Open Access
Articles tagged with Open Access
Rare extraluminal esophageal cancer invades spine despite normal endoscopy
Rare laryngeal leiomyosarcoma successfully treated with surgery and adjuvant chemotherapy
A rare case of high-grade laryngeal leiomyosarcoma was successfully treated with extended laryngectomy, left neck dissection, and adjuvant chemotherapy. Complete surgical excision remains the cornerstone of therapy, while multidisciplinary-guided adjuvant treatment may benefit selected high-grade or high-risk patients.
Aging immune systems show reduced ability to clear tuberculosis during treatment
Preprints.org celebrates 10th anniversary with new award
Preprints.org announces a new award to recognize widely read and shared preprints from the past decade. The platform, which hosts over 126,000 preprints, aims to increase early research dissemination across the scholarly community and the wider public.
Agentic AI systems may transform nutritional care in oncology
A new editorial proposes the use of agentic AI systems to address cancer-related malnutrition, a prevalent issue affecting up to 80% of patients. These systems aim to coordinate multiple functions simultaneously and support ongoing clinical decision-making throughout treatment.
Taylor & Francis reports 35% reduction in supply chain emissions and training of 70,000+ researchers in low-income regions
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
Large-scale multi-omics study aims to decode aging in the Indian population
Low-cost color sensor device enables rapid detection of ovarian cancer biomarkers
Mind the detection gap: Why publishing needs a multilayered defense against industrial-scale papermills
Rare dual-mutation GIST responds to targeted therapy, challenging established tumor biology
A rare case of a small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation showed a strong response to high-dose imatinib, despite the presence of the SDHC mutation. Integrated molecular interpretation is crucial in GIST management.
Human telomerase shows selective cross-species activity, revealing limits of animal models
The study reveals that human TERT is only compatible with non-human primate cells, while other species show limited or no telomere lengthening. This highlights the importance of using suitable preclinical models for telomerase-based therapies.
JMIR Publications and the University of California announce multi-year extension of open access partnership
The University of California and JMIR Publications have extended their institutional membership agreement, reinforcing a commitment to advancing open science. The multi-year extension supports over 450 articles published under the agreement, making open access publishing more equitable for UC researchers.
Stage-specific gene expression changes reveal early triggers of cellular aging
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
Targeted therapies drive long-term decline in multiple myeloma mortality in the US
A new study found a clear shift in mortality trends in multiple myeloma closely parallels major therapeutic advances. Targeted therapies, including immunomodulatory drugs and CAR T-cell therapies, have significantly improved disease control and induced deep responses.
Lifestyle, diet, and clinical factors shape the gut microbiome in cancer patients
A new review found that lifestyle behaviors like physical activity and diet can positively modulate the gut microbiome of cancer patients, but these effects are often influenced by non-modifiable variables. The study also highlighted the role of intrinsic patient characteristics in shaping microbial composition.
Rachele Hendricks-Sturrup named as lead editor of the Journal of Medical Internet Research
Dr Hendricks-Sturrup brings expertise in biomedical research, bioethics, and policy to lead the editorial board. Her experience will focus on disseminating high-quality research globally.
From hydra to rotifers: A new hypothesis explores pathways to delay aging in humans
A new hypothesis proposes that introducing Hydra-like gene expression patterns into rotifers could delay senescence and extend healthspan. The study focuses on conserved molecular pathways, including FoxO, which plays a central role in maintaining stem cell function and cellular resilience.
Epigenetic aging linked to MRI signatures of neurodegeneration but not general brain aging
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
Deceptive ovarian cancer case mimics pelvic abscess, delaying diagnosis in postmenopausal woman
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
Global experts highlight path toward actionable interventions in human aging
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
World’s leading science competition announces 25 international pioneers who can help humanity live within Earth’s boundaries
The Frontiers Planet Prize has announced its 25 National Champions, who offer scalable, evidence-based solutions to the planetary crisis. The report highlights the urgent need for national and multilateral policies to incorporate these pioneering scientific solutions.
Rare scalp reaction identified in lung cancer patient receiving amivantamab after radiotherapy
A rare scalp reaction resembling erosive pustular dermatosis was identified in a lung cancer patient treated with amivantamab following cranial radiotherapy. The reaction appeared to be related to impaired wound healing due to dual inhibition of EGFR and MET signaling pathways.
Epigenetic dysregulation of PDX1 drives prostate cancer progression
Research finds PDX1 gene plays a tumor-promoting role in human PCa cells by influencing metabolic pathways. The study identifies PDX1 as differentially hypermethylated in prostate cancer tissues, contributing to its aggressive characteristics.
Gene–phenotype catalogue provides new insights into premature aging disorders
A new gene catalogue provides comprehensive insights into premature aging disorders, highlighting the central role of genome maintenance and DNA repair pathways. The catalogue organizes genetic and clinical information for 56 syndromes and 160 distinct clinical entities, offering a valuable framework for future research.
Frontiers launches unique AI practical guidance for researchers, editors, and reviewers, and calls for policy evolution
The new guidance provides practical routes forward for AI use in every publishing role, promoting accountability, transparency, risk-awareness, and innovation. It introduces structured checkpoints and ready-to-use tools to make responsible AI use practical, not theoretical.
Cancer care in conflict zones remains critically neglected
Oncology services are often excluded from emergency health priorities, resulting in delayed diagnosis and treatment interruptions. Vulnerable populations, including women and children, face advanced disease stages due to delays in care.
Oncotarget editorial highlights advances in scientific integrity and publishing transparency
The Oncotarget Editorial Board discusses the journal's evolving approach to scientific integrity, highlighting the importance of modern image forensics tools. The article emphasizes the need for independent analytical and AI-based tools in journal evaluation.
Fast-Track Health announces launch of the Journal of Fast-Track Health in partnership with MDPI
ATF5 required for maintaining mitochondrial homeostasis and skeletal muscle health during aging
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
Frontiers Research Foundation signs multilateral declaration at One Health Summit to advance open data sharing for healthy lives on a healthy planet
The Frontiers Research Foundation has endorsed the One Health Data Convergence Declaration of Intent, aiming to make existing and future research data interoperable and coherent. This declaration sets out a shared framework to unlock data for the benefit of One Sustainable Health for All.
Italian Society of Gerontology and Geriatrics signs publishing agreement with MDPI
The Italian Society of Gerontology and Geriatrics has partnered with MDPI to publish its Journal of Gerontology and Geriatrics in open access. The journal, which was founded in 1953, will transition to a digital-only format starting with Volume 74, Issue 1 in March 2026.
JMIR Publications examines AI-driven discovery bottleneck: scientific evidence trapped in a predigital system
The article highlights the urgent need to modernize scientific record with AI-powered discoveries trapped in a predigital system. Top-tier research universities face $10-15 million annual subscription expenditures, while author-facing processing charges range from $5,000 to over $11,000 per article.
Adjuvant PD-1/PD-L1 inhibitors show efficacy but highlight safety considerations in solid cancers
The study found that immune checkpoint inhibitors significantly improved key clinical outcomes, including disease-free survival and distant metastasis-free survival. However, no clear improvement in overall survival was observed across studies, highlighting the need for careful patient selection and monitoring.
Small-volume hypertonic saline plus furosemide linked to lower inflammatory and remodeling markers in acute heart failure
Treatment with i.v. furosemide plus HSS significantly decreased serum levels of inflammatory biomarkers IL-6, sST2, hsTnT, galectin-3, and NT-proBNP. The study found that this combination therapy modulated some miRNA expression and was associated with reduced miR181b expression compared to furosemide alone.
Bibliometric mapping reveals the evolution of glioma classification research
A new review analyzes how glioma classification research has evolved across clinical, molecular, and social domains. The study highlights the prominent role of DNA methylation profiling and advanced imaging techniques in molecular biomarker-based classification models, while finding social factors to be relatively scarce.
COCOON trial shows proactive skin care can halve dermatologic toxicity in EGFR-mutant NSCLC
The COCOON trial found that a structured dermatologic prophylaxis regimen reduced moderate-to-severe dermatologic adverse events by half, with fewer grade ≥3 events and treatment discontinuations. This approach could improve tolerability and maintain dose intensity for EGFR-mutant non-small cell lung cancer patients.
JMIR Publications and Jisc announce renewal of flat-fee unlimited open access partnership for 2026-2027
The renewed agreement allows eligible researchers at participating UK institutions to publish unlimited articles across JMIR's portfolio of journals without APCs. This simplifies the publication workflow and increases equity for researchers at all career stages.
BOLD variability modulation linked to age-specific bimanual performance
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
MDPI opens first US office in North American expansion
MDPI has opened its first US office in Philadelphia, serving as a central hub for scholarly engagement across the country. The new office will provide regional support to US scholars, manage scholar visits, and represent MDPI at conferences throughout the US.
Targeting MD2 could limit prostate cancer bone metastasis
Researchers found that targeting MD2 could reduce tumor growth in a mouse model of prostate cancer bone metastasis. High MD2 expression was associated with metastasis, immune suppression, and increased resistance to PARP inhibitor therapy.
JMIR Publications names Dr. Amy Shirong Lu as Editor-in-Chief of JMIR Serious Games
Dr Amy Shirong Lu joins JMIR Serious Games as Editor-in-Chief with extensive research on digital health technologies and their impact on physical activity and cognitive health.
The SCD1 inhibitor aramchol, regorafenib, and metformin combine to kill uveal melanoma cells
Researchers found that the three-drug combination increased autophagosome formation and autophagic flux in uveal melanoma cells, killing them via enhanced autophagy. The study suggests a potential therapeutic approach for treating metastatic uveal melanoma, particularly in liver-targeted disease.
Plant-based dietary patterns linked to slower epigenetic aging
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
MDPI in 2025: Growth and Impact in Open Access Publishing
In 2025, MDPI saw a 12% increase in manuscript submissions while growing its journal portfolio to 500 titles. The publisher invested in new staff members globally, focusing on research integrity and technology, resulting in comprehensive indexing in leading databases. This reflects sustained researcher confidence and MDPI's commitment ...
Frontiers’ Head of Editorial Ethics and Quality Assurance elected as a Trustee of COPE
Marie Soulière, Frontiers' Head of Editorial Ethics and Quality Assurance, has been elected as a Trustee of the Committee on Publication Ethics (COPE). She brings expertise in rigorous editorial practices, integrity, and transparency to COPE.
Taylor & Francis converts six further journals to open access through Collective Pathway to Open Publishing
The company has announced an expansion of its innovative diamond open access (OA) model, Collective Pathway to Open Publishing, through agreements with Jisc in the UK and CAUL in Australasia. Six new journals will make their 2026 volumes open access without charging authors an article publishing charge.
Surgical management and reconstruction strategies highlighted for head and neck basal cell carcinoma
The review emphasizes surgical excision as the cornerstone of curative treatment, with recommended margins depending on tumor risk stratification. Reconstruction should be individualized according to defect size, anatomic subunit involvement, and patient factors.
Exergames could improve mood in older adults
A systematic review of experimental studies found exergames to be associated with better mood outcomes, including reductions in tension and depressive symptoms. The evidence base remains small and heterogeneous, but the study calls for longer-term interventions and larger samples to determine the durability of benefits.
JMIR Publications and the University of Nevada, Las Vegas announce flat-fee unlimited open access publishing partnership
JMIR Publications and the University of Nevada, Las Vegas announce a new Flat-Fee Unlimited Open Access Publishing Agreement. The agreement eliminates financial obstacles for researchers, reducing administrative workload for library staff and ensuring research findings are available via immediate open access in JMIR's high-impact journ...
New framework addresses privacy, dignity risks posed by modern ai systems
Researchers introduce the capabilities approach-contextual integrity (CA-CI) framework to address privacy and dignity risks in AI systems. The framework evaluates normative appropriateness of AI systems beyond narrow tasks and stable contexts, securing social life and human dignity.
CREB5 linked to stem cell-like programs that promote prostate cancer progression
A study found CREB5 regulates basal and SCL transcriptional programs and tumor-forming phenotypes in prostate cancer, suggesting a central role in aggressive prostate cancer. Disrupting CREB5-regulated pathways may improve therapeutic responses in advanced disease.
New blood- and microbiome-based neural networks forecast human biological age
Researchers developed two neural network models predicting human biological age based on blood biochemistry and gut microbiota. The models demonstrated high predictive accuracy and explainability, holding potential for monitoring intervention effects in clinical trials.
A new interdisciplinary journal - Advanced Scientific Instruments – has launched its inaugural issue
The journal focuses on advancing scientific understanding and expanding engineering horizons through rigorous peer-reviewed, open-access research. ASI aims to be the preeminent hub for pioneering next-generation scientific tools and fostering global collaboration.
Tumor-informed liquid biopsy suggests structural-variant ddPCR can monitor high-grade serous ovarian cancer
A novel method for monitoring on-treatment disease burden in high-grade serous ovarian cancer uses tumor-informed breakpoints-spanning ddPCR, detecting superior sensitivity and specificity compared to real-time PCR. The approach may enable sensitive and specific detection of minimal residual disease and early relapse detection.
Frontiers and LIBER announce Gold Sponsorship to support the vision and mission of LIBER’s Strategy
Frontiers, a leading open access publisher, has joined the LIBER sponsorship program as a Gold Sponsor to support European research libraries. This collaboration aims to promote open science, address the challenges of the publishing landscape, and better support researchers and research libraries.
Impact Journals to participate at AACR Annual Meeting 2026 in San Diego
Impact Journals is exhibiting at the AACR Annual Meeting 2026 in San Diego, showcasing recent publications and discussing collaboration opportunities. The meeting highlights the latest advances in cancer science and medicine, with a focus on research impact, ethical standards, and scientific integrity.
JMIR Publications welcomes Dr. Sara Simblett as Editor in Chief of JMIR Neurotechnology
Dr. Sara Simblett brings expertise in digital health innovation, patient engagement, and technology integration to JMIR Neurotechnology. Her research focuses on improving access, quality, and outcomes of care through digital interventions.
BSO recapitulates anti-obesity effects of sulfur amino acid restriction without bone loss
Researchers found that D, L-buthionine-(S, R)-sulfoximine (BSO) replicates the anti-obesity effects of sulfur amino acid restriction without causing bone loss in male mice. The study suggests BSO as a promising tool for dissecting the beneficial versus deleterious axes of sulfur amino acid biology.
MYC amplification in metastatic prostate cancer associated with reduced tumor immunogenicity
A new study found that MYC amplification in metastatic prostate cancer is associated with reduced tumor immunogenicity, making it harder for the immune system to detect and attack the tumor. This reduction in immunogenicity was linked to poorer progression-free survival outcomes in patients with MYC-amplified tumors.