Researchers at Case Western Reserve University have developed an electrochemical CRISPR platform that can detect specific viruses, such as HPV and parvo, in a single droplet of blood. This innovative device has the potential to provide accurate results in under an hour, compared to existing tests which take three to five days.
A beetle preserved in mid-Cretaceous Burmese amber exhibits a suite of features suggesting its role as a pollinator, including curved body and fine hairs for holding pollen. The discovery deepens the history of insect pollination by around 50 million years, dating back at least to 99 million years ago.
Researchers have identified individual neurons in the entorhinal cortex that target specific memories during recall. These 'memory-trace cells' exhibit spatially tuned activity corresponding to remembered locations, suggesting a mechanism for selectively recalling past events.
Preliminary research suggests that higher levels of social support can reduce the negative effects of discrimination on heart health in transgender and gender non-conforming adults. The study found a link between lower levels of social support and increased rates of risky drinking and lower sleep duration.
Preliminary research suggests that weight-reduction surgery can help reduce the risk of stroke and death in obese patients. The study found that participants who underwent bariatric surgery were 69% less likely to experience a clot-caused stroke and 68% less likely to die during follow-up compared to those who did not receive surgery.
Researchers found that patients who stopped using meth experienced a 43% improvement in their heart's pumping ability, while those who continued to use the drug saw a 4% worsening. These findings suggest that addressing meth abuse can lead to significant improvements in heart failure treatment.
Research suggests that individuals with a specific gene variant are less likely to consume vegetables due to their intense bitterness. The study found that super-tasters, who perceive bitter tastes more strongly, tend to avoid certain heart-healthy vegetables.
Researchers found that humans' ability to recognize dog emotions is mainly acquired through age and experience, rather than being an evolutionarily selected trait. Participants who grew up in a cultural context with a positive attitude towards dogs were better at recognizing their emotions, regardless of whether they owned a dog themse...
Researchers found that larval fish in ocean surface slicks ingest prey-size plastics, which could impact their development and survival. The study highlights the importance of understanding complex gradients in plankton and larval fish abundance to protect these vulnerable life-history stages.
Researchers have developed a new way to measure white blood cell function, providing more accurate prognostic information for patients with sepsis. The technology assesses activation state and function of white blood cells from small blood samples, allowing for earlier diagnosis and treatment.
Researchers at the Niels Bohr Institute find that hurricanes have increased in size and destructive force, with a clear climate signal behind the trend. The new calculation method reveals a significant increase in the frequency of the most destructive hurricanes, which now rival those from the past century.
Scientists at ETH Zurich created quadrupole magnetic building blocks that can be assembled into any two-dimensional shape using attractive south and north poles. These modules have potential applications in soft robotics and could be used to create robots controlled by a magnetic field.
A study from 1900 to 2018 found that hurricanes have become more damaging over time. The researchers developed a method to compare the impact of hurricanes across centuries and found that storms with high land area destruction increased in frequency faster than moderately damaging storms.
Anemonefish have a unique visual system that allows them to detect ultraviolet (UV) light, which may aid in finding both friends and food. This specialisation in the eye enables them to distinguish colour and see UV light, making it easier to navigate their environment.
American adults on cholesterol-lowering medications have seen improved overall cholesterol levels since the 2013 ACC/AHA Cholesterol Guideline was implemented. This is largely attributed to a shift towards a risk-based approach over target LDL-based management.
Researchers found over a million variants of nucleic acid analogues, suggesting a vast unexplored universe of chemistry relevant to pharmacology and efforts to understand the origins of life. The molecules revealed by this study could be further modified to give hundreds of millions of potential pharmaceutical drug leads.
Researchers at Martin-Luther-Universität Halle-Wittenberg have developed new active ingredients that target the pyruvate kinase enzyme in pathogenic bacteria. These substances were shown to be effective against staphylococcus and MRSA, potentially offering a solution to the growing problem of antibiotic resistance.
Researchers propose MGES technology for long-term energy storage using mountains, filling a gap in the market for smaller locations. Sand or gravel is transported from bottom to top, storing potential energy, which can be reused and generates electricity.
The NIH invests significantly less money in cardiac arrest research than in other diseases, such as diabetes, stroke, and ischemic heart disease. The study suggests that low funding may be due to an inadequate number of grant applications being submitted to the NIH.
A US-led study found that anticoagulants for atrial fibrillation lose their effectiveness in older patients due to increased mortality from non-stroke causes. The study of nearly 15,000 AF patients aged 75+ found warfarin and apixaban were not beneficial after age 87 and 92, respectively.
Scientists at CSH Vienna create model to determine regional health care system's resilience in real-time, focusing on physicians' networks and patient flows. The model helps identify critical points where the system can absorb or compensate for lost doctors without collapse.
Researchers at McGill University have made significant strides in understanding the functioning of enzymes that produce antibiotics and therapeutics. The study found a surprising level of flexibility in the assembly line of nonribosomal peptide synthetases (NRPSs), which could lead to new therapeutic design possibilities.
A group of scientists from the Science for Nature and People Partnership (SNAPP) urge policymakers to take action on soil carbon despite ongoing debates. They highlight the importance of rebuilding soil carbon for environmental and agricultural benefits, such as sustainable agriculture systems and water quality.
Researchers found that first permanent molars carry life-long records of health information from the womb, storing vital data on Vitamin D intake and its impact on health. These 'living fossils' can provide clues connecting maternal health to a child's eventual fate.
Larval fish from various ocean habitats consume plastic, affecting development and survival. Surface slicks act as nursery habitats, concentrating planktonic prey and plastics.
Researchers at Wyss Institute develop 'eRapid' technology enabling low-cost, handheld electrochemical devices to detect a range of biomarkers with high sensitivity and selectivity. The platform overcomes biofouling problem with simple yet robust design, allowing mass-production of biochemical sensors at low cost.
Researchers found that northern tree species, including pine, birch, and spruce, release nitrous oxide into the atmosphere. The emissions vary by season, with peaks in summer, and are linked to physiological activity. The study suggests trees play a significant role in the global N2O balance.
A new study from the University of Bristol found a significant association between generalized anxiety disorder at age 18 and harmful drinking three years later. The research used data from the Children of the 90s cohort to investigate the relationship between anxiety, drinking motives, and alcohol use.
The American Society of Nephrology has announced the inaugural winners of its new Midcareer Awards. The awards recognize clinicians, researchers, and educators who have made substantial contributions to nephrology in areas such as clinical service, education, leadership, mentorship, and research.
Chemistry Professor Siegfried R. Waldvogel from Johannes Gutenberg University Mainz has received the 2020 Manuel M. Baizer Award, an international recognition of his pioneering work in electrochemistry and its applications. The award highlights Waldvogel's contributions to sustainable chemical product manufacturing through electrosynth...
Researchers found that using non-dominant hands activates both sides of the brain's motor pathway, suggesting a shared talent for tool use and language development. This discovery challenges traditional theories of human intelligence, which often emphasize dominant hand skills and linguistic abilities.
A combined test of Renal Angina Index (RAI) and urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) can predict severe acute kidney injury risk in critically ill children, according to a recent study. This early identification allows for targeted interventions to reduce morbidity and hospital stay duration.
A new study reveals that bariatric surgery can lead to successful weight loss and better diabetes control in older adults. After two years, the patients had lost an average of 24% of their body weight and seen a significant reduction in HbA1c levels. The study suggests that age alone should not be considered a contraindication to baria...
A study published in Scientific Reports has uncovered the role of FLC gene expression in regulating flowering time in B. rapa, a crucial trait for efficient cultivation under changing climate conditions. The research found that higher BrFLC gene expression is essential for inhibiting flowering in the absence of cold exposure.
Research suggests that impaired liver function during pregnancy can lead to altered gut bacteria composition in children, increasing the risk of obesity. Maintaining a healthy diet and targeting gut microbiome composition with pre-biotics or pro-biotics may help prevent childhood obesity.
A Rutgers study found that creating a sustainable neurosurgical program in Santarém, Brazil requires recruiting and training local doctors, who can navigate healthcare barriers with limited resources. The five-year residency program has improved conditions and access for patients.
A new study found that limited access to lupus lab tests in developing nations, particularly ANA tests, affects the usefulness of SLE diagnosis. The lack of testing, especially immunologic and hematologic studies, leads to discrepancies in diagnostic criteria adherence. The 2019 ACR/EULAR classification criteria performed better than o...
Annual spending on biologics in US public programs nearly doubled from 2012 to 2016 due to rising drug prices. Post-market price changes accounted for 56% of the five-year spending increase, with unit price hikes alone responsible for $1.7 billion of the growth.
A study found associations between environmental factors and organ-specific lupus flares, including temperature, ozone concentration, wind, humidity, PM2.5 concentration, and barometric pressure. The research suggests atmospheric changes may impact lupus clinical trial design and outcomes.
Researchers found ADA2 levels above normal limits strongly indicative of concomitant MAS in children with systemic JIA. The study establishes ADA2 as a valuable diagnostic marker to distinguish MAS from other forms of systemic inflammation.
Researchers found that using ultrasound to guide treatment strategy does not improve treatment decisions in patients with early rheumatoid arthritis. The study used MRI imaging to assess inflammatory activity and structural damage progression, but found no significant difference between the two groups.
A new study found that the live zoster vaccine is safe and effective in patients taking TNF inhibitors, with no cases of confirmed disseminated or local varicella infection. The researchers observed a very low risk of infection, with an upper bound confidence interval of approximately one percent.
A large cohort study found that children exposed to non-TNFi biologics or tofacitinib in utero experienced very few serious infections, with only two cases reported. The study provides the first data on infectious risk in offspring exposed to these drugs during pregnancy.
A new study published in JAMA found that patients with kidney dysfunction who were prescribed high doses of the muscle relaxant baclofen were more likely to experience cognitive-related symptoms such as severe confusion. The research team analyzed data from over 16,000 patients and found a significantly higher risk of hospitalization a...
A new study found that tocilizumab is more effective than rituximab in reducing disease activity in patients with rheumatoid arthritis who have low B-cell infiltration in their synovial tissue. Tocilizumab achieved significant improvements in both low levels and falls in disease activity, particularly in the B-cell poor patient subgroup.
Researchers found that methotrexate significantly reduced joint damage progression compared to placebo in patients with erosive hand osteoarthritis, while also facilitating bone remodeling. The study's findings suggest that treatment should be initiated earlier to have a positive effect on pain.
Researchers found small, statistically significant benefits on pain and function with opioids, but no impact on quality of life or depression for patients with osteoarthritis. Strong opioids had consistently worse pain relief benefits and a greater risk of adverse events compared to weak opioids.
Patients with Down syndrome arthropathy experience a 11.5-month delay in diagnosis from symptom onset, and optimal therapy remains unclear due to medication intolerance and ineffectiveness. The study aims to raise awareness and improve screening for this condition.
A study found that RA patients receiving immune checkpoint inhibitors for cancer experience flares, with a 50% rate. The researchers also noted that the rate of immune-related adverse events was comparable to those without autoimmune diseases.
Researchers found that hydroxychloroquine significantly reduces the recurrence rate of congenital heart block in subsequent pregnancies, regardless of health status. The study evaluated 74 mothers who had a previous child with congenital heart block and were exposed to HCQ during pregnancy.
An observational study of nearly 16,000 older adults with chronic kidney disease (CKD) found that higher doses of the muscle relaxant baclofen were associated with a greater risk of hospitalization due to encephalopathy. The study suggests that patients with CKD may need closer monitoring when prescribed baclofen.
Research found that SLE Medicaid patients have a double 30-day death rate after coronary revascularization compared to diabetes patients, highlighting the need for further investigation into cardiovascular disease and overall health status in SLE patients.
A new study finds that gadolinium-enhanced MRI is a useful tool in diagnosing polymyalgia rheumatica (PMR), with 76% sensitivity and 85% specificity. The test can also predict recurrence, with patients who developed recurrences having less enhancement of their rotator cuff tendon and more synovial hypertrophy findings.
A recent analysis found increasing rates of acute kidney injury in pregnant women, especially those with diabetes. The study revealed a significant increase in the rate of hospitalizations involving acute kidney injury from 0.04% in 2006 to 0.12% in 2015.
A study of 4,567 hemodialysis patients found that those in residential areas with a high percentage of Black residents had significantly higher hospitalization rates. The association remained after adjusting for individual and community factors, suggesting unidentified health determinants at play.
Children with JIA continue to have active arthritis despite available medications, highlighting a need for additional treatments. Researchers found that 52% of patients had ongoing active JIA despite treatment with two or more biologics.
Researchers found that psoriasis onset age determines whether arthritis starts first, with a 65-month delay for arthritis onset after psoriasis. Early-onset psoriasis is strongly associated with arthritis onset, suggesting a different subgroup of PsA patients.
A study found that children with Down syndrome are at an increased risk of developing inflammatory and erosive arthritis. Researchers estimate that around 20 per 1,000 children with Down syndrome have this condition.
The American Society of Nephrology has honored five individuals for their outstanding contributions to kidney disease research, education, and clinical practice. Mitchell Rosner received the Robert G. Narins Award for his work in education and teaching, while Toshiro Fujita was recognized for his groundbreaking research on hypertension.
A six-week treatment with low-dose oral prednisolone substantially improves pain and decreases signs of inflammation in patients with painful hand osteoarthritis. Substantial improvements in pain and function were seen, exceeding effects of currently available therapies.