A study published in Nature Genetics identified the T-box 22 gene as the cause of a rare form of cleft palate. The gene's mutation leads to catastrophic effects on protein production, resulting in the birth defect. The discovery may lead to prenatal therapeutic interventions for cleft palate.
A recent audit reveals major deficiencies in funding, staff, and service provision for head injured patients. Rehabilitation and follow-up services are poor, with only a third of A&E departments involved in recommended care.
A new study published in Social Science Research found that racial barriers to marriage are a significant obstacle to immigrant assimilation. The researchers discovered that the majority of immigrants marry within their own racial group, rather than with native-born individuals or those from different racial groups.
Researchers developed a new outpatient treatment for snoring that uses radiofrequency energy to create multiple lesions in the soft palate, reducing vibrations and improving effectiveness. The study showed significant reduction in snoring and increased success rates compared to single lesion methods.
Criminal warfare and terrorism require a similar response to traditional armies, with patient police work and no decisive victories. Mueller argues that the US must adopt different strategies outside of traditional military tactics.
Researchers found that a high pulse pressure during exercise was associated with endothelial cell dysfunction and blood-vessel stiffening, which may be an early sign of heart disease. This finding suggests that measuring blood pressure during exercise could be a more sensitive marker for detecting cardiovascular risk.
Researchers used gene transfer to increase vasopressin receptor density in the ventral pallidum of prairie voles, leading to increased pair bonding. The study shows that higher levels of vasopressin receptor expression are associated with more affiliative behavior and stronger pair bonds.
Researchers found that p53 and GR interact to balance cell survival and death in response to environmental stress. JIP1 protein is crucial for activating the JNK signaling pathway, which helps neurons respond to severe hypoxic stress.
Researchers at Ohio State University have discovered a natural parasite that can control leaf-eating slugs, which destroy crops every spring and fall. The parasite, known as Phasmarhabditis hermaphrodita, is effective in killing American slugs just as well as the most popular slug poison, metaldehyde.
Researchers found that tiny holes etched in silicon chips can move and align themselves with increased heat, leading to more energy-efficient configurations. This knowledge could help lead to smaller, more precise silicon chips for computers and other devices.
The report highlights the need for a universal paid leave policy and flexible scheduling to support working families. Employers and governments are urged to adopt holistic approaches to work-life integration, including joint planning and community initiatives.
A new paper predicts that silicon semiconductors can continue miniaturization for at least two decades, driven by clever engineering and nanotechnology innovations. The researchers identify the fundamental limits governing future miniaturization, including energy requirements and material constraints.
Research found that patients taking Reminyl experienced reduced time spent supervising and assisting daily activities, while caregivers reported a decrease in stress and an increase in independence. The medication may delay institutionalization and have a positive economic impact.
Researchers at UC Berkeley have discovered a single gene that can stimulate the immune system to reject a range of cancer tumors. The gene, which activates natural killer cells and other immune cells, shows promise as a potential basis for a vaccine therapy.
A study found that elderly individuals with low thyrotropin concentrations are at an increased risk of death from cardiovascular disease. The mortality rate doubled in the first five years of follow-up, and cardiovascular disease was up to three times more likely to occur.
Research in mice reveals that TAFII105 is a cell-type specific component of the transcription machinery, controlling egg formation and potentially linked to female infertility. The study provides new avenues for understanding the complex transcriptional mechanisms underlying cell-specific gene expression.
A recent study found that warmer water temperatures in Narragansett Bay result in 10-16% fewer winter flounder larvae surviving to the metamorphosis stage. The increase in temperature also affects the availability of food for higher-level organisms, leading to increased predation rates.
A new trial found that warming patients before short duration, clean surgery significantly reduced wound infection rates. The study compared warmed and non-warmed groups and found a substantial reduction in infections in the warmed group, with only 5% of patients developing wound infections.
Researchers propose a novel strategy for anti-angiogenic treatment by normalizing tumor blood vessels, improving drug delivery and reducing side effects. Clinical trials are planned to test the efficacy of this approach.
A gene similar to the human cancer-suppressing gene has been identified in a nematode worm, which protects against cancer-causing agents and extends life span under stress conditions. The discovery may lead to novel anti-cancer drugs and a better understanding of human longevity.
Researchers have found that a gene therapy technique can reduce alcohol consumption in rats by increasing dopamine receptor levels. This approach may offer a new potential treatment for human alcohol abuse.
Recruitment to breast cancer chemotherapy trials for women at high risk of the disease remains a concern in the UK. A recent study found that only 10% of eligible women opted for these trials, highlighting the need for increased recruitment efforts.
Researchers identify a consistent seismic pattern suggesting a recurrence time of 1,500-2,500 years for the 1356 Basel earthquake. This discovery could help safeguard infrastructure and fine-tune emergency procedures before a potential major earthquake strikes.
Research reveals US boys are reaching puberty earlier than in past years, with average ages of pubic hair growth and genital development being significantly lower. This could have implications for testicular cancer risk, sex education, and psychosocial challenges.
A population-based study found that women who experienced childhood abuse are two and a half times more likely to be depressed in adulthood. Women who reported both physical and sexual abuse were over three times more likely to be depressed.
Researchers used DNA-coated microchips to discover that flavopiridol works by broadly inhibiting messenger RNA molecules, which are responsible for carrying genetic information to cellular protein factories. This inhibition ultimately leads to a halt in the production of certain proteins, allowing normal cellular processes to continue.
The Lazarus Team has made predictions for the gravitational waves emitted during black hole mergers, allowing for the first-ever detections. These simulations will provide astronomers with a set of templates to recognize signals in noise from detectors and deduce the masses and distances of the holes.
Researchers used fMRI to analyze brain activity in people pondering moral dilemmas, finding that emotions play a significant role in shaping moral judgments. The study's results suggest that different areas of the brain are engaged depending on the level of personal involvement and emotional response.
Neurons use Eph receptors and ephrin ligands to guide nerve fiber growth and form connections in the developing brain, a process called axon pathfinding. This research may ultimately lead to understanding how to coax nerves to regrow and regenerate.
A UMass research team has developed a new technique for depositing copper films within tiny channels in silicon wafers, promising efficient fabrication of future generations of integrated circuits. The process uses carbon dioxide as a supercritical fluid, offering environmental benefits and the ability to create complex features.
Fossils from three different humans estimated to be about 175,000 years old show a stage of evolutionary development that led to the Neandertals. The jaw fragment reveals signs of reduced chewing force due to food preparation changes, suggesting extensive community support for individuals with difficulty caring for themselves.
A massive star's remnant is discovered in the Milky Way galaxy, moving at an incredible speed of 300,000 miles per hour. The black hole, called XTE J1118+480, was gravitationally ejected from a globular cluster and has consumed its companion star.
Researchers at Dana-Farber Cancer Institute have identified a crucial protein called PGC-1 that regulates glucose production in the liver. This breakthrough could lead to new treatments for diabetes by targeting this protein with future drugs.
Researchers have discovered that chemokine expression plays a crucial role in enhancing antibacterial immunity. This finding is significant for the development of novel therapeutic strategies against bacterial infections.
Researchers reexamine the process of reverse cholesterol transport, a critical mechanism for removing excess cholesterol from peripheral tissues. The study reveals that this process may have both protective and detrimental effects on cardiovascular health.
Researchers have discovered two distinct pathways leading to cell death in the diseased kidney, which could lead to new therapeutic targets for kidney disease. These findings provide a better understanding of kidney pathology and may enable the development of more effective treatments.
UT Southwestern Medical Center has acquired a custom-crafted cryo-electron microscope to propel its cell-research capabilities. The new technology enables the analysis of sub-cell structures at sites in the cell where processes take place, providing valuable insights into cellular biology and disease mechanisms.
Researchers are enrolling patients in a clinical trial to investigate the safety and tolerability of early antiretroviral therapy for recently infected HIV patients. The study aims to determine whether early intervention can reduce disease progression, viral mutations, and immune system damage.
A groundbreaking study has found that Avandia can prevent the development of Type 2 diabetes in patients with impaired glucose tolerance, a condition affecting millions worldwide. The results have provided proof of concept for a larger prospective study to establish the effectiveness of Avandia in preventing Type 2 diabetes.
A computerized tool called Prostogram offers about 66% accuracy in predicting five-year prognosis following brachytherapy treatment for early-stage prostate cancer. The nomogram is based on individual factors such as PSA levels, Gleason score, and disease stage.
Most adult patients with sore throats receive antibiotic prescriptions, despite antibiotics being effective in only 10% of cases. The study highlights the misuse of broad-spectrum antibiotics for viral infections, which can lead to resistance and harm.
A Mayo Clinic study found that patients with obstructive sleep apnea syndrome experienced a 24% rate of adverse postoperative outcomes compared to 9% without the condition. The study also revealed longer hospital stays and increased severity of upper airway obstructions in these patients.
A study published in Obesity Research found that bupropion, an antidepressant approved for depression and smoking cessation, is effective for long-term weight loss in obese women. Women who took bupropion combined with a 1,600-calorie diet lost significantly more weight than those on placebo, with sustained effects for up to two years.
Researchers argue that the cervix is a 'hot spot' for HIV infection and that physical barrier devices like the diaphragm could increase HIV prevention. The diaphragm's ability to block fluid transport may enhance the effectiveness of microbicides in killing HIV on contact.
Researchers found that a cooling vest improved MS patient symptoms by reducing muscle strength and fatigue, as well as balance. Nitric oxide levels decreased significantly in patients receiving active cooling.
A new study reveals that many Parkinson's patients are using alternative therapies, despite a lack of physician knowledge on the topic. The research found no correlation between disease severity and use of alternative therapies, suggesting that patients are seeking these treatments for other reasons.
Researchers found that death rates from brain cancer were close to expected levels for the general population, with no increased risk of lifetime or recent exposure. Socioeconomic factors played a role in increasing premature death risk, but not brain cancer risk.
A study of over 1200 Canadian manual workers found that moderate occupational solvent exposure was associated with a significant increase in low sperm counts. Painters, decorators, and builders were at the highest risk, while glycol ethers are suspected to be hazardous to male fertility
The von Liebig Center will provide mentorship and commercialization services to UCSD inventors, awarding pre-seed funds to assess new discovery potential. The center will also support academic courses preparing engineering students for entrepreneurial environments.
A clinical study using human fetal tissue transplants suggests that the procedure may be logistically feasible and procedurally safe for patients with syringomyelia cavities. The study's primary goal is to evaluate the safety of transplantation with respect to possible early complications and long-term consequences.
Researchers found that black swallowtail caterpillars fed on Bt corn pollen experienced significant growth rate reduction, varying up to three times smaller in distance from the crop. The discovery suggests sublethal effects of Bt corn pollen on non-target species and emphasizes the need for careful event selection by producers.
Dr. Greg Bossart, head of Marine Mammal Research and Conservation at HARBOR BRANCH Oceanographic Institution, led a team to transport four critically endangered Antillean manatees from Mexico to their final destination near Cancun for medical evaluation.
Researchers have successfully used gene therapy to reduce new blood vessel growth by up to 90% in mice with conditions similar to macular degeneration and diabetic retinopathy. Two genes, endostatin and pigment epithelium-derived factor (PEDF), were injected into the animals' eyes or tails to demonstrate the potential of gene therapy a...
Researchers discovered that adding crumb rubber to PCC improves durability and reduces thermal expansion, cracking, and brittleness. The technology has the potential to recycle all 5 million scrap tires produced annually in Arizona.
A study found that younger and more educated Parkinson's patients are more likely to use alternative treatments such as vitamins and acupuncture. These patients are also more likely to be married and have developed the disease at a younger age.
Researchers at the University of Wisconsin-Madison have made a breakthrough in gene transfer technology by inserting a jellyfish gene into rhesus monkey embryos, resulting in transgenic placentas that produce the desired protein. The study promises new insights into pathologies of pregnancy and has implications for human gene therapy.
A recent study has found that shift workers are more likely to experience abnormal heart rhythms, with the risk increasing with the number of night shifts worked. The study measured changes in premature ventricular complexes and heart rate variability among employees working day and night shifts.
Researchers have developed a system that generates a public key directly from a user's email address, eliminating the need for individuals to create and store their own public keys. This innovation simplifies online transactions by allowing users to securely share public keys without having to create or look up new ones.
Researchers have developed a new database security system that enables anyone with a computer connected to the Internet to provide database services. The system uses digital signatures and proofs to guarantee the authenticity of data entries, making it difficult to forge or falsify information.
Researchers at UGA have discovered an enzyme, GnT-V, that accelerates cancer invasion. Inhibiting this enzyme may slow cancer progression and even enable early detection through blood samples.