News on open-access publishing and its reach. Covers journal launches, open-access agreements, and research made freely available.
CHARGE syndrome is a rare developmental disorder that may be linked to developmental senescence, a tightly controlled cellular program involved in embryonic tissue remodeling. Disruption of this program may contribute to the characteristic abnormalities associated with the disorder.
Dr. Constanze Schelhorn takes on the role of Chief Publishing Officer, bringing 10 years of experience to strengthen MDPI's publishing practices and navigate the evolving scholarly publishing landscape. Her expertise and perspective will be valuable in developing publishing practices and serving researchers and academic communities.
The OS10 programme aims to develop open science infrastructure in accordance with UNESCO's Recommendation on Open Science. The collaboration between National Science Library, Chinese Academy of Sciences, and PLOS will explore cooperation in sharing scientific research and open science resources.
The human microbiome may influence cancer development, treatment response, and emerging precision-oncology strategies. Dysbiosis, or an imbalance in microbial communities, has been associated with several cancers, while favorable gut microbial profiles may support responses to immune checkpoint inhibitors.
Researchers are exploring biomarker-guided patient selection and combination therapies to overcome glioblastoma's biological barriers. Agents targeting tumor metabolism, immunotherapies, and oncolytic viruses are being investigated.
JMIR Publications earned a spot on the 2026 Report on Business magazine ranking of Canada's Top Growing Companies, driven by the value it delivers to the scientific community. The company's sustained growth is attributed to its open science work, innovative practices, and global network of talented staff and authors.
A study published in the International Journal of Molecular Sciences found that creatinine-based formulas failed to detect rapid kidney function decline in 37% of cases, while classifying nearly 40% of cases incorrectly. The research highlights the need for more accurate methods for estimating kidney function.
Long-lived organisms exhibit better DNA maintenance, stress resistance, regenerative capacity, and stem-cell populations compared to shorter-lived species. Comparative genomic studies have identified longevity-associated pathways, including apoptosis, protein homeostasis, and oxidative-stress resistance.
A new framework proposes that chronic overactivation of the DNA damage response may drive biological aging. Persistent DDR signaling can stabilize p53, increase p21 and p16INK4a, promoting cell-cycle arrest and senescence. This forms the basis of the
ORPHO is a collaborative scientific writing platform that streamlines writing and publishing processes. Key features include real-time collaboration, automatic semantic enrichment, and machine-readable content for discoverability and interoperability.
The 12th World Sustainability Forum (WSF-12) recognized scientific excellence through Oral Awards and Poster Awards, celebrating outstanding research contributions. The MDPI Sustainability Foundation Awards honored three researchers for advancing sustainability science and delivering meaningful societal impact.
A new commentary calls for consistent evaluation of potential links between COVID-19, vaccination, and cancer, highlighting potential associations and biological mechanisms. The author argues that similar mechanisms reported in connection with COVID-19 vaccination warrant consideration and further study.
A new study published in Aging reveals that a mutation affecting the immune and metabolic regulator SHP-1 reshapes liver function during aging, showing improved glucose metabolism can coexist with immune-cell accumulation and liver fibrosis. The findings separate liver inflammation and fibrosis from insulin resistance, obesity and lipi...
The study validated the Cancer Stigma Scale (CASS) in the Greek context, examining its relationship with attitudes toward mental illness. The Greek CASS demonstrated high internal consistency and construct validity, with moderate correlations between cancer stigma and attitudes toward mental illness.
Cellular senescence is recognized as a key driver of aging, linked to telomere dysfunction, chronic inflammation, and stem cell exhaustion. Experimental evidence supports its causal role, with removal of senescent cells delaying age-related pathologies.
JMIR Publications and ZB MED extend their Flat-Fee Unlimited Open Access Publishing Agreement for two years, covering over 30 Gold Open Access journals with zero Article Processing Charges (APCs) for participating German research institutions. The new agreement provides predictable and sustainable funding for open access publishing.
Research reveals that targeting insulin/IGF-1 signaling pathway in C. elegans extends male lifespan by 446% and improves reproductive healthspan, with whole-body degradation required for reproductive benefits. The study highlights the importance of coordinated effects across multiple tissues and physiological systems.
A new case report describes a 68-year-old woman with stage IV lung adenocarcinoma who developed severe hemolysis after receiving pembrolizumab, despite a negative Coombs test. The patient's hemoglobin declined from 11-12 g/dL to 6.4 g/dL, and laboratory markers of hemolysis improved with corticosteroid treatment. The case highlights th...
Researchers explored strategies to restore MHC-I expression in CNS cancers to make them more visible to the immune system. Approaches include epigenetic therapies, AAV vectors, PCSK9 inhibition, and modifying the tumor microenvironment. However, efficient delivery, antigen processing, and a limited neoantigen repertoire remain signific...
Researchers found three herbal extracts protect mitochondrial function in a cellular model of Parkinson’s disease, suggesting a potential treatment. The extracts, including Uncaria rhynchophylla, Gardenia jasminoides, and Scutellaria baicalensis, improved cell viability and mitochondrial function in cells with reduced VPS13C expression.
The Open Access Journal of Italian Medical Laboratory (JDReAM) has been revived by MDPI, aiming to promote high-quality, interdisciplinary research in medicine. The journal, led by Prof. Michele Maffia and Prof. Prisco Piscitelli, publishes research addressing human health and disease from various scientific perspectives.
The WIN 2026 Symposium will bring together experts to explore advances in precision oncology and strategies for improving personalized cancer care. The symposium, themed Precision Oncology: Innovation and Equity Across the Globe, will feature an international lineup of distinguished oncology and biomedical research leaders.
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
MRI revealed rare cervical cancer spread into the uterine corpus, which was confirmed by histopathology. The unusual pattern created diagnostic challenges and required careful individual assessment. The study highlights the importance of recognizing less typical imaging features in evaluating suspected cervical malignancy.
Tumor-derived extracellular vesicles exhibit intrinsic organotropism and participate in establishing premetastatic niches, making them promising vehicles for targeted imaging probe delivery. However, current imaging approaches have limitations, including difficulty distinguishing between tumor-derived EVs and normal host cell-derived EVs.
Six UK universities have renewed their unlimited OA publishing agreement with JMIR Publications, allowing corresponding authors to publish APC-free in all JMIR journals. This sustainable model establishes a more predictable and equitable publishing environment.
Tumor-infiltrating lymphocyte therapy has shown potential in several types of solid tumors, including metastatic melanoma, breast cancer, and ovarian cancer. Despite challenges, the approach has favorable clinical outcomes, and researchers are exploring combination strategies and advanced technologies to improve treatment durability.
Higher TMAO concentrations were associated with older age, cardiometabolic risk factors, and brain atrophy, but not cognitive performance. The study suggests TMAO may be a marker of systemic aging processes rather than a direct mediator of neurodegeneration.
The Plant Journal has transitioned to gold open access, removing paywalls and making its research freely available. This change is part of the Society for Experimental Biology's strategy to support the plant science community and ensure discoveries reach the widest audience.
Dr. Sebastian Spethmann joins JMIR Cardio as Editor-in-Chief, bringing expertise in heart failure, cardiomyopathies, and digital health. He aims to integrate digital advancements into routine clinical care, enhancing cardiovascular health systems and patient outcomes.
The MDPI Subject Workshop: Microelectronics, Microsystems, Sensors, and Their Applications will explore a broad range of topics, including microelectronics, microsystems, sensors, and their applications. Researchers and industry professionals will gather to exchange knowledge and discuss emerging technologies.
JMIR Publications invites submissions on misinformation in scientific publishing to advance research integrity and quality. The journal explores mechanisms, detection, and mitigation strategies to counter the spread of misinformation in scholarly publishing.
A new review suggests metformin's interactions with multiple hallmarks of aging, including cellular energy balance, nutrient-sensing pathways, and epigenetic regulation. The study identifies strong evidence for metformin's effects on aging biology, including improved insulin sensitivity and reduced oxidative stress.
A review suggests targeting LRG1 could provide a new approach to cancer therapy, with extracellular blockade and intracellular degradation potentially addressing different components of LRG1 biology. This could complement established anti-angiogenic treatments and enhance apoptosis in cancer cells.
A new precision oncology paper critiques the methodology used in a 2025 study on mRNA vaccine residual DNA, arguing that it systematically underestimates DNA impurities. The analysis highlights key methodological flaws, including primer design, sample preparation, and analytical platform limitations.
Researchers found that silencing POLG1 and POLG2 reduced mtDNA content, impaired mitochondrial function, and decreased stemness-related properties in breast cancer cells. POLG inhibition also suppressed colony formation and mammosphere growth, suggesting its potential as a therapeutic target and prognostic biomarker in breast cancer.
The CHEST Journal received a 2025 Impact Factor of 10.2, indicating its continued impact in the field of pulmonary and critical care medicine. The journal publishes original research, guidelines, and reviews on chest diseases, serving an international audience of clinicians and researchers.
A machine learning-based algorithm analyzes player behavior patterns to estimate risks, providing a transparent frame of reference for regulators. The model, made publicly accessible, can calculate risk scores and compare them to existing systems, leading to more effective player protection.
Taylor & Francis is sharing standardized metadata for all new journal articles, including funding information and author details. Participating institutions will receive automated real-time notifications when their researchers publish in Taylor & Francis journals.
A study found 161 differentially expressed genes in individuals with opioid dependence, including genes involved in immune and inflammatory processes. The researchers also developed a transcriptomic aging clock that predicts chronological age from gene expression patterns.
Taylor & Francis introduces Plain Language Reviews to make technical information accessible to non-specialists. These open-access articles summarize multiple peer-reviewed articles on a single topic, empowering readers with complete understanding.
Researchers develop new CAR-T engineering strategies to address the barriers of solid tumors, including tumor access, targeting specificity, cellular resilience, and patient physiological context. The approaches aim to build cellular fitness and overcome immunosuppressive signals, with promising results in clinical trials.
Researchers find that targeting Trk and IGF1R pathways can delay Ewing sarcoma tumor growth, but effect is temporary. NTRK gene expression associations with patient OS were found, indicating potential biomarker value.
Misha Blagosklonny's work challenged traditional paradigms in aging biology, proposing that persistent growth-promoting signals drive age-related pathology. His hyperfunction theory integrates evolutionary concepts with molecular pathways, offering a comprehensive framework for understanding aging.
A new research perspective proposes that developmental and growth programs continue operating beyond their beneficial period, driving aging. Programmatic mechanisms of aging are supported by evidence from animal models and experimental observations.
JMIR Publications has partnered with UMass Chan Medical School to provide unlimited open access publishing in over 30 high-impact journals. The agreement eliminates individual Article Processing Fees (APF) and is supported by the Lamar Soutter Library at UMass Chan.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
Professor Röthlisberger's work has pioneered ab initio molecular dynamics and QM/MM multiscale simulation methods, providing rigorous frameworks for investigating complex molecular processes. Her research has guided scientific discovery in areas like quantum chemistry, materials science, and sustainable energy.
A rare case of uterine carcinosarcoma was reported, characterized by a dual molecular signature that may refine prognosis and guide treatment decisions. The patient's tumor displayed a high-grade endometrioid homologous uterine carcinosarcoma with TP53 and MSH6 genetic alterations.
Qassim University researchers can now publish their work openly in hundreds of top journals, increasing international collaboration and knowledge exchange. The partnership supports the university's values of transparency, innovation, and collaboration, and aims to amplify its growing research influence.
A new combination therapy selectively targets cancer cells and senescent cells by exploiting metabolic vulnerabilities, improving physical performance and extending lifespan. The treatment eliminates senescent cells, reduces cancer cell viability and improves metabolic profiles in aged mice.
The article proposes a healthspan-focused framework for Italy's National Health Service to promote healthy aging, prevent chronic diseases, and improve functional independence. The framework emphasizes prevention-oriented approaches, personalized healthcare, and multidisciplinary research.
A review highlights the role of culturally rooted practices in oral squamous cell carcinoma (OSCC) risk across global populations. Culturally sensitive prevention strategies combining education, harm reduction, and community engagement are crucial in reducing OSCC incidence and disparities. Dermatologists can play a key role in early c...
Researchers found that long-term systemic treatment with senolytic PROTAC 753b slowed several features of age-related intervertebral disc degeneration in male mice, preserving extracellular matrix protein aggrecan and reducing inflammatory markers. However, female mice showed little improvement, suggesting a sex-specific response.
Two interconnected signaling pathways, MAPK and PI3K/AKT, drive papillary thyroid carcinoma development and progression. Molecular diagnostics and targeted therapies are transforming treatment approaches.
Researchers have identified transmembrane 4 L six family member 1 (TM4SF1) as a highly selective surface marker of senescent β-cells in both mice and humans. This discovery provides an important step toward developing targeted senotherapies that could preserve insulin secretion and slow the progression of type 2 diabetes.
A new precision oncology paper presents a case of a 48-year-old woman with multiple primary cancers, including breast cancer, basal cell carcinoma, ovarian carcinoma, colon cancer, and small bowel adenocarcinoma. The study demonstrates how an international molecular tumor board developed personalized treatment recommendations based on ...
Researchers found that preserving peroxisomes preserves mitochondrial health during aging by maintaining long, interconnected mitochondrial networks and reducing oxidative stress. The study identifies peroxisome homeostasis as a promising area for future aging research.
Researchers discovered that senescent cells accumulate high levels of triacylglycerols and increase glycolytic activity, leading to increased lipid droplet accumulation. This finding suggests that lipid droplets may contribute to the harmful effects of senescent microglia in Alzheimer’s disease.
FAIR² Data Management, powered by Senscience, has been named a 2026 CODiE Award Winner in the category Best AI Data and Analytics Solution. The platform enables researchers to turn data into trusted resources that can be discovered, built upon, and used responsibly with AI.