Pilot data shows that short sleep duration is associated with a double risk of hospital readmission in acute coronary syndrome patients. The study found that patients with less than 6 hours of sleep per night were two times more likely to be rehospitalized within 30 days.
Research published in the European Journal of Preventive Cardiology found that stressful jobs are associated with a higher risk of atrial fibrillation. The study included 13,200 participants and found that employees with stressful jobs were almost 50% more likely to develop the condition.
Researchers found ancient lake mud and fly species that record two interglacial periods in northwest Greenland, revealing warmer temperatures than previously thought. This discovery could improve climate models and predictions of how the ice sheet might respond to man-made global warming.
A new study suggests inadequate sleep has grave economic consequences, affecting over 33% of Australian adults and costing billions. The financial cost of $17.88 billion represents 1.55% of the country's GDP.
A recent study by a multi-institutional team identifies new linkages between quorum sensing activity and sugar metabolism in the gut, using AI-2 as an autoinducer secreted by various species of bacteria.
Researchers found that activating inflammatory signaling in heart cells can lead to abnormal electrical patterns similar to those observed in atrial fibrillation. This suggests a potential new target for therapies aiming to treat the condition.
Researchers at the University of Tsukuba and the University of Dayton discovered a novel gene, Newtic1, expressed in red blood cells that may contribute to adult newt limb regeneration. The study found that Newtic1-expressing erythrocytes play a crucial role in releasing growth factors into regenerating blood vessels.
Researchers have successfully replicated ovarian tumors inside chicken eggs, paving the way for patient-centred cancer treatment. The 'chicken egg tumour model' allows for rapid testing of anti-cancer drugs tailored to each patient's needs.
A study found that providing chocolate cookies to students improved their evaluation of teachers and teaching materials. This simple intervention had a significant effect on course evaluation results, suggesting that standardized tools like end-of-course evaluation surveys may not accurately measure the quality of education.
Researchers at North Carolina State University have created ChemMaps, a webserver that allows users to interactively navigate the chemical space of over 8,000 drugs and 47,000 environmental compounds in 3D. The platform features two main maps: DrugMap and EnvMap, which include approved drugs and environmental chemicals, respectively.
A study published in the Journal of the American Academy of Child and Adolescent Psychiatry found an association between preschool and school-age irritability and aberrant reward-related brain connectivity. This suggests possible mechanisms underlying mood dysregulation in youth with increased irritability during these developmental st...
Researchers at the University of Toronto found that vervet monkeys use heuristics to plan their routes when foraging for food, finding relatively short paths without much thought. This ability is similar to that of humans and highlights the cognitive abilities of these primates.
European countries showed no short-term aggravation of health inequalities following the 2008 financial crisis. In fact, mortality trends among low and high education levels remained steady in western European countries, while a decline in less-than-good self-assessed health accelerated in some eastern European nations.
Researchers developed a statistical approach combining astronomical theory and rock formation data to estimate Earth's axial precession rate and distance from the Moon. The study also reconstructed periods of astronomically influenced climate cycles, providing insights into ancient Solar System behavior.
A novel actuating material system, nickel hydroxide-oxyhydroxide, has been developed at HKU Engineering that can be triggered by visible light and electricity. This material can exert a force equivalent to 3000 times its own weight, making it suitable for various applications in micro-robotics, human assist devices, and medical devices.
A quality playground experience is crucial for elementary school children's physical, cognitive, social and emotional development. Researchers found that engaged adults, smooth transitions, and abundant play equipment are key factors in a high-quality recess experience.
The ILLUMINATE-204 trial shows an overall response rate of 38% with 2 complete responses, suggesting a promising strategy for treating patients with metastatic melanoma unresponsive to PD-1 therapy. The combination regimen is generally well-tolerated, with fewer than a quarter of patients experiencing immune-related toxicities.
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
Review papers explore how technology will change cardiovascular care, with artificial intelligence enhancing personalized medicine and digital health accelerating clinical research. Mobile health advances track physical activity and fitness, promoting heart-healthy habits.
Researchers used ESMD and BGSA to study temporal and spatial patterns of drought in the Yellow River basin. The results showed that drought frequency varied by season, with summer being the driest, and suggested targeted drought resistance measures for the region.
A study led by Drexel University's Amanda Lough has shown that East Antarctica is seismically active, contradicting the long-held assumption that its inactivity was caused by ice. The seismic array detected 27 earthquakes in 2009, tripling the total number of recorded events.
A survey of Russian teachers found that those using performance-based contracts are more satisfied with their finances and have greater trust in the system. However, excessive assessment procedures can reduce teaching time.
A recent study found that sleep paralysis and dream-like hallucinations are prevalent in student athletes, with 18% and 24% of the sample reporting occasional experiences. These symptoms were independently associated with symptoms of depression, even after controlling for sleep duration and quality.
Researchers at UCLA have developed a personalized glioblastoma vaccine that shows promise in increasing long-term survival. The vaccine, known as DCVax-L, has been shown to extend median survival time from 15-17 months to 23.1 months.
Researchers at the University of Illinois have developed an algorithm that combines high-resolution and high-frequency satellite data to produce continuous, daily images. This allows for near-real-time monitoring of various applications, including agriculture, urban development, environmental quality, and economic development.
A recent study found that virtually all of Madagascar's native predators are highly sensitive to the toxic bufadienolides secreted by invasive Asian toads. This could have a significant impact on the island's already threatened fauna, including iconic species like tenrecs and fossa.
A new study reveals that ultracold paired particles called fermions behave even weirder than expected, flying with unique trajectories carved by spins, momenta, and energies. The researchers predict that fermions can mimic the behavior of bosons, adding new weirdness to the already established particle-wave duality.
Researchers found that proxies who viewed a 12-minute advanced care planning video were more likely to have residents with advance directives indicating tube-feeding should be withheld. When proxies preferred comfort care, advance directives aligned with that preference.
Researchers found that T cells can establish and maintain HIV infection in the brain, suggesting a reservoir for future HIV cure approaches.
A new Canadian guideline recommends screening for hepatitis C virus (HCV) in people born between 1945 and 1975 due to high rates of infection. The guideline also advocates for curative therapy for all individuals affected by HCV, aiming to prevent premature death.
A Rutgers-led team has developed a new material that conducts electricity without energy loss, paving the way for low-power electronics and potentially faster quantum computing. The material, which combines magnetic and insulator properties, can be used for electronic interconnections within silicon chips.
The multicenter phase II trial assessed the safety and efficacy of lurbinectedin in different solid tumors, with an ORR of 39.3% seen in recurrent small-cell lung cancer patients. The median duration of response was 6.2 months and the median overall survival was 12 months.
Researchers discovered that aspirin blocks TIF-IA, a molecule essential for the nucleolus to function, driving tumour formation and dysfunction. Regular use of aspirin may help pinpoint those most likely to benefit from the treatment.
A comprehensive analysis of Medicaid expansion found significant improvements in various health outcomes, including increased insurance coverage among adults without a college degree, higher use of primary care and preventive services, and reduced reliance on emergency departments. The study also reported declines in short- and long-te...
Researchers observed radio waves to measure carbon monoxide gas in distant galaxies, revealing that stars born during intense starbursts are massive. The findings challenge classical ideas about star formation and galaxy evolution over cosmic time.
A new Collaborative Research Center will investigate complex interactions between platelets and inflammatory processes. The project aims to develop novel treatment concepts for diseases associated with platelet dysfunction, such as stroke and acute respiratory failure.
New research from Michigan State University suggests that abusive supervisors are motivated to repair relationships by engaging in more effective leader behaviors. This is driven by feelings of guilt and a desire to restore moral credit, which can lead to positive changes in workplace dynamics.
The study uses archaeological evidence and physics-based processes to describe how the islanders placed the hats on the statues. The researchers propose that workers would rotate, leverage, and pivot the hats onto the statue tops using small wooden levers.
A recent study by the American Academy of Sleep Medicine found that NFL teams perform better at night due to their circadian rhythms. The research revealed fewer turnovers and mental errors during late evening games compared to afternoon games, suggesting a significant impact of circadian timing on game-day statistics.
Updated phase 1 clinical trial results of crizotinib against MET-amplified non-small cell lung cancer show a 40 percent response rate and 6.7-month median progression-free survival. The study defines new criteria to define 'highly MET-amplified' cancer, suggesting that crizotinib may benefit more patients than previously thought.
The ALEX trial results show alectinib achieving a median progression-free survival of 34.8 months compared to 10.9 months for crizotinib in ALK-positive non-small cell lung cancer patients. Alectinib also demonstrated an improved overall response rate and fewer side effects than crizotinib.
A landmark study published in the New England Journal of Medicine found that most breast cancer patients with intermediate scores on a 21-gene test can safely avoid chemotherapy. The study's results have significant implications for doctors and patients, allowing for more personalized treatment options.
Research suggests that police officers on night shifts are more likely to receive public complaints due to elevated fatigue. Going to court during the day after a night shift further increases this risk, highlighting the need for duty schedules to consider court appearances.
Researchers at Kyoto University found that bonobos show a strong aversion to food contaminated with feces or soil, indicating an adaptive system of disgust. This instinctual response helps protect against parasites and pathogens in the environment.
A Phase II trial suggests that erdafitinib, an FGFR inhibitor, benefits patients with metastatic urothelial cancer harboring FGFR3 mutations. The therapy achieved a 40% overall response rate, including complete and partial responses, as well as stable disease in nearly half of patients.
A study published by the European Society of Anaesthesiology and Intensive Care found that taking aspirin before and after CABG surgery significantly reduced mortality risk. Patients who took aspirin had a 4-year mortality rate of 10.7%, compared to 16.2% in non-aspirin patients.
A new study found that hypnosedation is an effective alternative to general anesthesia for various surgeries, including breast cancer treatments, gynecological procedures, and superficial plastic surgeries. The technique reduces adverse effects, accelerates postoperative rehabilitation, and improves patient comfort.
A new journal paper highlights the limitations of economic models in assessing climate change impacts, particularly at moderate to high levels of warming. The authors argue that current models inadequately account for tipping points and uncertainties, leading to large discrepancies between scientific and economic estimates.
A study of 15,450 adult survivors of childhood cancer found that vigorous exercise reduces mortality risk. Regular physical activity is associated with a significant decrease in the risk of death among these patients., who have an elevated risk due to late cancer treatment effects.
Researchers at London School of Hygiene & Tropical Medicine identified six common categories of disgust related to infectious diseases, including infected wounds and poor hygiene. These findings could help target public health messaging and develop new methods to keep environments healthy.
A new Penn study finds that microRNAs in the blood can track responses to total sleep deprivation and predict individual differences in cognitive performance. The study identified 14 miRNAs reliably predicting behavioral attention performance, 7 for cognitive throughput, and 10 for memory performance.
The TAILORx trial found no benefit from chemotherapy for 70% of women with hormone receptor-positive, HER2-negative breast cancer. Treatment with hormone therapy alone after surgery was as effective as hormone therapy plus chemotherapy in reducing invasive disease-free survival and overall survival.
A new trial presented at ASCO18 shows that PET scans can improve treatment outcomes for esophageal cancer patients. Patients who responded to induction chemotherapy had a median overall survival of 46 months, while those who did not respond had a 27-month median survival, significantly better than previous studies.
The global burden of cancer has increased significantly over the past decade, with 17.2 million new cases and 8.9 million deaths reported in 2016. Cancer control planning and implementation are crucial to fulfill global commitments for cancer control and noncommunicable diseases.
The study found that matching targeted therapies to tumor-specific gene mutations improved progression-free and overall survival in patients with advanced disease. Receiving matched targeted therapy was also an independent factor for predicting longer overall survival.
Researchers at Dana-Farber Cancer Institute have developed a blood test that can detect early-stage lung cancer using genome sequencing. The test, which analyzes free-floating DNA in the blood, has shown promise in detecting lung cancer with a low rate of false positives.
A new fossil study reveals that tiny babies of ancient giant predators were also proficient killers, challenging current understanding of their evolution. The discovery sheds light on the rapid evolution of the first animals over half-a-billion years ago, with implications for Cambrian marine food webs.
The study reveals a universal increase in lifestyle-related cancers between 2006 and 2016, with significant disparities persisting between high- and low-Socio-demographic Index countries. Breast cancer is the leading cause of cancer death in women, while lung cancer tops the list for men, accounting for nearly 20% of global cancer deaths.
A phase 1 trial of ivosidenib against IDH1+ acute myeloid leukemia (AML) achieved an overall response rate of 41.9% and median progression-free survival of 8.2 months. Twenty-four percent of patients reached a complete response.
A Phase I trial shows ivosidenib, a protein inhibitor drug, is safe and effective for treating acute myeloid leukemia (AML) patients with IDH1 mutations. The study achieved an overall response rate of 41.6% and complete remission rates of 21.6%, with improved survival rates at 18 months compared to historical controls.