Researchers have discovered that ovarian cancer begins with cancerous lesions in the fallopian tube linings of women with BRCA-1 mutations. The study's findings hold promise for predicting which women will develop ovarian cancer years or decades in advance, allowing for early detection and prevention strategies.
The study found that the prevalence of serious hearing loss declined by 2.5% among older Americans between 2008 and 2017. Notably, females experienced a significant decline in serious hearing loss, with a 10% decrease in odds of serious hearing loss observed across all age cohorts.
Researchers found that the fetus uses a signal called IGF2 to control nutrient supply from the placenta. The team discovered that only the paternal copy of the IGF2 gene is active, while the maternal copy inactivates it.
A new study reveals that children globally will confront peers when rules are broken, but their approach differs across cultures. Children from rural areas tend to use verbal protests more than urban kids, who may rely on indirect methods like reputation to enforce compliance.
A study at the University of Helsinki found that the APOE4 allele may increase cerebral microhaemorrhages and mental fatigue in COVID-19 patients. The risk of developing severe COVID-19 more than doubled in carriers of this allele.
A clinical trial will harness synthetic chimeric antigen receptor (CAR) T cells to deplete immune B cells and plasma cells producing donor-specific antibodies, aiming to achieve a compatible kidney match for patients with pre-existing antibodies. The NIH-funded study, led by Penn Medicine, intends to begin enrolling patients in 2022.
Researchers developed OptoMYPT, an optogenetic tool that reduces actin and myosin-based contractile force. By applying blue light, they accelerated cell cleavage furrow ingression speed and disrupted cortical tension, revealing the importance of optimal forces for normal cell division.
Scientists successfully extracted DNA from sediment blocks stored up to 40 years ago, providing access to a vast untapped repository of genetic information. The study reveals that specific sediment features are more conducive to ancient DNA preservation than others.
A study published in Science Advances found that high-sucrose diets contribute to brain angiopathy with impaired glucose uptake, leading to psychosis-related higher brain dysfunctions in mice. The researchers created a novel mouse model exhibiting mental disorder-like symptoms after excessive sugar intake at puberty.
A team of international researchers, led by Jenny McGuire from Georgia Tech, aims to understand the long-term relationships between animals, their traits, and environmental changes. The project will use the late Cenozoic fossil record in Africa to forecast future changes and inform conservation biology decisions.
Oceanographers replaced ship-based studies with sensors attached to seals to navigate icy waters, revealing seasonally varying water flows and their impact on biological production. The study found that warm, low-salinity water appears during autumn, positively affecting seal foraging behavior and potentially enhancing prey availability.
Scientists developed a breakthrough fabrication process for microneedle arrays capable of administering protein-based drugs without damaging the skin. The microneedles offer several advantages, including being painless and easy to dispose of.
A new combination therapy using rifampicin and resveratrol administered intranasally has shown to improve cognitive function in mouse models of Alzheimer's disease, frontotemporal dementia, and Lewy bodies. The treatment effectively reduces oligomer accumulation and restores brain-derived neurotrophic factor expression.
The American Academy of Neurology has issued a guideline on oral and topical treatments for painful diabetic neuropathy, updating the 2011 AAN guideline. The guideline recommends several drug classes, including tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, gabapentinoids, and sodium channel blockers.
Researchers developed a simple synthesis method for Co nanoparticles using melted imidazole as solvent, improving activity and stability. The synthesized material simulates the function of natural NADH oxidase, consuming NADH in cancer cells to induce oxidative damage.
Researchers developed a new hand gesture recognition algorithm that surpasses current methods in accuracy, complexity, and applicability. The algorithm combines adaptive hand type classification and a shortcut feature for efficient real-time recognition.
A new study reveals that the superior colliculus, a lesser-studied region responsible for saccades and facial recognition, dynamically changes its clustering of neurons depending on the mouse's conscious state. This finding suggests that the brain optimizes visual information processing based on its awake or anesthetized state.
A recent study published in CJASN found that patients who undergo retransplantation after a failed first kidney transplant have a longer average survival time compared to those on dialysis. The study analyzed data from 2,346 adults and showed that retransplantation resulted in an additional 5.8 months of life expectancy.
A study by researchers at JAIST found that adding score-based incentives for quick answers led to higher learning gains, while varying difficulty levels boosted the thrill factor. Gamification strategies improved classroom activity, but exceeded a certain threshold, students felt disengaged.
Researchers discover a chromatin degrader that blocks cancer-causing genes, offering potential treatment for over 90% of prostate cancers. The study found that blocking the SWI/SNF complex slowed cancer cell growth and induced cell death, especially in tumors driven by FOXA1 or androgen receptor.
Researchers have created nanoparticles that can store hydrogen, reducing the need for pressurized tanks and cooling. The discovery could enable climate-friendly fuels and production methods for airplanes, ships, and steel.
Researchers at Penn Medicine have developed a structural blueprint for nanoparticles that can target and deliver treatment to white blood cells, such as neutrophils, that contribute to acute lung inflammation. The findings represent a significant step in understanding the condition and function of the immune system.
Scientists have observed that ionizing radiation can cause intermolecular Coulombic decay in organic molecules, leading to damage in DNA and proteins. This new understanding could lead to the development of more effective substances for radiation therapy and improve knowledge of how radiation damages healthy tissue.
Per capita morphine milligram equivalents (MME) volume declined most in metropolitan counties and counties with higher fatal opioid overdoses. Clinical specialties showed significant declines, except for some states' counties with both increases and decreases.
Researchers identified antibodies targeting conserved sites on the spike protein, showing promise against future variants. Antibodies from vaccinated individuals retained some activity, while those with prior infection had reduced effectiveness.
Researchers found scarring in COVID-19 patients' kidneys, which may lead to long-term kidney outcomes. The virus directly causes cell damage, independent of the immune system, according to a new study published in Cell Stem Cell.
Researchers have discovered that individuals with a specific HLA type can mount a strong killer T cell response to COVID-19 due to cross-reactivity with seasonal coronaviruses. This finding may lead to the development of new vaccines targeting this immune response.
A team developed a new optical imaging method that can quantify optical properties of strongly turbid media at high-speed (e.g., kHz) capabilities. The halftone spatial frequency domain imaging technique projects sinusoidal light patterns onto the sample and collects reflectance images, increasing the measurement speed by approximately...
Researchers have proposed a new method for controlling the polarization of cylindrical vector beams (CVBs) using a metal-dielectric-metal metasurface. This enables independent modulation of the left- and right-handed circularly polarized components, allowing for efficient multiplexing and demultiplexing of CVBs.
Scientists observe increased ring-like fringes with higher optical-path-difference, outperforming equal-inclination interference. The ASD interference exhibits improved sensitivity and accuracy for measuring small displacements and refractive index changes.
Recent advancements in machine learning and neural networks enable real-time computer-generated holograms, overcoming data transmission challenges. Larger spatial light modulators and improved rendering hardware are also bringing holographic projection systems closer to consumer market.
Researchers developed a new fluorescence lifetime imaging (FLIM) technique to study DNA compaction and gene activities in live cells. The method enables fine measurements of DNA compaction, revealing differences in compaction between gene-rich and gene-poor chromatin domains.
A study by Kanazawa University researchers found that the chemokine CCL3 plays a significant role in inducing inflammation as nonalcoholic fatty liver disease develops. The presence of CCL3 increased liver macrophage accumulation, leading to liver inflammation and scarring.
Researchers discover that lipid droplets can be used as endogenous intracellular microlenses to enhance fluorescence imaging in living cells. This technique reduces the required excitation power by up to 73% and enables efficient detection of fluorescent signals from extracellular environments.
Researchers have developed a new laser speckle imaging technique that can monitor blood flow velocity in thick tissue without the need for surgical windows or optical clearing. This non-invasive method uses transmission detection to improve signal-to-background ratio and enables individual-vessel resolution in human subjects.
NAU astronomers, planetary astronomers and their students will conduct experiments using the JWST to expand their research and advance our understanding of the solar system. The telescope's advanced suite of instruments will explore planets, stars, nebulae, galaxies and beyond.
A new smart probe has been developed to enhance tumor photoacoustic imaging using a cathepsin B biomarker. The probe shows a 4.9-fold PA signal enhancement in cancer cells and tumors compared to unmodified probes.
A study of fully vaccinated patients with cancer who experienced breakthrough COVID-19 found a 13% mortality rate. Fully vaccinated patients were at high risk for hospitalization and death, even after receiving booster vaccines.
A research team from USTC has constructed a theoretical framework and thinking mechanism model to help students solve bound and scattering state problems in quantum mechanics. The study found three key nodes of difficulty: recognizing Schrodinger equations, selecting energy constants, and using superposition forms.
An international team of scientists proposes a global network to monitor hazards threatening Earth's ecosystems and human activities. The International Meridian Circle Program aims to track space weather events, geomagnetic field changes, and atmospheric disturbances using a diverse range of instruments.
Researchers used an SIR model to show COVID-19 convergence in Japan, with growth rates initially high then decreasing as cumulative infected people increase. The study aims to control infections and mitigate economic impact through risk management.
Research finds GNAO1 expression affects calcium ion regulation in cardiomyocytes, leading to cardiac dysfunction and heart failure progression. Suppression of GNAO1 improves pathology in multiple mouse models.
Researchers found that CBD shrinks glioblastoma tumors by reducing inflammation and restoring immune balance. The compound also suppresses key proteins involved in tumor growth and spread, making it a potential novel adjunct therapy for glioblastoma patients.
Scientists identify a new site of vulnerability on the influenza virus called the anchor, which has potential to recognize broad variety of flu strains. The discovery paves way for rational vaccine design and could lead to improved universal flu vaccines.
A team of researchers found a connection between energy production and Alzheimer's disease in zebrafish with mutated genes. They discovered that Alzheimer's disease affects the use of oxygen within cells to produce energy, leading to severe deficiency in brain function.
Over 30,000 farms worldwide participate in On-Farm Experimentation (OFE), fostering locally-relevant knowledge and innovation. OFE's six guiding principles prioritize pragmatic collaboration between farmers, researchers, and industry partners to create directly applicable knowledge.
Researchers identify a previously overlooked site on the HA protein, known as the 'anchor epitope', which can neutralize a wide range of influenza strains. This discovery has significant implications for the development of universal influenza vaccines and antibody therapies.
Researchers found that fibrin buildup triggers an overactive immune response, damaging gums and underlying bone. Suppressing abnormal fibrin activity could hold promise for preventing or treating periodontal disease.
A new study found that infection-fighting B cells retain better memory of the coronavirus spike protein in patients who recover from less-severe cases of COVID-19 than those recovering from severe cases. This hints at subtle differences in the quality of immune response based on COVID-19 severity.
A phase 3 trial has shown that one dose of the Ad5-nCoV COVID-19 vaccine is highly effective against severe disease, with an efficacy rate of 91.7% at 28 days post-vaccination. The vaccine has also been found to be safe, with no serious vaccine-related adverse events or deaths reported among trial participants.
Researchers have made significant breakthroughs in understanding the human gut microbiome by focusing on bacterial strains rather than species. By using a new computational method, scientists can analyze the strains of bacteria present in a microbiome sample more quickly and affordably.
Researchers at the University of Bonn have developed a new method to introduce heavy hydrogen isotopes into drugs, potentially making them more effective. The technique involves the use of epoxides and a titanium-based catalyst, allowing for precise control over the placement of deuterium atoms.
Scientists have created a new tool that monitors the electrical activity inside individual heart cells using tiny 'pop-up' sensors. The device directly measures signal movement and speed within single heart cells and between multiple cells, offering potential breakthroughs in diagnosing arrhythmia and cardiac fibrosis.
Researchers create new method to genetically analyze resting CD4+ T cells, allowing targeted modifications and insights into HIV interaction. This enables the investigation of cellular factors playing a role in infection and the development of new therapeutic approaches for eliminating HIV from the body.
A UTEP research team found SARS-CoV-2 neutralizing antibodies in over a third of Texas deer blood samples, indicating widespread infection among white-tailed deer. The study suggests that deer should not be neglected as a possible source of human infection.
A study by Ann & Robert H Lurie Children's Hospital of Chicago found that cochlear implantation can improve language skills and social engagement in deaf children with autism spectrum disorder. The study reported improved outcomes in 86% of children, including enhanced communication and interaction with families.
A new study found that high dietary fiber intake and no probiotic use are associated with better disease non-progression among melanoma patients on ICB therapy. The results support the idea that a high-fiber diet may be crucial for anti-tumor immunity.
Researchers at Michigan State University's National Superconducting Cyclotron Laboratory have created the world's lightest version of magnesium, a highly unstable isotope that can help scientists better understand how atoms are made. This breakthrough is part of a larger effort to refine theories and models that explain the formation o...
Researchers from Australia, China, Japan and Russia successfully created a tiny transistor 25,000 times smaller than a human hair using an electron microscope. The innovation demonstrates the ability to control the electronic properties of individual carbon nanotubes, opening up new possibilities for the development of tiny transistors.
Kids consider track record of accuracy and degree of access to knowledge when judging a communicator's trustworthiness. Children who received accurate non-verbal cues in the familiarization phase followed them in the test phase 83% of the time.