News on open-access publishing and its reach. Covers journal launches, open-access agreements, and research made freely available.
The report highlights 10 technologies with the greatest potential to reduce pressure on the planet and make power supply more reliable. These include calcined-clay limestone cement, virtual power plants, and thermal energy storage, which can store energy in sand and brick.
Researchers found potentially beneficial molecular changes in the liver and kidneys of aged mice, alongside signals in the spleen that raise concerns about long-term safety. However, larger controlled studies are needed to assess functional outcomes and safety in humans.
The Croatian Academic and Research Libraries Consortium has renewed its partnership with MDPI until 2027, providing open access benefits to over 70 institutions across Croatia. Since 2023, MDPI has published over 7,170 articles from Croatian institutions, with 79% receiving article processing charge discounts through the Institutional ...
The Journal of Maps will be published on Elsevier's platform, with a new dedicated site for optimal map presentation. All articles will remain gold open access, and the journal will expand its scope to include more subject areas and reach new researchers.
Reducing DUSP4 activity slows cancer cell proliferation, but related protein DUSP5 helps compensate and restore cell growth. Adaptive feedback mechanisms limit the therapeutic potential of DUSP4 in treating colorectal cancer.
A new framework proposes that communication between cells and organs plays a central role in amplifying age-related changes, shifting focus from cellular damage to systemic signaling. The framework suggests that restoring healthier systemic communication could be important for coordinated late-life rejuvenation.
Tracking hCG levels over time helps clinicians assess disease risk, guide treatment decisions, and detect possible relapse. Regular monitoring also supports early detection and timely intervention, even after treatment.
Preprints.org hosted a webinar on the cost of knowledge, discussing human and environmental costs driven by private interests. The event highlighted the role of preprints in addressing these issues and lowering barriers to sharing knowledge.
Extracellular vesicles, including exosomes, play critical roles in intercellular communication, influencing aging and cancer progression. Research highlights similarities in molecular signals between aging and cancerous cells, suggesting potential links between the two conditions.
A new study identifies three genes associated with ferroptosis and immune infiltration in Duchenne muscular dystrophy, suggesting a connection to age-related muscle degeneration. The findings may reveal new approaches to preserving muscle function and guiding future research into molecular biomarkers.
A new study found associations between coagulation-related genes and lung cancer survival, with varying prognostic significance depending on mutation status and tumor location. The research identified four genes, F2, F5, PROS1, and SERPINC1, which may provide additional information for understanding lung cancer prognosis.
The MDPI workshop will bring together scholars to discuss advances in soil health research and explore new opportunities for collaboration across various fields. The event will examine current approaches to soil health assessment and management, as well as emerging technologies shaping the future of soil science.
A new review proposes the Polycentric Aging Framework, which suggests that epigenetic regulation is a dominant factor limiting human lifespan. The framework identifies three major constraint layers, including epigenetic regulation, irreversible genetic and physical damage, and the accumulation of damaged proteins and organelles.
Research highlights the interconnected regulatory network of programmed cell death pathways in cervical cancer, influenced by HPV-related signaling and the tumor microenvironment. This review proposes targeting multiple pathways, including ferroptosis, to restore cancer-cell susceptibility to destruction and improve treatment responses.
Researchers found that small extracellular vesicles released by senescent cells can induce senescence in neighboring cells, promoting a stable growth-arrested state without activating classical inflammatory pathways. These findings reveal a key mechanism of intercellular communication and tissue aging.
JMIRx journals have joined the Publish, Review, Curate (PRC) Alliance as a founding member to help advance more open and transparent approaches to scholarly publishing. This move reflects the commitment of JMIRx journals to the PRC approach, which prioritizes openness, equity, interoperability, and stakeholder governance.
A study found that body composition, particularly fat-free mass percentage and body fat distribution, is associated with inflammation and growth hormone levels in middle-aged men. However, these associations disappeared after adjusting for body fat, suggesting that body fat may help explain the observed relationships.
The Research Ideas and Outcomes journal has joined the Publish, Review, Curate Alliance as a founding member, adopting an open-science model that promotes timely publication and open peer review. This transition aims to increase the visibility and discoverability of research outputs, aligning with the Alliance's goals.
Francis Peyton Rous identifies transmissible cancer agent in chickens, challenging established ideas about cancer. His discovery leads to the development of viral oncology and modern understanding of cancer as a genetic disease.
The case report highlights the challenges of monitoring residual disease in stage IIIc colon cancer, where conventional imaging shows no measurable tumor but circulating tumor DNA and DNA methylation patterns suggest molecular residual disease. Molecular profiling and international collaboration may help guide treatment decisions in su...
A 55-year-old man with glioblastoma exhibiting amplifications in MDM2 and EGFR genes underwent comprehensive genomic profiling and an international molecular tumor board. The case highlights the potential for precision oncology to identify potential treatment strategies for aggressive brain cancer.
Researchers found that hypomagnetic fields extend survival in a fly model of Parkinson's disease, but reduce mobility. The study suggests that magnetic field strength may be a potential therapeutic strategy, particularly in the context of ageing and neurodegenerative disease.
A case report describes a patient who developed toxic epidermal necrolysis after combination therapy with pembrolizumab and enfortumab vedotin for metastatic urothelial carcinoma. The patient's high-grade urothelial carcinoma and recent radiotherapy may have contributed to the severe skin reaction.
The mTOR signaling pathway is a central regulator of cellular metabolism, stress adaptation and tissue maintenance. Carefully controlled modulation of mTOR signaling could support future strategies for healthy aging.
Taylor & Francis has announced a new open access partnership with CRUI, the largest university association in Italy, supporting OA publishing of over 2,100 journals across various disciplines. The agreement enables researchers at CRUI-affiliated institutions to choose OA without paying a charge, with articles becoming OA immediately up...
Frontiers will provide AI-powered data curation for 1,000 Horizon Europe datasets and award 100 FAIR Data Publication Grants to early-career researchers. This initiative aims to make research data easier to discover, understand, and reuse, supporting the European Strategy on AI in Science.
A new study found that adding 3D goggles to deep-inspiratory breath-hold radiotherapy did not significantly reduce treatment time. However, setup time was longer when goggles were used, and treatment efficiency improved with repeated sessions.
Cog, a new journal published by AAAS and SJTU, aims to bridge neuroscience, psychology, and artificial intelligence to understand cognition, emotion, and behavior. The journal welcomes interdisciplinary research with clear mechanistic insights and encourages studies bridging fundamental discovery and translational applications.
A new control theory framework introduces a mathematical framework for understanding aging and guiding the development of therapies. The framework prioritizes maintaining or recovering acceptable physiological function, rather than targeting every molecular feature to a youthful state.
Researchers identified fagopyrine, a naturally occurring compound in buckwheat, as a potential starting point for developing new AKT1-targeting drugs. The analysis revealed substantial variation in AKT1 expression across 33 cancer types, with increased expression linked to poorer outcomes in certain malignancies.
The agreement enables participating institutions to publish open access in Frontiers' full journal portfolio without individual author costs, streamlining budget planning and reducing administrative burdens. Institutions can join the agreement before the end of 2026, with early joiners gaining access to FAIR² Data Management offering.
The study found that disrupting PLA2G15 reduced stress-induced cellular senescence in mouse kidney cells while altering the composition of phospholipids involved in lysosomal function. This suggests a possible connection between lipid metabolism, mitochondrial pathways, and kidney aging.
A rare case of high-grade serous ovarian carcinoma diagnosed during early gestation at 10 weeks of pregnancy was reported, highlighting the challenges of identifying ovarian malignancy during early pregnancy. The patient underwent surgical management and received adjuvant chemotherapy, and remained disease-free at one-year follow-up.
A new commentary proposes expanding gerophysics to include behavioral complexity, which may complement molecular and biological markers of aging. Measuring changes in movement, physiological rhythms, and other behavioral patterns could help identify declining resilience and the transition to frailty. The concept of complexity reserve m...
MDPI's journal portfolio is now indexed in Scite and discoverable through the Scite MCP, enabling researchers to access content in AI tools like Claude, ChatGPT, and Microsoft Copilot. This collaboration provides attribution, links to the Version of Record, and article-level usage reporting.
Researchers investigated the effects of mini-GRID radiotherapy on glioma cells, finding it reduced senescence and preserved growth inhibition, whereas conventional radiotherapy induced senescence. The study suggests that mini-GRID's spatial dose distribution may be responsible for this difference.
The 11th International Cell Senescence Association Conference brings together researchers worldwide to advance understanding of cellular senescence and its roles in aging, cancer, and disease. Aging supports the conference through a $200 cash poster prize recognizing outstanding scientific research.
Research found that unfavorable social determinants of health are associated with a higher risk of dementia in adults with and without type 2 diabetes, with particularly strong associations observed among women with T2D. The study also found that diabetes-related dementia risk varies across social environments.
A new study found a higher prevalence of prior breast cancer in patients with gallbladder cancer compared to patients with other biliary tract cancers. The association was observed in two independent cohorts, with 25.7% of patients with gallbladder cancer having a history of breast cancer.
Dr. Constanze Schelhorn takes on the role of Chief Publishing Officer, bringing 10 years of experience to strengthen MDPI's publishing practices and navigate the evolving scholarly publishing landscape. Her expertise and perspective will be valuable in developing publishing practices and serving researchers and academic communities.
The OS10 programme aims to develop open science infrastructure in accordance with UNESCO's Recommendation on Open Science. The collaboration between National Science Library, Chinese Academy of Sciences, and PLOS will explore cooperation in sharing scientific research and open science resources.
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
The human microbiome may influence cancer development, treatment response, and emerging precision-oncology strategies. Dysbiosis, or an imbalance in microbial communities, has been associated with several cancers, while favorable gut microbial profiles may support responses to immune checkpoint inhibitors.
Researchers are exploring biomarker-guided patient selection and combination therapies to overcome glioblastoma's biological barriers. Agents targeting tumor metabolism, immunotherapies, and oncolytic viruses are being investigated.
JMIR Publications earned a spot on the 2026 Report on Business magazine ranking of Canada's Top Growing Companies, driven by the value it delivers to the scientific community. The company's sustained growth is attributed to its open science work, innovative practices, and global network of talented staff and authors.
A study published in the International Journal of Molecular Sciences found that creatinine-based formulas failed to detect rapid kidney function decline in 37% of cases, while classifying nearly 40% of cases incorrectly. The research highlights the need for more accurate methods for estimating kidney function.
Long-lived organisms exhibit better DNA maintenance, stress resistance, regenerative capacity, and stem-cell populations compared to shorter-lived species. Comparative genomic studies have identified longevity-associated pathways, including apoptosis, protein homeostasis, and oxidative-stress resistance.
A new framework proposes that chronic overactivation of the DNA damage response may drive biological aging. Persistent DDR signaling can stabilize p53, increase p21 and p16INK4a, promoting cell-cycle arrest and senescence. This forms the basis of the
ORPHO is a collaborative scientific writing platform that streamlines writing and publishing processes. Key features include real-time collaboration, automatic semantic enrichment, and machine-readable content for discoverability and interoperability.
The 12th World Sustainability Forum (WSF-12) recognized scientific excellence through Oral Awards and Poster Awards, celebrating outstanding research contributions. The MDPI Sustainability Foundation Awards honored three researchers for advancing sustainability science and delivering meaningful societal impact.
A new commentary calls for consistent evaluation of potential links between COVID-19, vaccination, and cancer, highlighting potential associations and biological mechanisms. The author argues that similar mechanisms reported in connection with COVID-19 vaccination warrant consideration and further study.
A new study published in Aging reveals that a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, showing improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The findings separate liver inflammation and fibrosis from insulin resistance, obesity and lipi...
The study validated the Cancer Stigma Scale (CASS) in the Greek context, examining its relationship with attitudes toward mental illness. The Greek CASS demonstrated high internal consistency and construct validity, with moderate correlations between cancer stigma and attitudes toward mental illness.
Cellular senescence is recognized as a key driver of aging, linked to telomere dysfunction, chronic inflammation, and stem cell exhaustion. Experimental evidence supports its causal role, with removal of senescent cells delaying age-related pathologies.
JMIR Publications and ZB MED extend their Flat-Fee Unlimited Open Access Publishing Agreement for two years, covering over 30 Gold Open Access journals with zero Article Processing Charges (APCs) for participating German research institutions. The new agreement provides predictable and sustainable funding for open access publishing.
Research reveals that targeting insulin/IGF-1 signaling pathway in C. elegans extends male lifespan by 446% and improves reproductive healthspan, with whole-body degradation required for reproductive benefits. The study highlights the importance of coordinated effects across multiple tissues and physiological systems.
A new case report describes a 68-year-old woman with stage IV lung adenocarcinoma who developed severe hemolysis after receiving pembrolizumab, despite a negative Coombs test. The patient's hemoglobin declined from 11-12 g/dL to 6.4 g/dL, and laboratory markers of hemolysis improved with corticosteroid treatment. The case highlights th...
Researchers found three herbal extracts protect mitochondrial function in a cellular model of Parkinson’s disease, suggesting a potential treatment. The extracts, including Uncaria rhynchophylla, Gardenia jasminoides, and Scutellaria baicalensis, improved cell viability and mitochondrial function in cells with reduced VPS13C expression.
The Open Access Journal of Italian Medical Laboratory (JDReAM) has been revived by MDPI, aiming to promote high-quality, interdisciplinary research in medicine. The journal, led by Prof. Michele Maffia and Prof. Prisco Piscitelli, publishes research addressing human health and disease from various scientific perspectives.
Researchers explored strategies to restore MHC-I expression in CNS cancers to make them more visible to the immune system. Approaches include epigenetic therapies, AAV vectors, PCSK9 inhibition, and modifying the tumor microenvironment. However, efficient delivery, antigen processing, and a limited neoantigen repertoire remain signific...