A new paper in Cell Reports breaks down the details of how salivary glands collectively produce proteins found in saliva. The study identifies which proteins are produced by each type of gland and shows that individual cells within a single gland can secrete different proteins.
The study provides milestone data from six growth studies, revealing consistent growth trajectories among the studies. Researchers aim to develop prediction models for clinicians to optimize treatment timing and develop individualized predictions of future growth.
Scientists at St. Jude Children's Research Hospital have identified how metabolic signaling pathways influence key immune cells, including eTreg cells. Understanding this regulation may aid in developing more specific drugs to target these pathways and treat diseases such as lupus, rheumatoid arthritis, and cancer.
The university's comprehensive approach, including pooled testing, daily symptom monitoring, and quarantine measures, significantly lowered infection prevalence. Combined with high compliance with masking and social distancing guidelines, the strategy successfully minimized large outbreaks.
A new study by Åbo Akademi University found that weak math students feel more shame in high-performing classes, while stronger students feel bored. The so-called big-fish-little-pond effect affects feelings of pride and shame more among weaker students.
Research presented at American Heart Association Scientific Sessions 2020 found that Black and Hispanic patients are more likely to be hospitalized with COVID-19 than white patients. Nonwhite men with cardiovascular disease or risk factors also face a higher risk of death from COVID-19.
A study by UNC Charlotte researchers found that 85% of large pharmaceutical firms had financial penalties for illegal activities, with the top offenders including GlaxoSmithKline and Schering-Plough. The majority of penalties were related to pricing violations, off-label marketing, and kickbacks.
Researchers used genetic evidence to explain how different species of capuchino seedeaters acquired distinct patterns of coloration. Soft selective sweeps were found to be the primary cause of these differences, driven by changes in environment and sexual selection.
The December special issue of SLAS Discovery focuses on drug discovery efforts for COVID-19, including reviews on repurposing drugs and testing novel proteins necessary for virus replication. The issue also includes articles on the efficacy of existing treatments and potential off-label candidates.
The study suggests that tropical peatlands could reduce the impacts of the COVID-19 pandemic and the likelihood of new diseases jumping from animals to humans. Conservation efforts in these areas could mitigate zoonotic disease transmission, protect human health, and strengthen arguments for their conservation and restoration.
The article emphasizes the importance of conducting rigorous evaluation to ensure COVID-19 vaccine safety and efficacy. Historical experience with vaccine development informs regulatory practices, including pre-licensure monitoring for rare adverse events and post-licensure pauses if serious adverse events are detected.
A Northwestern University research team has uncovered new findings on the role of ionic interaction within graphene and water. The insights could inform the design of energy-efficient electrodes for batteries and provide backbone ionic materials for neuromorphic computing applications.
Researchers will analyze human tissue samples to determine genetic predispositions to liver side effects from antiviral drugs. The study aims to identify potential genetic factors and dosing recommendations for safer treatment.
A study published in Nature Medicine found that survivors of SARS-CoV-2 infection develop long-lasting immunity through memory T-cells, providing protection against re-infection. The research team's findings raise hopes for the development of effective vaccines.
A new toolkit developed by Brigham and Women's Hospital has significantly reduced falls and fall-related injuries among hospitalized patients. The toolkit, which engages patients and families in fall prevention strategies, was associated with a 15% reduction in falls and a 34% reduction in injurious falls.
Researchers developed a computer algorithm that captures traffic network topology to identify congestion hotspots. The algorithm suggests ways around congested areas in cities.
Researchers have used powerful seismic imaging techniques to study the Alaska coastline's volcanic activity, revealing unexpected details about tectonic plates and volcano distribution. The new research highlights complexities in subduction zones and how they control volcano formation.
A West Virginia University study suggests that local health departments are crucial in getting the hepatitis B vaccine to those who need it most, particularly individuals at risk of contracting the virus. The study found that partnerships between health departments and local drug treatment programs significantly increased vaccine compl...
Researchers have developed a thermoplastic resin for wind blades, enabling recyclability and reducing costs. The material can be melted and reused, decreasing the need for landfills.
A team of scientists from the University of Leeds has developed a new hydrogel to act as an alternative to saliva without additional lipid content. The formulation can also replicate lubricating properties in food products, providing a potential solution for dry mouth therapy and non-obesogenic nutritional technologies.
Researchers used advanced technology to study fish communities residing on two World War II shipwrecks off the North Carolina coast. The study found large predatory fish thriving on the wrecks, challenging current understanding of how they find such remote habitats.
A Rutgers study of 3,500 Americans found that those who purchased firearms during the pandemic were more likely to experience suicidal thoughts, with 70% reporting lifetime suicidal ideation. Unsafe firearm storage habits also increased the risk of suicide in homes with a firearm.
A novel diabetes medication, sotagliflozin, significantly reduces hospitalization for heart failure, heart attack, and stroke in patients with Type 2 diabetes and chronic kidney disease. The study found a 26% decrease in cardiovascular deaths and hospitalizations.
By expressing neuron-enriched mitochondrial proteins at an early stage, researchers achieved a four times higher conversion rate and increased the speed of reprogramming. This breakthrough may lead to developing reliable regenerative medicine therapies for brain diseases and injuries.
Research published in Journal of Banking and Finance found that stress tests reduce a bank's risk and increase lending capital, strengthening the entire banking industry. The study also found that investors perceive stress-tested banks as having a higher probability of earning expected gains.
A recent study published in Medical Cannabis and Cannabinoids found that CBD oils are equally or less effective than pure CBD at inhibiting the growth of certain cancer cells. The researchers tested different types of CBD oil against pure CBD on various cancer cell lines, including brain, skin, and colorectal cancers.
Researchers analyzed North Americans' foreign policy preferences, finding that coercive measures are more likely to be supported in highly personalized and consolidated autocracies without US ties. In contrast, foreign democracy aid is preferred in regimes with strategic or financial ties and multi-party elections.
A new study from the New England Aquarium improves species distribution models for predicting whale habitats by incorporating food availability, such as zooplankton. The prey-centric model suggests that protections are needed in areas where whales are currently found and may be migrating to due to climate change.
Researchers at the Stowers Institute for Medical Research identified tiny variations in an amino acid sequence critical to retaining ancestral gene function. The study found that small differences can lead to significant evolutionary changes and highlights the importance of studying protein sequences.
Researchers at Massachusetts General Hospital found a unique mechanism of protection against Vibrio cholerae, the bacterium that causes cholera. Human antibodies block the bacteria's motility, preventing it from causing disease. This breakthrough could lead to more effective vaccines for cholera, particularly in young children.
A new radar system developed by UC San Diego engineers can accurately predict object shapes and sizes in various weather conditions. The two-sensor setup improves imaging quality compared to traditional single-radar systems.
Scientists found that sex-specific differences in variability depend on individual physical and physiological features in mice, debunking theories about male or female variability. The study suggests including both males and females in studies, with statistical adjustments necessary to account for variation in traits among sexes.
The new ATS clinical practice guideline provides comprehensive guidance on long-term and ambulatory oxygen therapy for adults with COPD and ILD. The guideline recommends LTOT for severe chronic resting room air hypoxemia in both COPD and ILD patients, and suggests ambulatory oxygen for moderate exertional room air hypoxemia in COPD pat...
New research reveals significant racial disparities in murder victimisation rates, with Black people facing over five times the risk of White British people. Researchers call for more accurate crime data to inform policing strategies and promote fact-informed dialogue with communities.
Researchers found that migrants develop faster, produce offspring earlier, and die younger due to energy constraints. This could explain the decline of many migratory species as they may struggle to adapt to changes in habitats and climate.
A researcher at Binghamton University has received an NSF grant to study hidden messages in digital images. The project aims to create steganographic schemes with mathematical guarantees, providing users with provable assurance of security. This research contributes to the fields of steganalysis and digital forensics.
Researchers found that displaying PAE labels alongside the Healthier Choice Symbol reduced its effectiveness in encouraging consumers to buy healthier options. The Healthier Choice Symbol alone led to a 5% increase in purchasing healthier products, but combining it with PAE labels had little impact.
Researchers developed sustainable shotcrete mixes with improved durability, using granulated blast furnace slag and ultrafine limestone powder to increase resistance against sulphate attack. This reduces maintenance costs and extends tunnel lifespan, making shotcrete a more environmentally friendly material.
The University of Texas at Arlington and North Central Texas Council of Governments partner to assess regional opportunities for diverting food waste, increasing renewable energy production, and reducing vehicle emissions. The project aims to capture methane gas and produce biogas from anaerobic digestion infrastructure.
A new global study from the University of Sydney found evidence of undernutrition in countries worldwide, with optimal supplies changing with age. For early life, high fat and protein supplies minimize mortality, while later life reduces fat and increases carbohydrate intake leads to lowest mortality rates.
Researchers found that children who received antibiotics before age 2 were more likely to develop multiple illnesses or conditions later in childhood. These include allergic rhinitis, food allergies, attention deficit hyperactivity disorder, celiac disease, and atopic dermatitis.
A study of 286,825 participants found a significant association between permanent night shift work and moderate to severe asthma. The researchers suggest that adapting shift work schedules to individual chronotype may be a worthwhile public health measure.
New research from Florida State University finds that groups with diverse thinkers make quicker and better decisions than homogenous groups. Mathematical modeling reveals that impulsive individuals can quickly reveal correct options to others, leading to faster and more accurate collective decision-making.
Researchers at the National Eye Institute have decoded brain maps of human color perception, finding unique patterns of brain activity for each color. The study may have implications for the development of machine-brain interfaces for visual prosthetics.
A US study found a decline in water usage for most crops and livestock production due to climate change and shifts in consumer demand. Water use decreased by 8.3% for irrigation, but increased for oilseed crops driven by international supply-chain linkages.
Researchers found that actively speaking two languages contributes to cognitive reserve and delays the onset of symptoms associated with cognitive decline and dementia. Bilingual individuals had a lower risk of developing mild cognitive impairment, which is a preclinical phase of Alzheimer's disease.
A collaborative study led by researchers from the University of Nevada, Reno, found that meadows throughout the region are both gaining and losing carbon at high rates. Meadows with wetland plant communities and dense root mats were large net carbon sinks during the year measured.
Population-wide screening of 30-year-old women resulted in 75 fewer cancer cases per 100,000 women, with a gain of 288 quality-adjusted-life-years compared to 97 for women aged 45.
Scientists have discovered that glycine can form on the surface of icy dust grains in dark interstellar clouds, bypassing the need for energy. This finding challenges previous assumptions and suggests a more widespread formation of amino acids in space.
Researchers at St Petersburg State University have discovered a new mineral called petrovite with unique properties that make it promising for use in sodium ion batteries. The mineral's structural type is suitable for ionic conductivity, which could lead to the development of more efficient cathode materials.
Research reveals that many songbird parents displace nestlings too early, reducing the offspring's chances of survival. However, this behavior allows parents to minimize risks and increase their own likelihood of raising at least one offspring to independence.
A study by Advanced Conservation Strategies reveals that conditions exist for seafood mislabeling to lead to negative outcomes on marine populations. Researchers estimate that Americans consume between 420-550 million pounds of mislabeled seafood every year, with much of it coming from imported products.
A new medication, mavacamten, has been shown to reduce heart muscle thickness and improve cardiac structure and function in patients with hypertrophic cardiomyopathy. The study found significant reductions in heart mass and improvements in blood flow, exercise capacity, and markers of fibrosis.
A new study has identified fifty protein fragments, termed peptides, in the urine of patients with liver fibrosis, which could be used to develop a diagnostic urine test for the condition. The research team found that these peptides were accurately detected in 84.2% of liver fibrosis patients and 82.4% of those without the condition.
Researchers emphasize the positive impact of culture and arts on health, citing World Health Organization benefits like social influence, children's development, and mental health support. Integrating art into healthcare services can promote more ethical care and improve trust among staff.
This study uses sedimentary DNA to track the abundance of three major fish species over 300 years, providing a new tool for evaluating evolution and responses to climate changes. The results suggest that sedimentary DNA concentrations can reflect the abundance of aquatic species, enabling long-term monitoring efforts.
Researchers uncover fossil specimens of ancient walruses in Orange County, revealing five distinct species, including two new species without tusks. The study provides insights into the dental and tusk evolution of walruses, suggesting that feeding ecology played a key role in the origin and early evolution of tusks.
A team of researchers from The University of Tokyo used electron spectroscopy and computer simulations to study the internal atomic structure of aluminosilicate glass. They found intricate structures that have not yet been analyzed by scientists, including complex coordination networks among aluminum atoms within phase-separated regions.
A study by Cincinnati Children's Hospital Medical Center found that targeting the BCAP protein could help control overactive immune responses and promote tissue repair in inflammatory diseases. The researchers suggest that modulating BCAP activity could be used to dampen inflammation and accelerate response against tumors.
Baikal seals have evolved to consume an abundance of amphipods due to their specialized teeth and foraging strategy. This study reveals the seals' high foraging rates make tiny endemic amphipods a profitable component of their diet.