Researchers discovered a link between genes nardilysin and OGDHL, which are crucial for mitochondrial function, and progressive loss of neurological functions in humans. Mutations in these genes lead to neurodegeneration, characterized by the accumulation of cellular trash.
Scientists found that defects in ARID1A gene caused sensitivity to ATR inhibitors, potentially personalizing treatment for cancer patients. The research could lead to identifying patients who will benefit most from the new drugs.
A study by UMass Amherst researchers found that bisphenol S (BPS) exposure during pregnancy and lactation impaired maternal behavior in mice, including increased infanticide rates. The compound also affected brain regions sensitive to estrogen, leading to changes in nesting behavior and care of offspring.
Scientists develop rigorous new method for modeling the accretion disk that feeds the supermassive black hole at the center of the Milky Way galaxy. This approach replaces traditional formulas with a kinetic method to trace collisionless particles, improving understanding of plasma behavior and radiative efficiency.
A new study reveals that temperature is the primary driver of biodiversity, with warmer climates hosting more diverse ecosystems. The research, conducted at Mount Kilimanjaro, examined eight plant groups and 17 animal groups, finding a strong correlation between temperature and species diversity.
Researchers at Northwestern University's Auditory Neuroscience Laboratory have discovered a biological marker in the auditory system that can reliably diagnose concussions. The study found that children who suffered concussions had a distinct pattern in their brain activity when exposed to sound, which could be used to identify them.
Researchers found that temporarily blocking type I interferon can restore immune function and speed up viral suppression in HIV-infected mice. This approach may help eradicate HIV throughout the body when combined with antiretroviral therapy.
A team of researchers from Swansea University has made a breakthrough in reducing corrosion by developing a new method that outperforms existing products. The new coating lasts up to 12 times as long and is 20 times faster than current methods.
A new type of 'tag' on whales allows researchers to record data every second for hours, days, and weeks at a time, providing insights into whale ecology, behavior, and interactions with prey. The technology has turned whales into scientific partners to help understand ocean conditions and climate change.
Researchers at OIST have created a novel sensor that detects biomolecules more accurately than ever before, using the additional function of measuring mass. This allows for more confident encapsulation of disease-detecting biomolecules within microfluidic platforms.
Researchers discovered an obesity-linked protein FTO's role in leukemia cell growth, survival, and drug response. FTO modulates gene expression by altering RNA modification, leading to cancer-promoting effects.
Scientists have successfully built a device that allows a single electron to communicate with a photon, paving the way for more efficient quantum computing. This breakthrough enables quantum information to be transferred between electrons and photons, reducing noise and increasing performance.
Researchers at Stanford University School of Medicine found that a subgroup of glioblastoma patients with highly vascularized tumors benefited from anti-angiogenic therapies, living an average of one year longer than those without. The study highlights the importance of properly categorizing tumors to personalize treatment.
A recent study found that genes controlling sugar content and acid metabolism played a key role in the domestication of jujube, a popular Asian fruit tree. The research reveals how humans selected plants with desirable traits to create the perfect balance of sweetness and acidity.
Meeting the 1.5°C Paris Agreement target could significantly benefit fisheries, with potential fish catches increasing by more than three million tonnes per year for every degree Celsius decrease in global warming.
The study provides a detailed genome sequence of the gulf pipefish, which can be used as a reference for other labs to follow. The genome reveals genetic changes responsible for the evolution of unique features in the species, including its ability to gestate embryos.
A Geisinger-Regeneron genomics study found that Familial Hypercholesterolemia (FH) is more common than thought, with 1 in every 256 people carrying a disease-causing mutation. The study identified 35 mutations causing FH and found many patients were undertreated due to lack of genetic confirmation.
Scientists have identified interleukin-1α as the key event triggering allergic reactions to air pollution. The release of IL-1α leads to inflammation in the lungs and intensifies the immune response, suggesting a promising therapeutic target for respiratory illnesses associated with air pollution.
Researchers at Washington University in St. Louis accelerate immune response to tuberculosis in mice by activating dendritic cells, leading to near-sterilizing immunity levels. The study could lead to improved TB vaccines for humans, addressing the variable protection provided by current BCG vaccine.
Researchers at the University of Warwick have developed a two-pronged approach combining active screening and vector control, which could eliminate Gambian sleeping sickness in key regions of DRC within four years. Without this combined strategy, elimination might not occur until the 22nd century.
Tropical Storm Nock-ten strengthened from a tropical depression, with maximum sustained winds near 52 mph. The storm is forecast to intensify into a typhoon by Dec 24 and track through the Philippines on Dec 25-26.
A study found that women with a history of recovered acute kidney injury had an increased rate of preeclampsia and delivered infants earlier than those with normal kidney function. Infants born to these women were also at higher risk for small-for-gestational-age births.
A Baylor College of Medicine team discovered that disrupting the natural cycle of muscle fuel usage can lead to diabetes but also enhances exercise endurance. Mice with disrupted HDAC3 showed superior endurance by burning more lipids and less glucose.
A Rutgers University research project aims to integrate critical infrastructures into a unified smart city, making them resilient and sustainable. The goal is to encourage behavioral changes through psychological influence, reducing waste and mitigating environmental impacts.
A study published in The American Journal of Clinical Nutrition found that weight loss reduced psoriasis severity and improved quality of life among obese test subjects. The results, which showed a lasting effect, underscore the importance of weight loss as part of a broader treatment regimen for overweight patients with psoriasis.
Scientists at Dana-Farber Cancer Institute discovered that brain and heart tissues in young children are more prone to apoptosis, making them vulnerable to chemotherapy and radiation damage. This understanding may lead to new treatments to selectively block apoptosis in healthy tissues while maintaining sensitivity in cancer cells.
The UK's abortion care system is facing a crisis due to an outdated law and inadequate access, according to an expert. Women seeking abortions face challenges including inequitable access, lack of trained staff, stigmatization, and exceptionalism.
Researchers found a 4.2% increase in heart-related deaths during the Christmas period, with average age of cardiac death being 76.2 years. The study suggests that patients may hold back seeking medical care due to travel, geographic isolation, and emotional stress associated with holidays.
Scientists have measured mass insect migrations in UK skies, with up to 3.5 trillion insects migrating annually over southern England. The movements are comparable to significant oceanic migrations and provide essential ecological services, including pollination and predation of crop pests.
A study by Massachusetts General Hospital found that women with a history of acute kidney injury have a higher risk of adverse outcomes during pregnancy, including preeclampsia and preterm delivery. Despite normal kidney function before pregnancy, these women were more likely to develop complications.
Researchers at RIKEN create genetic knock-out rescue mice to study circadian timekeeping and identify key sites in the CRY1 gene that affect the duration of the circadian period. They find that specific mutations near the p-loop region influence phosphorylation levels, leading to longer or shorter circadian periods.
Researchers at Oregon State University developed a new method for sintering nanoparticles using intense pulsed light, enabling faster and more efficient production of advanced flexible electronics. The breakthrough allows for larger areas to be processed in seconds, reducing the need for high-temperature equipment.
Researchers at Wayne State University have made a groundbreaking discovery about B lymphocytes and their role in preventing preterm birth. The study found that these cells produce molecules to suppress uterine inflammation and premature birth, potentially leading to new therapeutic approaches.
A major clinical trial has found that adding bortezomib to a standard two-drug regimen significantly prolongs the time before multiple myeloma cancer returns, giving patients about another year of remission. The study also shows that patients who receive this combination therapy live an average of six years after initial treatment.
An experimental Ebola vaccine was highly protective against the deadly virus in a major trial in Guinea, showing no cases among those vaccinated within 10 days. The vaccine's efficacy also led to indirect protection through herd immunity in unvaccinated people, providing weight to early trial results.
Researchers at UT Southwestern Medical Center have discovered a receptor on the inner mitochondrial membrane plays a crucial role in guiding autophagosomes to damaged mitochondria for destruction. The process, called mitophagy, is essential for cellular health and preventing diseases like cancer and neurodegenerative disorders.
Researchers linked RBC size to oxygen delivery efficiency in extinct mammals and birds using fossilizable indicators. They found that these organisms had smaller RBCs and were likely better athletes than earlier terrestrial vertebrates.
Researchers at Osaka University discovered a new subgroup of monocytes called SatM, which may contribute to fibrosis. These cells showed characteristics that suggested they were hybrids of different immune cells and can be regulated by C/EBPβ.
Researchers have identified rare genetic variants linked to observable physiological characteristics in over 50,000 individuals. This approach has the potential to inform healthcare and prevent undiagnosed single-gene disorders like familial hypercholesterolemia.
Researchers at Brookhaven National Laboratory developed a way to efficiently create complex nanoscale structures by leveraging self-assembly and guided layering. The technique enables the creation of intricate 3D structures with internal channels or pockets, advancing nanotechnology for medicine, energy generation, and other applications.
Researchers designed a new diagnostic tool that measures gene activity in skin samples to predict disease progression of autoimmune diseases like systemic sclerosis. The test, called the SSc Skin Severity Score, can distinguish between patients who are improving and those who are not 12 months after treatment begins.
Researchers have found that ceratosaurian theropod dinosaurs had teeth as young juveniles that were gradually lost as they grew up. The discovery reveals a unique developmental process where the toothed jaws of juvenile individuals transition to a completely toothless beaked jaw in more mature individuals.
Scientists at InSilico Medicine developed a proof-of-concept AI model using Generative Adversarial Autoencoders (AAEs) to generate molecular fingerprints of cancer-killing molecules. The study demonstrates the potential for AI to accelerate pharmaceutical R&D and improve clinical trial success rates.
Tropical Cyclone Yvette's center of circulation has seen an increase in continuous rainfall area, with convective storms dropping rain at rates over 60 mm per hour. The storm's maximum sustained winds have reached up to 52 mph, with forecast predictions indicating landfall on Christmas Day.
A study found that over half of Brazilian women aged 18-39 avoided pregnancy due to the Zika epidemic. The authors urge the government to review reproductive health policies and improve access to safe and effective contraceptives.
Researchers developed a method for generating Leydig cells by directly converting adult skin cells into functional testosterone-producing cells. The approach successfully restored normal testosterone levels in male rodents with hypogonadism, offering a promising alternative to existing therapies.
Researchers have successfully filmed protein folding in three dimensions for the first time, enabling them to observe minute changes in protein structures during transformation. The technique, developed using Japan's XFEL facility, has significant implications for drug development and studying membrane transport proteins.
A team of researchers observed Hawaiian false killer whales removing fish from longline fishing gear for the first time, gaining insight into a behavior that has led to unsustainable entanglements. The study provides new information on the animals' behavior and may lead to the development of 'smart hooks' to reduce bycatch.
Children whose mothers smoked during pregnancy are more likely to show signs of kidney damage. Maternal smoking is linked to an increased risk of childhood proteinuria, a sign of reduced kidney function that can lead to chronic kidney disease and end-stage renal disease in adulthood.
Researchers at Tufts University have identified over 200 identifiable proteins within firefly nuptial gifts, including structural proteins, enzymes and anti-predator toxins that may influence female reproductive success and paternity rates
Researchers analyzed data from 3,473 adults with mental illnesses to identify key indicators of subsequent risk of becoming victims or perpetrators of violence. The study found that affective symptoms, such as anxiety and depression, were closely associated with both committing and being a victim of violence.
A team of researchers used mathematical models to study the emergence of treatment-resistant populations in bacteria and cancer cells. They found that biological redundancy can lead to bet-hedging, a mechanism that allows cells to survive even when faced with catastrophic environmental changes. The study suggests that traditional strat...
A TSRI study found that the Piezo2 protein plays a critical role in sensing lung expansion and regulating breathing. Researchers discovered that newborn mice lacking Piezo2 channel show severe respiratory distress, while adult mice with deleted channels inhale more air than normal.
Researchers created tools called disturbance observers using fractional calculus, which estimate and eliminate disturbances in systems. The new approach outperformed existing methods, particularly when combined to handle highly fluctuating disturbance signals.
A new study highlights the urgent need for global action to limit temperature increases to 1.5°C due to its critical role in preserving marine ecosystems and limiting species turnover for the fishing industry. The results show that exceeding this target could lead to a three-fold decline in marine biomass.
A genetic library of cowpea varieties is being developed to improve crop resilience and yield. The library, which contains 6,000 samples, will help crop scientists make informed decisions using genetic information.
Researchers have discovered that the RAGE receptor plays a key role in regulating inflammation through its binding to the leukotriene B4 receptor 1. This interaction modifies LTB4-BLT1 signaling, which modulates the inflammatory response.
Researchers found a balance between two genes, spns1 and atp6v0ca, that maintains normal cell function. Disrupting one gene can induce premature aging, while the other can suppress degradation, extending lifespan in zebrafish.
Tropical Depression 30W has formed over the Northwestern Pacific Ocean with strong thunderstorms and a concentrated area of cold cloud top temperatures. The storm is moving west-northwest at 9.2 mph and is expected to intensify into a typhoon by Dec. 24.
Scientists from the Niels Bohr Institute have identified a new way to control the production of important proteins that regulate the immune system. The discovery could provide a new opportunity to fight diseases such as cancer, Alzheimer's, and diabetes by controlling the cell's genetic response.