniazid. The study identified age-associated immune abnormalities linked to impaired bacterial clearance, including chronic inflammatory signaling and mitochondrial dysfunction.
Preprints.org announces a new award to recognize widely read and shared preprints from the past decade. The platform, which hosts over 126,000 preprints, aims to increase early research dissemination across the scholarly community and the wider public.
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.